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1 pairment on the right side, and his gait was ataxic.
2 and in 5 nonprogressive ataxia patients from ATAXIC.
3 veral months, limb movements became severely ataxic.
4 neuromuscular control, could be described as ataxic.
5 he extent of tolerance that developed to the ataxic action of ethanol in experimental designs in whic
6 ring the chronic treatment, tolerance to the ataxic actions of ethanol was unaffected.
7 , nimodipine did not affect tolerance to the ataxic actions of ethanol.
8 ells, and flies that lack Atonal protein are ataxic and blind.
9 tant mouse was first identified based on its ataxic and convulsive phenotype.
10                         beta1-/- mice appear ataxic and display spontaneous generalized seizures.
11                                Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA
12 ing TARPs gamma-2 and gamma-3 are profoundly ataxic and fail to thrive.
13                We found that these mice were ataxic and had a reduction of Purkinje-cell axon termina
14 erebellar deficient folia (cdf) mutation are ataxic and have cerebellar hypoplasia and abnormal lobul
15  Mice homozygous for mutations in Unc5h3 are ataxic and have cerebellar hypoplasia and laminar struct
16 ele at codon 129; 25% of cases displayed the ataxic and kuru-plaque variants, associated to PrP(Sc) t
17                          Mutant med mice are ataxic and lack expression of the Scn8a gene, which enco
18                Adult Egr3-deficient mice are ataxic and lack muscle spindle proprioceptors that norma
19  recovered faster from the administration of ataxic and sedative doses of ethanol.
20  recovered faster from the administration of ataxic and sedative doses of ethanol.
21                        L7-PP2B mice were not ataxic and showed proper basic motor performance during
22 arch for anticonvulsants devoid of sedative, ataxic, and amnestic side effects.
23 idepressant, anti-epileptic, analeptic, anti-ataxic, and anorectic properties.
24 e ethanol (EtOH), has stimulant, anxiolytic, ataxic, and depressant effects.
25 rebellar Purkinje neurons progressively, are ataxic, and show parallel progressive declines in rotoro
26 n reelin, dab1, or both vldlr and apoER2 are ataxic, and they exhibit severe lamination defects withi
27  expressed Dpl at twice the level and became ataxic approximately 5 months earlier.
28 ase characterized by cerebellar dysfunction, ataxic attacks, persistent myokymia with painful cramps
29                       OAZ-deficient mice are ataxic, attributed to the reduction of the cerebellar ve
30 g the pattern of gene expression in the SCA1 ataxic B05-ataxin-1[82Q] transgenic mouse line with thos
31        Heterozygous Lc/+ mice are viable but ataxic because Lc/+ Purkinje cells die by apoptosis with
32        Homozygous weaver mice are profoundly ataxic because of the loss of granule cell neurons durin
33 tion (pcd), was first identified through its ataxic behavior.
34                            Instead, a severe ataxic breathing pattern emerged with many apnoeas.
35 n of preBotC NK1R neurons results in both an ataxic breathing pattern with markedly altered blood gas
36 s at 9 months of age, although they were not ataxic by cage behavior.
37 r patients in our cohort with a diagnosis of ataxic cerebral palsy.
38 istent with inner ear anomalies, as they are ataxic, circle, display head tilting behavior and do not
39 tage of SCA1, SCA2 and SCA3, relative to non-ataxic controls, had significantly reduced CSA and incre
40 spasticity, as in those with a dyskinetic or ataxic disability.
41 /ptosis and spastic ataxia, or a progressive ataxic disorder.
42 te how our knowledge of the genetic basis of ataxic disorders has come about by novel techniques in g
43 lastic and 55 patients had nonparaneoplastic ataxic disorders.
44  the practice sessions, the tolerance to the ataxic effect of ethanol was increased.
45                 MK-801 potentiated ethanol's ataxic effects in the grid test, but had no effect on to
46 tivity but was devoid of the muscle relaxant/ataxic effects of "classical" 1,4-benzodiazepines (i.e.,
47 ns lead to reduced responsiveness to certain ataxic effects of ethanol without affecting dependence.
48 ntoxicating effects of ethanol and the motor ataxic effects of general anesthetics.
49 I-048A induced sedative, muscle relaxant and ataxic effects, reversed mechanical hyperalgesia 24h aft
50                                              Ataxic episodes in EA-1 patients are often associated wi
51 exhibit partial epilepsy and myokymia but no ataxic episodes, supporting the suggestion that there is
52                            Both animals were ataxic from day 2 onward.
53 ubjects), neuropathic gait (in 11 subjects), ataxic gait (in 10 subjects), parkinsonian gait (in 8 su
54                       Cluster 2 patients had ataxic gait and cerebellar syndrome (77%, 0%, and 0%; p
55 stantial improvement in myoclonic movements, ataxic gait and dysarthric speech after treatment.
56 nd gives rise to functional deficits such as ataxic gait and trembling in the reeler mutant mouse.
57                  Stargazer mice also have an ataxic gait and vestibular problems, including a distinc
58 , affected mutants present with a wide-based ataxic gait and whole body tremor.
59 ressive motor deterioration, with wide-based ataxic gait around 22 weeks of age and death around 30 w
60           There were notable improvements in ataxic gait as well as renal (serum creatinine) and card
61  inhibitory RORbeta IN function result in an ataxic gait characterized by exaggerated flexion movemen
62 ion of the FBXO41 gene results in a severely ataxic gait in mice, which show delayed neuronal migrati
63 lly, this developmental defect results in an ataxic gait in some mice.
64                                   The severe ataxic gait of the older mice was likely due to the dram
65 argeted mutant mouse appeared normal with no ataxic gait or absence seizures, suggesting that other m
66 eurological condition that features a marked ataxic gait that progressively worsens over time.
67  the poor proprioception at the knee and the ataxic gait typical of HSAN III.
68 hibit growth retardation, reduced life span, ataxic gait with apoptosis of cerebellar granule cells f
69  by severe mental retardation, 'puppet-like' ataxic gait with jerky arm movements, seizures, EEG abno
70 potonia, feeding difficulties, spasticity or ataxic gait, and abnormal brain MRI.
71 worsening systemic manifestations, including ataxic gait, dysarthria, and upper and lower limb weakne
72 n Chromosome 10 characterized by progressive ataxic gait, dystonic movements, spontaneus seizures, an
73                              The animals had ataxic gait, hyperactivity and decreased hearing.
74  genetics in a spontaneous mouse mutant with ataxic gait, upward head-elevating movements (hence the
75  intention tremor, dysarthric speech, and an ataxic gait.
76 enal abnormalities, spine abnormalities, and ataxic gait.
77 nje cell loss as the underlying cause of the ataxic gait.
78 d dystonia, and a characteristic hobby horse ataxic gait.
79 n challenging because of the large number of ataxic genetic syndromes, many of which overlap in their
80                                   In the pre-ataxic group at baseline, we compared phenoconverters wi
81 stricted deficits after small focal lesions (ataxic hemiparesis, dysarthria-clumsy hand syndrome, dys
82 ngiform encephalopathy (BSE) are manifest as ataxic illnesses.
83  and slips while traversing a narrow beam of ataxic Kcnc3-null mice were corrected by restoration of
84 nxiolytic-like effects with reduced sedative/ataxic liabilities.
85 sgenic mouse line with those seen in two non-ataxic lines, A02-ataxin-1[30Q] and K772T-[82Q], nine ge
86  were characterized in Purkinje neurons from ataxic mice lacking expression of the sodium channel Scn
87 ivo perfusion of EBIO into the cerebellum of ataxic mice significantly improved motor performance.
88   However, recent evidence from patients and ataxic mice suggests that SCA2 can also share the sympto
89            The scrambler mutation results in ataxic mice that exhibit several neuroanatomic defects r
90 py for both ataxia and non-motor symptoms in ataxic mice without affecting the firing frequency of PC
91 cutely restored normal motor function in the ataxic mice.
92 xed CP (dyskinetic, athetoid, hypotonic, and ataxic) more often had high myopia, CVI, dyskinetic stra
93  cerebellar degeneration show characteristic ataxic motor impairments.
94  chromosome 10 associated with the recessive ataxic mouse mutant jittery.
95 II and methylated H3-K79 are observed in the ataxic mouse mutant robotic, an over-expression model of
96                 Here, we describe a severely ataxic mouse strain that harbors a single, destabilizing
97 d as the defective gene in the epileptic and ataxic mouse, stargazer.
98 d that was first identified in the 'lurcher' ataxic mouse.
99                                              Ataxic movements were less accurate than normal in two w
100 hin-3 (NT-3) mRNA expression patterns in the ataxic mutant mouse stargazer (stg).
101                           In the spontaneous ataxic mutant mouse stargazer, there is a selective redu
102                 BDNF expression in a related ataxic mutant, tottering, was unaltered.
103 clonal antibodies from patients with chronic ataxic neuropathies and Miller Fisher syndrome were stud
104                                   Autoimmune ataxic neuropathies are a subset of the sensory ataxic n
105 oglobulin G (IgG) antibodies, and in chronic ataxic neuropathies associated with persistently elevate
106         The major known causes of autoimmune ataxic neuropathies include sensory variants of the Guil
107    The major site of pathology in autoimmune ataxic neuropathies is the dorsal root ganglion, but dor
108 xic neuropathies are a subset of the sensory ataxic neuropathies which are characterized by ataxia as
109 anti-GD1b ganglioside antibody in autoimmune ataxic neuropathies.
110 ole of human anti-GD1b antibodies in sensory ataxic neuropathies.
111 y sensory neuropathy (HSN, 6.1%), 38 sensory ataxic neuropathy (2.5%), 72 hereditary neuropathy with
112          The combination of CPEO and sensory ataxic neuropathy (SANO, incomplete SANDO) was found in
113 Huttenlocher syndrome to adult-onset sensory ataxic neuropathy dysarthria and ophthalmoparesis.
114 c neuropathy syndrome termed chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies is
115                                  The sensory ataxic neuropathy with dysarthria and ophthalmoparesis (
116                   The combination of sensory ataxic neuropathy with ophthalmoparesis (SANO) was obser
117 -dependent, predominantly sensory, sometimes ataxic neuropathy, frequently accompanied by upper limb
118 reviously under the acronym CANOMAD: chronic ataxic neuropathy, ophthalmoplegia, IgM paraprotein, col
119                             CANOMAD (chronic ataxic neuropathy, ophthalmoplegia, immunoglobulin M [Ig
120 should be considered in all cases of sensory ataxic neuropathy, particularly, but not only, if cerebe
121 nction in Purkinje cells are involved in the ataxic null phenotype and motor coordination, but not mo
122 ement disorders, but not those who exhibited ataxic or indeterminate symptoms as well.
123                         Here we show that in ataxic P/Q channel mutant mice, the precision of Purkinj
124  is focused on the motor decline observed in ataxic patients and animal models of the disease.
125 ntify new mutations in a large population of ataxic patients and to functionally analyze their cellul
126                Our objective was to report 9 ataxic patients carrying 8 novel ANO10 mutations to impr
127 uting for the normal smooth LVOR slow phase, ataxic patients employed catch-up saccades 150-250 ms af
128                     In contrast, the LVOR of ataxic patients had normal latency but significantly dec
129 mportant cause, albeit rare, of a late-onset ataxic PEO phenotype due to a disturbance of mtDNA maint
130 hological care should be provided in the pre-ataxic phase of the disease.
131 e first time develops a progressively severe ataxic phenotype associated with atrophy of the cerebell
132      Contactin-/- mutants displayed a severe ataxic phenotype consistent with defects in the cerebell
133           Here we report a spontaneous Novel Ataxic Phenotype in mice.
134 bellar BDNF expression may be related to the ataxic phenotype in stg mice.
135  +/du(2J), mice; these data suggest that the ataxic phenotype is associated with lack of precision of
136 rophy (DRPLA), progressive acquirement of an ataxic phenotype is linked to severe cerebellar cellular
137                                 However, the ataxic phenotype is present from a very early stage (bef
138                       To explore the lethal, ataxic phenotype of complex I deficiency in Ndufs4 knock
139 s of type II UBCs may both contribute to the ataxic phenotype of these mice and that different calciu
140  the CSB gene (Csb-/-) exhibit a much milder ataxic phenotype than human patients.
141 ous Grid2 deletion, resulting in an aberrant ataxic phenotype that recapitulates the extensive bialle
142  vivo loss of TK2 activity leads to a severe ataxic phenotype, accompanied by reduced mtDNA copy numb
143 CB1 R deficits may also induce a progressive ataxic phenotype.
144 ased Ca(2)(+) influx in PCs and reversed the ataxic phenotype.
145 ompromised Ca(2)(+) channel activity and the ataxic phenotype.
146  of the SACS gene, and 156 patients from the ATAXIC project presenting with congenital ataxia were in
147                          Analysis of visibly ataxic Purkinje cell degeneration (pcd) mice reveals tha
148 deficits in locomotor coordination in mildly ataxic Purkinje cell degeneration mice (pcd; Machado et
149 e analyze the locomotor behavior of severely ataxic reeler mutants and compare and contrast it with t
150 hat ENT1-null mice show reduced hypnotic and ataxic responses to ethanol and greater consumption of a
151 en preataxic SCA (n = 11 SCA1, n = 28 SCA3), ataxic SCA (n = 14 SCA1, n = 37 SCA3), and control (n =
152 Ataxia consortium, including 364 people with ataxic SCA, 56 individuals with preataxic SCA and 394 no
153 0.57+/-0.21, p=0.01) but not in controls and ataxic SCA1 (0.31+/-0.26, p=0.24 and 0.26+/-0.42, p=0.55
154 ignificantly increased in non-converters and ataxic SCA3 (1.06+/-0.33 pg.mL-1/year, p=0.002 and 0.57+
155 orally, knockout mice are insensitive to the ataxic, sedative, and analgesic effects of the novel hyp
156                                          Two ataxic siblings and 2 asymptomatic family members were e
157                  By week 4, mutant mice were ataxic, some PCs had died, and remaining PC soma and den
158 ied a novel EA2 kindred in which members had ataxic spells induced by fevers or high environmental te
159                                              Ataxic spells lasting minutes to hours are provoked by s
160 e expression in blood was altered in the pre-ataxic stage and simultaneously, correlated with ataxia
161                           Individuals in the ataxic stage of SCA1, SCA2 and SCA3, relative to non-ata
162  behavioral symptoms: pre-symptomatic stage, ataxic stage, early post-opisthotonus stage, or the late
163                Converters from pre-ataxic to ataxic stages represented 5/22 (22%) and 12/38 (32%) for
164 ynaptic plasticity in SCs from epileptic and ataxic stargazer mutant mice.
165 ssion in carriers of the ATXN3 mutation (pre-ataxic subjects and patients).
166  LTBP4 were consistently dysregulated in pre-ataxic subjects compared to controls, displaying a combi
167    This work is the first to report that the ataxic subtype of cerebral palsy can be caused by de nov
168                                           As ataxic symptoms occur in other diseases of heme deficien
169 ctive neurodegeneration and suggest that the ataxic symptoms of NPC disease arise from Purkinje cell
170  HE, which is characterized by cognitive and ataxic symptoms, resulting from the buildup of metabolic
171   Thus, Dpl levels in brain and onset of the ataxic syndrome are inversely correlated.
172          More importantly, the history of an ataxic syndrome in a parent does not exclude the diagnos
173 he Prn gene complex, was responsible for the ataxic syndrome, we placed the mouse Dpl coding sequence
174  mice resulted in a phenotypic rescue of the ataxic syndrome, while Dpl overexpression was unchanged.
175 of the arm were examined in 17 patients with ataxic syndromes due to degenerative disease of the cere
176 c lateral sclerosis, prion disease, and many ataxic syndromes, have been found.
177   Homozygous Zfp423 null mice are runted and ataxic, the cerebellum is underdeveloped, and the vermis
178                          Converters from pre-ataxic to ataxic stages represented 5/22 (22%) and 12/38
179  We examined medical records of 117 sCJDVV2 (ataxic type), 65 sCJDMV2K (kuru-plaque type) and 121 sCJ
180                       Mutant mice display an ataxic, unstable gait accompanied by an intention tremor
181  as that with dementia of long duration, the ataxic variant, and the variant with kuru plaques were l
182 r from impaired motor learning without being ataxic, were tested for social behavior using a sociabil

 
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