ライフサイエンスコーパス: ascertainment

1 der family sampling bias and/or case-control ascertainment.

2 hat permit heterogeneity in case and control ascertainment.

3 l as the number and time points of mortality ascertainment.

4 o the interpretation modality during outcome ascertainment.

5 ave population-based ALS Registers with full ascertainment.

6 le sources were used to ensure complete case ascertainment.

7 tudy hypothesis was formulated prior to PTSD ascertainment.

8 s because of inadequate exposure and outcome ascertainment.

9 on sample size and severity of case-control ascertainment.

10 iderations such as familial correlations and ascertainment.

11 nalysis was used to estimate completeness of ascertainment.

12 D OCT ascertainment of ERM with photographic ascertainment.

13 ed and with either random or phenotype-based ascertainment.

14 lematic because of potential difficulties in ascertainment.

15 P carriers are high even after adjusting for ascertainment.

16 stimation/extrapolation, and sources of case ascertainment.

17 ed segregation analysis, with correction for ascertainment.

18 altered the benefits and costs of mortality ascertainment.

19 2 cases, suggesting very high levels of case ascertainment.

20 tain and might be over-estimated by clinical ascertainment.

21 the method of exposure assessment or outcome ascertainment.

22 h records rather than comprehensive dementia ascertainment.

23 obably underestimated due to incomplete case ascertainment.

24 so includes a built-in approach for handling ascertainment, a helpful integrated tool for genetic dat

25 ction, and variability in the influenza case ascertainment across seasons.

26 ugh limited by incomplete long-term outcomes ascertainment, active surveillance of the ICD Registry s

27 This review highlights the ascertainment and assessment approaches to such populati

28 uo intervention was defined in terms of case ascertainment and capacity of EVD treatment centres on S

29 ors for measles death, we enhanced mortality ascertainment and conducted a case-control study among i

30 disorder were identified following extensive ascertainment and diagnostic assessment and matched to 1

31 Incomplete ascertainment and follow-up may have underestimated subs

32 s the validity of ICD-9 codes in stroke case ascertainment and for AF across 3 institutions.

33 inhibitor-associated myocarditis, have made ascertainment and identification of myocarditis with hig

34 evaluate RV144 for completeness of end point ascertainment and integrity of blinding, necessary tasks

35 RATIONALE: Difficulty of asthma ascertainment and its associated methodologic heterogene

36 then the urgency of interventions to improve ascertainment and management of chronic hepatitis B in t

37 Using rigorous case ascertainment and outcome assessment in a population-bas

38 equire tackling challenges such as worldwide ascertainment and phenotypic characterization of familie

39 f subjects with 22q11DS separated by time of ascertainment and processing.

40 r these observations simply reflect pedigree ascertainment and publication bias.

41 that when appropriate corrections for panel ascertainment and rare-allele omission are used, the bia

42 s in the ICD system contributes to a lack of ascertainment and recognition of their importance for he

43 ociated myocarditis that may facilitate case ascertainment and report and therefore may enhance the u

44 CoA varies considerably, likely secondary to ascertainment and reporting biases and inconsistent defi

45 Ascertainment and reporting of adverse events was not un

46 in some contexts, due to limitations in case ascertainment and specimen collection and processing.

47 surveillance system, including the method of ascertainment and the case definitions.

48 nding EVD treatment centres, increasing case ascertainment, and allocating protective kits for contro

49 disease events varied by age, sex, method of ascertainment, and geography.

50 Patients were identified using rapid case ascertainment, and Latinas and blacks were oversampled.

51 bers enrolled and lost to follow-up, outcome ascertainment, and results were abstracted.

52 explained by the GRS, biases in case-control ascertainment, and the limitations implicit to Mendelian

53 nic risk scores (PRSs), other tic disorders, ascertainment, and tic severity were examined.

54 revalent users, with the timing of covariate ascertainment, and with varying time between exposure an

55 omission are used, the biases introduced by ascertainment are largely correctable, but recovered est

56 years old, and uncovered a decrease in case ascertainment as age increased from 65 to 85 years of ag

57 mography, echocardiogram, and renal function ascertainment at Brigham and Women's Hospital were studi

58 residual confounding (shared risk factors), ascertainment bias (sicker patients have more follow-up

59 opulations incur greater inaccuracies due to ascertainment bias and a lack of representation among re

60 e the potential for residual confounding and ascertainment bias and an inability to examine dosage ef

61 n populations in this study, are affected by ascertainment bias and have low levels of linkage disequ

62 n phenotypically extreme individuals display ascertainment bias and may demonstrate inflated effect-s

63 degree relatives affected with CRC to reduce ascertainment bias and overestimation of penetrance.

64 een reported twice before, which suggests an ascertainment bias attributable to a very mild phenotype

65 We accounted for possible confounding and ascertainment bias by adjusting for family-level socioec

66 The RCT study design mitigated ascertainment bias by randomizing patients to receive ei

67 rs anticipation (p = 0.002), indicating that ascertainment bias can entirely explain observed anticip

68 To account for case-control ascertainment bias for the analysis of multiple secondar

69 ifferent loci and effectively eliminates the ascertainment bias from the functional characterization

70 en populations, which is much more robust to ascertainment bias in SNP discovery than methods based o

71 We then show that there is a global ascertainment bias in the experiment-based GO annotation

72 mented case reports at the county level with ascertainment bias information obtained via population-w

73 A case ascertainment bias may therefore exist, with mild cases

74 Earlier studies may have harbored an ascertainment bias of overemphasizing the confirmation o

75 her this younger age of onset is a result of ascertainment bias or has a genetic basis.

76 The rate adjusted for ascertainment bias was 27 of 435 (6.2%).

77 To adjust for potential ascertainment bias, a modified segregation analysis mode

78 ic map, haplotype phase uncertainty, and SNP ascertainment bias, affect our method.

79 data, short-term trial data showed possible ascertainment bias, and most RCTs used protocols that di

80 ed data with substantive evidence of outcome ascertainment bias, and only 2 studies with a double-bli

81 ce of infectious-disease data, missing data, ascertainment bias, consistency between molecular and ep

82 Ps on the X chromosome is not an artifact of ascertainment bias, nor is it specific to the population

83 lthough these findings might in part reflect ascertainment bias, our results suggest that arterial di

84 To reduce ascertainment bias, we distinguished probands from nonpr

85 After accounting for the potential of under-ascertainment bias, we found a null association between

86 differences, inter-laboratory variation and ascertainment bias.

87 d injuries, misclassification of intent, and ascertainment bias.

88 pecies than Grevy's zebra, despite potential ascertainment bias.

89 genetic prion disease are driven entirely by ascertainment bias.

90 tcomes, partly attributable to selection and ascertainment bias.

91 stly, our analysis also revealed evidence of ascertainment bias.

92 d genotyping arrays that are hindered by SNP ascertainment bias.

93 iants lowering the age of onset, rather than ascertainment bias.

94 logies used, data processing techniques, and ascertainment bias.

95 in the United States and avoid selection or ascertainment biases and sample size limitations.

96 l work is warranted to better understand how ascertainment biases and study design impact PRS for CAD

97 because of a focus on coding polymorphisms, ascertainment biases in favor of common variation, and a

98 using whole genome sequences to correct for ascertainment biases in genome-wide genotype data, we da

99 ic variables of the populations and possible ascertainment biases to explain the variance in the samp

100 in the United States suffer from population ascertainment biases, with individuals of American India

101 n specialist clinics, resulting in potential ascertainment biases.

102 ot correct for important selection and under-ascertainment biases.

103 s and is not confounded by ancestry or other ascertainment biases.

104 ge effects are common, or are instead due to ascertainment biases.

105 d biology rather than technical artifacts or ascertainment biases.

106 erquartile range [IQR], 3.0-8.4) years after ascertainment, BRCA testing, or RRSO (whichever occurred

107 After adjusting for family ascertainment, breast cancer risk estimates on the basis

108 y with ALS was living on Guam at the time of ascertainment but had been born in the United States.

109 ds suffer a loss in power under case-control ascertainment, but no solution has been proposed.

110 sible non-differential or differential under-ascertainment (by migrant status) of those only seen via

111 Previous work has shown that this type of ascertainment can severely bias heritability estimates;

112 At ascertainment, CKD-associated polymorphisms (risk varian

113 , polygenic effects, shared environment, and ascertainment combined with confirmatory factor analysis

114 ex phenotypes, especially in the presence of ascertainment conditions, the specification of such mode

115 An ascertainment-corrected likelihood that combined populat

116 We describe ascertainment-corrected maximum likelihood and multiple-

117 arental ages were similarly distributed; (2) ascertainment criteria like early-onset breast cancer (a

118 Modified segregation analysis conditioned on ascertainment criteria was used to estimate age- and sex

119 from 1980 to 2007), definitions of SCD, case ascertainment criteria, methods of estimation/extrapolat

120 of sensitivity analyses using different case ascertainment criteria.

121 Overall strong performance for case ascertainment, CSF collection, and laboratory confirmati

122 specificities from 85 to 98%, with ICD-9-CM ascertainment demonstrating the highest case sensitivity

123 re remain major limitations to accurate case ascertainment despite automated electronic laboratory re

124 results have implications in regards to case ascertainment, diagnosis, and surveillance of sCJD and p

125 fer by adiponectin assay, method of diabetes ascertainment, duration of follow-up, or proportion of w

126 ers strengthens the observation that bias of ascertainment exists when recent generations are include

127 While improvements in ascertainment explain some of these trends, deferred chi

128 at EVD treatment centres and increasing case ascertainment five-fold in November, 2014, can avert 77

129 d possibly on systems of diagnosis and trait ascertainment for developmental disorders.

130 to data collected from traditional means of ascertainment for neuropsychiatric disease genomics.

131 ths of this study include near-complete case ascertainment for state residents and well-characterized

132 1036 [29.6%] were women), 99.1% had complete ascertainment for the primary outcome.

133 1997, 2003, and 2008; and additional disease ascertainment from hospital data and registry linkage on

134 articipating physicians or staff; (2) active ascertainment from patients, who were encouraged to self

135 clinical relevance useful to assist clinical ascertainment, genetic counseling, guidance of symptomat

136 e same physician during a 12-month period of ascertainment had all images from their entire follow-up

137 e the role of administrative claims in event ascertainment in both prospective and retrospective stud

138 ce was evaluated through sensitivity of case ascertainment in case-based versus aggregate meningitis

139 Case ascertainment in most previous studies was based on auto

140 tions for left ventricular systolic function ascertainment in patients with HF and support evidence-b

141 ation of risk compared with conventional FHH ascertainment in primary care.

142 udy illustrates the value of monitoring case ascertainment in stroke registries using external data s

143 analysis suggests that early fasting insulin ascertainment in the general population may help clinici

144 We assessed case ascertainment in the Michigan Stroke Registry by linking

145 on statistic (LTMLM) to address case-control ascertainment in unrelated samples.

146 se populations and reevaluated their initial ascertainments in the medical literature.

147 at least 593 kilobases at 16p11.2 and whose ascertainment included cognitive deficits.

148 y using multiple overlapping sources of case ascertainment (including a Scotland-wide collaboration o

149 CPE case ascertainment increased over the study period to 1.42 ca

150 Case ascertainment is based on multiple sources (neurologic d

151 Accurate case ascertainment is essential for clinical registries to be

152 Accelerated case ascertainment is needed to maximise effectiveness of exp

153 t constitutes a positive family history, and ascertainment is unreliable for many reasons.

154 Assuming ascertainment levels equivalent to that of other human p

155 simulations with family-biased case-control ascertainment, LT-Fam was correctly calibrated (average

156 cohort, downsampled to induce family-biased ascertainment, LT-Fam was correctly calibrated whereas A

157 identified hospitals that changed their case ascertainment method to a case sampling approach.

158 alue and sensitivity for each identification/ascertainment method were calculated.

159 registry information on these cancers, these ascertainment methods have not been previously validated

160 ity of neurological endpoint definitions and ascertainment methods in clinical trials has led to unce

161 Venezuela), which used identical risk factor ascertainment methods in each country.

162 by differences in patient populations, cost ascertainment methods, and length of follow-up.

163 gher in the sites that used prospective case ascertainment methods.

164 ng methods, peer visit schedule, and outcome ascertainment methods.

165 e partially explained by differences in case ascertainment methods.

166 In addition to case ascertainment, molecular typing of isolates was performe

167 pulation sample not biased to cardiovascular ascertainment (n = 221 vs. 37,486).

168 ug Evaluation) trial, 592 (86%) had complete ascertainment of 7 pre-specified risk factors at baselin

169 s clinician-triggered event adjudication for ascertainment of adverse events in structural heart dise

170 Complete ascertainment of AF during follow-up was identified from

171 subgroups; and correcting for assumed under-ascertainment of autism by level of maternal education.

172 Whole-genome sequencing enables simultaneous ascertainment of both monogenic mutations and polygenic

173 sence of precursor conditions or patterns in ascertainment of cancer and screening.

174 Follow-up ascertainment of cancer diagnoses was complete through S

175 ndardized epidemiological approaches for the ascertainment of cardiovascular risk factors and events.

176 t to selection bias when there is incomplete ascertainment of cases among pregnancies that are termin

177 IPSWs and the bias introduced by incomplete ascertainment of cases among terminated pregnancies cond

178 udies may have been confounded by incomplete ascertainment of cognitive status at baseline.

179 specially within 24 h of birth, making under-ascertainment of community-born cases highly likely, bot

180 There is no clear reference data source for ascertainment of conditions.

181 ta, illustrating GWCoGAPS and patternMarkers ascertainment of data-driven biomarkers from whole-genom

182 between the beginning of recruitment and the ascertainment of death by National Death Index (December

183 NG, AND PARTICIPANTS: A National Death Index ascertainment of death in the long-term follow-up of a r

184 National Death Index (NDI) in improving the ascertainment of deaths among people diagnosed with acqu

185 A limitation of our study is ascertainment of dementia status from electronic health

186 ionnaires' disease outbreaks relies on rapid ascertainment of descriptive epidemiological data, combi

187 Ascertainment of differences between institutions might

188 Limitations of this study include the ascertainment of dysglycemia only among patients with av

189 photographs were reviewed to compare SD OCT ascertainment of ERM with photographic ascertainment.

190 and the study design did not ensure complete ascertainment of false-negative results.

191 Because of the high costs associated with ascertainment of families, most linkage studies of Bipol

192 Ascertainment of fungal components associated with immun

193 A SACO design allows the ascertainment of genotype and exposure for cases and exp

194 aset to further alleviate concerns of biased ascertainment of GWAS loci and showed that the Sardinian

195 Outcome assessment was not blinded, and ascertainment of harms in trials was poor.

196 Rapid ascertainment of HCV infection status with reflex testin

197 receive 1-time testing for HCV without prior ascertainment of HCV risk.

198 surface antigen (HBsAg) tests may facilitate ascertainment of hepatitis B virus (HBV) infection in se

199 ts are sufficiently rare that genotype-based ascertainment of homozygous or compound heterozygous 'kn

200 Mobile application-based ascertainment of hospitalizations can be achieved with m

201 Ascertainment of hospitalizations is critical to assess

202 urban sites in Peru, Mexico, and China, with ascertainment of incident 10/66 and DSM-IV dementia 3-5

203 er Prevention II Study cohort, with baseline ascertainment of individual characteristics in 1982 and

204 We show through simulation that selective ascertainment of individuals whose onset falls within th

205 h FHR </=3(rd) percentile for GA may improve ascertainment of LQTS in fetuses, neonates, and undiagno

206 Ascertainment of major malformations from infant primary

207 h as endorsed by SM&T might not suffice for ascertainment of maximum (steady-state) bioaccessibility

208 linical diagnoses alone are insufficient for ascertainment of MI.

209 s between settings have been limited by poor ascertainment of mortality in high burden African settin

210 While bias due to under-ascertainment of mortality was minimised through death r

211 Ascertainment of mortality, heart failure hospitalizatio

212 After accounting for under-ascertainment of mortality, with increasing duration on

213 Ascertainment of mothers in well-defined sensitivity gro

214 Neuronal viability was assessed through ascertainment of N-acetyl aspartate (NAA)-an amino acid

215 Observed DMF/CLU ascertainment of NDI-identified decedents increased from

216 urviving [72%]) then underwent follow-up for ascertainment of new-onset heart failure (2004-2010).

217 Ascertainment of nine conditions, using individually-lin

218 based on fluorescence microscopy for prompt ascertainment of non-enzymatic browning initiation in fr

219 ng, ocular biometry assessment, and clinical ascertainment of ocular hypertensive or glaucoma status

220 They capitalized on their ascertainment of other endpoints in members of the cohor

221 The ascertainment of outcomes has depended on self-reporting

222 Ascertainment of outcomes was complete for 284 participa

223 al bias in the selection of participants and ascertainment of outcomes.

224 zed trials are limited by lack of systematic ascertainment of pneumonia; they depended on adverse eve

225 ngths of the cohort included nearly complete ascertainment of pregnancies in Finland (N=1.2 million)

226 /L), 12 633 (96.6%) completed the trial with ascertainment of primary end point status.

227 ning (NBS) programs provide population-scale ascertainment of rare, treatable conditions that require

228 The overall rate of ascertainment of RAS status was 90%.

229 spective studies using refined approaches to ascertainment of RLS and depression are warranted.

230 ldren are never tested, estimating the under-ascertainment of RSV infection is imperative.

231 ts, inadequate follow-up, and limitations of ascertainment of second malignancies.

232 s and to the National Crime Register enabled ascertainment of self-harm and violent offending, respec

233 model accounts for two biases: preferential ascertainment of severe cases and right-censoring of mor

234 djusted for right-censoring and preferential ascertainment of severe cases, are measures that can be

235 Population-based case ascertainment of stroke was conducted, and all participa

236 However, ascertainment of structural variants (SVs) has been rest

237 Studies that use unblinded ascertainment of subjective infection endpoints are at r

238 design considerations that include increased ascertainment of subjects in the earliest phases of illn

239 Main outcomes included ascertainment of symptoms/disease onset by questionnaire

240 in study limitation is the difference in the ascertainment of the clinically defined CVD endpoints an

241 This requires prior ascertainment of the cSNP genotypes for all individuals.

242 outcomes in populations depends on accurate ascertainment of the history of these disorders.

243 s; 618 women [25.6%]), 2320 (95.7%) had full ascertainment of the primary outcome.

244 d a nonrandomized design limiting definitive ascertainment of the robustness of a PrEP-dedicated nurs

245 g analytic epidemiologic studies can improve ascertainment of these factors.

246 Data were obtained through blinded ascertainment of trial clinical and safety databases.

247 In the HiR and SURTAVI trials, ascertainment of trial primary end points using claims r

248 h prospective cohort studies included annual ascertainment of urine protein-to-creatinine ratio, eGFR

249 ents with similar ratings of attributes, and ascertainment of whether membership in a particular grou

250 chanism in Thalassiosira pseudonana, but the ascertainment of which proteins are responsible for the

251 in the general population, used active case ascertainment or clinic-based methods, and specified the

252 Dec 31, 2014), adjusting for changes in case ascertainment over time.

253 isk factors, and different methods of stroke ascertainment (range of RR estimates 1.30-1.42).

254 ich requires properly adjusting for the case ascertainment rate and the delay between symptoms onset

255 We estimate an under-ascertainment rate of about one-third (95% confidence in

256 esymptomatic infectiousness(2), time-varying ascertainment rates, transmission rates and population m

257 ted respiratory infections by severity, case ascertainment, region, and age.

258 Dementia case ascertainment relied on a consensus review of the cognit

259 gesting that current standards for Zika case ascertainment require revision.

260 alised CPE control programs to increase case ascertainment, resolve risk factors and identify putativ

261 er comparable with STRP loci (theta=10); (6) ascertainment schemes that select highly variable STRP o

262 er and were adjusted for the family-specific ascertainment schemes.

263 d through aggregate surveillance, for a case ascertainment sensitivity of 112.3%.

264 Prospective population-based ascertainment showed that hospital-based registries will

265 Ethnicity, age and study ascertainment significantly modulated the association of

266 hop.Irrespective of clinical condition, case ascertainment strategies are required to overcome report

267 were identified from claims data using three ascertainment strategies.

268 rders, there has been a gradual shift in the ascertainment strategy toward population-based cohorts f

269 hrough a prospective, population-based rapid ascertainment system.

270 ing of 629,433 sites with clearly documented ascertainment that was specifically designed for populat

271 Adjusted for completeness of ascertainment, there was a 21.1% (95% CI, 15.6%-27.0%) i

272 Adjusted for completeness of ascertainment, there was a 30.5% (95% CI, 17.3%-45.1%) o

273 three areas: new EVD treatment centres, case ascertainment through contact tracing, and household pro

274 r Research into Familial Breast Cancer, with ascertainment through family clinics (94%) and populatio

275 Asthma ascertainment through NLP should be considered in the er

276 Further, we discerned case ascertainment to be higher for young infants compared to

277 s have grown exponentially in both power and ascertainment to detect rare variation.

278 ornia, and Detroit, Michigan, for rapid case ascertainment to identify a sample of women aged 20 to 7

279 thm, the familial hypercholesterolaemia case ascertainment tool (FAMCAT), and compare it with current

280 s from our ENU screen in which we biased our ascertainment toward mutations affecting neurodevelopmen

281 Microbiological NJSA case ascertainment underestimates case numbers as it frequent

282 Performance of NLP-based asthma ascertainment using predetermined asthma criteria was as

283 ement and Transplantation Network, with ESRD ascertainment via Centers for Medicare and Medicaid Serv

284 ounter, agreement between the two sources of ascertainment was 48.2%, and the kappa statistic was 0.2

285 pture-recapture analysis suggested that case ascertainment was 89% (95% CI 77-97) complete.

286 Mortality ascertainment was censored 31 December 2009.

287 Outcome ascertainment was complete given that the participants w

288 Ascertainment was designed to enrich the families for my

289 Follow-up ascertainment was done at three specialised clinical ser

290 Possible case under-ascertainment was only discussed in 2 studies.

291 The sensitivity of case ascertainment was significantly lower in teaching hospit

292 le sensitivity and specificity, although NLP ascertainment was superior.

293 dy population, and the methods used for case ascertainment, we analyzed 80 qualifying reports regardi

294 ted associations corrected for assumed under-ascertainment were 1.06 (0.98, 1.14) for all ASDs, 1.12

295 Positive predictive values for NMSC ascertainment were calculated.

296 CA identified using prospective, multisource ascertainment were evaluated for history of epilepsy.

297 mitations: Interventions and methods of fall ascertainment were heterogeneous.

298 Here, we consider family-biased case-control ascertainment, where case and control subjects are ascer

299 ccount for disease prevalence and non-random ascertainment, which can induce a correlation structure

300 pon how strictly the data are limited by the ascertainment window.