ライフサイエンスコーパス: asymmetric division

1 ordinate furrow and spindle positions during asymmetric division.

2 learance from the mother cell at the time of asymmetric division.

3 ing Drosophila male germline stem cell (GSC) asymmetric division.

4 by downregulated in differentiated cells via asymmetric division.

5 nogaster male germline stem cells undergoing asymmetric division.

6 dered: bounded variations in growth rate and asymmetric division.

7 maintain cell polarity during migration and asymmetric division.

8 metric distribution provides a mechanism for asymmetric division.

9 through its role in balancing symmetric and asymmetric division.

10 the progenitor cell following completion of asymmetric division.

11 iated polarity to ensure a robust pattern of asymmetric division.

12 maintain their epigenetic information during asymmetric division.

13 e stem cell population is maintained through asymmetric division.

14 sufficient to result in a robust pattern of asymmetric division.

15 1), and differentiation was stopped prior to asymmetric division.

16 rhaps facilitating their differentiation via asymmetric division.

17 for conserved mechanisms of polarization and asymmetric division.

18 osome behavior in developmentally programmed asymmetric division.

19 ise to daughters with different fates is via asymmetric division.

20 terior spindle displacement during the first asymmetric division.

21 oriented within their niche and this ensures asymmetric division.

22 uroblasts are excellent models for stem cell asymmetric division.

23 (motifs) that could support human stem cell asymmetric division.

24 of centrosomes disrupts the high fidelity of asymmetric division.

25 s to regulate spindle positioning and ensure asymmetric division.

26 s determines the fate of daughter cells upon asymmetric division.

27 ession to achieve the sexually dimorphic SGP asymmetric division.

28 signaling pathway in cell polarity and cell asymmetric division.

29 y dividing) blastomeres during the period of asymmetric division.

30 riction of developmental potential following asymmetric division.

31 ng complex that positions the spindle during asymmetric division.

32 that is required for Caulobacter growth and asymmetric division.

33 e a novel regulatory mechanism for stem cell asymmetric division.

34 osition of the mitotic spindle to facilitate asymmetric division.

35 EAGE (BASL) is polarized to control stomatal asymmetric division.

36 erentially expressed after the first wave of asymmetric divisions.

37 r of apical nuclei and doubles the number of asymmetric divisions.

38 occurs in dividing cells undergoing repeated asymmetric divisions.

39 tablishing proper spindle orientation during asymmetric divisions.

40 localized junctional complexes to carry out asymmetric divisions.

41 ch in turn drives the production of terminal asymmetric divisions.

42 translated at the cellular level to promote asymmetric divisions.

43 ty to prospectively analyze progeny from HSC asymmetric divisions.

44 n and segregates unevenly during meristemoid asymmetric divisions.

45 that early neurogenic progenitors arise from asymmetric divisions.

46 y attract asters and nuclei, yielding marked asymmetric divisions.

47 romote, respectively, Notch signaling during asymmetric divisions.

48 vel of single cells and are mediated through asymmetric divisions.

49 ual and mechanistic similarities with animal asymmetric divisions.

50 tablished as a result of Notch/Numb-mediated asymmetric divisions.

51 In C. elegans, Wnt/MAPK signaling controls asymmetric divisions.

52 imity to the niche rather than by programmed asymmetric divisions.

53 ole of non-muscle myosin II (nmy-2) in these asymmetric divisions.

54 pond to SHH and hence maintain slow-cycling, asymmetric divisions.

55 ol is not necessarily associated with purely asymmetric divisions.

56 liferative (symmetric) to neuron-generating (asymmetric) divisions.

57 During asymmetric division, a cell polarizes and differentially

58 Asymmetric division, a hallmark of endospore development

59 During asymmetric division, a mother cell generates daughter ce

60 l neural progenitors shift from symmetric to asymmetric divisions across the lateral-medial axis.

61 l amplification of AMPs, while the switch to asymmetric division additionally requires Wingless, whic

62 Furthermore, NOTCH signaling can activate asymmetric division after intestinal inflammation.

63 and lhx2/9-expressing cells can undergo both asymmetric divisions, allowing for progression towards a

64 Asymmetric division also triggers cell-specific transcri

65 dual role to regulate Notch signaling during asymmetric divisions - amplifying Notch signaling in the

66 in turn, sets in motion events that lead to asymmetric division and activation of the cell-specific

67 ed in the neuroblasts which are required for asymmetric division and differentiation.

68 Deletion of miR-34a inhibits asymmetric division and exacerbates Lgr5+ ISC proliferat

69 6 depletion during mitosis suffices to cause asymmetric division and failure in cytokinesis, with a d

70 pensable for Cdc42-dependent activity on HSC asymmetric division and fate.

71 and differentiation of stem cells depend on asymmetric division and polarized motility processes tha

72 ansport, fusion, and fission is critical for asymmetric division and rejuvenation of daughter cells.

73 noallelic regulation, which is retained upon asymmetric division and relaxed during epithelial cell d

74 Cell fate can be controlled through asymmetric division and segregation of protein determina

75 em cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and

76 ination of differences established from both asymmetric division and the timing of treatment relative

77 role of LET-99 in cytokinesis is specific to asymmetric division and whether it acts through Galpha t

78 rophectoderm, whereas reducing Cdx2 promotes asymmetric divisions and consequently contribution to th

79 of MUTE, meristemoids abort after excessive asymmetric divisions and fail to differentiate stomata.

80 portance of posttranslational regulation for asymmetric divisions and germline progression in plants

81 temporal relationship between symmetric and asymmetric divisions and how this contributes to the gen

82 PKCzeta or PKClambda/iota, partially impairs asymmetric divisions and increases CD8(+) T lymphocyte d

83 n GlsA (Gonidialess A) is required for these asymmetric divisions and is believed to function with an

84 ate of cells, and may identify symmetric and asymmetric divisions and predict cell fate.

85 RADIX family (BRXf) proteins is required for asymmetric divisions and proper stomatal pattern, but th

86 tissues during postembryonic growth requires asymmetric divisions and the specification of cell linea

87 ing spoIIE, sporulation was blocked prior to asymmetric division, and no mature spores or any disting

88 , preferentially renew through perpendicular asymmetric divisions, and are less responsive to injury.

89 to instability of chromosomes, imbalance in asymmetric divisions, and reorganization of tissue archi

90 of Spo0A takes place abruptly just prior to asymmetric division; and (iv) the primary source of nois

91 Asymmetric divisions are a feature of the C. elegans sea

92 ver, cells internalized by the first wave of asymmetric divisions are biased toward forming pluripote

93 How asymmetric divisions are connected to the terminal diffe

94 In plants, as in animals, asymmetric divisions are correlated with the production

95 Asymmetric divisions are essential for the generation of

96 These asymmetric divisions are regulated by Wnt signaling; in

97 stem cells and mark its directed control of asymmetric division as a critical regulator of normal an

98 e between these two populations and promotes asymmetric division as a mechanism for interconversion i

99 segregation of cell fate determinants during asymmetric division, as well as for proper cellular arra

100 nism is broadly applicable for symmetric and asymmetric divisions, as well as for different growth ra

101 rospores undergo polar nuclear migration and asymmetric division at pollen mitosis I to segregate the

102 ells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeo

103 investigated, the specific problem caused by asymmetric division at the transcription level has not y

104 With Mv-mago silenced, asymmetric divisions become symmetric, cell fate is disr

105 -like property and undergo several rounds of asymmetric divisions before further differentiation.

106 In C. elegans, four asymmetric divisions, beginning with the zygote (P0), ge

107 onsistent with the idea that SYS-1 regulates asymmetric divisions broadly during C. elegans developme

108 e forces are implicated in cell polarity and asymmetric division, but their contribution to cell fate

109 vidence suggests that microRNAs can initiate asymmetric division, but whether microRNA and protein ce

110 heir output by varying between symmetric and asymmetric divisions, but have rarely been observed in l

111 olon cancer stem cells (CCSCs) and initiates asymmetric division by directly targeting the microRNA m

112 ogen would evoke reiterative, self-renewing, asymmetric division by memory T cells.

113 The facultative use of symmetric or asymmetric divisions by stem cells may be a key adaptati

114 ay precursor cell, through several rounds of asymmetric division called the ray sublineage.

115 systems that suggest that the subversion of asymmetric division can contribute significantly to the

116 at shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest

117 hastic analysis and simulations we show that asymmetric divisions can either stabilize or destabilize

118 o lead to an imbalance between symmetric and asymmetric divisions, causing reduced or excessive cell

119 ute a switch from symmetric to predominantly asymmetric divisions concomitant with stratification.

120 of subtle but iterative and finely patterned asymmetric divisions controls the shape of an entire org

121 eins (DivJ, DivK, CckA, and CtrA) during the asymmetric division cycle of a Caulobacter cell.

122 ortical flows to dynamically polarize during asymmetric division cycles.

123 rl2 deletions, microtubule abnormalities and asymmetric division defects were observed.

124 r to continuously flux between symmetric and asymmetric division depending on the precise state of th

125 Processes such as symmetric and asymmetric divisions, differentiation, de-differentiatio

126 We tested a hypothesis that stem cell asymmetric division/differentiation is spontaneously cre

127 We show that in larval seam cell asymmetric divisions, EGL-18 is expressed strongly in th

128 Asymmetric division enables self-renewal to be coupled t

129 Near the end of neural development, most asymmetric division ends and precursors differentiate.

130 the crypt may contribute mechanically to the asymmetric division events typically associated with the

131 C pool whose expelled progeny differentiate, asymmetric divisions first specify and displace early SC

132 tinct stages of cytokinesis and show that an asymmetric division fold bisects the two daughter cells,

133 s is a multilayered epithelium that requires asymmetric divisions for stratification.

134 Asymmetric divisions generate cell fate diversity and ep

135 eparation of these lineages takes place when asymmetric divisions generate inside and outside cells t

136 Asymmetric division generates cellular diversity by prod

137 are stem cell-like precursor cells, undergo asymmetric divisions, generating several pavement cells

138 mulate the understanding of the processes of asymmetric division, generation of neuronal lineages and

139 which a series of post-embryonic, stem-like asymmetric divisions give rise to an anterior daughter t

140 genitors are apical progenitors (APs), whose asymmetric division gives birth directly to neurons.

141 une response, CD8+ T lymphocytes can undergo asymmetric division, giving rise to daughter cells that

142 We then find that all asymmetric divisions happen when nuclei are located basa

143 h originally characterized in invertebrates, asymmetric division has recently been shown to regulate

144 of an egg and sperm cell and its subsequent asymmetric division herald the start of the plant's life

145 ity, cycling quiescence, long doubling time, asymmetric division, high metastatic and invasive capabi

146 phospho-histone positive cells demonstrates asymmetric division in 65% of the CPC population in hear

147 ommonly used for the regulation of stem cell asymmetric division in both animals and plants.

148 While asymmetric division in Caulobacter normally yields large

149 s provide evidence for an important role for asymmetric division in CD8(+) T lymphocyte fate specific

150 segregation and cell division may result in asymmetric division in damage-induced filaments and faci

151 These results demonstrate a new role for asymmetric division in directly shaping a developing org

152 Asymmetric division in female meiosis creates selective

153 hat replication and growth could occur after asymmetric division in mother cells with no active sigma

154 Here, we found an asymmetric division in the Caenorhabditis elegans Q neur

155 or absence (perigenous type) of at least one asymmetric division in the cell lineage leading to the g

156 microscopy were used to assess frequency of asymmetric division in the CPC population.

157 An asymmetric division in the epidermis of plants initiates

158 e, which suggests a change from symmetric to asymmetric division in the radial progenitor cells.

159 Caulobacter carries out an asymmetric division in which FtsZ and FtsA are stable in

160 report the first example of lineage-specific asymmetric division in yeast.

161 Here, we identify BASL, a novel regulator of asymmetric divisions in Arabidopsis.

162 tioning is required to achieve high-fidelity asymmetric divisions in CySCs, thus maintaining both GSC

163 Inactivation of aPKClambda produced more asymmetric divisions in different compartments, includin

164 ell-fate determinant Numb appear to regulate asymmetric divisions in flies and vertebrates.

165 regulates mitotic spindle orientation during asymmetric divisions in the vertebrate brain.

166 te in various developmental processes during asymmetric divisions in vertebrate oocytes, cell migrati

167 habditis elegans, neurons are generated from asymmetric divisions in which a mother cell divides to p

168 ric divisions and is followed by a switch to asymmetric divisions in which the AMPs self-renew and ge

169 Asymmetric division, in which a single mother cell gives

170 /beta-catenin and POP-1/TCF regulate several asymmetric divisions, including that of the somatic gona

171 both aPKC isoforms resulted in a deficit in asymmetric divisions, increasing the proportion of daugh

172 Following a series of asymmetric divisions, INPs normally exit the cell cycle

173 study establishes how transient lineage and asymmetric division inputs are integrated and suggests t

174 m cells go through a reproducible pattern of asymmetric divisions, instructed by divergent canonical

175 ation of apical-basal determinants, ensuring asymmetric division into daughter cells of different fat

176 We find that asymmetric division invariably generates a basal self-re

177 Furthermore, with the asymmetric divisions invoked by stem cells, the passage

178 Asymmetric division is an evolutionarily conserved proce

179 While asymmetric division is critically important in generatin

180 tipotent progenitors, and suggesting that an asymmetric division is involved in the acquisition of go

181 Thus, asymmetric division is not necessary for stem-cell ident

182 TBC1D15-NuMA1 association impaired asymmetric division machinery by hijacking NuMA from LGN

183 ro and Brat, but not other components of the asymmetric division machinery.

184 Asymmetric divisions maintain long-term stem cell popula

185 Whereas physical asymmetric division mechanisms and cell fate consequence

186 s the first known marker of polarity in this asymmetric division model and is required for PAN polari

187 A particularly prominent such asymmetric division occurs when the EMS blastomere divid

188 During spore formation an asymmetric division occurs, yielding the smaller prespor

189 During asymmetric division of a type II neural stem cell (neuro

190 Asymmetric division of adult stem cells generates one se

191 EGFL6 signaling promoted the migration and asymmetric division of ALDH(+) ovarian CSC.

192 role in modulating BMP signaling during the asymmetric division of an adult stem cell population and

193 mber in mother and daughter cells during the asymmetric division of budding yeast.

194 is known about the factors that regulate the asymmetric division of cancer stem-like cells (CSC).

195 e asymmetry plays a key role in ensuring the asymmetric division of Drosophila neural stem cells (neu

196 Asymmetric division of each stem cell into one stem cell

197 aminoglycan chains, regulates the number and asymmetric division of germline stem cells (GSCs) in the

198 recursors in mid-globular embryos and second asymmetric division of ground tissue stem cells in early

199 oning of centrosomes, a process required for asymmetric division of GSCs.

200 the PML-PPAR-delta-FAO pathway controls the asymmetric division of HSCs.

201 shed a model of tissue turnover based on the asymmetric division of intestinal stem cells.

202 protein that has a pivotal role in directing asymmetric division of mammalian stem cells to sustain t

203 ates translocation of the meiotic spindle in asymmetric division of mouse oocytes.

204 signaling and cell fate determination during asymmetric division of neural progenitors (NPs) in mouse

205 Asymmetric division of neural stem cells is a fundamenta

206 rotubule growth is a new paradigm regulating asymmetric division of neural stem cells.

207 is required for establishing polarity during asymmetric division of neuroblasts in Drosophila, and it

208 e known to be required for the selection and asymmetric division of neuroblasts in the fruit fly D. m

209 n somatic cells but is not essential for the asymmetric division of neuroblasts.

210 ation is linked to fate determination during asymmetric division of plant stem cells, but the underly

211 e complete picture of the events surrounding asymmetric division of precursor cells.

212 Asymmetric division of progenitor/stem cells generates b

213 the more differentiated daughter cell during asymmetric division of satellite cells and promotes the

214 We also show that orb2 funtions in asymmetric division of stem cells and precursor cells du

215 Asymmetric division of stem cells results in both self-r

216 aintained by a balance between symmetric and asymmetric division of stem cells.

217 ) centrosome, yet it is not required for the asymmetric division of stem cells.

218 During the asymmetric division of the C. elegans zygote, the RNA-bi

219 During the asymmetric division of the Caenorhabditis elegans zygote

220 During the asymmetric division of the Caenorhabditis elegans zygote

221 on electron microscopy of these voids showed asymmetric division of the cytoplasm in the absence of o

222 We found that this asymmetric division of the ER depends on the highly cons

223 fore the start of gastrulation disrupts this asymmetric division of the ER.

224 d ARF activity cell-autonomously control the asymmetric division of the first ground tissue cells.

225 aughter, the ganglion mother cell (GMC), the asymmetric division of the GMC and the fate specificatio

226 The asymmetric division of the larval neural stem cells, how

227 mGRP7, which are potentially associated with asymmetric division of young epidermal cells and stomata

228 stry indicated that the pattern of symmetric/asymmetric divisions of a blastomere can be influenced b

229 t vacuolar acidity declines during the early asymmetric divisions of a mother cell, and that preventi

230 houses 1-4 ORN identities that arise through asymmetric divisions of a single sensory organ precursor

231 autosomes, are segregated nonrandomly during asymmetric divisions of Drosophila male germline stem ce

232 During the asymmetric divisions of Drosophila neuroblasts, the Par

233 It is initiated via asymmetric divisions of eight- and 16-cell blastomeres t

234 tion of cellular mechanics to the strikingly asymmetric divisions of female meiosis is very poorly un

235 n mutant cells, and approximately 30% of the asymmetric divisions of larval neuroblasts are abnormal.

236 f interneurons appeared to be generated from asymmetric divisions of MGE progenitor cells, followed b

237 e, and we observe only subtle defects in the asymmetric divisions of mutant neuroblasts.

238 Our results show that the asymmetric divisions of n blast cells result from a post

239 ring Caenorhabditis elegans development, the asymmetric divisions of neural progenitors generate neur

240 emonstrate that the gene pig-1 regulates the asymmetric divisions of neuroblasts that divide to produ

241 We reveal that an increased rate of asymmetric divisions of NPCs leads to proliferation defe

242 fate determination that might operate during asymmetric divisions of polarized neural progenitor cell

243 They arise from asymmetric divisions of radial glia and undergo self-ren

244 Asymmetric divisions of radial glia progenitors produce

245 ulation of gene expression, such as limiting asymmetric divisions of stem-like cell types.

246 try into the stomatal lineage; MUTE controls asymmetric divisions of stomatal precursor cells; and FA

247 e Arabidopsis leaf epidermis [5], polarized, asymmetric divisions of stomatal stem cells (meristemoid

248 We also demonstrate that the asymmetric divisions of the primary nf and ns blast cell

249 However, the mechanism controlling the asymmetric divisions of these stem cells prior to differ

250 an ISC becoming a new ISC and an EE through asymmetric division, or an ISC becoming two EEs through

251 cell fate allocation, and misorientation of asymmetric division planes.

252 ll polarity, mitotic spindle orientation and asymmetric division play a crucial role in the self-rene

253 divide symmetrically and asymmetrically, but asymmetric division predominates, and the replicating CS

254 ulator SHR is critical for the most frequent asymmetric division previously described for quiescent c

255 ls that are identical to each other, whereas asymmetric divisions produce two sister cells with disti

256 on the mechanisms controlling self-renewing asymmetric divisions producing a differentiating daughte

257 in Arabidopsis thaliana begins with de novo asymmetric divisions producing meristemoids, proliferati

258 were thought to exclusively undergo oriented asymmetric divisions, producing one stem cell that remai

259 are conducted to estimate GSC symmetric and asymmetric division rates and explore potential mechanis

260 ctions between cell specification, polarity, asymmetric division, rearrangements, and growth.

261 rpinning polarity establishment required for asymmetric division remains largely unknown.

262 enter the cell cycle and a subset undergoes asymmetric division, renewing the satellite cell pool.

263 s suggest that Pim-1 overexpression leads to asymmetric division resulting in maintenance of the CPC

264 establishing polarity in CE cells, and that asymmetric divisions resulting from CE polarity are requ

265 tion in Bacillus spp. is the formation of an asymmetric division septum between mother cell and fores

266 ultipotent progenitor cells undergo repeated asymmetric divisions, sequentially generating neurons in

267 m cells are generated through four rounds of asymmetric divisions, starting from the zygote P0, each

268 e regeneration and epidermal homeostasis: 1) asymmetric division (stem-transit amplifying cell); 2) p

269 ision is taken when cells undertake waves of asymmetric division that generate one daughter on the in

270 We show that SPCH directs the first asymmetric division that initiates stomatal lineage.

271 line and is first detected shortly after the asymmetric division that segregates the germ cell lineag

272 ast mother cells undergo a limited number of asymmetric divisions that define replicative lifespan.

273 t in developing hair buds, SCs are born from asymmetric divisions that differentially display WNT and

274 tor that is necessary and sufficient for the asymmetric divisions that establish the stomatal lineage

275 pol pll1 mutant embryos lack key asymmetric divisions that give rise to the root stem cel

276 The series of asymmetric divisions that produce the micromere quartets

277 ws that Carm1 affects cell fate by promoting asymmetric divisions, that direct one daughter cell insi

278 After asymmetric division, the ee daughter cell acts as a sour

279 Although satellite cells are capable of asymmetric division, the mechanisms regulating satellite

280 Following asymmetric division, the mother cell engulfs the forespo

281 While all lineages were preserved in asymmetric division, the vast majority were lost when as

282 pletely abolishes the generation of terminal asymmetric divisions, these results suggest a model in w

283 Arl2 regulates microtubule growth and asymmetric division through localizing Msps to the centr

284 antly undergo symmetric division but turn on asymmetric division to curb the number of ISCs when proi

285 st- and slow-cycling CCIC, which can undergo asymmetric division to generate each other, highlighting

286 e, independently acting mechanisms to ensure asymmetric division to maintain tissue homeostasis.

287 Many stem cells undergo asymmetric division to produce a self-renewing stem cell

288 hat neuroblasts in lgl mutant brains undergo asymmetric division to produce progenitor cells, which t

289 blish here a transcriptional cascade linking asymmetric division to this differentiation program.

290 go proliferative divisions and self-renewing asymmetric divisions to generate neuronal progenitor cel

291 ons of radial glia and undergo self-renewing asymmetric divisions to generate neurons.

292 Each NB undergoes repeated asymmetric divisions to produce a series of smaller gang

293 stem cell research is how stem cells achieve asymmetric divisions to replicate themselves while produ

294 can undergo different modes of symmetric and asymmetric divisions to self-renew as well as produce di

295 activation, CD8(+) T lymphocytes can undergo asymmetric division, unequally distributing factors to t

296 e GMC-1 to the Numb domain and Neur mediates asymmetric division via two distinct, sequential mechani

297 roduction rates (allowing both symmetric and asymmetric divisions), we found that dedifferentiation b

298 f Ptc1-Gli1 signaling induced NSCs/GPCs into asymmetric division, which results in an increase in the

299 rtical precursor cells undergo symmetric and asymmetric divisions while producing large numbers of di

300 with the timing and orientation of the first asymmetric division--with zygotes having to pass through