ライフサイエンスコーパス: assembly

1 pool of mRNAs as virion genome during virus assembly.

2 etic analysis of magnetic nanoparticle (MNP) assembly.

3 r a certain sequencing technology or a small assembly.

4 rature by circa 4-7 degrees C for isothermal assembly.

5 ng in at least three different blocks in 60S assembly.

6 revealed the mechanisms and consequences of assembly.

7 very little is known about cytoplasmic cilia assembly.

8 e to A22, a small-molecule inhibitor of MreB assembly.

9 thaliana contribute to the plant microbiome assembly.

10 ecular clips" using coordination-driven self-assembly.

11 involved in cell signaling, regulation, and assembly.

12 determinants involved in templating amyloid assembly.

13 ne inversion and to support global haplotype assembly.

14 for fatty-acyl-CoA and is active in membrane assembly.

15 ffect our understanding of NPC structure and assembly.

16 in negatively regulating APC-mediated actin assembly.

17 gradable and biocompatible polymers via self-assembly.

18 protein (NiV M) plays a major role in virus assembly.

19 el counts and required time-consuming manual assembly.

20 ostly long-read data to produce high-quality assemblies.

21 atalytic applications of such supramolecular assemblies.

22 struction of redox-controlled supramolecular assemblies.

23 Whether the NR controls neuronal assemblies, a hallmark of information exchange between t

24 re properly aligned to the bovine Y sequence assembly accounted for 46.49%, indicating the success in

25 N6 protein and inhibited respiratory complex assembly/activity.

26 otein and other candidate components of this assembly, aiding future investigations on the role of ba

27 ts, as assumptions made by the single genome assembly algorithms do not apply when assembling multipl

28 Generating high-quality genome assemblies and annotations for many aquatic species stil

29 ryo-EM structures reveal conserved intricate assemblies and human-specific features associated with p

30 sic concepts about inflammasome composition, assembly and activation, effector functions and role in

31 n the raw data, which are called Rmaps, make assembly and alignment of them challenging.

32 oligospora natural strains, calculated after assembly and annotation of the genomes of 20 isolates.

33 A chromosome-level genome assembly and annotation were established for one of the

34 ents of this matrix and are required for the assembly and architecture of biofilms produced by a wide

35 The assembly and associated functions of RC also depend on t

36 This study identifies mechanisms of V-ATPase assembly and biogenesis that rely on the integrated role

37 d highly dynamical chemical process involves assembly and disassembly of many molecules in multiple c

38 processes in cytoskeletal bundles: filament assembly and disassembly, the attachement-detachment dyn

39 ses and processing methods, details of virus assembly and egress at (sub)nanometer resolution were un

40 xes affords us a better understanding of the assembly and function of metalloclusters in diverse appl

41 lux transporters with a primary focus on the assembly and function of the inner membrane pumps.

42 ular mechanisms regulating DG neural circuit assembly and function remain unclear.

43 ding effects of organismal tolerances on the assembly and functioning of reef fish communities are la

44 differences that significantly affect COPII assembly and identify a specific function for SAR1B in l

45 viruses, may direct activities such as virus assembly and innate immune modulation.

46 However, our molecular understanding of the assembly and internal organization of these multicompone

47 Cell division requires the assembly and organization of a microtubule spindle for t

48 By modeling viral lattice assembly and recapitulating oscillations in protein expr

49 Retroviral Gag polyproteins orchestrate the assembly and release of nascent virus particles from the

50 microcage designs with such straight-forward assembly and scalability, as well as controllable loadin

51 availability of genomic data, phased genome assembly and structural variant (SV) analyses are limite

52 and simulations on the dynamic network self-assembly and subsequent collapse of the synthetic homopo

53 sembly is well established, the mechanism of assembly and the dynamics of PIC components are not full

54 itry controls the average final complexoform assembly and the variation in the assembly structure.

55 ng samples with a mean of >99.8% identity to assemblies, and increased the proportion of mapped reads

56 ns that play roles in UAF complex integrity, assembly, and biological function, and provide roles for

57 ter confined in a supramolecular tetrahedral assembly, and determined that a dynamically distinct net

58 h a combination of imprint lithography, self-assembly, and electrodeposition.

59 ogical processes thought to govern community assembly, and facilitate development of microbiota-direc

60 ransition prior to further viral maturation, assembly, and release, implying additional steps in IB f

61 structures define the mechanism of filament assembly, and reveal how filament-dependent allosteric r

62 or eIF4E, and reduces cell growth, polysome assembly, and translation of reporter mRNAs with structu

63 igomerization of PrPSc into small multimeric assemblies appears to be a critical biophysical feature

64 Current trio assembly approaches are not designed to incorporate long

65 lar mechanisms of multivalent WW domain-PPXY assemblies are still poorly understood.

66 Third, interparticle interactions in the assembly are closely related to the symmetry of the part

67 ors critical for its entry, replication, and assembly are poorly understood.

68 a key role in architecting the Cep63-Cep152 assembly around centriolar MTs and promoting centriole b

69 lex but did exhibit intrinsic focal adhesion assembly as well as contractile differences that resulte

70 provides a model for nucleic acid/amyloid co-assembly as well as insight into the energetic determina

71 sembly interfaces, and the development of M1 assembly assays with purified proteins are crucial advan

72 hermodynamics of a transition metal (TM) ion assembly be it in proteins or in coordination complexes

73 identification of native protein quaternary assemblies (binders/nonbinders) based on statistical pot

74 The structure reveals a tetrameric IN assembly bound to two molecules of the phosphatase via a

75 s its cargo, at most, to the site of exosome assembly, but it is not itself incorporated into exosome

76 re and Cappuccino synergize to promote actin assembly, but the mechanism of their synergy is controve

77 ) are essential regulators of neural circuit assembly, but their roles in vertebrate neural circuit f

78 ." Inhibition of Arp2/3 complex inhibits TMT assembly by both mechanisms.

79 onents are displaced before nuclear envelope assembly by the movement of chromosomes to a dense clust

80 faces upon confined evaporation-induced self-assembly (C-EISA).

81 GO self-assembly can be controlled by changing the degree of oxi

82 modulating parasite transmission, community assembly can modify the relationship between host and pa

83 , this system highlights the remarkable self-assembly capacity of 3D cultures to form functional circ

84 tid cohesion defects and an impaired spindle assembly checkpoint (SAC), thus undergoing mitotic slipp

85 vacuole protein sorting) tethering and SNARE-assembly complex, and the Rab Ypt7, bound to membranes b

86 cultures store memories in large distributed assemblies composed of individual brains, intrageneratio

87 we show that spatially segregated functional assemblies composed of interneurons and pyramidal cells

88 tips are remarkably consistent under various assembly conditions, including different tubulin concent

89 maging microscopy we identified higher order assemblies containing 40 molecules (median) (IQR: 23, 87

90 f future biocompatible devices where peptide assemblies could complex with native and non-native syst

91 stalk, and 30S contact sites all show severe assembly defects.

92 ered that the efficiency of the NCLP (N-RNA) assembly depends on the length and sequence of the RNA i

93 le superresolution microscopy to study TNFR1 assembly directly in native cellular settings and at phy

94 3-1, NSF and alphaSNAP, which coordinate the assembly-disassembly cycle of neuronal SNARE complexes.

95 perates with RPS2B to facilitate the dynamic assembly/disassembly of the 90S/SSU processome during ri

96 s define a mechanism essential for replisome assembly during DNA replication initiation that is vulne

97 sights into the factors governing hemoglobin assembly during erythropoiesis.

98 ive priority effects, which altered parasite assembly during natural epidemics.

99 mmetric subphthalocyanine 1 can undergo self-assembly either as a tail-to-tail dimer, showing monomer

100 Our work shows that centromere assembly epigenetically drives GSC maintenance and occur

101 ent Merqury, a novel tool for reference-free assembly evaluation based on efficient k-mer set operati

102 rol mechanism in which the abundant ribosome assembly factor, RbfA, suppresses protein synthesis by i

103 eta gradually tune the activities of spindle assembly factors.

104 he creation of high quality chromosome scale assemblies feasible and low cost.

105 terative mapping" approach, conducts de novo assembly, filters and disentangles the assembly graph, a

106 Here we show that acentrosomal spindle assembly following PLK4 inhibition depends on levels of

107 ies of soft tissue systems and multimaterial assemblies for next generation wearable devices and robo

108 te the importance of chromosome-scale phased assemblies for the discovery of structural variants (SVs

109 We describe a convenient assembly for screen printed carbon electrodes (SPCE) sui

110 These assemblies form after attachment of short cytosolic prot

111 region to dock onto the side of the helicase assembly formed by Cdc45 and GINS.

112 ation factor 2 subunit 1 (eIF2alpha), the SG assembly G3BP paralogs, or release of mRNAs from ribosom

113 onents using sequence composition, coverage, assembly graph information and network partitioning base

114 novo assembly, filters and disentangles the assembly graph, and produces all possible configurations

115 for identifying viral genomes in metagenomic assembly graphs that is based on analyzing variations in

116 Mechanically guided, 3D assembly has attracted broad interests, owing to its com

117 actory in the nonneuronal cells in which its assembly has been best studied.

118 Template-directed assembly has been shown to yield a broad diversity of hi

119 Hybrid genome assembly has emerged as an important technique in bacter

120 Our assembly has excellent agreement overall with the curren

121 or the discovery of unconventional spherical assemblies in other related discotic molecules by the in

122 tivity and the dynamics of microtubule/motor assemblies in vitro as well as in diverse intracellular

123 Finally, continued CENP-A assembly in differentiated cells is nonessential for egg

124 d its effector, MAPK Sty1, downregulates CAR assembly in S. pombe when its integrity becomes compromi

125 Primordial follicle assembly in the mouse occurs during perinatal ages and l

126 a highly efficient inhibitor of protein self-assembly in vivo and in vitro that forms functional olig

127 of animal complexes with distinct molecular assemblies, including a megadalton-scale tRNA multi-synt

128 ul means for studying macromolecular protein assemblies, including accessing activated states.

129 duces collagen cross-linking and fibronectin assembly, increases drug penetration, and downregulates

130 shape or composition, but not both, as self-assembly inherently entangles shape and composition.

131 M1 structure, the identification of critical assembly interfaces, and the development of M1 assembly

132 discernible in the lattices we predict early assembly intermediates, and indeed we observe such struc

133 otropic nanoparticles into complex 2D and 3D assemblies is one of the most promising strategies towar

134 A high quality genome assembly is a vital first step for the study of an organ

135 e Golgi is a dynamic organelle whose correct assembly is crucial for cellular homeostasis.

136 of di(2-pyridyl)ketone in subcomponent self-assembly is introduced.

137 ynthetic targets because a three-dimensional assembly is necessary for their formation.

138 f the fusogenic ectodomain to branched actin assembly is sufficient to drive cell-cell fusion.

139 Although the pathway of PIC assembly is well established, the mechanism of assembly

140 ays through seeded growth can accelerate the assembly kinetics and increase the optimal temperature b

141 errogate structure-function relationships of assembly line PKSs.

142 anotechnology is systems able to achieve the assembly-line like production of molecules.

143 onstruction and design of biological machine assembly lines.

144 Our work provides insight into the assembly mechanism of these bacterial organelles and wil

145 framework to quantitatively infer community assembly mechanisms by phylogenetic bin-based null model

146 imilar to previous work on TNTs, we find two assembly mechanisms for TMTs, which we term "pull-away"

147 om regional species pool and local community assembly mechanisms.

148 e is known about the mechanisms required for assembly membrane proteins.

149 We present an updated reference genome assembly (Mmul_10, contig N50 = 46 Mbp) that increases t

150 We show that our assembly model reproduces many key features of ecologica

151 significantly improve the physiology of NPC assembly mutants, despite having only negligible effects

152 itive to feedback inhibition, explaining why assembly occurs under physiological conditions that requ

153 lupin (2n = 50, 451 Mb), as well as de novo assemblies of a landrace and a wild relative.

154 Creating gapless telomere-to-telomere assemblies of complex genomes is one of the ultimate cha

155 Supramolecular assemblies of enamel matrix proteins (EMPs) play a key r

156 Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be sep

157 f hypotheses on the structures of biological assemblies of many systems.

158 They are composed of multichain assemblies of misfolded cellular prion protein.

159 The PVH uses combinatorial assemblies of molecularly defined neuron populations for

160 Stress granules (SGs) are cytoplasmic assemblies of proteins and non-translating mRNAs.

161 erate some of the first telomere-to-telomere assemblies of whole chromosomes.

162 l architecture, and demonstrate hierarchical assembly of a 100 megadalton DNA-origami barrel of ~90 n

163 The successful assembly of a closed protein shell (or capsid) is a key

164 ture of adaptive immunity is achieved by the assembly of a functional AgR gene on one allele, with su

165 prehensive method that enabled the efficient assembly of a high-quality and diverse library containin

166 , along with a gapless, telomere-to-telomere assembly of a human chromosome.

167 clic tri-adenylate second messenger promotes assembly of a NucC homohexamer competent for non-specifi

168 first example of the enzyme-instructed self-assembly of a synthetic peptide for trafficking endogeno

169 To gain insights into the structure and assembly of Abeta oligomers, our laboratory has previous

170 Solution-phase self-assembly of anisotropic nanoparticles into complex 2D an

171 Despite advances in directing the assembly of biomacromolecules into well-defined nanostru

172 at conformational switching may modulate the assembly of CD81-partner protein networks.

173 HIV transcription requires assembly of cellular transcription factors at the HIV-1p

174 ion of the dynamic ejection, deformation and assembly of charged droplets by control of Taylor cone i

175 ves the tissue's water content, allowing the assembly of collagen fibrils to be imaged in high resolu

176 played by internal double bonds on the self-assembly of discrete large molecules at the liquid/solid

177 ic field, conditions the nonequilibrium self-assembly of domains, and bridges nucleation and spinodal

178 In contrast, assembly of equimolar mixtures of mutant and wild-type d

179 olid-state CNT mimic structures via the self-assembly of fluorinated nanohoops, which can be synthesi

180 t catalytic inhibitors prevent the chromatin assembly of functional replisomes.

181 f a subtype-specific Kv7 activator to assess assembly of heteromeric KCNQ2/KCNQ3 (Kv7.2/Kv7.3) channe

182 We report the self-assembly of hierarchically organized particles (HOPs) fr

183 tion of peptide nanotubes was applied in the assembly of highly ordered two-dimensional droplet netwo

184 and regulates contraction by catalysing the assembly of integrin-associated adhesome complexes that

185 resting cells that is poised to orchestrate assembly of key signaling components upon reception of a

186 Here, we report a chromosome-level genome assembly of L. japonica, comprising nine pseudochromosom

187 se sites and its oligomerization promote the assembly of large nuclear bodies, which sequester SRSF7

188 linking early rostrocaudal patterning to the assembly of limb control circuits.

189 Finally, we detail the design and assembly of microfluidic paper-based devices that use Ca

190 n of alpha-tubulin, and promotes the dynamic assembly of microtubules, remodels the cytoskeleton, and

191 oding RNA NEAT1 serves as a scaffold for the assembly of paraspeckles, membraneless nuclear organelle

192 n the lipid-packing order takes place during assembly of pre-pore oligomers.

193 How functional assembly of presynaptic active zones is controlled via t

194 The structure and assembly of SGs and how different components contribute

195 at the cellular interface mediate organized assembly of single cells into tissues and, thus, govern

196 irects the composition and register-specific assembly of synthetic collagen heterotrimers.

197 nsively investigate proteins involved in the assembly of the 1,2-propanediol utilization bacterial mi

198 Here we report the molecular assembly of the authentic SARS-CoV-2 virus using cryoele

199 xtile manufacturing: from fiber extrusion to assembly of the fibers to fabrics.

200 with MinC and MinE, the Min system restricts assembly of the FtsZ-ring to midcell, oscillating betwee

201 nism of interplay between the expression and assembly of the LH1 complex that is regulated through in

202 ivision in eukaryotes requires the regulated assembly of the spindle apparatus.

203 Here, we report a chromosome-scale assembly of the T. sinense genome.

204 Assembly of the Tat translocon is dynamic and is trigger

205 imity guided assembly to generate a 15.87 Mb assembly of the Y chromosome.

206 ns for the organizing principles that govern assembly of these large loci as well as for mechanisms t

207 The developmental assembly of this binocular circuit, especially the trans

208 The assembly of this catalytic centre is essential for the a

209 o domains is mediated by recognizing stalled assembly of triple-helical domains or by direct engageme

210 The self-assembly of Tween 80 (T80) micelles loaded with plant-ba

211 of the helical membrane tube arises from the assembly of two distinct bundles of helical filaments th

212 elucidate how HSV gE/gI and US9 promote the assembly of virus particles and sorting of these virions

213 iversity in function, basic insight into the assembly of well-defined amphiphilic polymers to form fu

214 1.5x and 12x were observed for these protein assemblies on integration of FAIMS.

215 ge, 10 kinesin-2 motors "line up" in a tight assembly on the trains [3], provoking the question of ho

216 hesis and with GTPases that control ribosome assembly or activity.

217 echanistic level, OOC-5/torsinA promotes the assembly or maintenance of the lamin-associated LINC com

218 s that are critical for transduction, capsid assembly, or DNA packaging.

219 The influence of various assembly parameters including type of mixing solvent, su

220 Our findings indicate a previously unknown assembly pathway and inspire a suggestion as to why this

221 that guanidinium reactivates a latent septin assembly pathway that was suppressed during fungal evolu

222 nase 2 (TTBK2) is a key player in the cilium assembly pathway, controlling the final step of cilia in

223 Traditionally, molecular assembly pathways for viruses are inferred from high res

224 ances in the physical understandings of self-assembly pathways obtained using in situ atomic force mi

225 -dependent assembly restrictions that render assembly pathways primarily dependent on nanoparticle sy

226 fully demonstrate that the regulation of the assembly pathways through seeded growth can accelerate t

227 t reversion to the unassembled form, even if assembly per se does not enhance biological function(3-7

228 However, current assembly polishing algorithms can only polish an assembl

229 ue to insufficient understanding of the self-assembly process at the nanoscale.

230 s across a membrane, offer insights into the assembly process of Complex III and allow mapping of hum

231 o-holes" interfaces, suggested a cooperative assembly process of heavy chains in heterodimers.

232 ochemistry of carbohydrates impacts the self-assembly process remains unclear.

233 olarographic technique was used to track the assembly process under flash illumination as a function

234 amer that precede the Cu(II)-induced amyloid assembly process, results which are distinct from beta2m

235 otein plays a central role in the flavivirus assembly process.

236 ommunity composition and inferring community assembly processes across four major habitat types (free

237 munity composition and underlying ecological assembly processes differ between lotic habitats by exam

238 llustrates the importance of local community assembly processes in shaping geographical patterns of s

239 o examine how a fungal pathogen affected the assembly processes structuring the amphibian skin microb

240 rays, and to correlate the bonds design with assembly processes.

241 the promises of ENS for developing molecular assemblies/processes for functions.

242 ng the power and limitations of various read assembly programs in practice is important for researche

243 n, and phosphatidylinositol binding clathrin assembly protein.

244 bule end density negatively influences their assembly rates.

245 structures by negative stain EM of in vitro assembly reactions.

246 tems, such as the role of generalists during assembly, realistic maximum trophic levels, and increase

247 oss of Smyhc1 results in defective sarcomere assembly, reduces larval motility and fish survival, but

248 et, the underlying mechanism for the network assembly remains unclear.

249 orally regulated to ensure efficient spindle assembly remains unclear.

250 Cell wall assembly requires harmonized deposition of cellulose and

251 The historic passing of a World Health Assembly resolution on RHD in 2018 now mandates a coordi

252 n emerges from competing chirality-dependent assembly restrictions that render assembly pathways prim

253 Magnetic measurements of these assemblies reveal Curie-Weiss behavior at high temperatu

254 ganic cations is crucial to control POM self-assembly, stabilization, solubility, and function.

255 d metal catalysts by employing a single self-assembly step where organic monolayer films were deposit

256 required complex and lengthy processing and assembly steps.

257 ntra- and intermolecular metal-mediated self-assembly steps.

258 Current self-assembly strategies allow impressive levels of control o

259 Such a self-assembly strategy is extensively used by viruses to incr

260 neral, and high throughput solvent-free self-assembly strategy to synthesize a series of MMOs includi

261 or a unifying quantitative framework for the assembly, structural maintenance and function of the nuc

262 mplexoform assembly and the variation in the assembly structure.

263 lutionally conserved, the mammalian ribosome assembly system is more complex than in yeasts.

264 configurable combinations to create chemical assembly systems (CAS) targeting compounds and libraries

265 of stress granules, the punctate protein-RNA assemblies that form during stress.

266 rious cellular activity are a set of protein assemblies that function as molecular motors to couple t

267 generation of disease-related multichain PrP assemblies that propagate by seeded protein misfolding.

268 rystallization is a ubiquitous means of self-assembly that can organize matter over length scales ord

269 nce-free workflow for diploid de novo genome assembly that combines the chromosome-wide phasing and s

270 Here we present a human genome assembly that surpasses the continuity of GRCh38(2), alo

271 e (NiB) as an acceptor into the NPS-SC4AD co-assembly, the light-harvesting system becomes near-infra

272 ne regulation and ribonucleoprotein particle assembly throughout the nucleus.

273 logists should explicitly consider grassland assembly time and endogenous disturbance regimes in stud

274 ate temperature, particle concentration, and assembly time is investigated.

275 ding relationships that organize compartment assembly to develop a new structural model.

276 novel strategy based on evaporation-induced assembly to enable directional ion transport via forming

277 equencing with a Hi-C-based proximity guided assembly to generate a 15.87 Mb assembly of the Y chromo

278 h dimeric 14-3-3 enforces a dimeric BRAF(KD) assembly to increase BRAF activity.

279 during fungal evolution in order to restrict assembly to octamers.

280 any viruses employ ATP-powered motors during assembly to translocate DNA into procapsid shells.

281 gellar biogenesis and implies that flagellar assembly transcriptionally regulates the production of m

282 hat inhibit viral entry, endocytosis, genome assembly, translation, and replication.

283 ll genes involved in heparin/heparan sulfate assembly uncovered a transcription factor-binding motif

284 ly reduced increase in V-ATPase activity and assembly upon starvation.

285 mbly polishing algorithms can only polish an assembly using reads from either a certain sequencing te

286 allowed us to determine that septin filament assembly was a diffusion-driven process, while formation

287 We found that bacterial community assembly was predictable from linear combinations of the

288 ies for exceedingly flexible and pleomorphic assemblies, we have determined cryo-EM structures of apo

289 These assemblies were tightly linked to LTB(4) formation.

290 Several tools, from base-calling to genome assembly, were ported and benchmarked on an Android smar

291 whereas diseased lipid membranes form folded assemblies with high local curvature.

292 rentiation compared to BMSCs cultured on the assemblies with larger pore size.

293 gated over graphitic domains to intercalated assemblies with polymer bilayers between sheets.

294 hymal stem cells (BMSCs) on the 3D nanofiber assemblies with smaller pore size show significantly hig

295 network yields a cooperative supramolecular assembly with a hybridization architecture that enhances

296 lated in a tissue-specific manner through co-assembly with beta subunits KCNE1-5.

297 (HDX-MS) to investigate how FIXa responds to assembly with FVIIIa in the presence of phospholipids.

298 Pt(II) thiolates and CB[8] form 2:1 assemblies, with both metallic centers sitting on top of

299 able selection, for soil bacterial community assembly within islands.

300 Synthetic assembly within living cells represents an innovative wa