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1 overexpressed by use of a cardiotropic adeno-associated virus.
2 RISPR/Cas9 gene editing machinery with adeno-associated virus.
3 ine heart was performed by means of an adeno-associated virus.
4 ceous nanocontainers and genome-packed adeno-associated viruses.
5 splantation of PCs pretransfected with adeno-associated virus 1-vascular endothelial growth factor-A1
6 r either virus to replicate.IMPORTANCE Adeno-associated virus 2 (AAV2) differs from most other viruse
9 cation, we constructed two recombinant adeno-associated-virus 2 (rAAV2) vectors encoding CIP fused wi
14 , were given injections of recombinant adeno-associated virus 8 vector that expressed the primary miR
15 fl) Shc mice on FFD were injected with adeno-associated virus 8-thyroxine-binding globulin-Cre-recomb
17 n primate model of HIV infection, with adeno-associated virus 9 (AAV9)-CRISPR/Cas9 gene editing const
18 e symporter) to noninvasively quantify adeno-associated virus 9 (AAV9)-mediated gene expression in a
20 ere, we demonstrate that a recombinant adeno-associated virus 9 (rAAV9) is highly effective for trans
22 e were injected with M7.8L packaged in adeno-associated virus 9 at 3 days of age and 60 days of age.
23 In the present study, we delivered adeno-associated virus 9 carrying green fluorescent protein-CI
24 e performed intramuscular injection of adeno-associated virus 9 carrying the TIPE2 gene in mdx mice.
25 and treated with a sCAR-Fc expressing adeno-associated virus 9 vector 1, 3, and 7 days after CVB3 in
26 ively in cardiomyocytes by using AAV9 (adeno-associated virus 9) to deliver multiplexed single guide
30 scending coronary artery ligation, and adeno-associated virus 9-mediated in vivo overexpression in mi
33 so increased in CPVT mice, and further adeno-associated virus-9-induced overexpression of SN attenuat
37 Here we report a rationally designed adeno-associated virus (AAV) 6 capsid that demonstrates effici
40 ACV CRISPR antivirals was tested using adeno-associated virus (AAV) as a packaging vector for both Sa
45 6 wks were injected unilaterally with adeno-associated virus (AAV) containing either NT3 or GFP gene
46 delivery with naturally recombinogenic adeno-associated virus (AAV) donor vectors enables site-specif
47 tasis in AMD, we delivered recombinant adeno-associated virus (AAV) encoding Abeta42 and Abeta40 pept
49 lpha-synuclein (alpha-syn) fibrils and adeno-associated virus (AAV) expressing human wild-type alpha-
50 ceived nodose ganglia injections of an adeno-associated virus (AAV) expressing short hairpin RNAs tar
51 nvolvement in conflict, we injected an adeno-associated virus (AAV) expressing the genetically encode
52 ffective long-term therapy for NIU, an adeno-associated virus (AAV) gene therapy approach was used to
53 e therapy for corneal vascularization, adeno-associated virus (AAV) gene therapy, exploiting a natura
54 d via intrathecal administration of an adeno-associated virus (AAV) gene transfer vector significantl
56 9 systems that can be packaged into an adeno-associated virus (AAV) hold great promise for gene thera
57 owever, in vivo delivery of mAgrin via adeno-associated virus (AAV) into FKRP mutant mice was unable
64 protein (AAP) is a recently discovered adeno-associated virus (AAV) protein that promotes capsid asse
65 s system, we systemically delivered an adeno-associated virus (AAV) serotype 9 carrying the human GBA
66 determine the efficacy of intrathymic adeno-associated virus (AAV) serotypes to transduce thymocyte
68 ent of SDS-PAGE for purity analysis of adeno-associated virus (AAV) therapeutic products of different
69 in adult animals successfully delivers adeno-associated virus (AAV) throughout the cervical, thoracic
70 ously reported compassionate use of an adeno-associated virus (AAV) vector containing the human AADC
72 ateral alBST-targeted injections of an adeno-associated virus (AAV) vector expressing short hairpin R
74 tered a single intravenous dose of the adeno-associated virus (AAV) vector, AAV-BR1-CAG-NEMO, deliver
75 ntracerebroventricular injection of an adeno-associated virus (AAV) vector-based system encoding an a
77 itical pre-clinical model for studying adeno-associated virus (AAV) vector-mediated gene therapies.
81 dentified Anc80L65 from a set of other adeno-associated virus (AAV) vectors as a potent vector for th
82 ntramuscular or systemic injections of adeno-associated virus (AAV) vectors encoding nuclease-dead Ca
86 these issues, and such approaches with adeno-associated virus (AAV) vectors have been shown to be saf
87 Immune responses in gene therapy with adeno-associated virus (AAV) vectors have been the object of a
91 HIV monoclonal antibodies (mAbs) using adeno-associated virus (AAV) vectors holds promise for the pre
96 e are systematically investigated with adeno-associated virus (AAV), an anterograde viral tracer.
97 present two methods for radiolabeling adeno-associated virus (AAV), one of the most commonly used vi
98 ilar efficacy by gene augmentation via adeno-associated virus (AAV), providing a proof-of-concept for
99 )-independent CRISPR-Cpf1 systems with adeno-associated virus (AAV), we were able to build a stable C
102 G proliferation, along with reports of adeno-associated virus (AAV)-based MG reprogramming and functi
104 a well-established mouse model, using adeno-associated virus (AAV)-delivered meganucleases, as a pot
105 ibozymes enabled in vivo regulation of adeno-associated virus (AAV)-delivered transgenes, allowing do
109 cy on atherosclerosis using a model of adeno-associated virus (AAV)-induced hypercholesterolemia.
110 an inflammatory disease model and used adeno-associated virus (AAV)-mediated Ac45 RNA interference kn
111 r HIV is a crucial public health need; adeno-associated virus (AAV)-mediated antibody gene delivery c
113 ort a genome editing approach in which adeno-associated virus (AAV)-mediated CRISPR/Cas9 delivery to
114 f a mouse model of SARS-CoV-2 based on adeno-associated virus (AAV)-mediated expression of hACE2.
117 rimary adult rat ventricular myocytes, adeno-associated virus (AAV)-mediated gene delivery in mice, a
123 ere, we describe the development of an adeno-associated virus (AAV)-mediated gene therapy to treat th
124 address this challenge, we first used adeno-associated virus (AAV)-mediated gene transfer to perform
129 ice that receive systemic injection of adeno-associated virus (AAV)2/1-carrying truncated gRNAs targe
130 144F) MNs, and intrathecal delivery of adeno-associated virus (AAV)9-mir-17~92 improves motor deficit
131 To address this, we developed a novel adeno-associated virus (AAV-GLP-1R) that utilizes short hairpi
134 ed by large size (limiting delivery by adeno-associated virus [AAV] vectors), off-target editing, or
135 CLC by delivering an adenovirus (or an adeno-associated virus [AAV]) that expresses Cre recombinase a
136 )/dy(2j) mouse model of MDC1A using an adeno-associated virus (AAV9) carrying a catalytically inactiv
137 was delivered to the brains of mice by adeno-associated virus (AAV9) via stereotactic injection.
138 (L-G6pc(-/-) ) mice were treated with adeno-associated viruses (AAVs) 2 or 8 directed against short
144 CRISPR-associated protein 9 (Cas9) and adeno-associated viruses (AAVs) evades adaptive immune respons
146 ined cell types, recombinase-dependent adeno-associated viruses (AAVs) have become the tool of choice
147 nt AAV genome transcription.IMPORTANCE Adeno-associated viruses (AAVs) have proven to be effective ge
148 nd tight junction integrity.IMPORTANCE Adeno-associated viruses (AAVs) have recently emerged at the f
150 neutralizing antibodies (NAbs) against adeno-associated viruses (AAVs) pose a major, unresolved chall
151 here by stamping cultured neurons with adeno-associated viruses (AAVs), is completed in a few minutes
152 showed 1.3- to 1.7-fold-lower growth of cell-associated virus and 3- to 6.2-fold-lower growth of cell
153 5 Snord115 genes were packaged into an adeno-associated virus and administered to a mouse model of AS
154 s versus D2-MSNs using a Cre-inducible adeno-associated virus and Cre lines during cocaine conditione
155 specific molecular interaction between adeno-associated virus and its host cell, which can be rapidly
156 amples showed similarity to Anthurium mosaic-associated virus and Persea americana chrysovirus, putat
157 ceptor 2 [sTGFbetaR2]) delivered using adeno-associated viruses and explored their ability to mitigat
161 animal host, endosymbiotic dinoflagellates, associated viruses, bacteria, and other microeukaryotes.
163 tment of a mouse model of OPMD with an adeno-associated virus-based gene therapy combining complete k
165 Moreover, intra-articular injection of adeno-associated virus carrying HPIP-specific short hairpin RN
166 y, overexpression of VZVsncRNA13 using adeno-associated virus consistently increased VZV spread and p
168 We have designed a double-stranded adeno-associated virus containing a rat proglucagon promoter (
170 uantitative viral load testing of transplant-associated viruses continues to be limited by interlabor
171 sequencing results confirmed that our adeno-associated virus-CRISPR/Cas9 strategy was very efficient
172 single-dose systemic administration of adeno-associated virus-delivered CRISPR-Cas9 components suppre
173 of the gyrencephalic brain by systemic adeno-associated virus delivery in human neurological diseases
176 worked with remarkable speed to identify the associated virus, determine its relationship to animal v
178 with a single intrathecal infusion of adeno-associated virus encoding a microRNA targeting SOD1.
180 dynamic injection or transduction with adeno-associated virus encoding the HBV genome (AAV-HBV).
182 Next, the anterograde transport of an adeno-associated virus expressing DREADDs was paired with loca
183 ress-susceptible or mice injected with adeno-associated virus expressing shRNA against Cldn5 caused i
185 uopathy utilizing neonatal delivery of adeno-associated viruses expressing wild-type (WT) or mutant t
186 similar results in mice infected with adeno-associated virus-expressing small hairpin RNAs targeting
188 sruption of anchoring in vivo using an adeno-associated virus gene therapy vector inhibited cardiac h
191 -Fos using photoreceptor-specific AAV (adeno-associated virus)-hRK (human rhodopsin kinase)-sh_c-fos
194 s, has greatly expanded our knowledge of gut-associated viruses in devils and provides important base
196 orter genes into the safe-harbor locus adeno-associated virus integration site 1 in human embryonic s
197 dition, introduction of 3xMyc-FXR1 via adeno-associated virus into mice leads to the redistribution o
198 ISPRa, we injected CRISPRa-recombinant adeno-associated virus into the hypothalamus, which led to rev
199 the packaging capacity of recombinant adeno-associated virus is limited while tissue-specific delive
200 Systemic delivery of dCas9/gRNA by adeno-associated virus led to reductions in pathological RNA f
201 e considered mechanical vectors of honey bee-associated viruses, making them a potential threat to po
202 rs virus function, and we suggest that tumor-associated viruses may be more likely to contain DNA mix
203 s of KLF5 function approaches and AAV (adeno-associated virus)-mediated Klf5 delivery in mice showed
204 on and that induction of NRF2 using an adeno-associated virus-mediated approach in hepatocytes in viv
205 ared axons, using projection-specific, adeno-associated virus-mediated chemogenetic neuronal silencin
206 striatal cell culture model of HD, and adeno-associated virus-mediated Elk-1 overexpression alleviate
207 we explored the effects of recombinant adeno-associated virus-mediated expression of Abeta38 and Abet
209 letion in the NAc in adult mice, using adeno-associated virus-mediated expression of cre recombinase,
210 e intravitreally delivered recombinant adeno-associated virus-mediated expression of soluble Fms-rela
211 To assess efficacy in vivo, we used adeno-associated virus-mediated expression of the most potent
213 the JCI, Wang et al. demonstrate that adeno-associated virus-mediated overexpression of TGF-beta1 pr
219 ction of an engineered virus, often an adeno-associated virus or herpes simplex virus, among many oth
221 stereotactic hippocampal injections of adeno-associated virus particles in mutant hAPP Tg mouse brain
222 We generated multifunctional hybrid adeno-associated virus/phage (AAVP) particles to enable simult
225 intranigral injections of recombinant adeno-associated virus pseudotype 2/5 to overexpress wildtype
228 recent market approvals of recombinant adeno-associated virus (rAAV) gene therapies in Europe and the
230 d release of a therapeutic recombinant adeno-associated virus (rAAV) vector overexpressing the chondr
231 he non-tumor-bearing (NT), recombinant adeno-associated virus (rAAV) vector-treated GSD-Ia mice (AAV-
232 microdystrophin genes and recombinant adeno-associated virus (rAAV) vectors is an attractive strateg
233 rapy in G6pt-/- mice using recombinant adeno-associated virus (rAAV) vectors, directed by either the
236 transducing the BSCs with recombinant adeno-associated viruses (rAAVs) that express alpha-synuclein
240 3 types of icosahedral viral capsids: Adeno Associated Virus serotype 2 (AAV2) and Minute Virus of M
242 n to recent clinical translation in an adeno-associated virus serotype 2-mediated human aromatic L-am
244 intravenous dose of a codon-optimized adeno-associated virus serotype 5 (AAV5) vector encoding a B-d
246 ological doses of MIS, using either an adeno-associated virus serotype 9 (AAV9) gene therapy vector o
247 gene therapy for NPC1, we constructed adeno-associated virus serotype 9 (AAV9) vectors to deliver th
249 e modulated expression of FTO by using adeno-associated virus serotype 9 (in vivo), adenovirus (both
250 s expressed using a self-complementary adeno-associated virus serotype 9 (scAAV9) viral vector in the
252 received a single dose of intravenous adeno-associated virus serotype 9 carrying SMN complementary D
256 An in vivo rescue experiment with adeno-associated virus serotype 9 TnT-MEK1-CA nearly abolished
257 /Cas9-based cardiac gene editing using adeno-associated virus serotype 9 to deliver a single short gu
260 lications, we found that prior in vivo Adeno-associated virus serotype 9-mediated gene delivery of GJ
263 ctivation by genetic overexpression or adeno-associated virus serotype-9-based gene delivery was capa
264 eover, IRE-1 activator, Quercetin, and adeno-associated virus serotype-9-delivered XBP-1s were able t
265 ced by intraparenchymal delivery of an adeno-associated virus-short hairpin RNA construct was suffici
266 was genetically targeted using a novel adeno-associated virus shuttle vector to deliver microRNA-adap
267 r administration of miR-204-expressing adeno-associated virus significantly decelerates OA progressio
268 We found a high prevalence of known tumor-associated viruses such as Epstein-Barr virus (EBV), hep
269 in the VTA, we delivered Cre-inducible adeno-associated virus that drives the expression of fluoresce
271 TS-HIF-1alpha(-/-) ) by microinjecting adeno-associated virus that expressed Cre-recombinase in HIF-1
272 that of crAssphage, the most abundant human-associated virus that is found in about 50% of human gut
273 ed into NAc variants of a new designer adeno-associated virus that permits robust retrograde access t
274 a transgene or after infection with an adeno-associated virus that transferred an overlength HBV geno
275 ce, using Cre recombinase delivered by adeno-associated virus to knockout endogenous hepatic Insr acu
277 in patients with hepatitis B virus or adeno-associated virus type 2 infection might involve activati
278 nts infected with hepatitis B virus or adeno-associated virus type 2, due to integration of the virus
279 t transgenic Cre mice or injected with adeno-associated virus type 8 (AAV8) Cre and fed diets to prom
280 XCL10(-/-) mice, using the neurotropic adeno-associated virus type 8 (AAV8) vector, boosted the numbe
281 reus) and guide RNA constructs into an adeno-associated virus vector and systemically delivered them
282 K(b) D(b)) (null) ( IA(null)) mice via adeno-associated virus vector increased human CD45(+) cell eng
284 administration of an FGF21-expressing adeno-associated virus vector recapitulated these complication
285 Intravascular injection of certain adeno-associated virus vector serotypes can cross the blood-br
286 approach for Alzheimer's disease using adeno-associated virus vector-based knockdown of CD33 reduced
287 tor retargeting.IMPORTANCE Recombinant adeno-associated virus vectors (rAAVs), based on AAV8 and AAVr
290 elements in the context of recombinant adeno-associated virus vectors has enabled cell-type-restricte
291 g in a common mouse model of AD, using adeno-associated virus vectors normalized glutamate signaling
292 patients, and gene augmentation using adeno-associated virus vectors robustly sustained the rescue o
294 type mice via stereotaxic injection of adeno-associated virus, we found that adult cerebellar neurons
295 e if any of six commonly occurring honey bee-associated viruses were present in ants collected from w
296 bited incomplete neutralization against cell-associated virus with T/F Envs, which was not observed w
297 simultaneously differentiates all 169 human-associated viruses with at least 10 published genome seq
298 understand the long-term impacts of outbreak-associated viruses within medical systems using traditio
299 ors can package larger transgenes than adeno-associated viruses, yet lentiviral vectors remain largel
300 specific overexpression of human ZIP8 (adeno-associated virus-ZIP8 [AAV-ZIP8]) resulted in increased