ライフサイエンスコーパス: asexual

1 a species previously thought to be anciently asexual.

2 ferns where 10% of all species are obligate asexuals.

3 nt promoting continuous reproduction through asexuals.

4 , the mode of daughter production (sexual or asexual) [2], and the mode of caste determination (genet

5 3, and 11 analogues were further assessed in asexual 3D7 (chloroquine-sensitive) strains of P. falcip

6 Following one asexual amplification cycle in the liver, parasites reac

7 malaria parasites during human infection are asexual and are unable to be transmitted to mosquitoes.

8 Eight of these species are functionally asexual and arose by hybrid speciation from parents span

9 lic localization of PfISN1 and expression in asexual and gametocyte stages of the parasite.

10 intraerythrocytic asexual cycle and between asexual and gametocyte stages was observed suggesting th

11 cin B is a potent inhibitor against both the asexual and sexual blood stages of malaria infection.

12 molds as a signaling molecule that modulates asexual and sexual development, the formation of infecti

13 In addition, cpsA is necessary for normal asexual and sexual development.

14 the importance of histone PTMs to the entire asexual and sexual developmental cycles of the parasite,

15 emarkable reproductive strategies, combining asexual and sexual modes of reproduction that allow for

16 m has a single-host life cycle in which both asexual and sexual processes occur in the intestine of i

17 egarding the advantages and disadvantages of asexual and sexual replication strategies among RNA viru

18 Asexual and sexual reproduction occur jointly in many an

19 Picornaviruses have both asexual and sexual RNA replication mechanisms.

20 chanisms.IMPORTANCE Picornaviruses have both asexual and sexual RNA replication mechanisms.

21 we report that beta-glucan synthesis in both asexual and sexual spores is turned off by the NF-kB lik

22 ng proper levels of beta-glucan synthesis in asexual and sexual spores.

23 Asexual and sexual stages and the formation of new oocys

24 icated that the protein is required for both asexual and sexual stages of development.

25 The dual activity of ACT-451840 against asexual and sexual stages of P. falciparum and the activ

26 tematically assessed the development of both asexual and sexual stages of P. falciparum in a defined

27 dentify AP2-G2 as a repressor active in both asexual and sexual stages.

28 uman malaria parasite Plasmodium falciparum (asexual and sexual) and Plasmodium vivax (asexual) as we

29 capter pachys gives clues as to how 'ancient asexual' animals can exist.

30 m (asexual and sexual) and Plasmodium vivax (asexual) as well as oral in vivo efficacies in two murin

31 ome of which showed cross-reactivity against asexual blood and liver stages.

32 Hit compounds showed moderate asexual blood stage activity.

33 life cycle and the subsequent transition to asexual blood stage culture followed by cloning of recom

34 We have investigated the role of cAMP in asexual blood stage development of Plasmodium falciparum

35 with pantothenate phosphorylation and block asexual blood stage development.

36 en tested for activity against P. falciparum asexual blood stage growth, selectivity and cytotoxicity

37 The asexual blood stage involves invasion of erythrocytes by

38 the parasite during the clinically relevant asexual blood stage life cycle.

39 portant to understand intrinsic variation in asexual blood stage multiplication rates of the most vir

40 ll division cycle in the clinically relevant asexual blood stage of infection(1).

41 reens have focused solely on the symptomatic asexual blood stage of the parasite life cycle; however,

42 eral protein kinases function redundantly in asexual blood stages and confirm the targetability of ki

43 mpart resistance to compounds active against asexual blood stages and mature gametocytes.

44 olar inhibition of the Plasmodium falciparum asexual blood stages and transmissible gametocyte forms.

45 ctions were evaluated experimentally against asexual blood stages of both sensitive and multi-drug-re

46 In the asexual blood stages of malarial infection, merozoites i

47 ls A-I (4-12) were also assessed against the asexual blood stages of Plasmodium falciparum and reveal

48 subnanomolar antiplasmodial activity against asexual blood stages of Plasmodium falciparum, excellent

49 alaria parasites with important functions in asexual blood stages responsible for malaria symptoms, t

50 o artemisinins, fast-killing potency against asexual blood stages that cause disease, and activity ag

51 mic map of the developmental transition from asexual blood stages to male and female gametocytes and

52 ke (5hmC-like) modification in P. falciparum asexual blood stages using a suite of biochemical method

53 nolines, as well as compounds active against asexual blood stages, lost most of their killing activit

54 In developing intracellular asexual blood stages, MyoA was synthesized in mature sch

55 rugs and inhibitors on Plasmodium falciparum asexual blood stages.

56 n culture of the malaria parasite during the asexual blood stages.

57 essential at the liver stages compared with asexual blood stages: type II fatty acid synthesis and e

58 ssing potent in vitro activities against the asexual blood, liver, and gametocyte stages of the Plasm

59 eomic comparison of a protein complex across asexual blood, sexual and sporozoite stages, along with

60 antibody prevalence to Plasmodium falciparum asexual blood-stage antigens, provide estimates of trans

61 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent

62 nt efforts in the design of vaccines against asexual blood-stage P. falciparum.

63 of the ATP synthase only marginally reduced asexual blood-stage parasite growth but completely block

64 -associated invariant T cells expanded after asexual blood-stage parasitemia induced by CHMI.

65 e identified as fast-acting agents that kill asexual blood-stage parasites at the trophozoite phase,

66 highly effective against intra-erythrocytic asexual blood-stage parasites, until resistance arose in

67 that, even in a low-transmission setting, an asexual blood-stage vaccine designed to reduce clinical

68 ection (CHMI) to assess the efficacy of this asexual blood-stage vaccine.

69 In the asexual blood-stage, the parasite resides within erythro

70 te with the aim of reducing sequestration of asexual "blood-stage" parasites in the placenta, the maj

71 Z Challenge is a potent new tool to validate asexual, blood-stage malaria vaccines in Africa.

72 continuously regenerates entire bodies in an asexual budding process.

73 Prokaryotes are asexual, but these organisms frequently engage in homolo

74 Trichogramma wasps can be rendered asexual by infection with the maternally inherited symbi

75 (RBCs) on completion of the malaria parasite asexual cell cycle.

76 The longevity of asexual clades may be correlated with the maintenance of

77 ave gc-rings, but the ratio of gametocyte to asexual-committed rings (GCR) varies widely (0-78%).

78 Aspergilli disseminate via asexual conidia passively travelling through air current

79 ducing one thousand times more single-celled asexual conidial spores, three times sooner than the anc

80 ircadian clock output, yielding a pattern of asexual conidiation similar to a ras-1 mutant that is us

81 Just like their asexual counterparts, gametocytes are contained within t

82 ol profile both within the intraerythrocytic asexual cycle and between asexual and gametocyte stages

83 Whereas the asexual cycle of the protistan parasite Toxoplasma gondi

84 gametocyte production and the length of the asexual cycle were noted between the two lines.

85 field isolates, 37 sexual offspring, and 19 asexual derivatives from single multinucleate sporangia

86 Asexual development (conidiation) in the filamentous fun

87 PfCDPK1 is critical for asexual development of Plasmodium falciparum, but its pr

88 kinase 1 (CDPK1) plays an important role in asexual development of Plasmodium falciparum.

89 otryllus schlosseri is an emerging model for asexual development studies.

90 During its asexual development within the red blood cell (RBC), Pla

91 ne resulted in defects in vegetative growth, asexual development, and infection of the host plant.

92 les include regulation of hyphal morphology, asexual development, as well as amino acid, iron, and se

93 fficking is important for vegetative growth, asexual development, conidial morphology and plant infec

94 ruct a comprehensive atlas of cell-cycle and asexual development, revealing hidden states and transcr

95 FlbB at the apex is required for triggering asexual development, the tip high nuclear gradient is no

96 A signaling pathway and negatively regulates asexual development, toxigenesis, melanin production, an

97 e bodies with minimal dynamic changes during asexual development.

98 g pathways at three blood stages of parasite asexual development.

99 bly marked with this modification throughout asexual development.

100 plained by measurement noise, cell cycle, or asexual development.

101 a and decreased mRNA levels of brlA, the key asexual developmental activator.

102 is work guides the exploration of sexual and asexual domestication trajectories in other clonally pro

103 During each cycle of asexual endomitotic division in erythrocytes, the malari

104 lciparum serine hydrolase superfamily in the asexual erythrocytic stage of P. falciparum.

105 ble to alkylate protein target(s) within the asexual erythrocytic stage of Plasmodium falciparum (3D7

106 y crash is likely to be a general feature of asexual evolution with clonal interference; however, bot

107 ences of interspecific hybridisation between asexual females and sexual males.

108 In this previously unrecognized strategy, asexual females produce few sexual males whose genes nev

109 al stage is known for C. beticola but in its asexual form it overwinters on infected plant debris as

110 The anamorphic (asexual) form produces prolific conidia, thought to func

111 The asexual freshwater planarian is a constitutive adult, wh

112 Asexual freshwater planarians reproduce by tearing thems

113 cond, lineage-specific factors might prevent asexuals from reaching their full potential (e.g., depen

114 cifically associated with development of the asexual fruiting bodies of the fungus on certain substra

115 facilitate the emergence of new lineages in asexual fungal populations.

116 female offspring, leaving them irreversibly asexual, further linking host and symbiont.

117 ure female fern gametophytes, turning nearby asexual gametophytes precociously male.

118 n unselected control populations within ~750 asexual generations.

119 Ulocladium was thought to be a strictly asexual genus of filamentous fungi.

120 ires that some blood-stage parasites abandon asexual growth and convert into non-replicating sexual f

121 support the role of MAT genes in controlling asexual growth in filamentous Ascomycetes but also confi

122 identified a compound, BCH070, that inhibits asexual growth of multiple antimalarial-resistant strain

123 stage comprises multiple steps: invasion of, asexual growth within, and egress from red blood cells.

124 Lactic acid did not impact asexual growth, as measured by blood film counts and luc

125 iploid sexual and both diploid and polyploid asexual (i.e., apomictic) lineages.

126 WM382 was efficacious against P. falciparum asexual infection in humanized mice and prevented transm

127 blood immediately following establishment of asexual infections-without the need for triggers such as

128 enome-wide levels of heterozygosity in these asexuals largely reflects the divergence of parental hap

129 morphologically and reproductively distinct asexual lichens.

130 As most asexual lineages are short-lived, abandoning sex is comm

131 Still, putative anciently asexual lineages challenge this view.

132 Asexual lineages of plants and animals are typically pol

133 However, are new asexual lineages really those powerful invaders that cou

134 examine the relationship between sexual and asexual lineages, we sequenced the mitochondrial 12S and

135 tricting or altering the ecological niche of asexual lineages.

136 a but neither gene flow nor formation of new asexual lineages.

137 hibition of PfCLK3 mediated rapid killing of asexual liver- and blood-stage P. falciparum and blockad

138 sinin combination therapy effectively clears asexual malaria parasites and immature gametocytes but d

139 as focused on either long-lived organisms or asexual microorganisms.

140 asite Plasmodium falciparum, the switch from asexual multiplication to sexual differentiation into ga

141 hitecture is shared by a long-lived clade of asexual nematodes closely related to the genetic model o

142 from queen flights, reported in the past, to asexual nest budding.

143 h dementia in a nursing home often viewed as asexual or incapable of being sexually active.

144 us stage in their life cycle, through either asexual or sexual reproduction, known as a cyst.

145 ssions of whole-animal vertebrate clonality (asexual organismal-level reproduction), both in the labo

146 on and chromosomal re-assortment in strictly asexual organisms results in homologous chromosomes irre

147 deletions influence genome size evolution in asexual organisms.

148 Second, there seems to be no lack of asexual origins because losses of sexual reproduction ha

149 o (capital of Mali) for eligibility (>/=2000 asexual P falciparum parasites per muL of blood).

150 moderate levels of preexisting antibodies to asexual P. falciparum lysate and another that, based on

151 Following subcurative piperaquine treatment, asexual parasite and gametocytes kinetics were assessed

152 llowing MB (P < 0.001), despite similar peak asexual parasite densities (P = 0.478).

153 studies, individuals infected with subpatent asexual parasite densities are found to be approximately

154 on) were determined mainly by modal stage of asexual parasite development, whereas the subsequent log

155 Results show that asexual parasite slide prevalence in humans has reduced

156 us to mosquitoes as individuals with patent (asexual parasite) infection.

157 ed census of active serine hydrolases in the asexual parasite, with identification of 21 active serin

158 t the need for triggers such as high-density asexual parasitemia or drug treatment.

159 ommitment is observed following recrudescent asexual parasitemia, and these gametocytes are again ref

160 vely associated with age and positively with asexual parasites (P < .001).

161 kely mediate critical metabolic reactions in asexual parasites and enable rational prioritization of

162 e composite primary outcome was clearance of asexual parasites and fever by day 7, and absence of rec

163 zonts produced mixed plaques containing both asexual parasites and gametocytes.

164 physiological differences between sexual and asexual parasites and provide a tool and starting points

165 lood, being associated with low densities of asexual parasites and the absence of gametocytes.

166 lation in bone marrow, where gametocytes and asexual parasites are therefore killed.

167 Plasmodium falciparum, a small proportion of asexual parasites differentiate into male or female sexu

168 Our data show that P. falciparum asexual parasites do not activate classical DC subsets b

169 y quantified male and female gametocytes and asexual parasites in: i) finger prick blood, ii) venous

170 he sexual conversion rate, the proportion of asexual parasites that convert into gametocytes at each

171 re no serious adverse events (grade 2-4) and asexual parasites were cleared by day 7 in both groups.

172 odium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if

173 ilic prodrug with nanomolar activity against asexual parasites.

174 However, unlike their asexual partners, they do not exit the RBC until they ar

175 The advantages of asexual persistence of heterokaryons may have been one o

176 le, the in vitro system is used to study the asexual phase of multiplication, which consists of two g

177 cycles - often heteroxenous with sexual and asexual phases in different hosts - rely on elaborate cy

178 lex life cycles that include both sexual and asexual phases with strict species specificity.

179 significant mechanism in the evolution of an asexual plant pathogen.

180 Gametophytic apomixis is a way of asexual plant reproduction by seeds.

181 acity (mainly derived from the production of asexual plantlets), K.

182 me neighboring monogyne population. Multiple asexual/polygyne genomes are transmitted undiluted in th

183 mate with polygyne males; and (3) different asexual/polygyne lineages evidently were founded separat

184 hat raise the genome-wide mutation rate - in asexual populations is often described as being frequenc

185 Evolutionary dynamics in large asexual populations is strongly influenced by multiple c

186 enetic variation in genetically impoverished asexual populations of a freshwater snail, Potamopyrgus

187 tal evolution to test whether large or small asexual populations tend to evolve greater complexity.

188 We further characterize two sexual and two asexual populations with increased mutation rate and obs

189 nt a successful strategy in rapidly adapting asexual populations, but theory predicts their eventual

190 In rapidly adapting asexual populations, including many microbial pathogens

191 In asexual populations, the identification of beneficial al

192 lacking, such as in small, bottlenecked, or asexual populations.

193 mutations hitchhike to fixation in adapting asexual populations.

194 is inversely correlated with genome size in asexual populations.

195 lva prolifera, which has sexual and obligate asexual populations.

196 iscovery of horizontal genome transfer as an asexual process generating new species and new combinati

197 e upregulated during chlamydosporulation, an asexual process leading to formation of large, spherical

198 that gametocytes-and not their noninfectious asexual progenitors-induce increased attractiveness of h

199 Our results demonstrate that regulating host asexual proliferation and modifying its sexual reproduct

200 on between five distinctive body plans, with asexual proliferation in the snail host and sexual proli

201 Asexual proliferation of the Plasmodium parasites that c

202 is restricted to reticulocytes, limiting its asexual proliferation.

203 The synthetic asexual-propagation trait is heritable through multiple

204 [6-9], or multicellular structures, such as asexual propagules or secretory hairs (papillae) [10-12]

205 olving the bone marrow, provides a niche for asexual replication and gametocyte development.

206 .54% (95% credible interval: 0.30-1.00%) per asexual replication cycle and 8.39 (6.54-10.59) days res

207 Malaria pathogenesis results from the asexual replication of Plasmodium falciparum within huma

208 erozoites, all committed to either continued asexual replication or differentiation into gametocytes.

209 ce within its human host requires continuous asexual replication within red blood cells, while its mo

210 r, parasites reach high burdens by rounds of asexual replication within red blood cells.

211 from an epigenetically silenced state during asexual replication.

212 on of Plasmodium mitotic spindles during the asexual reproduction and results in aberrant tubulin mor

213 -an effect that can emerge in evolution with asexual reproduction and results in delayed fixation tim

214 and how a planarian rips itself apart during asexual reproduction can be fully explained through biom

215 abolomic variation is likely impacted by the asexual reproduction cycle of D. magna; however, the rel

216 Asexual reproduction in animals, though rare, is the mai

217 This work establishes the feasibility of asexual reproduction in crops, and could enable the main

218 xual fertility that accompanied the shift to asexual reproduction in cultivars was reflected by signa

219 Apomixis is a naturally occurring mode of asexual reproduction in flowering plants that results in

220 ther the presence of Rickettsia is linked to asexual reproduction in Liposcelis.

221 Stolons (elongated stems) are used for asexual reproduction in the crop species potato (Solanum

222 However, the hypothesis that asexual reproduction in the snail leads to a high abunda

223 The commonest type of asexual reproduction is clonal growth (vegetative propag

224 Asexual reproduction is expected to reduce the adaptive

225 ature of sessile organisms, but this form of asexual reproduction is thought to interfere with sexual

226 Asexual reproduction is widespread in land plants, inclu

227 gamy and somatic embryogenesis and that such asexual reproduction may be ancient.

228 Asexual reproduction of the parasite within its host cel

229 Apomixis is an asexual reproduction system without fertilization, which

230 Apomixis, asexual reproduction through seed, enables breeders to i

231 Apomixis or asexual reproduction through seeds, enables the preserva

232 Introduction of apomixis, asexual reproduction through seeds, into crop species ha

233 osphaera plantaginis employs both sexual and asexual reproduction to increase its chances of infectin

234 MAT genes can also affect similar aspects of asexual reproduction when expressed in C. heterostrophus

235 pitulate existing models, which suggest that asexual reproduction will overpower horizontal transfer

236 allocation (carbon storage, root biomass and asexual reproduction) in both treatments relative to the

237 fe history of multigenerational, stolon-like asexual reproduction, interspersed with dispersal by wat

238 r switches between, for instance, sexual and asexual reproduction, or cyclic and non-cyclic life hist

239 e data reveal the crucial role of sexual and asexual reproduction, polyploidy and host domestication

240 ce of apomixis-the transition from sexual to asexual reproduction-is a prominent feature of modern ci

241 me, proteome, metabolome and host growth and asexual reproduction.

242 e dormancy, and to switch between sexual and asexual reproduction.

243 eby alleviates some of the usual pitfalls of asexual reproduction.

244 obacterium Burkholderia, which controls host asexual reproduction.

245 symptomless phase and facilitating Septoria asexual reproduction.

246 ols the transition from vegetative growth to asexual reproduction.

247 marily multiplying through a budding type of asexual reproduction.

248 rates the germline during repeated cycles of asexual reproduction.

249 vidence that TE loads decrease rapidly under asexual reproduction.

250 ysiology of plant and pathogen throughout an asexual reproductive cycle of Z. tritici on wheat leaves

251 manner these amoebae reap the benefits of an asexual reproductive existence: principally, that it is

252 ich functional antagonism between sexual and asexual reproductive modes can negatively affect the fit

253 zed Wolbachia strains infecting irreversibly asexual, resistant to horizontal transfer Trichogramma w

254 Asexual RNA replication mechanisms involve one parental

255 E loads over time in experimental sexual and asexual Saccharomyces cerevisiae populations, we provide

256 ics of adaptation in experimental sexual and asexual Saccharomyces cerevisiae populations, which allo

257 6 promising antimalarial molecules with dual asexual/sexual activity, representing starting points fo

258 ubsets of autophagy genes were necessary for asexual/sexual differentiation and deoxynivalenol (DON)

259 t autophagy plays a critical role in growth, asexual/sexual sporulation, deoxynivalenol production an

260 First, asexuals should enjoy various growth benefits because th

261 tential explanation for the capacity of this asexual snail to spread by adaptive evolution or plastic

262 distinct clones belonging to two obligately asexual species of the D. pulex species complex: D. midd

263 ybrid origins shape patterns of diversity in asexual species remains underexplored.

264 Asexual species thus provide an opportunity to gain insi

265 n retained as heterozygosity in functionally asexual species, and that genome-wide levels of heterozy

266 highlights, such as the potential for sex in asexual species, organic acid production genes being a k

267 adox of the presence of meiotic machinery in asexual species.

268 of whole-genome diversity and the origin of asexual species.

269 the disease cycle is unique, having only the asexual spore.

270 feature of these fungi is the production of asexual spores (conidia) within fruiting bodies called c

271 a ubiquitous human fungal pathogen, produces asexual spores (conidia), which are the main mode of pro

272 mcrA led to a loss of long-term viability of asexual spores (conidia), which is likely associated wit

273 gus Neurospora crassa, genetically identical asexual spores (germlings) communicate and fuse in a hig

274 is a key repressor affecting the quantity of asexual spores in Aspergillus.

275 rcd-1), a gene controlling PCD in germinated asexual spores in the filamentous fungus Neurospora cras

276 Larvae were injected with conidia (asexual spores) of two different wild-type strains of N.

277 s in elevated accumulation of beta-glucan in asexual spores.

278 role in repressing beta-glucan synthesis in asexual spores.

279 ion of the beta-glucan synthase gene fksA in asexual spores.

280 fting from weak vegetative growth to induced asexual sporulation (conidiation) along a decreasing phe

281 deletion (Delta) of rgsD results in enhanced asexual sporulation coupled with increased mRNA levels o

282 nd arrest parasites at the ring phase of the asexual stage and also gametocytogensis.

283 gh these are known to be nonessential at the asexual stage of parasite development.

284 Treatment of the symptomatic asexual stage of Plasmodium falciparum relies almost exc

285 Pbyop1Delta asexual stage parasites display abnormal ER architecture

286 stage parasites significantly stronger than asexual stage parasites.

287 lacking either PanK1 or PanK2 undergo normal asexual stages development and sexual stages differentia

288 omplexan genomes and is essential during the asexual stages of the malaria parasite Plasmodium falcip

289 an children who were parasite free, harbored asexual stages, or had gametocytes at submicroscopic den

290 e sexually committed stages develop from the asexual stages, yet the factors behind this transition a

291 , to study the distinctiveness of sexual and asexual taxa currently in sympatry, and to analyse the e

292 ion counteracts the negative consequences of asexual template-dependent RNA replication mechanisms, n

293 PCR of mating type (MT)-locus genes revealed asexual thalli carrying both MT genomes.

294 Our results strongly suggest that asexual thalli originally evolved via apomeiosis in spor

295 of reproductive cell revealed that cells in asexual thalli performed apomeiosis without chromosome r

296 T genes play essential roles for controlling asexual traits (conidial size and number).

297 The parasite asexual trophozoite stage is susceptible to iron-induced

298 Asexual urediniospore infection of primary cereal hosts

299 ar trees, including the clade comprising the asexual vagrant species R. arbuscula, R. haydenii, R. id

300 l stressors such as high aphid density cause asexual, viviparous adult female aphids to alter the dev