ライフサイエンスコーパス: astroglia

1 a1 (microglia), COX-1 (microglia), and GFAP (astroglia).

2 th the bacterial lipopolysaccharide (LPS) in astroglia.

3 ession of inducible NO synthase in activated astroglia.

4 ve intranuclear inclusions in neurons and in astroglia.

5 he substantia nigra but in the microglia and astroglia.

6 ting the selective uptake of angiogenin into astroglia.

7 n contributed to activation of microglia and astroglia.

8 nthase (CerS) 6 in monocytes/macrophages and astroglia.

9 nd resulted in fewer activated microglia and astroglia.

10 were purely via contact between T cells and astroglia.

11 e role of N-SMase in the activation of human astroglia.

12 d generation of proinflammatory molecules in astroglia.

13 nuclear factor-kappaB in Abeta1-42-activated astroglia.

14 hat the phenotype may be cell autonomous for astroglia.

15 ion in primary microglia, but not in primary astroglia.

16 d NFkappaB were associated with this site in astroglia.

17 ructural characteristics of both neurons and astroglia.

18 ld, suggesting AQP4-dependent K(+) uptake by astroglia.

19 dendrocytes, whereas BCATm is the isoform in astroglia.

20 omically defined subset of adult gray matter astroglia.

21 in human U373MG astroglial cells and primary astroglia.

22 mal models to be metabolized specifically in astroglia.

23 nduced the production of NO in human primary astroglia.

24 hat Tat is secreted from RSV-tat-transfected astroglia.

25 stochemistry for microglia, macrophages, and astroglia.

26 hat monensin also raises intracellular pH in astroglia.

27 (ADNF), a protein secreted by VIP-stimulated astroglia.

28 stributed glial fibrillary acidic protein-ir astroglia.

29 ynthesis by mobilizing [Ca2+]i in developing astroglia.

30 xamined, including fibroblasts, myeloma, and astroglia.

31 ivity in these cells indicates that they are astroglia.

32 enduring reduction in synaptic proximity by astroglia.

33 urce and metabolic function are regulated by astroglia.

34 exity of calcium signaling mechanisms in CNS astroglia.

35 r dense perisynaptic expression primarily on astroglia.

36 the end feet and radial processes of Muller astroglia.

37 to the multitude of adaptive roles played by astroglia.

38 ed abnormal gene expression profiles from DS astroglia.

39 synthase, and thrombospondins 1 and 2 in DS astroglia.

40 onal, but not transcriptional, mechanisms in astroglia.

41 rminals accumulate d-aspartate as quickly as astroglia.

42 nction of interneurons, oligodendrocytes and astroglia.

43 ls in the VZ/SVZ region are neurons, 30% are astroglia, 15% are nestin+ cells, with other cell types

44 fferent percentages of microglia (10-20%) or astroglia (40-50%) back to the neuron-enriched cultures

45 strocyte preparations indicate that cortical astroglia account for approximately one-third of the tot

46 Here, we aimed to evaluate the role of astroglia activation in vivo in patients with Parkinson'

47 regulation and in correlation with prominent astroglia activation.

48 of fluorescently labeled AQP4+/+ and AQP4-/- astroglia after implantation into mouse brains in which

49 nd characterize an inhibitory role played by astroglia after neuronal transplantation.

50 low input resistance of electrically passive astroglia allows extracellular currents to pass through

51 n the human brain, SVZ cells including local astroglia also express EZH2, correlating with postnatal

52 hic GFAP(+)/vimentin(+)/nestin(+) "reactive" astroglia and also the plasticities and lineage relation

53 embryonic stem cell programs in NPC-derived astroglia and altered their 3D cellular morphology by ac

54 t targets: a neurotrophic effect mediated by astroglia and an anti-inflammatory effect mediated by th

55 nd post-synaptic compartments of neurons and astroglia and are a unique model for studying the synapt

56 water-selective channel that is expressed in astroglia and basolateral plasma membranes of epithelia

57 Non-neurogenic cell types, such as cortical astroglia and fibroblasts, can be directly converted int

58 s, especially mGluR5) in developing cortical astroglia and found that developmental arborization of a

59 ut regional or functional subgroups of brain astroglia and how they may interact with neurons.

60 pecified during mid-embryogenesis to produce astroglia and interneurons, switch their fate and genera

61 phagocytic cells (e.g. activated microglia, astroglia and macrophages) for the efficient removal of

62 nally secreted factor that is endocytosed by astroglia and mediates neuroprotection in paracrine.

63 resent experiments, we studied activation of astroglia and microglia after intraocular scrapie infect

64 xpression of Socs3 mRNA and protein in mouse astroglia and microglia in both a time- and dose-depende

65 e in the activation of brain-derived primary astroglia and microglia in prion disease and perhaps oth

66 To study the roles of astroglia and microglia in these cytokine responses, pri

67 onneuronal pathology in neocortex (activated astroglia and microglia) is consistent with findings in

68 pha was observed only in neurons, but not in astroglia and microglia, and it was contingent on the ac

69 s contained micro-opioid receptor-expressing astroglia and microglia, and since glia are the principa

70 hanges in the number and activation of brain astroglia and microglia, particularly in the region of t

71 ts induced strong COX-2 expression mainly in astroglia and microglia, whereas COX-1 expression was pr

72 progenitor cells (GPCs), which give rise to astroglia and myelin-producing oligodendrocytes.

73 ise precursors displaying traits of juvenile astroglia and neural stem cell markers.

74 ate/glutamine neurotransmitter cycle between astroglia and neurons (0.32 +/- 0.07 micromol x gm(-1) x

75 tmentalization of glucose metabolism between astroglia and neurons but indicate that the compartmenta

76 Rapid signal exchange between astroglia and neurons has emerged as a key player in neu

77 Rapid signal exchange between astroglia and neurons has emerged as an essential elemen

78 ies and functional disorders, affecting both astroglia and neurons with a pathogenesis that is only m

79 gical features of intranuclear inclusions in astroglia and neurons.

80 mma was unique in inducing Shh expression in astroglia and NSCs, while paradoxically suppressing Gli1

81 roglia) or neuroepithelial progenitor cells (astroglia and oligodendrocytes).

82 but each progenitor compartment produces new astroglia and oligodendroglia; the latter expand 10- to

83 but not A-SMase, decreased the activation of astroglia and protected neurons from fibrillar Abeta tox

84 PVN LepR are not expressed in astroglia and rarely in microglia; instead, glutamatergi

85 ndings demonstrate heterogeneity of reactive astroglia and show that scar borders are formed by newly

86 awareness that synaptic plasticity involves astroglia and the extracellular matrix is revealing new

87 d the association between digitally isolated astroglia and the presynaptic marker synapsin I was quan

88 opriate targets, whereas Pax2(+) optic nerve astroglia and Vim(+) radial glia may aid in early axonal

89 the extrinsic factors (such as perisynaptic astroglia) and the intrinsic factors (such as core subce

90 neurons survived longer than either NPCs or astroglia, and a small proportion were alive until at le

91 es showed marked activation of microglia and astroglia, and cytokine profiling indicated that macroph

92 in vivo include immature and mature neurons, astroglia, and endothelial cells.

93 active sites in hippocampal pyramidal cells, astroglia, and in microglia within 72 h after a period o

94 rillary acidic proteins (GFAPs), a marker of astroglia, and interleukin-1beta (IL-1beta), a prototype

95 lectively named endozepines, are secreted by astroglia, and ODN is a potent anorexigenic factor.

96 entiate into three neural lineages (neurons, astroglia, and oligodendrocytes) when cultured in differ

97 rebellum give rise to cortical interneurons, astroglia, and oligodendroglia.

98 etained the size and pleomorphism of hominid astroglia, and propagated Ca2+ signals 3-fold faster tha

99 neurons, giant neuroglial cells, dysplastic astroglia, and reactive astrocytes.

100 dentity of cells induced from Ink4a/Arf-null astroglia, and short hairpin RNA-mediated acute knockdow

101 eful for studying the heterogeneity of human astroglia, and the unique Olig2PC-Astros may constitute

102 molecules, such as NO, IL-1beta, and IL-6 in astroglia, and these responses were purely via contact b

103 ttern recognition receptors on microglia and astroglia, and trigger an innate immune response charact

104 Astroglia are a principal target of long-term mu antipro

105 These astroglia are enriched in mouse cortical layer V; expres

106 Astroglia are heterogeneous, and not all astroglia are equivalent in promoting neural repair.

107 Astroglia are heterogeneous, and not all astroglia are e

108 Double null mutant astroglia are hyper-responsive to stimulation with epide

109 Astroglia are interposed between the cerebral vasculatur

110 Activated microglia and astroglia are known to be involved in a variety of neuro

111 Astroglia are multifunctional cells that regulate neuroi

112 These data suggest that astroglia are not involved in the generation or migratio

113 ical evidence strongly suggests that resting astroglia are potential sources of nitric oxide--a power

114 ocomotion-induced Ca(2+) elevations in mouse astroglia are profoundly inhibited by ethanol, an effect

115 Because astroglia are the predominant cell type contacting LHRH-

116 ese results indicate that some microglia and astroglia arise from a precursor that is a normal consti

117 troglia, but the utilization of hPSC-derived astroglia as cell therapy for neurological diseases has

118 g-dependent interactions between neurons and astroglia, as well as distinct sensorimotor signal propa

119 expression of mSOD1(G93A) in motoneurons and astroglia, as well as microglia, was required to produce

120 SCI, cell processes deriving from different astroglia associated into overlapping bundles that quant

121 yte precursor-correlated proneural toward an astroglia-associated gene expression pattern, manifest i

122 ssage in vitro, wild-type postnatal cortical astroglia become progressively resistant to Dlx2-induced

123 (14)C]lactate oxidation to (14)CO(2) only in astroglia but not in neurons, indicating a kinetic prefe

124 ibrillary acidic protein immunoreactivity in astroglia, but it was not colocalized with markers for o

125 3-HM was neurotrophic after the addition of astroglia, but not microglia.

126 t to volume regulation is provided by Muller astroglia, but the identity of their osmosensor is unkno

127 em cells (hPSCs) have been differentiated to astroglia, but the utilization of hPSC-derived astroglia

128 , it is apparent that both the activation of astroglia by Abeta and that the cytotoxicity of activate

129 neurons from cytotoxic effects of activated astroglia by antisense knockdown of N-SMase, but not aci

130 y corrects the pathological phenotypes of DS astroglia by specifically modulating the expression of S

131 Since abolition of astroglia Ca(2+) activation does not affect motor coordi

132 owever, increases in Ca(2+) concentration in astroglia can also release other signalling molecules, m

133 These results demonstrate that astroglia can play a causal role in regulating the synch

134 ceptors (NMDARs), and it has been shown that astroglia can regulate their activation through Ca(2+)-d

135 lay of Glu and GABA transporters of adjacent astroglia can result in shortened seizures.

136 trocyte-conditioned medium collected from DS astroglia causes toxicity to neurons, and fails to promo

137 licated in dorsal telencephalic neuronal and astroglia cell fate decisions.

138 -dependent chemotactic activity of OPN in C6 astroglia cells and normal human astrocytes.

139 Similar results were observed in human astroglia cells, where endogenous CXCR4 was rapidly phos

140 optic tract and tectum, radial glia and free astroglia coexist.

141 Thus, neuron-astroglia communication via NRG-erbB4/2 receptor signali

142 e in cytokine response between microglia and astroglia correlated with 20-fold-higher levels of PrP e

143 that shape both short- and long-range neuro-astroglia coupling, as these are manifest in epilepsy ph

144 We reported previously that astroglia cultured from aquaporin-4-deficient (AQP4-/-)

145 Immunostaining of astroglia cultured from rat neonatal SON-VGL confirmed t

146 es, motoneuron-like NSC34 cells, and primary astroglia cultures as model systems, we here demonstrate

147 es but not in enriched neuron, microglia, or astroglia cultures nor in mixed neuron-astroglia culture

148 a, or astroglia cultures nor in mixed neuron-astroglia cultures.

149 rected production of interleukin-6 (IL-6) by astroglia decreased overall neurogenesis by 63% in the h

150 Astroglia demonstrate morphological and molecular change

151 he effect of kappa-agonists on the growth of astroglia derived from 1-2-day-old mouse cerebra was exa

152 Furthermore, 3-HM-treated astroglia-derived conditioned media exerted a significan

153 ause we have reported that IL-1 can regulate astroglia-derived dopaminergic neurotrophic factors, it

154 Blocking astroglia-derived Wnt signaling reduces astroglial HIFal

155 ese Olig2PC-Astros differ substantially from astroglia differentiated from Olig2-negative hESC-derive

156 is a critical strategy for cytokine-induced astroglia differentiation and lineage-characteristic gen

157 Transplantation studies show that DS astroglia do not promote neurogenesis of endogenous neur

158 at morphological activation of microglia and astroglia does not predict glial function, and that the

159 ulates the functional maturation of cortical astroglia during development.

160 mplementary and often contradictory roles of astroglia during neuronal integration.

161 [Ca(2+)] inside neuronal dendrites or inside astroglia dye-filled via gap junctions.

162 These findings remind us that astroglia exert positive and negative influences on neur

163 DS astroglia exhibit higher levels of reactive oxygen speci

164 The activated astroglia exhibited hypertrophy and an increased level o

165 harvested from N-PPARgamma-KO mice, but not astroglia, exposed to ischemia in vitro demonstrated mor

166 found that rat Per1::luc and mouse Per2::luc astroglia express circadian rhythms with a genetically d

167 plastic neurons, giant cells, and dysplastic astroglia express high levels of pS6 and demonstrate alt

168 its DNA synthesis and proliferation in human astroglia expressing IL-4 receptors.

169 segregated clusters, whereas STAT3-deficient astroglia failed to do so.

170 sly absent, suggesting that the emergence of astroglia from CN occurred only with passage.

171 We generated functional astroglia from human induced pluripotent stem cells carr

172 ifferentiation and maintenance of functional astroglia from human pluripotent stem cells in a chemica

173 thed by processes from individual developing astroglia from postnatal day (P) 14 to P26, when astrogl

174 fluence of ethanol on proliferation of human astroglia from the gray and white matter of adult tempor

175 ot express markers characteristic for mature astroglia (GFAP), oligodendroglia (CNPase), or neurons (

176 was carried out for 21 days to obtain either astroglia (>95% GFAP(+)) or a 1:5 mixed neuron/astroglia

177 Although it has been suggested that astroglia guide pioneering axons during development, the

178 s regulating the early fate specification of astroglia have been characterized, mechanisms regulating

179 Astroglia have long been thought to play merely a suppor

180 sis that matrix proteins generated by mature astroglia impose temporal and spatial limitations on axo

181 proliferation of both gray and white matter astroglia in a dose and duration dependent manner.

182 dly upregulated by reactive and perivascular astroglia in areas of injury in MS lesions and during EA

183 trigeminal sensory neurons and activation of astroglia in brainstem trigeminal sensory nuclei.

184 al function and injury leads to dysregulated astroglia in CNS disease.

185 ernalized synaptic elements in microglia and astroglia in gp120Tg mice, in a region- and synapse-type

186 by phenotypic transformation of protoplasmic astroglia in gray matter.

187 te expanding knowledge regarding the role of astroglia in regulating neuronal function, little is kno

188 on, probably occurring almost exclusively in astroglia in response to glutamate stimulation, followed

189 find that Syt IV is located in processes of astroglia in situ.

190 oach could potentially enlighten the role of astroglia in supporting brain glutamatergic activity and

191 leads to long-term changes in the density of astroglia in the brain regions involved in stress respon

192 Midline astroglia in the cerebral cortex develop earlier than ot

193 e 2 binding sites are expressed on activated astroglia in the cortex, hippocampus, basal ganglia and

194 control of the production of neurons versus astroglia in the developing hippocampus.Finally, we conf

195 TFAM was reduced in neurons and increased in astroglia in the hippocampi of TDF-treated wt and gp120-

196 of GLT1 in the cortex, but has no effect on astroglia in the hypothalamus, where non-VGluT1(+) synap

197 These findings support a role for astroglia in the hypoxic induction of VEGF expression an

198 This study demonstrates in vivo the role of astroglia in the initiation and progression of Parkinson

199 tly, pioneer RGC axons run among the Pax2(+) astroglia in the optic nerve and reach the superficial o

200 ion and phenotypic transformation of fibrous astroglia in white matter, and solely by phenotypic tran

201 jor cell types, neural precursors (nestin+), astroglia including radial glia (GFAP+, vimentin+), and

202 CO(2) and reduced lactate release mainly in astroglia, indicating that limitations in glucose and la

203 letion of alpha(1A)-adrenergic receptor from astroglia, indicating that norepinephrine acts directly

204 oducts released from activated primary human astroglia induced the activation of neutral sphingomyeli

205 Astroglia interact with cerebral endothelia to maintain

206 Our findings suggest that a microglia-astroglia interaction occurs in rat hippocampus via cell

207 Finally, we show that reprogramming of astroglia into neurons is dependent on the presence of S

208 ably disrupted the organization of elongated astroglia into scar borders, and caused a failure of ast

209 The communication medium of astroglia involves intracellular [Ca(2+)] waves, which u

210 flammation involving activated microglia and astroglia is becoming a hallmark of many human diseases,

211 neurogenic competence of Ink4a/Arf-deficient astroglia is both greatly increased and does not diminis

212 Functional maturation of astroglia is characterized by the development of a uniqu

213 Activation of microglia and astroglia is seen in many neurodegenerative diseases inc

214 hat soluble products released from activated astroglia kill neurons via N-SMase but not A-SMase.

215 to assess METH toxicity in differentiated C6 astroglia-like cells through biochemical and toxicity ma

216 renewal and spontaneous differentiation into astroglia-like cells.

217 es and significant neurodegeneration occurs, astroglia lose their reactive function and such loss in

218 Astrocytes, also called astroglia, maintain homoeostasis of the brain by providi

219 vestigated how these T cells interacted with astroglia, major resident glial cells of the CNS.

220 tem; however, the specific contribution that astroglia make to neurodegeneration in human disease sta

221 itations in glucose and lactate oxidation by astroglia may be due to a greater balance of PDH toward

222 These observations indicate that astroglia may contribute strongly to the abnormal cholin

223 ients with Parkinson's disease and therefore astroglia may play an important role in the initiation a

224 Targeting the JNK pathway in spinal astroglia may present a new and efficient way to treat n

225 First, astroglia mediated the 3-HM-induced neurotrophic effect

226 suggesting that high-level PrP expression on astroglia might be important for induction of certain cy

227 In transwell assays, AQP4+/+ astroglia migrated faster than AQP4-/- cells in a manner

228 a possible correlation between microglia and astroglia morphology in rat models of chronic neuroinfla

229 AQP4+/+ astroglia moved on average 1.5 mm toward the stab compar

230 dysfunctional crosstalk between neurons and astroglia, neurons and innate immune system cells, as we

231 We subsequently demonstrated that it was the astroglia, not the microglia, that contributed to the ne

232 Reactive astroglia observed early in Parkinson's disease could re

233 Cholinergic neurons and cerebral cortical astroglia, obtained separately from Ts16 mouse fetuses a

234 Augmented synapse proximity by astroglia occurred selectively at D2-dopamine receptor-e

235 kI expression was found in testis, heart and astroglia of the qk(v)/qk(v) mice, suggesting that the r

236 rate a subtype of previously uncharacterized astroglia (Olig2PC-Astros).

237 maturation of affected cell types, including astroglia, oligodendroglia and neurons.

238 concept that non-neuronal cells (microglia, astroglia, oligodendroglia) participate in the degenerat

239 deletion of Dicer selectively from postnatal astroglia on brain development.

240 Abeta and that the cytotoxicity of activated astroglia on neurons depend on N-SMase.

241 loid-beta 1-42 (Abeta1-42) peptide-activated astroglia on neurons.

242 ned medium (ACM) to examine the influence of astroglia on the regulation of GABAA receptor/Cl- channe

243 eir low proliferative rate, nor give rise to astroglia or OPCs.

244 Astroglia outside the subventricular zone niche can supp

245 Astroglia play active and diverse roles in modulating ne

246 Developing astroglia play important roles in regulating synaptogene

247 While astroglia play positive roles in the life of the neuron,

248 troglia (>95% GFAP(+)) or a 1:5 mixed neuron/astroglia population (beta-tubulin III(+)/GFAP(+)).

249 a produced only IL-12p40 and CXCL10, whereas astroglia produced these cytokines plus CCL2, CCL3, CCL5

250 characterised by activated CNS microglia and astroglia, proinflammatory peripheral lymphocytes, and m

251 onin may represent a mechanism through which astroglia provide these polyunsaturated fatty acids to n

252 Selective deletion of STAT3 from astroglia quantifiably disrupted the organization of elo

253 Astroglia regulate synaptic glutamate, via neurotransmit

254 echanisms regulating postnatal maturation of astroglia remain essentially unknown.

255 Angiogenin uptake into astroglia requires heparan sulfate proteoglycans, and en

256 conditions on hippocampal neurogenesis from astroglia, resulting in a robust increase in the number

257 Astroglia secrete factors that promote synapse formation

258 Dystrophic neurites and astroglia showed no M-CSFR labeling in the transgenic an

259 ems, we demonstrated that microglia, but not astroglia, significantly enhanced the progression of MPT

260 pattern of cytokine release by microglia and astroglia similar to that induced by scrapie-infected br

261 We show that a small population of Gfap+ astroglia spans the midline of the zebrafish forebrain i

262 We use an astroglia-specific promoter fragment in transgenic mice

263 In cocultures, wild-type astroglia spontaneously corralled inflammatory or fibrom

264 ven the differences between human and rodent astroglia, study of human cells in this way will be cruc

265 identification and characterization of this astroglia subpopulation.

266 udies provide evidence that human and rodent astroglia subtypes are regionally and functionally disti

267 ast, phosphacan message was detected only in astroglia, such as the Golgi epithelial cells of the cer

268 o inhibition of miR-128-3p in FMRP-deficient astroglia sufficiently rescues decreased mGluR5 function

269 at Cx43 was expressed in punctate fashion on astroglia, surrounding all types of blood vessels and in

270 In astroglia, TDF caused a dose-dependent increase in oxyge

271 ypertrophic, vimentin(+)/nestin(+), reactive astroglia that accumulated in spinal cord in this multip

272 2 in mice with conditional MeCP2 deletion in astroglia, these data support the hypothesis of an impor

273 By contrast, long-range activation of astroglia through gap junctions may promote recurrent se

274 nuclear inclusions were found in neurons and astroglia throughout the brain in cortical and subcortic

275 To specifically measure the contribution of astroglia to brain energy metabolism in humans, we used

276 ut the cortex; furthermore, the targeting of astroglia to dorsolateral cortex requires FGFr2 signalin

277 a major receptor in mediating developmental astroglia to neuron communication.

278 a into scar borders, and caused a failure of astroglia to surround inflammatory cells, resulting in i

279 t mice, suggesting that precise targeting of astroglia to the cortex has unexpected roles in axon gui

280 oglia from postnatal day (P) 14 to P26, when astroglia undergo dramatic postnatal maturation.

281 After hypoxia, immature cortical astroglia underwent a shift toward neuronal fate and gen

282 h 20-fold-higher levels of PrP expression in astroglia versus microglia, suggesting that high-level P

283 t proinflammatory molecules in microglia and astroglia via cell-to-cell contact.

284 ial processes are abnormal and GFAP-positive astroglia were aberrantly present on the pial surface.

285 idermal growth factor (EGF)-stimulated human astroglia were arrested in G1 phase by IL-4, even though

286 Activated astroglia were detected in the cortex and hippocampus fo

287 Primary human astroglia were exposed to increasing doses of TDF for 24

288 sessing the morphological characteristics of astroglia were weakly immunoreactive for the endothelial

289 ein was expressed primarily in microglia and astroglia, whereas DR5 co-localized with neurons and OPC

290 fibrillary acidic protein-positive (GFAP(+)) astroglia, which also express immunoreactive nestin and

291 lutamate receptor 5 (mGluR5) signaling in S1 astroglia, which elicits spontaneous somatic Ca2+ transi

292 is assisted by another glial population, the astroglia, which forms a dense meshwork of cytoplasmic p

293 d the release of neurotrophic factor(s) from astroglia, which in turn was responsible for the neurotr

294 are formed by newly proliferated, elongated astroglia, which organize via STAT3-dependent mechanisms

295 iR-128-3p, in mouse and human FMRP-deficient astroglia, which suppresses developmental expression of

296 ained in the adult, defining the optic nerve astroglia, which wrap the left and right nerves separate

297 s unidirectionally to induce RNA cleavage in astroglia, while the ALS-associated K40I mutant is also

298 CI consisted primarily of newly proliferated astroglia with elongated cell processes that surrounded

299 Surprisingly, the reassociation of astroglia with synapses was compensatory, and preventing

300 human glia were gap-junction-coupled to host astroglia, yet retained the size and pleomorphism of hom