ライフサイエンスコーパス: at position

1 hereas some rotamers of the buried arginines at position 0' conferred high selectivity for anions, ot

2 -linked glycosylation site at the N terminus at position 1 (equivalent to Asp-221 in the Fc of IgG1)

3 presented by a lipophilic n-octyl side chain at position 1 and a positively charged azepanyl or 1,4-d

4 based on the incorporation of a [(13)C] atom at position 1 in specific amino acids.

5 Conservative changes at positions 1 and 2 were well-tolerated, with Val(1)-Va

6 r-containing motifs with a glutamine residue at position +1 and a hydrophobic residue at position -1,

7 mes utilize non-canonical sequence variants (at position -1 relative to BP adenosine) more frequently

8 rthermore, we found that modeling glutamates at position -1' of the anion-selective alpha1 glycine re

9 due at position +1 and a hydrophobic residue at position -1, thus elucidating the molecular basis for

10 sitions -2 to -5 of the PFS and by a guanine at position -1, which is not recognized by base pairing.

11 least 13 species have a target-site mutation at position 106 of EPSPS.

12 t positions 70-74 in combination with valine at position 11 (11-V) is highly protective in PD, while

13 ffers from apoE3 by only a single amino acid at position 112, which is arginine in apoE4 and cysteine

14 2, present in Ng-NspA) or replacing V and D at positions 112 and 113 in Nm-NspA loop 3 with A and H

15 e largely controlled by only two amino acids at positions 112 and 139, and that the same residues app

16 denoted apoE2, apoE3, and apoE4 which differ at positions 112 and 158 and which occur at different fr

17 le amino acid alanine to valine substitution at position 117 (A117V) in the NS2A was sufficient to co

18 e methylation at position 2, but insensitive at position 12 of the 15-bp core sequence.

19 tation that substitutes lysine with arginine at position 120 of human p53 has been characterized as a

20 These methods confirm that ALT initiates at positions 120739/121012 and encodes a single splice s

21 Mutations at positions -124/125 and -146 were associated with the

22 Here, we show that an aspartate at position 1261 is the most critical residue of the N-t

23 eceptor, with the substitution of Leu to Gln at position 129 (3.43).

24 Escape mutations were identified at position 129, 165, or 166 in the major antigenic site

25 riants, encoding either methionine or valine at position 1316.

26 bonding with a conserved asparagine residue at position 132.

27 S protein with an arginine-to-glycine change at position 135 [liaS(R135G)]) recapitulated a carrier p

28 An arginine residue at position 136 was found to be essential for PvrA to bi

29 s136, which is disrupted when Gln is present at position 136.

30 apie is strongly influenced by polymorphisms at positions 136, 154, and 171 of a sheep's normal cellu

31 used to detect and quantitate polymorphisms at positions 136, 154, and 171 of sheep PrP(C) or PrP(Sc

32 ion site at residue 144 and a deleted lysine at position 147 residue were more effective at protectin

33 (8.34-fold reduction); the combinations of V at position 150 and E at position 206 reduced the virus

34 A common polymorphism, V at position 150 in the HCV genotype 3a NS5b polymerase,

35 In cells, V at position 150 reduced the response to sofosbuvir 7-fol

36 mino acid 150 (alanine [A] to valine [V]), V at position 150 was observed in 42% of patients) with a

37 an insertion in the 150-loop (loop beginning at position 150) of the receptor-binding site common to

38 In 326 patients with V at position 150, 71% achieved an sustained virologic res

39 ed virologic response compared to 88% with A at position 150.

40 ting in an alanine to threonine substitution at position 152 (A152T tau) has recently been described

41 In silico analysis suggests that a threonine at position 152 of tau confers a new phosphorylation sit

42 Finally, C/T polymorphism of MMP-9 gene at position -1562, which upregulates MMP-9 expression, c

43 genetics, we found that a single amino acid at position 158 of the hemagglutinin (HA) protein substa

44 utation introduced an N-linked glycosylation at positions 158 to 160 of the HA protein and that this

45 In this study, we identified glycosylation at positions 158 to 160 of the HA protein of two natural

46 se results suggest that the tyrosine residue at position 16 is necessary to constrain TCR reactivity

47 t the hypothesis that the amino acid residue at position 163 of canine cellular prion protein (PrP(C)

48 mino acid substitution, lysine to glutamine, at position 166 (H3 numbering) in the major antigenic si

49 d substitution from aspartic acid to alanine at position 168 (D168A) reduced the potency of grazoprev

50 ed with a linear epitope at a lysine residue at position 169 (K169) in the HIV-1 envelope (Env) V2 re

51 ccupancy at exon 1 and codon-specific pauses at positions 171 (CCG) and 172 (CGT) in HD striatal cell

52 ycine (G), serine (S), and glutamic acid (E) at positions 172, 207, and 212, respectively.

53 However, a negatively charged residue at position 180 was necessary to convey the CaValpha2del

54 highly conserved tryptophan or phenylalanine at position 182.

55 d a mutant DSPP in which the proline residue at position 19 was replaced by a leucine residue.

56 like receptors, describing amino acid motifs at positions 190, 226 and 227 that play a major role in

57 es identified, two C-terminal phosphoserines at positions 1938 and 1989 showed increased phosphorylat

58 each of four different hydrophobic residues at position 195 served as input data for mutant cycle an

59 oisosteric replacement of the carbonyl group at position 2 in a series of 3,4-dihydropyrimidin-2-ones

60 nalogue with a terminal alkyne functionality at position 2 of the adenine (2-alkyne adenosine or 2YnA

61 ituted 1-methylcyclohexyl-carboxamide groups at position 2 of the benzothiazole scaffold and endowed

62 However, replacing even one PS-linkage at position 2 or 3 from the 5'-side of the DNA-gap with

63 CTCF is sensitive to cytosine methylation at position 2, but insensitive at position 12 of the 15-

64 izing their N-terminal Pro residues or a Pro at position 2, in the presence of distinct adjoining seq

65 r either the N-terminal Pro residue or a Pro at position 2, together with adjacent sequence motifs.

66 adamantylation and tert-butylation of pyrene at positions 2 and 2,7 along with the synthesis of compo

67 ituents (alkyl/alkyl, aryl, and alkyl/ester) at positions 2 and 3 (beta-pyrrole sites, ring A) and 13

68 Each BP lacked canonical uridines at position -2 relative to the BP adenines, with efficie

69 e transcripts are recognized by base pairing at positions -2 to -5 of the PFS and by a guanine at pos

70 the combinations of V at position 150 and E at position 206 reduced the virus response to sofosbuvir

71 another rare substitution, glutamic acid (E) at position 206, significantly reduced the response to s

72 patients is due to amino acid substitutions at positions 206, 281, and 284 of the human STING protei

73 ates that the 3 disease-associated mutations at positions 206, 281, and 284 of the STING protein defi

74 a critical role for substitution of arginine at position 207 (S207R) in mediating resistance to 53C10

75 ecent studies imply that an HLA-B dimorphism at position -21 in the gene segment encoding the leader

76 -SOD), with arginine to glycine substitution at position 213 (R213G), redistributes EC-SOD from the m

77 ntrast to mutations in the adjacent cysteine at position 214 which result in RP.

78 red an aspartic acid-to-glycine substitution at position 222 (D222G) of the hemagglutinin protein.

79 ne (Q) to lysine (K) amino acid substitution at position 223 of the lectin domain, was shown to alter

80 r recognition via a single amino acid change at position 226 (H3 numbering), from glutamine (Q226) to

81 vitro IMPORTANCE A single amino acid change at position 226 in the hemagglutinin (HA) from glutamine

82 otential of having any of the 20 amino acids at position 226 on a prototypic H9 HA subtype IAV.

83 types, and variants not found in any subtype at position 226.

84 the disease-associated PTM, L-isoaspartate, at position 23 (L-isoAsp23).

85 s that the introduction of aryl substituents at position 23 of the helical moieties has a negligible

86 lacks potential N-linked glycosylation sites at positions 230, 241, and 289.

87 l role of the highly conserved dual glycines at position 236-237 in the lower hinge region of human I

88 C(H)2s, except for two cysteines introduced at positions 242 and 334.

89 In contrast, the common variant rs2853669 (at position -245) was significantly associated with long

90 gnificantly higher detection of gyrA mutated at position 248 at time points 7 (OR = 11.5; P value = 0

91 cluding as selenocysteine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1).

92 e mapped to a single amino acid polymorphism at position 26 of the endonuclease domain shared by the

93 main in maspin consists of 27 aa, is located at position 268-294, and is responsible for the interact

94 s include lysine-to-methionine substitutions at positions 27 and 36 of histone H3.3.

95 es retained the GTFs when pol II was stalled at position +27 relative to the transcription start site

96 sis, that replacement of the proline residue at position 28 of the insulin B-chain (ProB28) by (4S)-h

97 nor in the liver codon changes were detected at position 282 that cause resistance to nucleos(t)ide a

98 el Fc mutation, a glutamate residue deletion at position 294 (Del) that endows IgGs with an up to 9-f

99 wn that cannabinoids target a serine residue at position 296 in the third transmembrane helix of the

100 in their Fc domain at a conserved asparagine at position 297.

101 bearing 3,5-dihydroxyphenylglycine residues at position 3 in their structures.

102 upled at -40 degrees C to the hydroxyl group at position 3 of glucopyranosyl acceptors to form beta-(

103 lfonyl entities were successfully introduced at position 3 of the 2-(dicyanomethylidene)-2,5-dihydrof

104 oleic acid and the synthesis of regioisomers at position 3'.

105 yl or 1,4-dioxa-8-azaspiro[4.5]decane moiety at position 3.

106 FmhA incorporates serine residues at positions 3 and 5 of the cross-bridge.

107 stitution reactions with phenols exclusively at positions 3 and 5.

108 re with distinct features anchoring peptides at positions 3 and 9, supported by an auxiliary anchor i

109 noleic) and regioselectivity (esterification at positions 3 vs. 3').

110 substitution, and additional hydroxyl groups at positions 3' and 4'.

111 tably protected for further chain elongation at positions 3, 4, and 6 of the terminal mannose.

112 ng occurred straightforwardly in high yields at positions 3, 5, and 6 of imidazopyridine derivatives,

113 revealed a preference for basic amino acids at position -3 and -2.

114 Positive determinants include adenine at position -3, reminiscent of the Kozak sequence of Euk

115 a four-carbon chain carrying a phenyl group at position-3 and a linear propyl group at position-4 of

116 We found that inserting glycans at positions 306 and 314 (termed M1 and M7) markedly red

117 viously reported mutant with a C-to-Y change at position 307 encoded by tel2 (tel2-C307Y mutant), thi

118 We now identify amino acid polymorphisms at positions 31 and 128 of HIV-1 Vif which selectively r

119 ly, we examined the role of the polymorphism at position 310 in venous thromboembolism (VTE) using th

120 bic interactions with the tryptophan residue at position 316 and with other topologically proximal si

121 lso modified from cytidine to 2-thiocytidine at position 32 (s(2)C(32)).

122 odon, suggesting that this function of s(2)C at position 32 is a generalizable property.

123 ne, causing a glycine-to-serine substitution at position 32 on the B chain of the preproinsulin 2 mol

124 ide 1965 producing a Val-to-Leu substitution at position 330 of the viral envelope (E) protein.

125 o NspA was human specific; the histidine (H) at position 337 of domain 6 contributed to human-specifi

126 ations are introduced at the wobble uridines at position 34 in transfer RNAs (tRNAs), which serve to

127 We also show that the nature of the purine at position 34 is correlated with the nucleotides presen

128 nse elements that target the wobble cytidine at position 34 of human elongator tRNA(Met)(CAT) for 2'-

129 inosine and 2-methyladenosine modifications at positions 34 (I(34)) and 37 (m(2)A(37)).

130 n caused by a single amino acid substitution at position 342 in the mature protein, resulting in the

131 on by covalent attachment of a photo-oxidant at position 355[beta].

132 However, mutants with S residues exchanged at positions 365, 368, and 373 exhibited a significantly

133 we have found that the histidine introduced at position 366 (L366H) can interact with the introduced

134 iates acetylation at lysine residues of SPZ1 at positions 369 and 374, and of TWIST1 at positions 73

135 ) can interact with the introduced histidine at position 370 (stabilizing that portion of the S4 segm

136 genetic group, M, which possess a serine (S) at position 375, those from CRF01_AE strains possess a h

137 titution of a conserved threonine by proline at position 387 (T387P) in hEAAT1.

138 st-translationally installed hydroxyl groups at position 4 of prolyl residues.

139 different pentagonal heterocyclic frameworks at position 4, was synthesized and evaluated.

140 ross-couplings or nucleophilic substitutions at position 4.

141 Mutation of the conserved small side chain at position 4.53 within packing cluster 2 is shown to di

142 ng electron-withdrawing and -donating groups at positions 4 and 5, using five molar equivalents of Si

143 Notch signaling among early progenitor cells at position +4/5 regulates their specification toward se

144 roup at position-3 and a linear propyl group at position-4 of the lactone ring confers excellent pote

145 e that missense mutations affecting arginine at position 402 (R402) of TUBA1A alpha-tubulin selective

146 A single nucleotide polymorphism, tyrosine at position 402 to histidine (Y402H), within the gene en

147 rtic acid (D) to asparagine (N) substitution at position 405 (D405N) mutant was partially inhibited b

148 th a complement-enhancing E-to-G Fc mutation at position 430 (2C7-Ximab-E430G).

149 in the NA stalk, and changing the amino acid at position 431 from Proline-to-Lysine.

150 Common substitutions at positions 431 and 442 did not confer high-level resis

151 Histidine at position 435 (H435) provides for optimal Fc-IgG bindi

152 Some haplotypes of IgG3 have histidine at position 435.

153 he enzymes responsible for the modifications at position 46 and 47 in the variable loop of E. coli tR

154 The change of Asn at position 460 to His, which corresponds to the natural

155 d yet for introducing the acp3U modification at position 47 in the variable loop of eight E. coli tRN

156 took advantage of a tryptophan substitution at position 471, proximal to the GAC catalytic site, to

157 itin, which has only a single lysine residue at position 48.

158 NSUN2 is necessary for the generation of m5C at positions 48, 49 and 50 of several mammalian mitochon

159 unctional (PAV: proline, alanine, and valine at positions 49, 262, and 296, respectively) or non-func

160 functional (AVI: alanine, valine, isoleucine at positions 49, 262, and 296, respectively) T2R38.

161 The conserved Glu residue at position 5 (E5) of mature (pseudo)pilins is essential

162 n, serotonylation of glutamine, which occurs at position 5 (Q5ser) on histone H3 in organisms that pr

163 aryotes-regulates phosphorylation of serines at position 5 (S5p), a conserved mark of polymerases ini

164 trated that a single nucleotide polymorphism at position 5 of the 3' conserved noncoding region in ID

165 e responsible for the nature of substituents at position 5 of the pyrrole ring in the newly formed ne

166 ,3- d]pyrimidines with various substitutions at position 5 with potent antiproliferative activity in

167 contrast, FmhC incorporates a single serine at position 5.

168 Furthermore, the substituents at positions 5,5' remain coplanar to the central rings.

169 H) mice having a premature termination codon at position +5 in leader exon of Igh (Ter5H) allele.

170 (RRM) of CSTF2 that changes an aspartic acid at position 50 to alanine (p.D50A), resulting in intelle

171 he508del mutation (the loss of phenylalanine at position 508) and increase the amount of cell surface

172 is the deletion of the phenylalanine residue at position 508) at the plasma membrane (PM), promoting

173 WT- and DeltaF508 (deletion of phenylalanine at position 508, the most common CF-causing mutant)-CFTR

174 rrected by inserting an additional reference at position 51 and amending the text in the Discussion r

175 Further, we redesigned the FP at position 518 to reinstate the bNAb VRC34.01 epitope.

176 in interacting with phosphoinositide 2) gene at position 5265458 (c.G745A;pV249M).

177 on, c.705G>C, causes replacement of cysteine at position 53 of the 191-amino-acid sequence of 22 kDa

178 Serine-to-alanine mutation at position 53 of the Kv7.5 amino terminus abrogated its

179 of the universally conserved methyl-uridine at position 54 stabilizes tRNAs from thermophilic bacter

180 er region), TR(46), G54W (a change of G to W at position 54), G54R, L98H, Y121F, and M220I mutations

181 tophosphorylation at the conserved aspartate at position 54.

182 atures of each parent, with the perturbation at position 546 predominantly influencing thermally acti

183 ne residue within the FGFR4 ATP-binding site at position 552, two positions beyond the gate-keeper re

184 minated phosphorylation of eEF2 at threonine at position 56, resulting in increased protein synthesis

185 Its genetic linkage to a single polymorphism at position 57 of the HLA class II DQbeta chain makes it

186 tivity, and that simply changing the alanine at position 578 in the S4-S5 helix of the chicken recept

187 We show that polymorphism at position 59, which differentiates HLA-B*27:03 from al

188 ing a frequent change of threonine to serine at position 590.

189 of the antisense strand, the siRNAs with ANA at position 6 or 7 in the seed region had activity compa

190 d unnatural amino acids and three dipeptides at position 6 that emerged as potent mu/delta opioid rec

191 , glycosylation, and final functionalization at position 6 through cross-couplings or nucleophilic su

192 ed sequences that had reduced hydrophobicity at positions 6 and 7 of CDR3betas, suggesting weaker int

193 A single amino acid substitution at position 61 in the SNH domain of MtAN3 protein abolis

194 o with several different oxazole amino acids at position 66, was also expressed in cellulo containing

195 esponds to an alanine to valine substitution at position 673 in APP (A673V), or position 2 of the amy

196 The siRNA with ANA at position 7 in the seed region was active in a mouse m

197 , we show how acetylation of lysine residues at position 7 of characteristic heptad repeats (K7ac)-on

198 the electronic character of the substituent at position 7 of the heterobicycle and on the counterion

199 Thymine substitutions for adenine at position -7 in the three rRNA promoters strongly incr

200 ine nucleosides, side chains were introduced at position-7 of the nucleobase.

201 at rs117648444, which encodes a substitution at position 70 of the IFN-lambda4 protein and reduces IF

202 stitution affects hydrogen bond interactions at position 70, required for NRTI excision.

203 ed epitope" (SE), the residues Q/R-K/R-R-A-A at positions 70-74 in combination with valine at positio

204 ned by a specific combination of amino acids at positions 70-74 on the HLA-DRB1 molecule.

205 eviously reported amino acid variant located at position 71, within the peptide-binding groove of HLA

206 is loop contains a functionally critical Tyr at position 71.

207 cal amino acid 5-hydroxytryptophan (5-OHTrp) at position 72 in recombinant human apoA-I and confirmed

208 issense isoleucine to threonine substitution at position 73 (I73T) in the alveolar type 2 cell-restri

209 d Nm-NspA better than Ng-NspA; introducing Q at position 73 (loop 2, present in Ng-NspA) or replacing

210 SPZ1 at positions 369 and 374, and of TWIST1 at positions 73 and 76, which are required for SPZ1-TWIS

211 tated by palmitoylation of a single cysteine at position 739 within the large intracellular loop of N

212 Phosphorylation of the conserved serine at position 742 (S742) within the neck region changes bo

213 variant, causing the substitution of leucine at position 752 to phenylalanine, in PLAA, which causes

214 a protein-solvent interface, while mutation at position 754 disrupts the ligand field and solvation

215 single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in t

216 on led to the identification of a tryptophan at position 76 in Vpu (W76) as a key determinant for the

217 We have previously identified a mutation at position 76 of the influenza A virus M2 protein that

218 ntroducing the alanine to threonine mutation at position 778 of mouse Hdac4 (corresponding to positio

219 ovides an explanation for the absence of Ser at position 78 in terrestrial plant species.

220 ier and negatively charged glutamate residue at position 787 could destabilize the finger domain of U

221 preference for rare peptides carrying a Trp at position 8 (p8) of 9-mer peptides bound to HLA-C*05:0

222 Here, we focused on the amino acid residue at position 8 (P8) of the proteolytic cleavage site of M

223 g all strains, except the amino acid residue at position 8 (P8) that shows a certain variability with

224 ic substitutions or cross-coupling reactions at position 8 and deprotection of the sugar moiety gave

225 ning all four stereoisomers of aza-threonine at position 8 were synthesized on a solid support from c

226 Then abruptly at position +8, the dynamic states of initiation make a

227 vardenafil with a single methionine residue at position 806 in mouse PDE5A.

228 rate that somatic mutations occur frequently at position 83, with corresponding domain conformations

229 Cytosine N (4)-methylation (m(4)C) at position 839 (m(4)C839) of the 12S small subunit mt-r

230 The amino acid mutation at position 84 from histidine to threonine minimizes the

231 A single amino acid mutation at position 85 (E85V) impairs PRAP1's ability to form a

232 revealed that substitution of the D1 residue at position 87 with alanine perturbs the chloride-bindin

233 he preference for different peptide residues at position 9.

234 showed that mutation of the arginine residue at position 92, which is in the linker between cap helix

235 Nitrosation of a conserved cysteine residue at position 93 in the hemoglobin beta chain (beta93C) to

236 learly dependent on the presence of tyrosine at position 93 of NS5A.

237 (METTL5) protein catalyzes m(6)A in 18S rRNA at position A(1832) We report that absence of Mettl5 in

238 electrostatic interactions between residues at positions a, d, e, and g of the heptad repeat.

239 cer positions A5-A7 and ~3.2x higher editing at positions A3-A4 and A8-A10 compared with ABE7.10.

240 at were detected mapped to the CMV UL56 gene at positions associated with reduced susceptibility to L

241 is their ability to introduce methyl groups at positions beta to the thiol ester in the growing poly

242 tential 4-bp insertion/duplication mutations at position c.863_864 over 4 orders of magnitude (rho =

243 functionalization of the core HCTD scaffold at position C1, or positions C1 and C4 are described.

244 e show that catechol estrogens, hydroxylated at positions C2 and C4 of the steroid A ring, rapidly po

245 t NSUN-5 is responsible for depositing m(5)C at position C2381 on the 26S rRNA in Caenorhabditis eleg

246 1 is writing the second known 26S rRNA m(5)C at position C2982.

247 otective groups from oxyarene N-heterocycles at positions capable for 2-/4-O-pyridine-2-/4-pyridone t

248 AOX1A carrying a serine residue at position CysI was activated by succinate, while corre

249 e, while for the VP4, amino acid differences at position D195G was radical in nature and resulted in

250 ins often result in flexibility changes even at positions distal from mutational sites, particularly

251 amino acids Ala, Asn, Gln, His, Ile, and Lys at positions equivalent to 782 and/or 786 in Fn-binding

252 ave any significant impact on the reactivity at positions [Formula: see text] far away from point [Fo

253 by a single leucine-to-isoleucine variation at position G.H5.23.

254 er peptides that undergo sequential cleavage at positions G17/G18 and G35/A36 during export through t

255 Genetic variation in SP-A2 at position Gln223Lys is present in up to ~30% of the po

256 i, the inhibitor caused RNA synthesis arrest at position i + 3.

257 position i causes delayed chain termination at position i + 3.

258 Incorporation of RDV-TP at position i caused termination of RNA synthesis at pos

259 the active triphosphate form of RDV (RDV-TP) at position i causes delayed chain termination at positi

260 sition i caused termination of RNA synthesis at position i+3.

261 Once incorporated at position i, the inhibitor caused RNA synthesis arrest

262 bonds to an over-coordinated carbonyl oxygen at position i-4, i-3, or i in the sequence.

263 -indan-2-carboxylic acid, have been inserted at positions i and i+3 of the pentapeptide Boc-(R)-Aic(N

264 ived for hydrophobic alpha-helical hot spots at positions i, i + 3, and i + 7.

265 Consistent with this, a point mutation at position I17 severely compromises binding.

266 substituting the variable cysteine residues at position III in the protein.

267 wave have acquired novel amino acid changes at positions involved in mammalian adaptation, antigenic

268 Mutations at position K205 in SUR1 affected both nucleotide affini

269 CpHK at position K274 reacted with the maleimide drug-linker

270 Previously, cAMP modifications at position N (6) of the adenine ring (PKA) and position

271 harbor two functional N-glycosylation sites at positions N65 and N94.

272 en conformation, and two new masses appeared at positions near Arp2 and Arp3.

273 nd they favour the methylation of linker DNA at positioned nucleosomes(3,4).

274 ve SNPs, it is possible to infer the alleles at positions of interest as well as the beacon query res

275 as most influenced by the amino acid residue at position P1.

276 ity experiments of Czon1107 and its variants at positions P5 and P7 revealed that the conformation ar

277 Strikingly, mutations at positions predicted to be highly frustrated were foun

278 ow that PRMT5 targets RUVBL1 for methylation at position R205, which facilitates TIP60-dependent mobi

279 Point mutations at position R882 have been shown to cause a dominant neg

280 vaccine-escape mutants, while substitutions at positions S195D and M217T may be due to natural fluct

281 Incorporation of CpHK at position S239 resulted in dimerization, which covalen

282 ing the R109Q replacement with modifications at position S70 removed the residual sodium pumping and

283 sets underlie distinct substitution patterns at positions subject to purifying and diversifying selec

284 The polarity change at position T91A/V of the neutralizing antigens might pl

285 epitopes, amino acid substitutions observed at positions T91A/V, S195D and M217T in relation to the

286 cross-links to nucleotides within the U6 PSE at positions that also cross-link to DmSNAPc.

287 to access borylated heterocycles with boron at positions that are difficult to access using alternat

288 GS domain structure with a slight enrichment at positions that interface with G proteins.

289 easing the size of the amino acid side chain at positions that project toward the superhelical axis p

290 We focus on the effects of phosphorylation at positions Thr18 and Ser20 including their substitutio

291 osphorylation of human Rab10 and human Rab12 at positions Thr73 and Ser106, respectively, was confirm

292 yme responsible for 2'-O-methyl modification at position U1369 in the human mitochondrial 16S rRNA.

293 esent in cellular RNA, and in yeast is found at position U54 of tRNAs where modification is catalysed

294 The recombination breakpoints were detected at positions varying from nucleotides 5009 to 5111, loca

295 for engaging the hydrophobic pocket of TRN-1 at position W730.

296 L1) and nucleus ambiguus motor pools located at positions where expiratory and laryngeal motor neuron

297 3' side of the nucleosomal DNA, particularly at positions where the DNA minor groove faces away from

298 Conversely, mutations at positions with low frustration were found to correlat

299 horylation of the T cell adapter protein LAT at position Y132 is a critical kinetic bottleneck for li

300 o tyrosine (NH2Y) by amber codon suppression at positions Y731 or Y730 and investigation of the NH2Y(