ライフサイエンスコーパス: aspartyl protease

1 2, but not by cathepsin D, a closely related aspartyl protease.

2 rary of inhibitors of cathepsin D (CatD), an aspartyl protease.

3 nalogs, suggesting gamma-secretase may be an aspartyl protease.

4 in systems: IMPDH, MAP kinase p38, and HIV-1 aspartyl protease.

5 inhibitors directed to the active site of an aspartyl protease.

6 g strong evidence that gamma-secretase is an aspartyl protease.

7 d suggesting that these compounds inhibit an aspartyl protease.

8 -secretase, an autoactivated intramembranous aspartyl protease.

9 he FK506 binding protein (FKBP-12) and HIV-1 aspartyl protease.

10 nes a functional domain for an intramembrane aspartyl protease.

11 butes one aspartate to the active site of an aspartyl protease.

12 (Spp) that encodes a multipass transmembrane aspartyl protease.

13 homologs are related intramembrane-cleaving aspartyl proteases.

14 t disturbing the functions of other cellular aspartyl proteases.

15 ectivity against other biologically relevant aspartyl proteases.

16 the catalytic mechanism of BACE and related aspartyl proteases.

17 omplex and its similarity to other polytopic aspartyl proteases.

18 rger family of polytopic membrane-associated aspartyl proteases.

19 define a new subfamily of membrane-anchored aspartyl proteases.

20 susceptibilities that are characteristic of aspartyl proteases.

21 glycosylphosphatidylinositol (GPI)-anchored aspartyl proteases.

22 recursor polyprotein (Pr55(Gag)) by cellular aspartyl proteases.

23 that act against both fungal and retroviral aspartyl proteases.

24 ecursor Gag (Pr55(Gag)) operated by cellular aspartyl proteases.

25 0 nM, and >100-fold selectivity over related aspartyl proteases.

26 -embedded enzyme in the presenilin family of aspartyl proteases.

27 cellular glycosylphosphatidylinositol-linked aspartyl proteases.

28 quently named it Malassezia globosa Secreted Aspartyl Protease 1 (MgSAP1).

29 Necator americanus aspartyl protease 1 (Na-APR-1) is one of the most promis

30 gs of beta-1,3-glucanases (16), metallo- and aspartyl proteases (13), glycerophosphodiesterases (6),

31 Here we establish that Toxoplasma gondii aspartyl protease 3 (ASP3) resides in the endosomal-like

32 Cysteine aspartyl protease-3 (caspase-3) is a mediator of apoptos

33 ort pathway that requires the Golgi-resident aspartyl protease 5 (ASP5).

34 (ii) Experiments designed to demonstrate aspartyl protease activity in a phage display system fai

35 des suppressed the activity of the lysosomal aspartyl protease activity, ASP-3/CTSD.

36 Inhibitors of gamma-secretase, an aspartyl protease, also prevented the appearance of the

37 do not resemble transition state analogs of aspartyl proteases, also displayed potent, non-competiti

38 but not by pepstatin A or EDTA that inhibit aspartyl protease and metalloprotease, respectively.

39 cterized mechanism-based inactivators for an aspartyl protease and show promise as novel antimalarial

40 II) is the most extensively studied of these aspartyl proteases and catalyzes the initial step in the

41 ey have a direct bearing on the mechanism of aspartyl proteases and efforts to model beta-secretase.

42 ycosylation sites and sequences conserved in aspartyl proteases and in zinc-binding proteins.

43 lls and filamentous, growth forms), secreted aspartyl proteases and phospholipases.

44 The genes encoding AED1, a predicted aspartyl protease, and another AED, LEGUME LECTIN-LIKE P

45 called gamma-secretase) has properties of an aspartyl protease, and mutation of either of the two asp

46 BACE is an aspartyl protease, and there is significant effort in th

47 d hydrolases (e.g., lipases, phospholipases, aspartyl proteases, and acid sphingomyelinases) was foun

48 hored protein with clear homology to soluble aspartyl proteases, and alpha-secretase displays charact

49 with a C2 GRAM domain protein (BAGP1) and an aspartyl protease (APCB1), both of which are required fo

50 The active site of this transmembrane aspartyl protease apparently lies at the interface betwe

51 eptide peptidase (SPP)-related intramembrane aspartyl proteases are a homologous group of polytopic m

52 gene for presenilin 1, a multi-transmembrane aspartyl protease, are known to cause familial Alzheimer

53 Identification of an aspartyl protease as the beta-secretase (beta-site APP c

54 +)-regulated calpain protease TRA-3, and the aspartyl protease ASP-4.

55 Here we identify a new membrane-bound aspartyl protease (Asp2) with beta-secretase activity.

56 The aspartyl protease B-site amyloid precursor protein cleav

57 by sequential proteolysis, catalysed by the aspartyl protease BACE, followed by presenilin-dependent

58 A type I transmembrane aspartyl protease, BACE (beta-site APP cleaving enzyme),

59 A recently identified aspartyl protease, BACE, cleaves the beta site and at re

60 The aspartyl protease BACE1 cleaves the amyloid precursor pr

61 cleavage of amyloid precursor protein by the aspartyl protease BACE1.

62 hough not selective over the closely related aspartyl protease BACE2, verubecestat has high selectivi

63 lectivity for the other structurally related aspartyl proteases BACE2, cathepsin D, renin, and pepsin

64 lectivity for the other structurally related aspartyl proteases BACE2, cathepsinD, renin, and pepsin.

65 rotein (APP) cleaving enzyme 1 (BACE1) is an aspartyl protease best known for its role in generating

66 ge of amyloid precursor protein (APP) by the aspartyl protease beta-secretase and the presenilin-depe

67 The aspartyl protease beta-secretase, or BACE, has been demo

68 The aspartyl protease beta-site amyloid precursor protein cl

69 otein (APP) in the brain is a membrane-bound aspartyl protease beta-site APP cleaving enzyme (BACE).

70 The membrane-anchored aspartyl protease beta-site APP-cleaving enzyme (BACE) e

71 We report the optimization of an aspartyl protease binding scaffold and the discovery of

72 the consensus sequences found in most known aspartyl proteases, but otherwise has only modest homolo

73 ive diseases involves activation of cysteine aspartyl proteases (caspases), which initiate and execut

74 Increasing evidence suggests that serine-aspartyl proteases-caspases are activated in the AD brai

75 obtained, validating the molecular design as aspartyl protease catalytic site inhibitors.

76 Edr bears both CCHC zinc-finger and putative aspartyl protease catalytic site retroviral-like motifs,

77 tes the in vitro maturation of the lysosomal aspartyl protease cathepsin D (CTSD).

78 Selected compounds inhibited the aspartyl protease cathepsin D but not the cysteine prote

79 selectivity against the structurally related aspartyl protease cathepsin D.

80 ly of 11 glycosylphosphatidylinositol-linked aspartyl proteases, CgYapsins.

81 ur in functionally interesting situations in aspartyl proteases, citrate synthase, EF hands, haemoglo

82 eta-secretase (BACE), a type-I transmembrane aspartyl protease, cleaves APP first to generate a 99-am

83 Notch cleavage as an aspartyl protease or di-aspartyl protease cofactor.

84 gamma-Secretase is a membrane-embedded aspartyl protease complex central in biology and medicin

85 Gamma-secretase is an intramembrane aspartyl protease complex that cleaves type I integral m

86 Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress an

87 HIV protease, an aspartyl protease crucial to the life cycle of HIV, is t

88 Furthermore, HSPCs display aspartyl protease-dependent H1.0 decreases, especially i

89 of XRN4 and VCS in seeds (PECTIN LYASE-LIKE, ASPARTYL PROTEASE, DWD-HYPERSENSITIVE-TO-ABA3, and YELLO

90 ficiency virus 1 (HIV-1) protease (PR) is an aspartyl protease essential for HIV-1 viral infectivity.

91 zyme 1) is a membrane-tethered member of the aspartyl proteases, essential for the production of beta

92 carrying domains for lectin kinase, R gene, aspartyl protease, etc.

93 BACE1 is a type 1 transmembrane aspartyl protease expressed predominantly in neurons of

94 c functions for members of the intramembrane aspartyl protease family.

95 also efficiently inhibited Sap9p, a secreted aspartyl protease from the human pathogen, Candida albic

96 ive catalytic component of the intramembrane aspartyl protease gamma-secretase complex.

97 senilin-1 (PS1) is the catalytic core of the aspartyl protease gamma-secretase.

98 Unlike beta-secretase, which is a monomeric aspartyl protease, gamma-secretase activity resides as p

99 regulation of a DHHC-type zinc finger and an aspartyl protease gene, possible candidates for the obse

100 in the sequence Asp-Thr-Gly, the hallmark of aspartyl proteases, had no effect on viral replication i

101 ases, plasmepsin I, II, and IV and the histo-aspartyl protease (HAP), have been identified in the foo

102 show that this dominant secretory Malassezia aspartyl protease has an important role in enabling a pl

103 cleaving enzyme) with characteristics of an aspartyl protease has been identified as the beta-secret

104 Inhibitors of the HIV aspartyl protease [HIV protease inhibitors (HIV-PIs)] ar

105 ase is a multiprotein intramembrane cleaving aspartyl protease (I-CLiP) that catalyzes the final clea

106 answered, particularly for the intramembrane aspartyl protease (IAP) subtype.

107 uration and expand the role of intramembrane aspartyl proteases in innate immunity.

108 estigate the role of SPPL3, an intramembrane aspartyl protease, in murine NK cell biology.

109 s in an unprecedented manner in the field of aspartyl protease inhibition.

110 The aspartyl protease inhibitor pepstatin, or specific inhib

111 ealed a novel spiropiperidine iminohydantoin aspartyl protease inhibitor template.

112 talloprotease inhibitor), or pepstatin A (an aspartyl protease inhibitor) but was inhibited by E-64 a

113 results from off-target interactions of HIV (aspartyl) protease inhibitor drugs with Ste24.

114 anomolar, low-molecular-weight plasmepsin II aspartyl protease inhibitors have been identified using

115 Aspartyl protease inhibitors preserve endogenous H1.0 le

116 roteasome inhibitors as well as cysteine and aspartyl protease inhibitors stabilize MHC class I compl

117 As aspartyl protease inhibitors, these compounds all posses

118 ysis within autolysosomes with cysteine- and aspartyl-protease inhibitors caused a marked accumulatio

119 teases and gamma-secretase, an intramembrane aspartyl protease involved in Alzheimer's disease, cleav

120 peptidase (SPP) is an intramembrane cleaving aspartyl protease involved in release of leader peptide

121 Renin is an aspartyl protease involved in the production of angioten

122 active site of gamma-secretase, a polytopic aspartyl protease involved in the transmembrane processi

123 sin D is unaffected, showing that this major aspartyl protease is not involved in degradation of Ii o

124 This unique intramembrane-cleaving aspartyl protease is required for the normal processing

125 The gamma-secretase aspartyl protease is responsible for the cleavage of num

126 which has little or no homology to any known aspartyl protease) is itself a transmembrane aspartyl pr

127 Cathepsin D (CD), the major intracellular aspartyl protease, is a mediator of IFN-gamma and TNF-al

128 In fish, cathepsin D, an aspartyl protease, is believed to mediate the processing

129 Gamma-secretase, a unique aspartyl protease, is required for the regulated intrame

130 Within lysosomes, cathepsin D (CtsD), an aspartyl protease, is suggested to be the main protease

131 the first cleavage event is a transmembrane aspartyl protease known as beta-site amyloid precursor p

132 Four aspartyl proteases known as plasmepsins are involved in

133 es are a highly conserved family of cysteine-aspartyl proteases known for their essential roles in re

134 tor motif that has not been described in the aspartyl protease literature and may serve as a starting

135 on of the previously characterized secretory aspartyl protease MGSAP1 in both diseased groups, in les

136 d glycosyl-phosphatidylinositol-linked yeast aspartyl proteases, Mkc7p and Yap3p (collectively termed

137 The beta-secretase is membrane-bound aspartyl protease, most commonly known as BACE1.

138 cursor protein (APP) by an integral membrane aspartyl protease named the beta-site APP-cleaving enzym

139 ecently identified as a novel membrane-bound aspartyl protease, named BACE1, Asp2, or memapsin 2.

140 Here we show that an inhibitor of the HIV aspartyl protease, Nelfinavir, triggers inflammasome for

141 as high selectivity for BACE1 over other key aspartyl proteases, notably cathepsin D, and profoundly

142 but otherwise has only modest homology with aspartyl proteases of known three-dimensional structure

143 An analysis of the diversity of the aspartyl proteases of Plasmodium falciparum, known as pl

144 ecretase complex, are intramembrane-cleaving aspartyl proteases of the GxGD type.

145 bers of the family of intramembrane-cleaving aspartyl proteases of the GXGD-type.

146 aspartyl protease) is itself a transmembrane aspartyl protease or a gamma-secretase cofactor, or help

147 h proteolysis near the plasma membrane as an aspartyl protease or cofactor.

148 s PS1 might function in Notch cleavage as an aspartyl protease or di-aspartyl protease cofactor.

149 y that results in the activation of cysteine-aspartyl proteases, or caspases.

150 Export is dependent on the activity of the aspartyl protease, plasmepsin V (PMV), which cleaves pro

151 opportunity to examine the role this unique aspartyl protease plays in altering Abeta metabolism and

152 no inhibition of other proteases such as the aspartyl proteases porcine pepsin, human cathepsin D, pl

153 igen, which is homologous to secreted fungal aspartyl proteases, protected mice against pulmonary inf

154 ts associated with strong inhibition of this aspartyl protease raised serious concerns regarding this

155 A second integral membrane aspartyl protease related to BACE1, referred to as beta-

156 The aspartyl protease renin catalyzes the initial and rate-l

157 fic inhibitors Aliskiren and VTP23999 of the aspartyl protease renin suppressed HSC EV-induced platel

158 The aspartyl protease renin was first isolated from the kidn

159 tanding of the mechanisms whereby BACE1, the aspartyl protease required for the initial cleavage of A

160 Gamma-secretase is an intramembrane-cleaving aspartyl protease required for the normal development of

161 ase enzyme 1 (BACE1), a type I transmembrane aspartyl protease required to cleave amyloid precursor p

162 osomal acidification as well as cysteine and aspartyl proteases resident within these organelles.

163 aving enzyme 1 (BACE1), an integral membrane aspartyl protease responsible for cleavage of amyloid pr

164 BACE1 is an aspartyl protease responsible for cleaving amyloid precu

165 eaved within the plane of the membrane by an aspartyl protease, resulting in a soluble MHC class I fr

166 s, including a nucleic acid binding protein, aspartyl protease, reverse transcriptase and integrase.

167 nts in galactose also inhibited secretion of aspartyl protease (Sap) and caused 90-nm secretory vesic

168 Coinfection with a secreted aspartyl protease (sap) mutant sap2456 and S. oralis inc

169 egy was also applied to a hemeprotein and an aspartyl protease, setting the stage for broad applicabi

170 Thus, human SPPL3 is the first GxGD-type aspartyl protease shown to be capable of acting like a s

171 cally cleavage by the intramembrane-cleaving aspartyl protease signal peptide peptidase (SPP), is inv

172 activity and inactivation studies, using an aspartyl protease specific suicide inhibitor, demonstrat

173 The GxGD aspartyl proteases SPPL2a and, to a lesser extent, SPPL2

174 The assay has also been applied to related aspartyl proteases such as cathepsin D (Cat D) and BACE-

175 A transmembrane aspartyl protease termed beta-site APP cleavage enzyme 1

176 ion of a gene encoding a chloroplast-located aspartyl protease that alters its pattern of expression.

177 effected by Presenilin, an unusual polytopic aspartyl protease that apparently cleaves Notch and nume

178 etalloprotease (glycoprotease) and one is an aspartyl protease that belongs to the recently described

179 cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease that catalyzes the proteolytic process

180 BACE1 is a type I transmembrane aspartyl protease that cleaves amyloid precursor protein

181 gamma-secretase complex is an intramembrane aspartyl protease that cleaves its substrates along thei

182 peptide peptidase (SPP) is an intramembrane aspartyl protease that cleaves remnant signal peptides a

183 beta-Secretase (BACE) is a membrane-bound aspartyl protease that cleaves the amyloid precursor pro

184 gamma-Secretase is an intramembrane aspartyl protease that cleaves the amyloid precursor pro

185 uct is a glycosylphosphatidylinositol-linked aspartyl protease that functions as a yeast secretase.

186 ified substrates of a unique intramembranous aspartyl protease that has presenilin as its active-site

187 HIV encodes an aspartyl protease that is activated during, or shortly a

188 BACE2, an aspartyl protease that is structurally related to BACE1,

189 Cathepsin D is an aspartyl protease that plays a crucial role in normal ce

190 rsor protein cleaving enzyme 1 (BACE1) is an aspartyl protease that plays a key role in the productio

191 BACE1 is a membrane-bound aspartyl protease that specifically cleaves amyloid prec

192 Caspases are a family of cysteine-aspartyl proteases that are well recognized for their es

193 (SPP) and gamma-secretase are intramembrane aspartyl proteases that bear similar active site motifs

194 ite of APP suggest that gamma-secretases are aspartyl proteases that catalyze a novel intramembranous

195 lin 2 (PS2) are proposed to be transmembrane aspartyl proteases that cleave amyloid precursor protein

196 se is a founding member of membrane-embedded aspartyl proteases that cleave substrates within transme

197 de peptidase (SPP) are related transmembrane aspartyl proteases that cleave transmembrane substrates.

198 (BACE1) is a membrane-tethered member of the aspartyl proteases that has been identified as beta-secr

199 sess a hydroxyethylene dipeptide isostere of aspartyl protease transition state analogs, suggesting g

200 ed by pepstatin and more potently by a novel aspartyl protease transition-state analog inhibitor that

201 Both proteases are inhibited by the same aspartyl protease transition-state analogue inhibitors,

202 Aspartyl protease upregulation occurred and may represen

203 hromatography on pepstatin-A agarose bed the aspartyl proteases were purified and concentrated over 2

204 cleaving enzyme 1 (BACE1), the transmembrane aspartyl protease which initiates Abeta production, is a

205 protease inhibitors (HIV-PIs) target the HIV aspartyl protease, which cleaves the HIV gag-pol polypro

206 results identify a mechanism that couples an aspartyl protease with a molecular cochaperone to trigge

207 gamma-Secretase is an unusual and ubiquitous aspartyl protease with an intramembrane catalytic site t

208 nhibitors suggest that gamma-secretase is an aspartyl protease with loose sequence specificity.

209 vious suggestions that gamma-secretase is an aspartyl protease with some properties similar to those

210 tor, Y1, of the basic residue-specific yeast aspartyl protease, yapsin 1, was synthesized and charact

211 racellular inhibitory domain of Msb2p by the aspartyl protease Yps1p generated the active form of the

212 ggesting that intact wild-type PS1 may be an aspartyl protease zymogen.