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1  was homologous to sequences of other fungal aspartyl proteinases.
2 ida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investi
3                                     It is an aspartyl proteinase able to specifically cleave fibronec
4 r virulence factors: the secretion of active aspartyl proteinases and the formation of hyphae.
5                                              Aspartyl proteinases are a widely distributed family of
6 ogenic cells resists inhibitors of serine or aspartyl proteinases as well as tissue inhibitor of matr
7 llmark of tumor invasion and metastasis, and aspartyl proteinase cathepsin D is implicated as a major
8 90 known substrates for gamma-secretase, the aspartyl proteinase complex that liberates the amyloid b
9  N-terminal amino acid sequence and a fungal aspartyl proteinase consensus amino acid sequence.
10 us mutants deficient in one or more secreted aspartyl proteinases encoded by SAP genes or in transcri
11 enetic analysis of the ALS and SAP (secreted aspartyl proteinase) families show that the ALS family i
12  structure for the possible evolution of the aspartyl proteinase family, with particular reference to
13 f intron positions and intron phases between aspartyl proteinases from nematodes and apicomplexans.
14 lytic gene expression, we compared secretory aspartyl proteinase gene (SAP) and phospholipase B gene
15 ure, but in other organisms the structure of aspartyl proteinase genes varies considerably.
16 c gene PEP1 (SAP1), which encodes a secreted aspartyl proteinase, in the expression of the unique opa
17 ed the role of Candida parapsilosis-secreted aspartyl proteinase isoenzyme 1 (SAPP1) in virulence.
18                                 The secreted aspartyl proteinases of Candida albicans have long been
19           The cDNA encoding the coccidioidal aspartyl proteinase open reading frame was cloned and th
20 ony appearances, mating competency, secreted aspartyl proteinase (Sap) activities, and virulence.
21 vivo expression of Candida albicans secreted aspartyl proteinase (SAP1-SAP8) and phospholipase B (PLB
22 phal-specific virulence factors, such as the aspartyl proteinases Sap4 and Sap5 and the proposed inva
23 enes that encode virulence-related secretory aspartyl proteinases (Saps).
24                               All vertebrate aspartyl proteinases share a conserved nine-exon gene st
25 ene of C. albicans encodes a unique secreted aspartyl proteinase that contributes to corneal pathogen
26 ntified substrates, including eight secreted aspartyl proteinases, the exoglucanase Xog1p, the immuno
27                              The recombinant aspartyl proteinase was purified by immobilized metal af