ライフサイエンスコーパス: aspartic

1 ds in alginate and alginate-arginine-glycine-aspartic acid (-RGD) microgel was demonstrated, with enh

2 le crystals containing glycine (0-7 mol%) or aspartic acid (0-4 mol%), we elucidate the origin of the

3 t-poly(ethylene glycol)-S-S-arginine-glycine-aspartic acid (Alg-g-RGD).

4 Enhanced levels of indole-3-aspartic acid (an indicator of high indole-3-acetic acid

5 Acidic amino acids, aspartic acid (Asp) and glutamic acid (Glu) can enhance

6 unctionalization of peptides that employs an aspartic acid (Asp) as a native directing motif, which d

7 ations including methionine (Met) oxidation, aspartic acid (Asp) isomerization, and asparagine (Asn)

8 t bridge between (4S)-aminoproline (Amp) and aspartic acid (Asp) that directs the composition and reg

9 We study a model system consisting of l-aspartic acid (Asp) which when added to the precipitatio

10 hosphomimetic mutant EWSR1/FLI1-T79D (Thr to aspartic acid (Asp)) retained the high activity as wild-

11 Aspartic acid (Asp), wool, parchment, and rabbit skin gl

12 transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown t

13 Specifically, a conserved aspartic acid (Asp53) of the LytR response regulator was

14 [X = U, C, A or G]), alanine (coded by GCX), aspartic acid (coded by GAY [Y = U or C]), glutamic acid

15 ionally-constrained, cyclic arginine-glycine-aspartic acid (cRGD) to enable highly selective binding

16 unctionalized with a cyclic arginine-glycine-aspartic acid (cRGD) tripeptide for targeting integrin a

17 pocket with conserved glutamic acid (E) and aspartic acid (D) residues.

18 Mice with various alanine (A) or aspartic acid (D) substitutions of the three main phosph

19 of transgenic mice carrying the mutation of aspartic acid (D) to alanine (A) at amino acid 20 (IL-37

20 dditionally, ICl of the mutant containing an aspartic acid (D) to asparagine (N) substitution at posi

21 48), Ser(226), and Ser(227) were replaced by aspartic acid (designated as D-Tg) or alanines (designat

22 iable gene segments encoding a glutamic acid-aspartic acid (ED) motif for K169 recognition.

23 ddition to the already known indole-3-acetyl-aspartic acid (IA-Asp) and indole-3-acetyl-glutamic acid

24 in the conjugated forms indole-3-acetic acid aspartic acid (IAA-Asp) and indole-3-acetic acid glutami

25 previous reports; brain volume and N-acetyl aspartic acid (NAA) decreased steadily, but no published

26 ppocampal neurons, treatment with N-methyl-D-aspartic acid (NMDA) (10 muM) for 48 hours reduced the s

27 -tert-nitrone (alphaPBN), and the N-methyl-D-aspartic acid (NMDA) antagonist MK801-in mouse and rat m

28 e sensitive conductances, such as N-methyl-D-aspartic acid (NMDA) channels can be more easily activat

29 ynaptic vesicles was dependent on N-methyl-D-aspartic acid (NMDA) receptor activation during LTP.

30 hetic ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is widely util

31 subunits required for assembly of N-methyl-d-aspartic acid (NMDA) receptors (NMDA-Rs), alpha-amino-3-

32 Blockade of N-methyl-D-aspartic acid (NMDA) receptors by intra-CA3 infusion of

33 is accompanied by the increase of N-Methyl-D-aspartic acid (NMDA) receptors in the hippocampus follow

34 st common targets and mechanisms: N-methyl-d-aspartic acid (NMDA) receptors, voltage gated calcium ch

35 < 0.05) and 200 mug/mL of glutamic acid and aspartic acid (p < 0.001) without affecting cell integri

36 Mutation of tyrosine 89 to aspartic acid (PrimPolY89D) has been identified in a num

37 ty and accessibility of the arginine-glycine-aspartic acid (RGD) binding site in FN, which, in turn,

38 Cyclic arginine-glycine-aspartic acid (RGD) containing peptides are known to mim

39 lphavbeta6, via a conserved arginine-glycine-aspartic acid (RGD) motif in the exposed, antigenic, GH

40 ecorated with two different arginine-glycine-aspartic acid (RGD) peptides: one is cyclic (RGDFC) and

41 eta5/beta3 integrins and an arginine-glycine-aspartic acid (RGD) sequence in the first extracellular

42 Arginyl-glycyl-aspartic acid (RGD), a cell adhesion tripeptide motif, i

43 Arginine-glycine-aspartic acid (RGD)-based imaging tracers allow specific

44 ith hydrogels modified with arginine-glycine-aspartic acid (RGD)-containing peptides.

45 o either alanine (S225A; phosphoablatant) or aspartic acid (S225D; phosphomimetic) in the context of

46 replacing serine with phosphoserine-mimetic aspartic acid (S386D) in ANDV N robustly inhibited inter

47 utation by substituting the S936-TRP site to aspartic acid (trp(S936D) ) set the frequency response o

48 -1-F-box protein (SCF)-[F-box and tryptophan-aspartic acid (WD) repeat domain containing 7 (FBXW7)] u

49 In both cases, we identify aspartic acid 137 as the caspase cleavage site and demon

50 mus), with the latter being reprotonated by aspartic acid 156 (t(1/2) = 2 ms).

51 ion of a fibril-specific salt bridge between aspartic acid 23 and lysine 28.

52 he N276 glycan, loop D, and V5, but not with aspartic acid 368, similarly to HJ16 and 179NC75.

53 ich is demonstrated to then be protonated by aspartic acid 396 to the neutral radical within 3.5 mus.

54 vibration of two non-natural amino acids, L-aspartic acid 4-methyl ester and L-glutamic acid 5-methy

55 vitro phosphorylation that histidine 245 and aspartic acid 536 are conserved sites of phosphorylation

56 that contributed to flavour (glutamic acid, aspartic acid and alanine) were present and the most abu

57 o catalyze the hydrolysis of asparagine into aspartic acid and ammonia has been recently put into que

58 he first time that a glycopeptide containing aspartic acid and an O-sulfated glycan was synthesized.

59 , are conserved, but the salt bridge between aspartic acid and arginine is lost.

60 (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epidermal growt

61 d proteins specifically at the C-terminus of aspartic acid and at the N-terminus of cysteine.

62 lysine, leucine, alanine, arginine, glycine, aspartic acid and glutamic acid residues represented the

63 equired for Aly1-mediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the

64 88 to lysine) and Nav1.6 (asparagine 1768 to aspartic acid and leucine 1331 to valine) by obtaining w

65 c acid is a nitrogen acceptor while alanine, aspartic acid and proline are nitrogen donors in cancero

66 ticed in the case of glutamic acid, alanine, aspartic acid and proline between cancer and healthy cel

67 y available and inexpensive materials (i.e., aspartic acid and purine heterocycles).

68 The major phosphoprotein in dentin is the aspartic acid and serine-rich protein called dentin phos

69 ven by competing effects of acidic residues (aspartic acid and sialic acid) on ion-pair formation and

70 linear relationship between the d/l ratio of aspartic acid and the age of the specimens.

71 ere prepared by coating protected chiral D/L aspartic acid appended polyfluorene in the pores.

72 how that when gas-phase mixtures of D- and L-aspartic acid are exposed to an achiral Cu(111) surface,

73 y on the PHR domain, that replacement of the aspartic acid Asp-396 with cysteine prevents proton tran

74 However, aspartic acid at amino acid position 9 in HLA-B (B(pos-9

75 in the substitution of an asparagine for an aspartic acid at position 10 of ACT1 (ACT1-D10N) is asso

76 hown to bind Mamu-KIR3DL01 allotypes with an aspartic acid at position 233.

77 en ablated by deletion of a highly conserved aspartic acid at position 385, which, for HIV-1, plays a

78 gnition motif (RRM) of CSTF2 that changes an aspartic acid at position 50 to alanine (p.D50A), result

79 Adding NLS, replacing aspartic acid by glutamic acid residues, or changing the

80 The phosphomimetic aspartic acid can restore activity at the two serine sit

81 )) tagged with the tripeptide arginyl-glycyl-aspartic acid cell adhesion motif RGD, which can be used

82 at the pH, saturation state and approximate aspartic acid concentrations inferred to occur at the co

83 io- and chemoselectively N-oxidized using an aspartic acid containing peptide catalyst to afford stab

84 n Dd2, whereas the phosphomimetic amino acid aspartic acid could fully and glutamic acid could partia

85 oxylacylcarnitine metabolites and asparagine/aspartic acid could serve as biomarkers associated with

86 suggests that ATP-binding shifts the pKa of aspartic acid D396, the putative proton donor to FAD.(-)

87 The most potent congeners were a l-aspartic acid diisoamyl ester phenoxy prodrug and a l-ph

88 Proteins composed exclusively of arginine-aspartic acid dipeptide repeats undergo length-dependent

89 Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1), a dN

90 observe changes in the protonation state of aspartic acid during folding that have not been captured

91 Amylopectin, agarose, and aspartic acid exhibited similar critical ice saturations

92 The dynamics of the aspartic acid follow the dynamics of the intermediate ph

93 The D/L ratio of aspartic acid for these specimens ranged from 2.4% to ~1

94 Free glutamic acid and free aspartic acid found in the PPI hydrolysate likely increa

95 chondrial import, whereas the presence of an aspartic acid in over 95% of all avian influenza viruses

96 cond transgenic model was generated in which aspartic acid in position 163 was substituted for aspara

97 ans, as well as metabolites such as N-acetyl-aspartic acid in the developing nervous system and N-ace

98 pled to protein folding; the apparent pKa of aspartic acid in the folded protein is 6.4.

99 The conversion of homoserine to aspartic acid in the glycopeptide was successfully accom

100 A motif of histidine, proline, and aspartic acid in the J domain of DNAJB6a was required fo

101 One compound with an aspartic acid in the P2 position (compound 16) displayed

102 tides, one challenge is the incorporation of aspartic acid in the peptide backbone and acid sensitive

103 We show that aspartic acid inhibits aragonite precipitation from seaw

104 mutation of a single leucine residue (L6) to aspartic acid inhibits proteolysis.

105 Substitution of the surface-exposed Y1544 to aspartic acid is able to stabilize the domain in the abs

106 The negative charge of aspartic acid is believed to be able to mimic the phosph

107 The protonation state of aspartic acid is coupled to protein folding; the apparen

108 c reaction mechanism when the catalytic base aspartic acid is missing, as is the case in some LTs (mu

109 FFD-NH2) and a second novel one in which the aspartic acid is substituted by an asparagine (Ac-LPFFN-

110 Aspartic acid isomerization rates can be predicted from

111 ifications such as asparagine deamidation or aspartic acid isomerization.

112 ict the effect of mutating each glutamic and aspartic acid located in MTBD domain to alanine.

113 use of asparaginase to convert asparagine to aspartic acid may provide a means to reduce acrylamide f

114 vivo MRI studies in mice; however, only the aspartic acid modified chelates produced an amide proton

115 n o-boronato-phosphonium amino ester with an aspartic acid moiety.

116 A phosphomimetic Ser-500 to aspartic acid mutation (eEF-2K S500D) enhances the rate

117 mHTT gene within a BAC to express either an aspartic acid or an alanine at position 421, mimicking t

118 For example, isomerization of aspartic acid or epimerization of any chiral residue wit

119 , we examined the impact of isomerization of aspartic acid or epimerization of serine at four sites m

120 ected mutagenesis of predicted histidine and aspartic acid phosphoacceptor residues.

121 idases exhibit a monoglutamase activity when aspartic acid precedes a single glutamate, which, togeth

122 mical design relies on the modification of l-aspartic acid precursor to controllably combine, through

123 egy was developed utilizing homoserine as an aspartic acid precursor.

124 ening that binds to a specific pocket of the aspartic acid protease, beta-secretase (BACE-1).

125 In addition, the aspartic acid racemization ratio of this specimen was al

126 to LRP1, we demonstrate that the N-methyl-D-aspartic acid receptor (NMDA-R) is expressed by macropha

127 K-801, a specific pore blocker of N-Methyl-D-aspartic acid receptor (NMDAR) channels, and this occurr

128 By measuring N-methyl-d-aspartic acid receptor (NMDAR)-driven calcium responses

129 (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA)

130 beta2* activation did not enhance N-methyl-D-aspartic acid receptor function.

131 The N-methyl-d-aspartic acid receptor hypofunction model of schizophren

132 chizophrenia, as predicted by the N-methyl-d-aspartic acid receptor hypofunction model.

133 ed to glucocorticoids, exhibit an N-methyl-d-aspartic acid receptor-independent form of long-term pot

134 panoic acid receptor-mediated and N-methyl-D-aspartic acid receptor-mediated synaptic currents in lam

135 cine agonist-binding sites of the N-methyl-d-aspartic acid receptor.

136 es by interacting and trafficking N-methyl-D-aspartic acid receptors (NMDAR) and alpha-amino-3-hydrox

137 asing glutamatergic excitation at N-methyl-D-aspartic acid receptors, alters both the amplitude and f

138 ymes share a consensus sequence harboring an aspartic acid residue as a catalytic nucleophile.

139 polymorphism, causing the replacement of the aspartic acid residue at position 398 with an asparagine

140 analysis of isomaltase predicts that another aspartic acid residue functions as a proton donor in hyd

141 tamic acid residues, or changing the l- to d-aspartic acid residue on MitoFlag abolishes the traffick

142 Whereas mutation of a key active-site aspartic acid residue prevents OAS2 activity, a C-termin

143 A nearby aspartic acid residue side-chain transiently stores prot

144 e carboxyl function at the side chain of the aspartic acid residue, which was selected on the basis o

145 absolute specificity of hydrolysis after an aspartic acid residue.

146 the L-selectin tail as well as a doublet of aspartic acid residues ((369)DD(370)) in the membrane-di

147 length LRPIV variants with glycine replacing aspartic acid residues 3394, 3556, and 3674 in the calci

148 nduced two-proton transfer between catalytic aspartic acid residues and the hydroxy group of the boun

149 alogues show that, like GH31 hydrolases, the aspartic acid residues Asp(553) and Asp(665) are the cat

150 pecificity for cleavage after asparagine and aspartic acid residues during in-solution digestions of

151 neutral, despite harboring the two conserved aspartic acid residues found in NapA and other bacterial

152 egration activity of PGBD5 requires distinct aspartic acid residues in its transposase domain, and sp

153 ked homodimers that contain a pair of acidic aspartic acid residues in their transmembrane (TM) domai

154 Focusing on the two key aspartic acid residues of NhaA, D163 and D164, shows tha

155 Mutation of the aspartic acid residues to alanine in the C-terminal doma

156 This peptide contains a blocking motif (aspartic acid residues) flanked on either side by cleava

157 inner Odelta1 oxygen atoms of the catalytic aspartic acid residues.

158 emonstrated with the accurate analysis of 10 aspartic acid samples covering a wide concentration rang

159 t peptides and small proteins containing the aspartic acid semialdehyde (Asa) side chain can be easil

160 heets and beta-turns, and negatively charged aspartic acid side chain of FiP35 were measured independ

161 d type (WT) or with alanine or glutamic acid/aspartic acid substitutions at the phosphorylation sites

162 Among all the substitutions screened, aspartic acid substitutions were generally well-tolerate

163 ect dog cells, a single mutation changing an aspartic acid to a glycine at capsid (VP2) position 300

164 Although an amino acid substitution from aspartic acid to alanine at position 168 (D168A) reduced

165 changing coat protein N-arm residue 14 from aspartic acid to alanine causes a lethal phenotype.

166 (glutamic acid to lysine at position 627 and aspartic acid to asparagine at position 701) of A(H7N9)

167 c.298G-->T) in LEP, leading to a change from aspartic acid to tyrosine at amino acid position 100 (p.

168 ment to the high density of arginine-glycine-aspartic acid tripeptide present in DAPF.

169 ctures of the WoA variants in complex with L-aspartic acid versus L-glutamic acid provide insights in

170 acterization of mutant enzymes in which this aspartic acid was substituted by other residues that cha

171 rylcarnitine/malonylcarnitine and asparagine/aspartic acid were associated with worse clinical rank s

172 lanine, glutamine, glutamic acid, aspargine, aspartic acid were detected.

173 multiple phyla reveals a uniquely conserved aspartic acid within an FFXRX6RX12PXD motif, two uniquel

174 lytic zinc ion ligated by the histidines and aspartic acid within the motif (HEXXHXXGXXD).

175 ic the tripeptide sequence (arginine-glycine-aspartic acid) of the natural ligands; however, the RGD-

176 report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified polylactic acid-co-glyco

177 n of CA2 synapses relies on NMDA (N-methyl-D-aspartic acid) receptor activation, calcium and calcium/

178 D-aas such as D-Asp (aspartic acid), D-Glu (glutamic acid), combined D-[Asp/G

179 made of cyanophycin [multi-L-arginyl-poly (L-aspartic acid)], which is synthesized by cyanophycin syn

180 o acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isol

181 jugate reactions targeting lysine, glutamine/aspartic acid, and cysteine residues.

182 ophan, l-cysteine, methionine, cycloleucine, aspartic acid, asparagine, tyrosine, and glutamic acid).

183 vels of amino acid racemization not only for aspartic acid, but also for phenylalanine and tyrosine,

184 of alanine, alpha-ketoglutarate, asparagine, aspartic acid, cystathionine, total cysteine, glutamic a

185 N-acetyl-l-aspartate (NAA) to acetate and l-aspartic acid, elevates brain NAA and causes "spongiform

186 traction of the C3 proton by the active site aspartic acid, forming Neu5Ac2en.

187 han in vegetable protein (alanine, arginine, aspartic acid, glycine, histidine, lysine, methionine, a

188 the DHHC (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the

189 beta-catenin, where serine 45 is mutated to aspartic acid, in mice resulted in improved liver regene

190 mologue of Garner's aldehyde, derived from l-aspartic acid, is reported.

191 Several carbon sources (L-Asparagine, L-Aspartic Acid, L- Glutamic Acid, m- Erythritol, D-Melezi

192 f cMyBP-C were replaced by either alanine or aspartic acid, mimicking the fully nonphosphorylated and

193 esults imply that the racemization ratios of aspartic acid, phenylalanine, and tyrosine can be used a

194 gher threonine, serine, proline, asparagine, aspartic acid, phenylalanine, tyrosine, and histidine le

195 c acid residues are replaced by arginine and aspartic acid, respectively as refractive increment incr

196 atives which are prepared from L-serine or L-aspartic acid, respectively.

197 velopment of an algorithm combining glycine, aspartic acid, SM(42:3), and SM(43:2) permitted to accur

198 ncluding 2-hydroxyglutaric acid and N-acetyl-aspartic acid, was also observed in the DESI mass spectr

199 lpha mutant, where serine 41 was replaced by aspartic acid, which mimics phosphorylation.

200 describe a method to characterize the human aspartic acid- and glutamic acid-ADP-ribosylated proteom

201 ving copper-catalyzed allylation of serine-, aspartic acid-, and glutamic acid-derived organozinc rea

202 The spike aspartic acid-614 to glycine (D614G) substitution is pre

203 k)](2) = glutamic acid-[cyclo(arginyl-glycyl-aspartic acid-D-phenylalanine-lysine)], both in several

204 (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine), as a therapeutic candidat

205 Food restriction also enhanced aspartic acid-induced burst firing of dopamine neurons i

206 ffinity amino acid sequence arginine-glycine-aspartic acid-phenylalanine-cysteine (RGDFC) attached.

207 nteracting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) a

208 ks containing cell adhesive Arginine-Glycine-Aspartic acid-Serene (RGDS) peptide and/or nanocrystalli

209 A/H1N1/pdm09 in the lung tissue harbored an aspartic acid-to-glycine substitution at position 222 (D

210 it makes an intramolecular salt bridge to an aspartic acid.

211 ugation of one of the alkyl side chains with aspartic acid.

212 phan triad and proton transfer from a nearby aspartic acid.

213 served element of the I-Ak binding motif, an aspartic acid.

214 ecycle except when serine 312 was mutated to aspartic acid.

215 lpiece or their mutation to glutamic acid or aspartic acid.

216 icular N-glycosylated asparagine residues to aspartic acid.

217 h alanine, present in higher plants, or with aspartic acid.

218 2-glutaric acid] and RGD is arginine-glycine-aspartic acid.) RESULTS: alphavbeta3 integrin is express

219 nd that concentrations of total amino acids, aspartic acid/asparagine (Asx), glutamic acid/glutamine

220 pitope could be engaged, despite the lack of aspartic acid/glutamic acid encoded in the mouse reperto

221 earing Vlambda rearrangements that expressed aspartic acid/glutamic acid in CDR L2.

222 ng seawater saturation state and increasing [aspartic acid], as occurs in some corals at high pCO(2),

223 ng transactivators with E [glutamic acid]/D [aspartic acid]-rich-carboxylterminal domain4) is induced

224 vels of asymmetric induction are provided by aspartic-acid-containing peptides as the aspartyl side c

225 Glycine, glutamic and aspartic acids accounted for 40% of total amino acids.

226 placing conserved serines 1712 and 1836 with aspartic acids individually or together.

227 Mg(2+), which neutralizes the Ca(2+)-binding aspartic acids that likely contribute to the C2B interfa

228 variability, which enables the two catalytic aspartic acids to be brought closer to each other.

229 ith cTn having cTnI serines 23/24 mutated to aspartic acids to mimic phosphorylation always shifted a

230 tamylases, with CCP3 being able to hydrolyze aspartic acids with similar efficiency.

231 nce of acidic amino acids (i.e. glutamic and aspartic acids).

232 d by the PPi dissociation from two catalytic aspartic acids, followed by a comparatively slow jump-fr

233 inine residue at a similar register to these aspartic acids, with the activating immunoreceptors.

234 ally catalytic residues, including essential aspartic acids.

235 that coding and non-coding regions explained aspartic and glutamic acid consumption differences, like

236 These peptides possess aspartic and glutamic acid residues at p4 and p7, respec

237 nd KIEs) of carboxylic groups of various key aspartic and glutamic acid residues by monitoring their

238 trategy was adopted to probe solvent-exposed aspartic and glutamic acid residues on the CP43 protein.

239 including the digestion motifs flanked with aspartic and glutamic acid.

240 Regarding total amino acids, aspartic and glutamic acids (9-10 mg/g) were the major c

241 contain proteins that are unusually rich in aspartic and glutamic acids [4-6], the role of these pro

242 frequently observed when acidic amino acids, aspartic and glutamic acids, are present near the cleava

243 l-isoleucine, l-valine, l-aspartic and ubiquitin carboxyl-terminal hydrolase invol

244 Inhibition of aspartic cathepsin D-like peptidases (APDs) has been oft

245 ydrolyzing sterile alpha motif and histidine aspartic domain containing protein 1 (SAMHD1) protein, w

246 acterized by a central tryptophan flanked by aspartic/glutamic acid residues (W-acidic).

247 Sterile alpha motif (SAM) and histidine-aspartic (HD) domains protein 1 (SAMHD1) was previously

248 eptidases and were not hydrolyzed by serine, aspartic, or metallo peptidases.

249 a exome sequencing that mutations in ASPRV1 (aspartic peptidase retroviral-like 1) cause a dominant M

250 Our results revealed an aspartic peptidase with molecular mass approximately 38k

251 and analysis of catalytic specificity of an aspartic peptidase.

252 , such as the (near) absence of cysteine and aspartic peptidases and peptidase inhibitors, whereas ot

253 forms highly swollen sponge phases to entrap aspartic protease (34 kDa), an enzyme used for food proc

254 struction through activation of the cysteine-aspartic protease (caspase) cascade.

255 approach based on proteolysis with secreted aspartic protease 9, Sap9, for analysis of monoclonal an

256 igher activity presented by the encapsulated aspartic protease compared to the free enzyme stored at

257 he absence of ERG-28, SLO-1 channels undergo aspartic protease DDI-1-dependent degradation, resulting

258 61-entry fragment library for binding to the aspartic protease endothiapepsin by crystallography.

259 ening to map the protein-binding site of the aspartic protease endothiapepsin by individual soaking e

260 rent milk clotting enzymes, belonging to the aspartic protease family, were extracted from both artic

261 Some have canonical pepsin-like aspartic protease features, whereas others have unusual

262 An aspartic protease from Salpichroa origanifolia fruits wa

263 ropathic pain), beta-secretase 1 (BACE-1, an aspartic protease in Alzheimer's disease), cathepsin B (

264 Finally, the encapsulation efficiency of aspartic protease in lipid sponge-like nanoparticles was

265 he multistage antiplasmodial activity of the aspartic protease inhibitor hydroxyl-ethyl-amine-based s

266 yethylamine peptide isostere developed as an aspartic protease inhibitor shows that it is a flexible

267 erefore, we have investigated the effects of aspartic protease inhibitors on both enzymes and compara

268 cted by proteasome, caspase-3, or serine and aspartic protease inhibitors.

269 stem using a B-cell epitope derived from the aspartic protease Na-APR-1 from N americanus, attached t

270 C. albicans secreted aspartic protease Sap6 is important for virulence during

271 Our findings showed that the alpine thistle aspartic protease was successfully immobilized at pH 7.0

272 BACE1 is an aspartic protease which functions in the first step of t

273 HTLV-1 protease (HTLV-1 PR) is an aspartic protease which represents a promising drug targ

274 cathepsin E is a nonlysosomal intracellular aspartic protease whose function has been described only

275 ling proteins such as receptor-like kinases, aspartic protease, a putative lipid-binding START domain

276 E reactivity with 60% of the sera, lysosomal aspartic protease, and "AAEL006070-PA" (Uniprot: Q177P3)

277 Human cathepsin D (CatD), a pepsin-family aspartic protease, plays an important role in tumor prog

278 particular cleavage specificity of the cocoa aspartic protease, which cannot be substituted by pepsin

279 peptide N-glycanase, and DDI-1, a conserved aspartic protease.

280 ed a provector that is activated by cysteine aspartic proteases (caspases), which have roles in infla

281 The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involve

282 Carnivorous plants primarily use aspartic proteases during digestion of captured prey.

283 use of porcine pepsin and three alternative aspartic proteases either in-solution or immobilized on-

284 HDX-MS studies, recently, it was shown that aspartic proteases from carnivorous pitcher plants of th

285 In contrast to most aspartic proteases from other origins, basic amino acid

286 recombinant nepenthesin I (one of two known aspartic proteases in the fluid) revealed a partial clea

287 Plasmepsins are a group of diverse aspartic proteases in the malaria parasite Plasmodium Th

288 Plasmepsins (Plms) are aspartic proteases involved in the degradation of human

289 Caspases are cysteine-aspartic proteases involved in the regulation of program

290 Recently, the aspartic proteases Plasmepsin IX and X (PMIX and PMX) we

291 jor fungal cell surface adhesin Als3 and the aspartic proteases Sap6 and Sap9.

292 otent peptidyl inhibitor of various malarial aspartic proteases, and also has parasiticidal activity.

293 nd NB-ARC, and five additional families: the Aspartic proteases, BTB/POZ proteins (BTB), Glutaredoxin

294 enzyme and may apply more generally to other aspartic proteases.

295 s that specifically inhibit CatD and related aspartic proteases.

296 l as poor selectivity over the related human aspartic proteases.

297 en undergo rapid degradation by cysteine and aspartic proteases.

298 that show high selectivity over other human aspartic proteases.

299 Aspartic proteinases, which include HIV-1 proteinase, fu

300 The first cleavage occurs at aspartic residue 332, located between the kinase domain