ライフサイエンスコーパス: astrovirus

1 n microscopy reconstruction image of a human astrovirus.

2 MAbs) were produced against serotype 1 human astrovirus.

3 to have potent neutralizing activity against astrovirus.

4 o those observed after infection with intact astrovirus.

5 ttended norovirus, rotavirus, sapovirus, and astrovirus.

6 ted for norovirus, rotavirus, sapovirus, and astrovirus.

7 entified cross-species transmission of a rat astrovirus.

8 bute to the adaptive immune response against astrovirus.

9 nt of vaccines and antiviral drugs targeting astrovirus.

10 ghly divergent from all previously described astroviruses.

11 sid protein, a property apparently unique to astroviruses.

12 mary site of infection and pathogenicity for astroviruses.

13 he molecular surfaces of immature and mature astroviruses.

14 that drive the cross-species transmission of astroviruses.

15 man and avian spikes, and studies with human astrovirus 1 (HAstV-1) suggest a minor role in infection

16 t a visit, 26% (78/305) were associated with astrovirus; 17% (78/452) of astrovirus infections were a

17 e report the crystal structure of the turkey astrovirus 2 (TAstV-2) capsid surface spike domain, dete

18 4.5-5.0), Campylobacter spp (3.5%, 0.4-6.3), astrovirus (2.7%, 2.2-3.1), and Cryptosporidium spp (2.0

19 (5.4%, 2.1-7.8), rotavirus (4.9%, 4.4-5.2), astrovirus (4.2%, 3.5-4.7), and Shigella spp (4.0%, 3.6-

20 arrhea outbreaks were more likely to contain astrovirus (40/476) than were samples not associated wit

21 avirus, 10% vs 1%; sapovirus, 10% vs 5%; and astrovirus, 5% vs 2%; P < .001 for each virus).

22 Of infants with astrovirus, 70% shed at multiple visits over a period of

23 In this report, we show that astrovirus activates ERK1/2 early in infection independe

24 fants and 268 older siblings were tested for astrovirus, adenovirus 40/41, rotavirus and Salmonella,

25 previously determined low-resolution maps of astrovirus allowed us to characterize the molecular surf

26 Here we discovered that murine astrovirus, an enteric RNA virus, persists indefinitely

27 Astrovirus and adenovirus 40/41 peaked during the rainy

28 nearly complete genomes of novel species of astrovirus and calicivirus in cloacal swabs of ruddy tur

29 with the notable characterization of a novel astrovirus and calicivirus.

30 The genomes of a previously uncharacterized astrovirus and picobirnaviruses were also partially or f

31 Astroviruses and bocaviruses showed the highest prevalen

32 genomes of multiple novel species of porcine astroviruses and bocaviruses were generated and phylogen

33 ther nonenveloped positive-stranded viruses (astroviruses and human noroviruses) and with flavivirus

34 The nonenveloped astroviruses and noroviruses similarly showed high frequ

35 Across all preparation methods, astroviruses and polyomaviruses were the most highly abu

36 , whereas ED rates were 2.4 (AdV40/41), 1.9 (astrovirus), and 5.3 (sapovirus) per 1000 children <5 ye

37 Hospitalization rates were 5 (AdV40/41), 4 (astrovirus), and 8 (sapovirus) per 100 000 children <11

38 Rotavirus, astrovirus, and adenovirus were more common among cases

39 yptosporidiosis, and giardiasis), rotavirus, astrovirus, and enterotoxigenic Escherichia coli (ETEC).

40 of the 3 E. coli, Campylobacter, adenovirus, astrovirus, and rotavirus (mean HRs of 0.52-0.75).

41 xamined for the presence of norovirus (NoV), astrovirus, and rotavirus (RV) by reverse transcriptase

42 Adenovirus, astrovirus, and sapovirus infections were detected in 22

43 s attributed to rotavirus, adenovirus 40/41, astrovirus, and sapovirus were 12.6%, 2.7%, 2.9%, and 1.

44 x assay to detect norovirus (types 1 and 2), astrovirus, and sapovirus.

45 ses, parechoviruses, rotaviruses, cosavirus, astroviruses, and hepatitis B virus.

46 most diarrheagenic Escherichia coli strains, astroviruses, and sapoviruses.

47 rty stool samples from 26 patients contained astrovirus antigen, while rotavirus was found in 34 samp

48 onal pathogens were identified in six of the astrovirus antigen-positive stool samples.

49 To better understand astrovirus antigenic structure and the basis of protecti

50 To better understand the astrovirus antigenic structure and the basis of protecti

51 centers (CCCs) and determined the infecting astrovirus antigenic types by reverse transcriptase-poly

52 Astroviruses are a common cause of gastrointestinal dise

53 Astroviruses are a global cause of pediatric diarrhea, b

54 Astroviruses are a leading cause of infantile viral gast

55 Astroviruses are a leading cause of viral diarrhea in yo

56 Human astroviruses are a major cause of pediatric diarrhea, ye

57 a leading cause of pediatric diarrhea, human astroviruses are among the least characterized enteric R

58 pism and neuropathogenesis of VA1.IMPORTANCE Astroviruses are an emerging cause of central nervous sy

59 XP-knockout astroviruses are attenuated and pseudo-revert on passagi

60 Astroviruses are highly divergent and infect a wide vari

61 Although human astroviruses are highly prevalent, no approved vaccine c

62 Astroviruses are important agents of pediatric gastroent

63 Astroviruses are known to cause enteric disease in sever

64 Human astroviruses are nonenveloped, positive-sense single-str

65 Astroviruses are nonenveloped, positive-sense single-str

66 Human astroviruses are recognized as a leading cause of viral

67 Human astroviruses are single-stranded RNA enteric viruses tha

68 Astroviruses are single-stranded, plus-sense RNA viruses

69 Human astroviruses are small non-enveloped viruses with positi

70 Astroviruses are small, nonenveloped, single-stranded RN

71 rovirus pathogenesis and immunity.IMPORTANCE Astroviruses are widespread in both birds and mammals; h

72 This study examines the importance of astroviruses as a cause of acute diarrhea in hospitalize

73 Clinical studies have established astroviruses as the second leading cause of viral diarrh

74 ne as well as small-molecule drugs targeting astrovirus assembly/maturation.

75 ne as well as small-molecule drugs targeting astrovirus assembly/maturation.

76 Of 179 children with diarrhea, 36 (20%) had astrovirus-associated diarrhea.

77 Hepatitis E virus (HEV), rotavirus (RV), and astrovirus (AstV) are important pathogens that transmit

78 Astrovirus (AstV) infections are among the most common c

79 Astroviruses (AstV) are a leading cause of diarrhea, esp

80 eminested PCR assays were used to screen for astroviruses (AsV), noroviruses (NoV), and rotaviruses (

81 A novel astrovirus (casa astrovirus) basal to those infecting mammals and birds,

82 d neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO cla

83 review summarizes these remarkable facets of astrovirus biology, highlighting critical steps toward i

84 To understand astrovirus biology, it is essential to understand factor

85 Adenovirus, Aichi virus, Anellovirus, Astrovirus, Bocavirus, Enterovirus, Parechovirus, Picobi

86 lizing but reacted to all seven serotypes of astrovirus by enzyme-linked immunosorbentassay (ELISA) a

87 first animal system to study human-infecting astroviruses by using mice.

88 Here, we report that murine astrovirus can complement primary immunodeficiency to pr

89 m analysis pipeline, we identified two novel astroviruses capable of infecting research mice, murine

90 logy modeling and produced a complete, T = 3 astrovirus capsid model with features remarkably similar

91 ires extensive proteolytic processing of the astrovirus capsid protein (CP) both inside and outside t

92 determined high-resolution structures of the astrovirus capsid protein in a complex with three virus-

93 we determined the crystal structures of the astrovirus capsid protein in complex with two virus-neut

94 Taken together, these data suggest that the astrovirus capsid protein VP29 may be important in viral

95 Pulse-chase experiments showed that the astrovirus capsid protein was initially translated as an

96 e high-resolution structures of the two main astrovirus capsid proteins.

97 y, we investigated the structure of an avian astrovirus capsid spike and compared it to a previously

98 distant structural similarities to the human astrovirus capsid spike and other viral capsid spikes.

99 Here, we report the structures of the human astrovirus capsid spike domain bound to two neutralizing

100 d compared it to a previously reported human astrovirus capsid spike structure.

101 f astroviruses, including the ability of the astrovirus capsid to act as an enterotoxin, disrupting t

102 the nature of proteolytic processing of the astrovirus capsid, we infected Caco-2 cells with a high

103 A novel astrovirus (casa astrovirus) basal to those infecting ma

104 At illness onset, ~60% of astrovirus cases experienced both diarrhea and vomiting.

105 Astroviruses cause acute gastroenteritis in children wor

106 endent diarrhea; however, the means by which astroviruses cause diarrhea remain unknown.

107 Unlike other human astrovirus cell culture systems, which require addition

108 against diarrhea, 0.67; 95% CI, 0.49-0.91), astrovirus (cHR, 0.62; 95% CI, 0.48-0.81), and Shigella

109 Astrovirus contains three open reading frames (ORF) on i

110 he ubiquitous nature and diversity of murine astroviruses coupled with the continuous likelihood of r

111 HAstV requires proteolytic processing of the astrovirus CP both inside and outside the host cell, res

112 This study describes the epidemiology of astrovirus diarrhea among a population-based cohort of 3

113 Because we observed 38% of the incidence of astrovirus diarrhea to occur in infants aged <6 months,

114 In determining whether astrovirus diarrhea was associated with a reduced incide

115 The overall incidence rate of astrovirus diarrhea was the same as that of rotavirus di

116 mune response is not the primary mediator of astrovirus diarrhea.

117 The age-specific incidence rates of astrovirus diarrheal episodes per person-year were 0.38

118 we report the crystal structure of the human astrovirus dimeric surface spike determined to 1.8-A res

119 velopment of a specific antibody therapy for astrovirus disease.

120 f developing a specific antibody therapy for astrovirus disease.

121 ovirus (MuAstV) could be used to model human astrovirus disease.

122 be an effective therapeutic strategy against astrovirus disease.

123 All tested negative for astroviruses, enteroviruses, Group A rotaviruses, Sappor

124 of sequence reads, consisted of kobuviruses, astroviruses, enteroviruses, sapoviruses, sapeloviruses,

125 Astrovirus, for which only rehydration therapy is requir

126 Different regions of the human astrovirus frameshift signal were cloned into the rhesus

127 An outbreak of astrovirus gastroenteritis occurred in the Primary Immun

128 w curtain of a patient who was admitted with astrovirus gastroenteritis.

129 ecombination events have occurred across the astrovirus genome.

130 genome sequence of newly identified porcine astrovirus genotype 3 (PAstV3) strain US-MO123 was deter

131 An astrovirus genotype 3 strain was identified in both envi

132 1; mamastrovirus 9) is a recently discovered astrovirus genotype that is divergent from the classic h

133 and birds, potentially representing a third astrovirus genus, was partially characterized.

134 he last decade, the detection of neurotropic astroviruses has increased dramatically.

135 K1(a), which was highly divergent from human astrovirus (HAstV 1-8) genotypes, but closely related to

136 This study assessed the role of human astrovirus (HAstV) in outbreaks and sporadic cases of di

137 Human astrovirus (HAstV) is a leading cause of viral diarrhea

138 Human astrovirus (HAstV) is a significant cause of acute diarr

139 articles of Human adenovirus C (HAdV), Human astrovirus (HAstV), and group A Rotavirus (RV-A) were es

140 Human astroviruses (HAstV) are major causes of gastroenteritis

141 future clinical therapeutic.IMPORTANCE Human astroviruses (HAstV) are thought to cause between 2 and

142 We identified an astrovirus, HAstV-VA1/HMO-C-UK1(a), which was highly div

143 Human astroviruses (HAstVs) are a leading cause of viral child

144 Human astroviruses (HAstVs) are a leading cause of viral diarr

145 Human astroviruses (HAstVs) are a leading cause of viral gastr

146 Human astroviruses (HAstVs) are a major cause of gastroenterit

147 IMPORTANCE Human astroviruses (HAstVs) are an understudied family of viru

148 AstV cell binding and entry.IMPORTANCE Human astroviruses (HAstVs) are common etiological agents of a

149 Human astroviruses (HAstVs) are nonenveloped, positive-sense,

150 Human astroviruses (HAstVs) belong to a family of nonenveloped

151 Human astroviruses (HAstVs) cause severe diarrhea and represen

152 Human astroviruses (HAstVs) have been historically associated

153 Human astroviruses (HAstVs) infect nearly every person in the

154 diverse loop conformations.IMPORTANCE Human astroviruses (HAstVs) infect nearly every person in the

155 Human astroviruses (HAstVs) were detected in 23 stool samples

156 pact on public health, no drug therapies for astrovirus have been identified.

157 nteric viruses like norovirus, rotavirus and astrovirus have long been accepted as spreading in the p

158 However, only human astroviruses have been well characterized at the nucleot

159 transmission zones determine the prevailing astrovirus host and virus diversity, which in turn sugge

160 functional studies provide new insights into astrovirus host cell entry, species specificity, and evo

161 d astrovirus VA1/HMO-C is the most prevalent astrovirus in cases of human encephalitis.

162 the presence of a specific strain of murine astrovirus in the gut, and this complementation of immun

163 suggestive of a diverse population of murine astroviruses in research mice.

164 genotypes, but closely related to VA1/HMO-C astroviruses, including one recovered from a case of fat

165 e discovered several important properties of astroviruses, including the ability of the astrovirus ca

166 Here, we demonstrate that astrovirus increases barrier permeability in a Caco-2 ce

167 Very little is known about the mechanisms of astrovirus-induced diarrhea.

168 to the lack of inflammation associated with astrovirus-induced gastroenteritis.

169 Together, these results demonstrate that astrovirus-induced permeability occurs independently of

170 del, we investigated the mechanisms by which astrovirus induces diarrhea and the role of both the ada

171 Astroviruses infect a wide range of hosts, affecting bot

172 teric viruses, the current dogma states that astroviruses infect in a species-specific manner; howeve

173 IMPORTANCE Human astroviruses infect nearly every person in the world dur

174 Astrovirus-infected animals were analyzed for changes in

175 led astrovirus proteins from supernatants of astrovirus-infected cells showed that all three neutrali

176 However, astrovirus-infected children had a lower median age, les

177 The symptoms of astrovirus-infected children were similar to those of ch

178 Studies of astrovirus-infected humans and turkeys have demonstrated

179 Only diarrhea was associated with astrovirus infection (odds ratio, 1.4; 95% confidence in

180 V STL permits the study of the mechanisms of astrovirus infection and host-pathogen interactions in a

181 Here we show that type I interferon limits astrovirus infection and preserves barrier permeability

182 Astrovirus infection causes gastrointestinal symptoms an

183 Astrovirus infection in a variety of species results in

184 e many viral infections, but its role during astrovirus infection is unknown.

185 Here, we show that astrovirus infection leads to an increase in DMV formati

186 Community-acquired astrovirus infection occurred in 6.8% of patients, and n

187 autophagy machinery in DMV formation during astrovirus infection reveals a potential target for ther

188 munocompromised mice were resistant to human astrovirus infection via multiple routes of inoculation,

189 Astrovirus infection was pathogenic and associated with

190 Symptomatic and asymptomatic astrovirus infection was prospectively determined in a 3

191 The point prevalence of astrovirus infection was significantly higher among infa

192 ll line, BHK, which is largely refractory to astrovirus infection, was found to support efficient gro

193 no antivirals have been identified to treat astrovirus infection.

194 and region of the gut for productive murine astrovirus infection.

195 ibe the potential role of innate immunity in astrovirus infection.

196 okine transforming growth factor beta during astrovirus infection.

197 , little is known about how antibodies block astrovirus infection.

198 However, no vaccines exist to combat human astrovirus infection.

199 intrinsic epithelial cell responses against astrovirus infection.

200 e currently no vaccines available to prevent astrovirus infection; however, antibodies developed by h

201 associated with astrovirus; 17% (78/452) of astrovirus infections were associated with diarrhea and

202 Half of the astrovirus infections were nosocomial.

203 Astrovirus infections were significantly more common tha

204 Human astrovirus is a positive-sense, single-stranded RNA viru

205 Human astrovirus is an important cause of viral gastroenteriti

206 Astrovirus is one of the major causes of infant and chil

207 ajor barrier to the study of human-infecting astroviruses is the lack of an in vivo model as previous

208 nd predicted amino acid sequence of a turkey astrovirus isolated from poults with an emerging enteric

209 Despite the prevalence of human astroviruses, little is known about how antibodies block

210 Despite the prevalence of astroviruses, little is known at the molecular level abo

211 ype that is divergent from the classic human astroviruses (mamastrovirus 1).

212 t into the molecular mechanisms that lead to astrovirus maturation and infectivity.

213 ttributable rotavirus, adenovirus 40/41, and astrovirus MSD cases occurred at all sites, with mVS of

214 ur studies aimed to determine whether murine astrovirus (MuAstV) could be used to model human astrovi

215 found similar results in vivo using a murine astrovirus (MuAstV) model, providing new evidence that v

216 s capable of infecting research mice, murine astrovirus (MuAstV) STL1 and STL2.

217 campylobacter) and viral (adenovirus 40/41, astrovirus, nonpolio enteroviruses, and rotavirus) infec

218 lytica, Giardia lamblia, adenovirus F 40/41, astrovirus, norovirus GI/GII, rotavirus A, and sapovirus

219 eater for 11/17 targets: adenovirus F40/F41, astrovirus, norovirus GI/GII, rotavirus A, Plesiomonas s

220 eropathogens, including viruses (adenovirus, astrovirus, norovirus GII, rotavirus, and sapovirus), ba

221 Other attributable pathogens included astrovirus, norovirus, Shigella, Salmonella, ETEC, sapov

222 io, and Yersinia (by culture), adenoviruses, astroviruses, noroviruses, rotavirus, and Shiga toxin-pr

223 re positive-strand RNA viruses (Aichi virus, astrovirus, or salivirus/klassevirus) suspected of being

224 entified in a highly conserved region of the astrovirus ORF2 product.

225 Eight astrovirus outbreaks occurred in 6 CCCs.

226 s known at the molecular level about how the astrovirus particle assembles and is converted into an i

227 that appeared quite similar to trypsin-grown astrovirus particles by negatively stained electron micr

228 It is still unknown how astrovirus particles exit infected cells following repli

229 e able to prevent attachment of radiolabeled astrovirus particles to human Caco 2 intestinal cell mon

230 s phenomenon, along with the pathogenesis of astroviruses, particularly in those strains that can cau

231 seful small-animal model with which to study astrovirus pathogenesis and immunity.

232 human infection and gaining insight into the astrovirus pathogenesis and immunity.IMPORTANCE Astrovir

233 The mechanisms of astrovirus pathogenesis are largely unknown, in part due

234 Our understanding of astrovirus pathogenesis trails behind our knowledge of i

235 ens (retroviruses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruse

236 an in vivo model, here we report that murine astrovirus preferentially infects actively secreting sma

237 Mapping conserved residues onto the astrovirus projection domain revealed a putative recepto

238 Immunoprecipitation of radiolabeled astrovirus proteins from supernatants of astrovirus-infe

239 Most (80%) of the astroviruses recovered were of serotype 1.

240 ies suggest that NO is important in limiting astrovirus replication and are the first, to our knowled

241 irus-induced type I IFNs may protect against astrovirus replication and pathogenesis in vivo.

242 characterized a new mouse model for studying astrovirus replication and pathogenesis.

243 g children, the cellular factors involved in astrovirus replication are not well defined.

244 nti-infective drug nitazoxanide (NTZ) blocks astrovirus replication in vitro with a 50% effective con

245 rated, for the first time, that NO inhibited astrovirus replication.

246 ASOs also act to inhibit replication in an astrovirus replicon model system in a sequence-specific,

247 ruses closely related to polymycoviruses and astroviruses, represent a new linkage between +ssRNA vir

248 , 100%, and 95.6%, for norovirus, sapovirus, astrovirus, rotavirus, and adenovirus, respectively.

249 5%, 2.4%, and 1.2% for norovirus, sapovirus, astrovirus, rotavirus, and adenovirus, respectively.

250 eric disease caused by norovirus, sapovirus, astrovirus, rotavirus, and adenovirus.

251 d by electron microscopy and were tested for astrovirus, rotavirus, and enteric adenovirus by EIA.

252 l-related viruses, comprising a sapelovirus, astroviruses, rotaviruses, picobirnaviruses, parvoviruse

253 Astroviruses routinely cause infections in humans; howev

254 8 kb, and were designated as Ruddy turnstone astrovirus (RtAstV) and Ruddy turnstone calicivirus (RTC

255 ted with other enteric viruses (Aichi virus, astrovirus, salvirus/klassevirus); however, none could b

256 Adenovirus, astrovirus, sapovirus, parechovirus, bocavirus, and aich

257 ber 2009 were tested for enteric adenovirus, astrovirus, sapovirus, parechovirus, bocavirus, and aich

258 ctivated virus or purified recombinant human astrovirus serotype 1 capsid in the form of virus-like p

259 terminally deleted forms of ORF1a from human astrovirus serotype 1 were expressed in BHK cells, and n

260 co-2 cells that had been infected with human astrovirus serotype 1, confirming the presence of the cl

261 tructed a genome-length cDNA clone for human astrovirus serotype 1.

262 mechanism by which several strains of human astrovirus serotype 2 (HAstV-2) are resistant to the pot

263 amino acids [aa] 71 to 415 of VP90) of human astrovirus serotype 8 at a 2.15-A resolution.

264 e crystal structure of VP90(71-415) of human astrovirus serotype 8.

265 tion and is effective against multiple human astrovirus serotypes, including clinical isolates.

266 c, another (7C2) neutralized all seven human astrovirus serotypes, while the third (3B2) neutralized

267 l similarity of the crystal structure of the astrovirus spike domain with the HEV P-domain.

268 portant impact on future characterization of astrovirus structure and function, and will likely have

269 s the genomic sequences of nine novel turkey astrovirus (TAstV) type 2-like clinical isolates.

270 Recently, we isolated a novel strain of astrovirus (TAstV-2) from turkeys with the emerging infe

271 e we describe two distinct strains of murine astrovirus that cause infections in immunocompetent mice

272 Astrovirus type 1 (37.7%) and genogroup I sapoviruses (5

273 Here we show that human astrovirus type 1 (HAstV-1) infection induces type I int

274 cases occurred from March through June, and astrovirus type 1 was the most common.

275 aptive and innate immune responses to turkey astrovirus type-2 (TAstV-2) infection.

276 enomic-length data set available for any one astrovirus type.

277 Adenovirus (type 41), astrovirus (types 1, 2, 3, 4, and 8), sapovirus (genogro

278 Our studies provide the first evidence that astroviruses undergo viral RNA-dependent assembly.

279 analysis demonstrated that this virus, named astrovirus VA1 (AstV-VA1), is highly divergent from all

280 Human astrovirus VA1 has been associated with neurological dis

281 IMPORTANCE Human astrovirus VA1 has been associated with neurological dis

282 Astrovirus VA1/HMO-C (VA1; mamastrovirus 9) is a recentl

283 al nervous system infections in mammals, and astrovirus VA1/HMO-C is the most prevalent astrovirus in

284 occur in infants aged <6 months, a candidate astrovirus vaccine would have to confer immunity very ea

285 eted with each other for binding to purified astrovirus virions, suggesting that their epitopes were

286 (vTF7-3), were transfected with the various astrovirus-VP4 constructs.

287 Astrovirus was a significant cause of diarrhea outbreaks

288 Astrovirus was detected in 164 infants (61%) and 20 sibl

289 Astrovirus was detected in 56 of 2688 (2.1%) children, s

290 Astrovirus was identified throughout the year, peaked in

291 In this population, astrovirus was the most common enteric pathogen isolated

292 An enzyme immunoassay for astrovirus was used to screen 357 stool samples from 267

293 for the majority of viral targets (excluding astrovirus) was unaffected (change in cycle threshold [D

294 mbined, norovirus, sapovirus, rotavirus, and astrovirus were associated with almost half of all AGE v

295 Astroviruses were detected in four environmental swabs a

296 ple sequences with limited identity to known astroviruses were identified.

297 Astroviruses were second only to rotaviruses as etiologi

298 g MAbs were used to select antigenic variant astroviruses, which were then studied in neutralization

299 s observed following serial passage of human astrovirus with a deleted s2m sequence.

300 ted Caco-2 cells with a high multiplicity of astrovirus without trypsin in the presence of 5 to 10% f