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1 .42-3.48 ng/bee/day) impaired bee ability to ascend.
2 and Safety in Idiopathic Pulmonary Fibrosis (ASCEND 016; 52 weeks)-for all-cause mortality, treatment
4 E. coli cells expressing FliC(N87K) sensed ascending a chemotactic gradient in liquid but did not s
5 the SAM stimulus would simulate the degraded ascending acoustic code seen in the elderly, increasing
9 e aortic arch, and Deltat was extracted from ascending and descending aortic velocity curves created
10 Wohlfarth model predicts the crossing of the ascending and descending branches of the hysteretic magn
11 and experimentally, that the crossing of the ascending and descending branches of the magnetization c
13 at homologous genes do not generate the same ascending and descending expression gradients as in huma
14 psule, the white matter (WM) bundle carrying ascending and descending fibers from the OFC and ACC.
15 ns reveals a novel and rapid link connecting ascending and descending pathways.SIGNIFICANCE STATEMENT
16 d sends a prominent descending projection to ascending and premotor, subpallial stages of these pathw
18 n conditions that cause them to destabilize, ascend, and accumulate in voluminous but ephemeral shall
20 nd diffuse dilatation of the aortic root and ascending aorta (16.2% versus 7.3%, P<0.001) than women.
21 icantly increased pulse wave velocity in the ascending aorta (3.4 versus 2.3 m/s for PAH and controls
25 stigate whether the pulmonary artery (PA)-to-ascending aorta (Ao) ratio is associated with outcome in
27 ll target-to-background ratio (TBR) from the ascending aorta (primary endpoint) (adalimumab: TBR = 0.
28 ange from start of treatment in TBR from the ascending aorta (TBR = -0.006, 95% CI = -0.049 to 0.038;
29 luded the following: type 1, dilation of the ascending aorta and aortic root; type 2, isolated dilati
30 ity (up to 26% and 12%, respectively) in the ascending aorta and underestimation (<12%) in the arch a
32 ted the heritability of fluid metrics in the ascending aorta calculated using patient-specific data f
33 ointimal formation at IEL disruptions in the ascending aorta confirms that the IEL is a critical phys
34 right/left ventricular and pulmonary artery/ascending aorta diameter ratios were higher (P<0.001, P=
37 BAVs with no AS or AI, there is significant ascending aorta dilatation independent of valve morpholo
39 AS, and AI are independently associated with ascending aorta dilatation, suggesting that hemodynamic
44 tubular junction, isolated dilatation of the ascending aorta distal to the sinotubular junction, or d
46 cessful flow optimization, downsizing of the ascending aorta in combination with the valve orientatio
47 oot reconstruction, or reconstruction of the ascending aorta or aortic arch) with intraoperative blee
48 ndoglin (ENG), and superoxide dismutase 3 in ascending aorta samples from 50 tricuspid and 70 patient
49 nd ENG were analyzed also by Western blot in ascending aorta samples from other 10 tricuspid aortic v
51 ten encounter discrepant measurements of the ascending aorta that impede, complicate, and impair appr
52 insufficiency or a dilated aortic annulus or ascending aorta were at greater risk for reintervention.
53 amount sign of PAH, we hypothesized that the ascending aorta will present signs of apparent stiffness
54 measurements, which individually look at the ascending aorta with different perspectives and dimensio
56 me local information about blood flow in the ascending aorta, based on maximum values at systole at a
57 include increased hemodynamic forces on the ascending aorta, typically due to poorly controlled hype
58 h bicuspid aortic valve and dilated proximal ascending aorta, we sought to assess (1) factors associa
59 d DNA strand breaks in SMCs within the human ascending aorta, which were specifically enriched in SMC
60 riction (TAC)-to increase wall stress in the ascending aorta-induces severe aortic pathology and mort
65 derm (LM, aortic root) and neural crest (NC, ascending aorta/transverse arch) SMC lineages to model M
66 ortic root; type 2, isolated dilation of the ascending aorta; and type 3, isolated dilation of the si
70 (standard deviation), 12 were women, 18 had ascending aortic aneurysms (maximal diameter > 4.0 cm),
71 TGFBR2) receptor contributes to formation of ascending aortic aneurysms and dissections (AADs) induce
75 observed a 58% increase in heart function in ascending aortic constriction ensuing heart failure, a 3
78 emphysema, the ratio of pulmonary artery to ascending aortic diameter, quantitative evaluation of em
79 d is associated with comorbidities including ascending aortic dilation and calcific aortic valve sten
83 ated with bicuspid aortic valves and dilated ascending aortic geometries that are not assessable by c
84 ft-sided suspected IE (188 prosthetic valves/ascending aortic prosthesis and 115 native valves) were
86 diatric PAH patients have increased apparent ascending aortic stiffness, which was strongly associate
88 We identified 11 major cell types in human ascending aortic tissue; the high-resolution reclusterin
89 ormed single-cell RNA sequencing analysis of ascending aortic tissues from 11 study participants, inc
90 valuation of the cellular composition of the ascending aortic wall and reveals how the gene expressio
91 characterize the cellular composition of the ascending aortic wall and to identify molecular alterati
92 );Ldlr(-/-) mice developed dilatation of the ascending aortic, with greater aneurysmal progression in
93 rt that tonic optogenetic manipulation of an ascending arousal system bidirectionally tunes cortical
94 suggest that the constraints imposed by the ascending arousal system constrain low-dimensional modes
95 dies of whole-brain network topology and the ascending arousal system with information processing dyn
96 (BF) receives inputs from many nuclei of the ascending arousal system, including the brainstem parabr
97 nversely, C1 stimulation strongly stimulates ascending arousal systems and sighs, consistent with the
98 Efficacy and Safety Outcomes] trials and the ASCEND [Assessment of Pirfenidone to Confirm Efficacy an
99 ea and eye, multiple changes occur along the ascending auditory and visual pathways that further redu
100 ) interneurons and projecting neurons in the ascending auditory path and coactivated frontostriatal n
101 ses include a common pathology affecting the ascending auditory pathway and multimodal cortex, deplet
102 HSNN predicts several transformations of the ascending auditory pathway including a sequential loss o
104 regulate IHC activity and maturation of the ascending auditory system in the developing cochlea.
106 ron, based on the position of the cell body, ascending axon, dendritic arborization pattern, and dye
107 very low-density, deep-seated upwelling that ascends beneath the Reunion hot spot at the time of the
108 isolated intracranial thrombus that impedes ascending blood flow) in the context of acute stroke.
109 brain, where the majority of descending and ascending brain pathways are overlapping, and did not in
110 Rigidity was mitigated by stimulation of ascending brainstem and intralaminar thalamic connection
111 characterizing LHb as a master controller of ascending brainstem state-setting modulatory projection
112 n order to innervate teeth, the IAN projects ascending branches directly through tooth roots [5, 6],
114 te to non-linear firing rate profiles during ascending but not descending phases of contractions.
115 duals (N = 52) assigned greater precision to ascending cardiac signals than individuals with symptoms
119 eptors (GPCRs) TACR1 and GPR83 form parallel ascending circuit modules that cooperate to convey therm
121 e of cytological dysplasia, primarily in the ascending colon (n = 6/42, 14%), Transverse colon (n = 2
122 ntent (SBWC), colonic volumes, and T1 of the ascending colon (T1AC) as measures of colonic water.
124 omparison of gene expression profiles in the ascending colon from a subset of patients with ASD, chro
128 ells are normally present in human cecum and ascending colon, but are rarely found in descending colo
129 s defined as any tumor arising in the cecum, ascending colon, hepatic flexure, or transverse colon.
131 signal intensity (r = 0.88, P = .033 for the ascending colon; r = 0.82, P = .006 for the descending c
132 ing) colon but not of the right (proximal or ascending) colon (HR = 1.03, 95% CI: 0.89, 1.18), while
136 sets the grounds for further analyses of the ascending connections of the nTTD and the afferents from
138 The following results were obtained: (a) Ascending dorsoventral gradient in the density of SMI-32
141 ere randomly assigned to receive HTT(Rx) (at ascending dose levels of 10 to 120 mg) and 12 were rando
142 enrolled in the single-ascending or multiple-ascending dose phase of part 1 between Nov 16, 2016, and
143 scending dose study [SAD]; n=56 for multiple ascending dose study [MAD]) were randomized 3:1 to evina
144 ein cholesterol >=100 mg/dL (n=83 for single ascending dose study [SAD]; n=56 for multiple ascending
145 lind, randomized, placebo-controlled, single ascending dose study consisting of 3 cohorts (40, 80, 12
146 ind, placebo-controlled, single and multiple ascending dose study of voxelotor in adult healthy volun
147 nd, randomised, placebo-controlled, multiple ascending dose, phase 1b trial was done at 13 outpatient
149 In a randomized, placebo-controlled, single ascending-dose study in overweight/obese human participa
151 , double-blind, placebo-controlled, multiple-ascending-dose trial of inclisiran administered as a sub
153 nducted a randomized, double-blind, multiple-ascending-dose, phase 1-2a trial involving adults with e
154 g/min, n = 5) or after oral intake of single ascending doses of erlotinib (300 mg, n = 7; 650 mg, n =
155 single subcutaneous injection of one of five ascending doses of givosiran (0.035, 0.10, 0.35, 1.0, or
156 , groups of 5 patients in 4 cohorts received ascending doses of OPT-302 (0.3 mg, 1 mg, or 2 mg) in co
157 rolled clinical trial of single and multiple ascending doses of remlarsen in normal healthy volunteer
158 clusters of sacral VF neurons to deliver the ascending drive required for direct rhythmic activation
161 k), passively stable (upright during flight) ascending flight as well as closed-loop, hovering flight
162 t environments, is crucial for understanding ascending fluid transport and for tracheary mechanical s
164 ies of genes with expression magnitudes that ascend from posterior (e.g., areas human occipital [hOc]
165 nary tract infections (UTIs), which commonly ascend from the bladder to the kidney, is a growing conc
166 on of the endometrium by pathogenic bacteria ascending from the lower female reproductive tract (FRT)
167 n gain access to the decidua and placenta by ascending from the lower reproductive tract or via hemat
168 xpression specifically to glycinergic fibers ascending from the VNLL, allowing for activation of fibe
169 NTS: In response to exercise, vasodilatation ascends from downstream arterioles into upstream feed ar
170 compared to the hypothesis that the disease ascends from the PNS to the CNS as proposed by Braak's h
172 ormation and records from approximately 4000 ascending genealogies to select individuals whose ancest
173 nique trajectories in human development: the ascending gradient is present at 10-12 gestational weeks
176 s demonstrate that magnetite-bubble pairs do ascend in silicate melt, accumulating in an upper layer
178 t than that of chlamydial pathogenicity with ascending infection in the genital tract, since attenuat
184 e mediated by cortico-LC connections, whilst ascending input from LC to cortex modulates belief updat
185 activation of fibers from a single source of ascending input in a way that has not been previously po
186 in the control of brain states owing to the ascending input it receives from the mid- and hindbrain,
188 The medial geniculate body (MGB) integrates ascending inputs with descending predictions to dynamica
193 ound 40% of preterm births are attributed to ascending intrauterine infection, and Ureaplasma parvum
194 seems to be mitigated by stimulation of the ascending, ipsilateral cerebellothalamocortical pathway,
199 concert to restrict distal early (DE)/thick ascending limb (TAL) segment lineage assignment in the d
200 and reduced sodium permeability in the thick ascending limb (TAL), leading to a urine concentrating d
201 in basolateral chloride channel in the thick ascending limb and in the aldosterone-sensitive distal n
202 with targeted deletion of PTH1R in the thick ascending limb of Henle (TAL) and in distal convoluted t
203 ; p-Creb was present in differentiated thick ascending limb of Henle, collecting duct, and stroma; ho
205 particular, we show that the diabetic thick ascending limb, late distal convoluted tubule, and princ
211 In response to pressure reduction, these ascending melts become first superheated and then satura
213 andom fashion, owing to the activity of both ascending modulatory and fast-acting corticocortical and
214 ilitates the local development of grid-scale ascending motion, low-level convergence and the accelera
215 trinsic primary afferent neurons (IPANs), to ascending motor and interneurons have been described in
216 We provide evidence for three groups of ascending motor neurons based on immunoreactivity and as
217 tion and segregation is under the control of ascending neuromodulatory systems, such as the noradrene
219 the signal of copulation to female-specific ascending neurons, LSANs, in the ventral nerve cord.
220 counters a dead-end, we identified a pair of ascending neurons, the TwoLumps Ascending (TLA) neurons.
221 The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modu
222 ability of spinal DYN interneurons to limit ascending nociceptive transmission to the adult brain.
223 ure and activity of the identified abdominal ascending opener interneuron, a homologous key component
224 althy volunteers were enrolled in the single-ascending or multiple-ascending dose phase of part 1 bet
225 hree study groups by a consecutive number in ascending order: FMD (n = 20), FMUD (n = 20), and Q-SRP
226 cted (iRBCs) with bound platelets during the ascending parasitemia in Plasmodium chabaudi- and Plasmo
228 n the ventral cochlear nucleus (VCN) form an ascending pathway that conveys spectral information from
232 he SAAs of both Adelta- and C-fibers at the "ascending" phase of microcontractions were significantly
233 esents it via 12 motors that are arranged in ascending pitch along the forearm, with each motor repre
234 tracing initiated from GRP neurons revealed ascending polysynaptic projections to distinct areas and
237 g a reduction in feedforward inhibition onto ascending projection neurons in the spinal dorsal horn.
238 ibuting to reduced feedforward inhibition of ascending projection neurons, and the priming of develop
239 l-type-specific alterations at synapses onto ascending projection neurons, or rather is indicative of
240 y neurons wire into a brainstem circuit with ascending projections into the submedius thalamic nucleu
243 ine can modulate locomotor behavior both via ascending projections to the basal ganglia and through d
244 o modulate locomotor behaviors through their ascending projections to the basal ganglia, which in tur
246 ise to descending projections, whereas major ascending projections, including focal projections to ve
249 l evolution of the false lumen distal to the ascending prosthesis can be a challenge both for the sur
250 d includes the only postcranial material and ascending ramus of the dentary known for any gondwanathe
253 mic nuclei) and both neocortex and brainstem ascending reticular activating system (ARAS) nuclei.
254 cortical activating structures including the ascending reticular activating system (ARAS), contributi
255 hether abnormal postural mechanisms override ascending sensory information and conscious intention, l
257 area using two time-series of descending and ascending Sentinel-1A acquisitions between 2014 and 2017
258 egory representations, their emergence in an ascending series of ferret auditory and frontal cortical
260 this gut-brain connection has focused on how ascending signals from the gut and its microbiome alter
264 tar Han male rats randomly underwent sham or ascending (supravalvular) aortic banding procedure.
269 ng chromatin immunoprecipitation, we show an ascending telomere-to-centromere gradient of ASY1 enrich
276 vivo aortic tissue elastic properties of two ascending thoracic aortic aneurysm (ATAA) patients from
280 xually transmitted Chlamydia trachomatis may ascend to infect the endometrium, leading to pelvic infl
281 mary glomeruli, olfactory projection neurons ascend to the brain and terminate in the mushroom body c
282 s (AMS) affects more than 25% of individuals ascending to 3500 m (11500 ft) and more than 50% of thos
283 o the rank of professor with tenure and none ascending to the role of department Chair of surgery.
284 tis can cause reproductive morbidities after ascending to the upper genital tract of women, and repea
289 92 from the CAPACITY trials and 555 from the ASCEND trial) were included in the pooled analysis.
293 fabricated tall synthetic trees where water ascends up an array of large diameter conduits, to enabl
294 Studies have suggested that the fenestrated ascending vasa recta (AVRs) drain the interstitial fluid
295 ementary endothelial signalling pathways for ascending vasodilatation ensure increased oxygen deliver
296 esized that the signalling events underlying ascending vasodilatation variy with the intensity and du