ライフサイエンスコーパス: artificial cell

1 d integration of phospholipid synthesis into artificial cells.

2 ems which are difficult to reconstitute into artificial cells.

3 mimetic chemistry serves the development of artificial cells.

4 autonomous memory transactions in DNA-based artificial cells.

5 nimal triggers of topological transitions in artificial cells.

6 tackle the bottom-up assembly of autonomous artificial cells.

7 could be tailored for memory transactions in artificial cells.

8 , at single vesicles further used to develop artificial cells.

9 y of types of cellular machinery in in vitro artificial cells.

10 of cell-mimetic biosensors, bioreactors, and artificial cells.

11 nced drug delivery vehicles, bioreactors and artificial cells.

12 ields ranging from targeted drug delivery to artificial cells.

13 s/oil/aqueous) to prototype mechanosensitive artificial cells.

14 processing with low-power consumption inside artificial cells.

15 ons of synthetic reaction systems, including artificial cells.

16 selection of restriction endonucleases using artificial cells.

17 Artificial cells (ACs) offer a powerful platform to repr

18 unaddressed in the bottom-up construction of artificial cells (ACs).

19 The resulting artificial cells act as microreactors for enzymatic reac

20 d by oxidative stress, lipid scrambling, and artificial cell aging modulate the cell response to the

21 c biology, vesicles define the boundaries of artificial cells and are increasingly being used as bioc

22 used to develop novel bioreactors, primitive artificial cells and plausible pathways to prebiotic org

23 r opens up new routes for lipid synthesis in artificial cells and sheds light on the origin and evolu

24 could transform the development of lifelike artificial cells and unlock new ways to explore lipid fu

25 cluding drug delivery, membrane bioreactors, artificial cells, and biosensors.

26 ications, including biosensing, constructing artificial cells, and engineering biological batteries.

27 s, which hold great promise as components in artificial cells, and in synthetic biology more widely.

28 ssays useful for drug delivery, for building artificial cells, and in synthetic biology.

29 ibuted system of on-chip DNA compartments as artificial cells, and measured reaction-diffusion dynami

30 lated droplet interface bilayers (eDIBs), or artificial cells, and the bioluminescence tracked in rea

31 tial and temporal behavior of assemblies of "artificial cells," and allows us to design a rich variet

32 tic cells, ranging from simple protocells to artificial cells approaching the complexity of bacteria,

33 Artificial cells are biomimetic microstructures that mim

34 Artificial cells are biomimetic structures formed from m

35 The artificial cells are generated in the form of a water-in

36 and comprehensive analysis of droplet-based artificial cells are still rare.

37 o cell-like containments aiming to assemble "artificial cells" are addressed.

38 omes offers an exceptional platform to build artificial cells as exemplified by the in vitro transcri

39 ogram and operate increasingly sophisticated artificial cells as life-like materials.

40 Here, artificial cells (as opposed to bacterial cells themselv

41 ted from the numerical model, we designed an artificial cell based on an optimized selection of condu

42 , we have also discussed the construction of artificial cells based on biomimetic materials, from sim

43 ne-based materials with applications such as artificial cells, biosensors, and therapeutic nanopartic

44 a step forward in the bottom-up creation of artificial cells, building analogous intracellular archi

45 y activated and deactivated in the levitated artificial cell by the application of acoustic and magne

46 It seems natural to ask if artificial cells can be built to use ion transport as ef

47 these systems in synthetic membranes to form artificial cells can reintroduce features of the cellula

48 However, it is clear that artificial cells cannot currently match the power and be

49 uggests a potential route to the assembly of artificial cells capable of evolution.

50 The assembly of artificial cells capable of executing synthetic DNA prog

51 -scale-integration of genetically programmed artificial cells capable of exhibiting collective expres

52 Building autonomous artificial cells capable of homeostasis requires regulat

53 al DNA compartments fabricated in silicon as artificial cells capable of metabolism, programmable pro

54 Bottom-up synthetic biology aims to engineer artificial cells capable of responsive behaviors by usin

55 er through cannabinoid CB(1) receptors in an artificial cell-cell communication assay that was develo

56 in eukaryotes, we developed and analyzed two artificial cell-cell communication systems in yeast.

57 ht become useful components for constructing artificial cell-cell communication systems that program

58 uses a common metabolite to achieve tunable artificial cell-cell communication.

59 el systems are becoming increasingly used as artificial cell chassis and as biomimetic constructs for

60 the development of small-scale, bio-inspired artificial cell components that recreate the function of

61 otein (red dots, see scheme) is expressed in artificial cells composed of biocompatible polymersomes,

62 the fabrication of microfluidic devices for artificial cell construction in bottom-up synthetic biol

63 ed on the efforts of bottom-up strategies in artificial cell construction.

64 non-equilibrium processes in communities of artificial cells could provide a step to life-like syste

65 -level QC workflow enables identification of artificial cells created not only by staining or imaging

66 microfluidic device to mechanically activate artificial cells creates new opportunities in force-acti

67 orts to create advanced cell mimics, namely, artificial cells, demands strategies for constructing si

68 the critical bottlenecks in the synthesis of artificial cell, depends on the properties of phospholip

69 tions for nanobiotechnology applications and artificial cell design.

70 Artificial cells designed for specific applications comb

71 Artificial cell development ultimately aims to produce m

72 hydrogels can be leveraged in the context of artificial cell development.

73 The artificial cells expand the senses of Escherichia coli b

74 storage or detoxification) organelles or as artificial cell factories for in situ biocatalysis.

75 The construction of artificial cells from inanimate molecular building block

76 The attractions of engineering artificial cells from scratch, as opposed to re-engineer

77 uce a platform for constructing membraneless artificial cells from the self-assembly of synthetic DNA

78 that it may be possible to construct simple artificial cells from two subsystems: a self-replicating

79 en substantial efforts aimed at constructing artificial cells from various molecular components with

80 occurs in polyploid hepatocytes generated by artificial cell fusion.

81 ology and bionic technology, the research of artificial cells has gradually become a subclass.

82 scale biological inspiration in the field of artificial cells has great potential for successes in th

83 The development of artificial cells has led to fundamental insights into th

84 uli-responsive elements compartmentalized in artificial cells has potential applications in therapeut

85 zing decision-making with a few molecules in artificial cells has remained a challenge.

86 Artificial cells have generated much interest since the

87 d cell models to decipher the rules of life, artificial cells have the potential to be designed as mi

88 ral living matter and work toward rebuilding artificial cells in vitro.

89 t, we apply this platform to build DNA-based artificial cells in which a prototypical nucleus synthes

90 Parallel efforts to construct more complex artificial cells, incorporating translational machinery

91 compartments, abiogenesis, and the design of artificial cell-inspired systems are considered.

92 sion system with a 30 x 30 square lattice of artificial cells interconnected by thin capillaries for

93 sults highlight a new strategy for designing artificial cell interfaces that can nondestructively pen

94 n polymerizes in the vesicles and alters the artificial cells' internal structure by creating interna

95 The problem of a self-replicating artificial cell is a long-lasting goal that might imply

96 A common method of generating artificial cells is to encapsulate protein expression sy

97 Artificial cell-like communities participate in diverse

98 paving the way towards rudimentary forms of artificial cell-like entities (protocells).

99 ms of collective behaviour in communities of artificial cell-like entities (synthetic protocells).

100 ad to new types of chemical bio-reactors and artificial cell-like entities, and bring new insights co

101 Coacervation creates an artificial cell-like environment in which the rate of mR

102 s atomic scale observation, we have built an artificial cell-like environment with nano-scale enginee

103 porters enable control over catalysis inside artificial cell-like systems, which could form the basis

104 has been restricted in higher eukaryotes to artificial cell lines and reporter genes.

105 R signaling is traditionally investigated in artificial cell lines which do not provide sufficient ph

106 ollowing transplantation in vivo arises from artificial cell manipulations ex vivo.

107 trast, the growth of tumor cells grown on an artificial cell matrix (Matrigel) was unaffected by deco

108 lar and extracellular environments across an artificial cell membrane construct.

109 he detection of gadolinium spin labels in an artificial cell membrane under ambient conditions using

110 ated into supported lipid bilayers (SLBs, an artificial cell membrane), which in turn were interfaced

111 ements of the interactions between SERMs and artificial cell membranes and independent observations o

112 cles through the integration of bio-inspired artificial cell membranes and naturally derived cell mem

113 Upon light or temperature stimulation, artificial cell membranes are activated, releasing signa

114 network that generates and maintains dynamic artificial cell membranes.

115 the bottom-up construction of hydrogel-based artificial cell microsystems which replicate fundamental

116 art materials, autonomous micromachinery and artificial cell-mimics.

117 e observations were collected in vitro using artificial cell models transfected with cloned receptors

118 ug delivery of proteins, and the creation of artificial cell networks.

119 drug/gene/protein delivery, biosensors, and artificial cells often requires the combination of lipid

120 with a 2D layout of 1024 DNA compartments as artificial cells on a 5 x 5 mm(2) area.

121 hetic lipid membranes as key constituents of artificial cells or to develop new tools for remodeling

122 rmacologic agents, recombinant proteins, and artificial cell-permeable proteins have been developed t

123 nd provide a step towards the development of artificial cell platforms capable of multiple operations

124 d sensors and establishes the feasibility of artificial cell platforms to detect environmentally rele

125 escribes the state and the development of an artificial cell project.

126 Typically, artificial cells rely on a bilayer membrane chassis and

127 The bottom-up engineering of artificial cells requires a reconfigurable cytoskeleton

128 way for solid-liquid interaction studies in artificial cell research.

129 volves a mechano-transduction axis including artificial cell rigidity, pseudopodia, and macrophage in

130 tworks is a crucial step towards engineering artificial cell-scale devices and systems.

131 We describe artificial cells, selected current applications and how

132 gohistidine affinity tags, we synthesized an artificial cell surface receptor comprising an N-alkyl d

133 ng membrane transport mechanisms relevant to artificial cell systems and drug screening.

134 ein and protein-nucleic acid interactions in artificial cell systems comprising water-in-oil emulsion

135 Whereas initial studies were performed in artificial cell systems, recent publications are shiftin

136 on/translation for applications of DIB-based artificial cell systems.

137 mploying receptor/arrestin overexpression in artificial cell systems.

138 broader engineering biology applications in artificial cell technologies.

139 sible to design and construct communities of artificial cells that can perform different tasks relate

140 We suggest methods for producing these artificial cells that could potentially be used to power

141 As such, engineering artificial cells that possess this behavior has been at

142 tic polymers to construct advanced biohybrid artificial cells that provide insights into phase segreg

143 and remaining challenges in the synthesis of artificial cells, the possibility of creating new forms

144 Engineering mechanosensitive artificial cell through bottom-up in vitro reconstitutio

145 as a response of our mechanically activated artificial cell through thinning of oil.

146 sins can be used for genetically programming artificial cells to display interacting peptide pairs, e

147 e incorporated within the next generation of artificial cells to engineer improved biological mimics

148 : is it possible to interface biological and artificial cells together to create hybrid living/synthe

149 We propose CITE-sort, an artificial-cell-type aware surface marker clustering met

150 tly and reliably separates multiplet-induced artificial-cell-type droplet clusters from real BCT drop

151 tely, multiplets in CITE-seq datasets create artificial cell types (ACT) and complicate the automatio

152 Multiplets create artificial cell types in the dataset.

153 eer complex emulsion-based, multicompartment artificial cells, using microfluidics and acoustic levit

154 In order to demonstrate mechanosensation in artificial cells, we develop a novel microfluidic device

155 Artificial cells were synthesized using biocatalytic ato

156 and functional scaffolds inside natural and artificial cells, where RNA produced by gene networks co

157 Efforts to create life-like artificial cells will likely involve mimicking the struc

158 mble biocompatible cell-sized hydrogel-based artificial cells with a variety of different embedded fu

159 ttom-up synthetic biology seeks to construct artificial cells with biomimetic or novel functionalitie

160 systems is a critical step towards preparing artificial cells with collective behaviour.

161 ecision-making by a bistable gene network in artificial cells with constant protein turnover.

162 ng the spontaneous bottom-up construction of artificial cells with high organizational complexity and

163 By incubating the artificial cells with macrophages, we investigate the me

164 study actin-based positioning mechanisms in artificial cells with persistently contracting actomyosi

165 port enzymatically synthesized polymer-based artificial cells with the ability to express proteins.

166 The bottom-up development of an artificial cell would provide a minimal system with whic