ライフサイエンスコーパス: assembly state

1 degrade specific protein pools depending on assembly state.

2 -GlcNAc sites and show that they regulate NF assembly state.

3 idual pigment sites as a function of protein assembly state.

4 ertoire of Lon substrates to be tuned by its assembly state.

5 latory mechanisms in controlling kinetochore assembly state.

6 ative electrophoresis (BNE) to study GluA1-3 assembly state.

7 eptors shows a strong dependence on the TMVP assembly state.

8 f NMIIB to mechanorespond by influencing its assembly state.

9 the coupling of molecular interactions with assembly state.

10 ciliogenesis, tubulin synthesis, and tubulin assembly state.

11 d structures but lacks temporal control over assembly state.

12 ein refolding activities enabled by distinct assembly states.

13 substrate that likely represent intermediate assembly states.

14 basis of aggregation of Abeta into distinct assembly states.

15 neurodegenerative diseases exist in diverse assembly states.

16 does not induce the formation of additional assembly states.

17 pping thousands of phosphopeptides and their assembly states.

18 or simultaneous characterization of PTMs and assembly states.

19 Two different assembly states (36-mers and 32-mers) coexist as well as

20 pH and metabolic inputs determine the final assembly state and activity of the V-ATPase.

21 We have studied the assembly state and affinity of OPG for RANK-L by sedimen

22 heavy chain regulates the molecular motor's assembly state and localization.

23 iate filaments (IF) is known to affect their assembly state and organization; however, little is know

24 ely freely through a large space of possible assembly states and demonstrates the power of characteri

25 tionships between phosphorylation events and assembly states and generates testable hypotheses for fo

26 a systematic method to simultaneously study assembly states and PTMs from the same sample is critica

27 ng the transition from dimeric to tetrameric assembly states and, second, at a postassembly trafficki

28 exhibited purification behavior, CD spectra, assembly state, and inducer binding properties similar t

29 examined the equilibrium folding properties, assembly states, and stabilities of the early folding st

30 valence of intermediate and large oligomeric assembly states are associated with both ageing and Alzh

31 These changes in cell shape and IF assembly states are reversible.

32 sitions through different conformational and assembly states as it matures into a functional helicase

33 gulation is morphogenetically coupled to the assembly state by control of the anti-sigma factor FlgM.

34 tamer is a physiological, stable, and active assembly state capable of forming lethal toxins that may

35 Transient assembly states coincided with electrochemically generat

36 abeled MNP monitored non-invasively based on assembly state-dependent changes in the emission spectru

37 ors that arrest SNARE complexes in different assembly states differentially modulate a-syn(FL)'s abil

38 ch represent the features of an intermediate assembly state during maturation, the SP1 peptide exists

39 We demonstrate that this assembly state exhibits the highest ATPase and proteolyt

40 le-particle electron microscopy confirms the assembly states for 11 designs.

41 C), self-association of cro to species with assembly states greater than dimers is not observed.

42 ons was performed to compare the microtubule assembly state in neurons of diseased and control cases

43 The ability to control assembly state in protein capsids such as AaLS could aid

44 x-ray scattering to reveal their oligomeric assembly states in solution.

45 rototypical SPI-1 NC in four distinct needle assembly states, including near-atomic resolution, and l

46 onassociating species or as a combination of assembly states independent of protein concentration.

47 osterically regulated by the transmission of assembly-state information from the C-terminal domain, w

48 strate that multiple inputs to the myosin II assembly state integrate at the level of myosin II to go

49 iological alpha-syn conformers into compact, assembly-state intermediates by glucosylceramide (GluCer

50 are highly dynamic, and the regulation of NF assembly state is incompletely understood.

51 ore dynamic than previously reported and its assembly state is sensitive to stimuli that alter cellul

52 ly, the relative population of the different assembly states is determined via a Bayesian-based Monte

53 st, a basis set comprising a small number of assembly states is generated from extensive CG simulatio

54 s in terms of their sizes, interactions, and assembly states is key to understanding their biological

55 We demonstrate wide tunability of transient assembly state lifetimes over two orders of magnitude by

56 ows that resistin circulates in two distinct assembly states, likely corresponding to hexamers and tr

57 r core, exhibits three microtubule-dependent assembly states, not directly dependent on tension.

58 on with Hsp104, in regulating the length and assembly state of [PSI+] prion fibrils in vivo.

59 Rho1p regulates the assembly state of actin on the peroxisome membrane, ther

60 be due, at least in part, to defects in the assembly state of actin.

61 We used mutagenesis to change the assembly state of Alzheimer disease (AD)-associated amyl

62 cate that, in addition to lipid content, the assembly state of apoE influences Abeta binding and rece

63 t studies have shown that the lipidation and assembly state of apolipoprotein E (apoE) determine rece

64 otide analogues, we have also correlated the assembly state of ClpA in the presence of these nucleoti

65 lytical ultracentrifugation to determine the assembly state of CVX in solution and surface plasmon re

66 otif is active as a kinase regardless of the assembly state of cytoskeletal septin filaments.

67 es of these mice showed, besides an abnormal assembly state of endocytic factors at synapses, the pre

68 Microtubules also alter the assembly state of FAs by modulating Rho GTPase signaling

69 r spatiotemporal expression and the physical assembly state of fibronectin (FN) matrix play key roles

70 pothesis that activity is dependent upon the assembly state of Gag.

71 While the assembly state of GerQ within the spores and the direct

72 nction as a dynamic, polymerized GTPase, the assembly state of its partner, FtsA, and the role of ATP

73 larity of migrating cells by controlling the assembly state of NMII-A, its cellular localization, and

74 en together, these data demonstrate that the assembly state of peroxisomal proteins and the chaperone

75 substrate and regulators that determine the assembly state of receptor-substrate complexes.

76 ect a general strategy for manipulating the] assembly state of substrate proteins.

77 self and foreign epitopes regardless of the assembly state of the antigen, suggesting that conjugati

78 n is temporally regulated in response to the assembly state of the growing flagellum.

79 Furthermore, the assembly state of the Mediator complex is dysregulated i

80 These data demonstrate that the assembly state of the Mediator complex undergoes physiol

81 ochemical studies conflict on the oligomeric assembly state of the protease complex, and its detailed

82 presented to show that Mmp37 may affect the assembly state of the TIM23 complex.

83 ontrol cardiolipin metabolism and affect the assembly state of TIM23 and its association with PAM in

84 However, solutions of the stacked disk assembly state of TMV are difficult to characterize quan

85 mine the effects of nestin expression on the assembly state of vimentin IFs in nestin-free cells.

86 disease (AD) is associated with pathological assembly states of amyloid-beta protein (Abeta).

87 The assembly states of apoBCCP and apoBCCP87 were determined

88 A total of eleven assembly states of BTV capsid were captured, with resolu

89 The observed changes in the biochemical assembly states of Cdc20 closely correlate to the known

90 heir GTP- and GDP-bound states, intermediate assembly states of GTP-tubulin, and final assembly stage

91 simulations is developed to characterize the assembly states of Hck, a member of the Src-family kinas

92 spectrometry experiments characterizing the assembly states of intact NtrC4 (a sigma(54) activator f

93 To examine the assembly states of isolated BRCT domains and pairwise do

94 rogress has been achieved in quantifying the assembly states of NE proteins in their native environme

95 how that smMDS is effective in resolving the assembly states of protein oligomers and in characterizi

96 mination of subunit-subunit interactions and assembly states of this enzyme.

97 Using CDMS, previously unobserved assembly states of TMV, including 16-monomer disks and o

98 Thus, initial stochasticity in assembly states on individual particles, amplified throu

99 s previously implicated in altering V-ATPase assembly state or glucose-induced assembly.

100 ternary structure occurs via changes in self-assembly state or through the gain or loss of protein su

101 RECQ1's assembly state plays a critical role in modulating its h

102 pramolecular structures were compared to the assembly states predicted by packing constraints that we

103 These findings demonstrate that UvrD assembly state regulates its DNA helicase activity with

104 tinct catalytic site coordination sphere and assembly state relative to QueD and possesses a dynamic

105 rbed, whereby a decrease in the III(2)-IV(2) assembly state relative to the III(2)-IV form is observe

106 sting state and the CymA-induced alternative assembly state rely on interactions between the ClpC1 co

107 relocalization and achieves its procentriole-assembly state remains unknown.

108 amer equilibrium that explains the different assembly states reported in previous studies.

109 Cryo-EM of the intermediate assembly states reveals two types of tubulin lateral con

110 Analysis of the assembly state showed that the His6-alpha and beta subun

111 IM21) degrades antibody-bound proteins in an assembly state-specific manner due to the requirement of

112 resist the effects of O-GlcNAcylation on NF assembly state, suggesting a potential link between dysr

113 imarily stable dimers, with the higher-order assembly states suppressed.

114 ion of the full repertoire of conformers and assembly states that can be accessed by PrP under specif

115 otides in the bI3 group I intron RNP in four assembly states: the free RNA, maturase-bound RNA, Mrs1-

116 nance biosensor analysis to characterize the assembly state, thermodynamics, and kinetics of the CD4-

117 uctural plasticity by forming diverse higher assembly states through interacting ClpL rings.

118 The ability to control their assembly state under physiological conditions would furt

119 and Abeta42 have different conformations and assembly states upon refolding from their unfolded ensem

120 rent shifts in the equilibrium population of assembly states upon the binding of different signaling

121 , stability, and dynamics of P8 in different assembly states using time-resolved Raman spectroscopy a

122 nting all viable individual or combinatorial assembly states, we dissect the basic organizational pri

123 dynamics as well as relative populations of assembly states, we here employ a combination of native