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1 However, T(reg) cells can become pro-atherogenic.
2 oth APOC3 and APOE content, are particularly atherogenic.
3 nhibit insulin-induced p-Tyr911 and its anti-atherogenic actions (p-Akt/eNOS) in endothelial cells.
4 , synthetic LXR agonists still elicited anti-atherogenic activity in the absence of hepatic LXRalpha,
6 en changes in CaI and on-treatment levels of atherogenic and antiatherogenic lipoproteins, and C-reac
9 poproteins, epsilon4 allele had consistently atherogenic and epsilon2 protective effect on particle c
11 ve pathology by increasing expression of key atherogenic and inflammatory cytokines and chemokines.
12 ng the mechanisms whereby statins reduce the atherogenic and inflammatory phenotype resulting from a
13 ream products, and related genes involved in atherogenic and inflammatory processes in vivo in humans
14 use some experimental studies have suggested atherogenic and lipotoxicity effects of long-chain and v
16 his leads to an up-regulation of several pro-atherogenic and pro-fibrotic targets including ICAM-1 an
19 with 10.0 g TRP supplementation reduced the atherogenic and thrombogenic indices of broiler chicken
21 licit a pro-inflammatory cascade known to be atherogenic and to precipitate acute ischemic events.
25 n of VLDL secretion reduces plasma levels of atherogenic apolipoprotein B (apoB) lipoproteins but can
26 lbumin excretion relates to higher levels of atherogenic apolipoprotein B fractions in the nondiabeti
27 CHD risk by lowering concentrations of other atherogenic, apolipoprotein B-containing lipoproteins (s
28 s mice were also backcrossed onto an Apoe KO atherogenic background and fed a western-type diet (WTD)
30 venous ECs switched its phenotype toward pro-atherogenic by up-regulating the expression of inflammat
31 atients with pediatric psoriasis have a more atherogenic cardiometabolic risk profile, with evidence
33 lating levels of CCL11-a proinflammatory and atherogenic chemokine also known as eotaxin (P for rs600
35 ins a target of interest because of its anti-atherogenic, cholesterol removal, and anti-inflammatory
36 ptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) ch
38 = 0.019), and reduced detoxification of the atherogenic compound methylglyoxal (+54%, P = 0.008).
40 s an important effector molecule integrating atherogenic conditions to direct inflammatory cell entry
42 ssified into eight groups: a normal control, atherogenic control and six other experimental groups (f
47 nthesized H2S protects vascular tissues from atherogenic damage by reducing vessel intimal proliferat
48 mice were fed with either a high-cholesterol atherogenic diet (HCD) or matching normal diet (ND), res
49 atherosclerosis was induced in 18 rabbits by atherogenic diet and double balloon endothelial denudati
50 ression of vascular damage in response to an atherogenic diet by quantifying the in vivo accumulation
51 nd tempers chronic inflammatory responses to atherogenic diet by restraining proinflammatory signalin
52 n rats as well as rabbits, fed on normal and atherogenic diet containing 10% of SL1 and SL2 (experime
58 ide transfer protein gene, were placed on an atherogenic diet for 16 weeks, then either made diabetic
62 ssess an antioxidant protective role against atherogenic diet induced oxidative stress in cardiac, he
65 ificantly inhibited the alteration effect of atherogenic diet on the lipid profile and antioxidant en
66 ant administration of allosamidin and fed an atherogenic diet showed aggravated atherosclerotic lesio
67 ntrol and six other experimental groups (fed atherogenic diet supplemented with different doses of P.
71 tial and peri-adventitial microvessels after atherogenic diet, suggestive of newly formed vasa vasoru
72 streptozotocin-induced diabetes consuming an atherogenic diet, without changes in gross glomerular mo
82 n observed in the arteries of rabbits fed on atherogenic diets was significantly reduced when structu
85 c target for the treatment and prevention of atherogenic dyslipidemia and NAFLD in young insulin resi
87 nonalcoholic fatty liver disease (NAFLD) and atherogenic dyslipidemia associated with the metabolic s
88 hat targeting the central abnormality of the atherogenic dyslipidemia complex, the elevation of trigl
89 e strategy in correcting most aspects of the atherogenic dyslipidemia complex, thereby preventing CVD
90 decades have resulted in an epidemic of the "atherogenic dyslipidemia complex," the main features of
93 lights the potential importance of targeting atherogenic dyslipidemia in diabetic patients with coron
94 VD risk, at least in part through effects on atherogenic dyslipidemia, a cluster of traits including
95 ue to be a viable treatment option for mixed atherogenic dyslipidemia, and recent reports from clinic
96 poprotein (sdLDL) particles are hallmarks of atherogenic dyslipidemia, and their cholesterol content
101 ified molecular explanation for fatty liver, atherogenic dyslipoproteinemia, hyperglycemia, and hence
107 sis that the vasculature is altered by known atherogenic effects of chronic HAART or the prolonged in
108 ves of this study were to determine the anti-atherogenic effects of Enano and L-Enano in LDL receptor
109 nt sterol levels and CVD, thereby suggesting atherogenic effects of plant sterols or of cholesterol u
110 he exposure of the entire vasculature to the atherogenic effects of systemic risk factors, atheroscle
111 ture model systems revealed protective, anti-atherogenic effects of the cytokine interleukin-33 (IL-3
113 e, FDR < 2.0 x 10(-16)), accompanied by anti-atherogenic effects on transcriptomic markers, decreased
116 nhancer-mediated inflammatory transcription, atherogenic endothelial responses, and atherosclerosis i
121 , which can be initiated by physiological or atherogenic factors, is a pivotal process in atherogenes
124 oprotein (apo) A-I mediates many of the anti-atherogenic functions attributed to high density lipopro
126 ngthen the theory that apoCIII exerts strong atherogenic functions through both indirect and direct m
128 ocked the increased lipid deposition and the atherogenic gene expression in the arterial wall and aor
129 which induces endothelial expression of pro-atherogenic genes and the subsequent endothelial dysfunc
130 ely regulated expression of IFNgamma-induced atherogenic genes in human EC and SMC by modulating STAT
131 d an increase in functionally important anti-atherogenic high-density lipoprotein -associated metabol
138 xcept possibly in patients with an increased atherogenic index (triglyceride : HDL-C ratio), or have
139 rol, triglycerides, LDL-cholesterol, and the atherogenic index of plasma (AIP) suggesting its hypolip
140 imed to evaluate the association between the atherogenic index of plasma (AIP), which has been sugges
146 mellitus skews plaque macrophages toward an atherogenic inflammatory M1 phenotype instead of toward
147 romatin-dependent signal transduction in the atherogenic inflammatory response, we characterized the
148 Platelet-derived exosomes mediate platelet atherogenic interactions with endothelial cells and mono
149 mations: (a) initial rapid generation of the atherogenic intermediate gammaBB, followed by (b) transf
150 (TMAO) via a multistep pathway involving an atherogenic intermediate, gamma-butyrobetaine (gammaBB).
151 xidative stress are up-regulated by the anti-atherogenic laminar blood flow often seen in straight or
152 ntly blocked the shift in buoyancy from less atherogenic lb-LDL to highly atherogenic sd-LDL, restori
153 atherogenicity that provides a new route to atherogenic LDL and may explain the escalation of cardio
155 es NF-kappaB-dependent inflammation in early atherogenic lesions, and knocking down RIPK1 will reduce
156 ared with SFAs, with smaller improvements in atherogenic lipid concentrations in obese than in normal
157 genes scavenger receptor BI (SR-BI), an anti-atherogenic lipid exchange mediator, activated internali
158 I, -69.64% to -25.35%]; P < 0.001] and other atherogenic lipid fractions, and it reduced all-cause mo
159 Evolocumab also significantly reduced other atherogenic lipid levels, including non-high-density lip
160 pothesized that orally ingested UFP promoted atherogenic lipid metabolites in both the intestine and
162 flammation, heightened oxidative stress, and atherogenic lipid profile that may increase women's risk
163 on-black race, metabolic risks, an increased atherogenic lipid profile, and elevated ALT overtime.
169 ficacy and safety of mipomersen for reducing atherogenic lipids and lipoproteins in patients with hyp
170 At the top of the checklist for reducing atherogenic lipids and recurrent event risk postmyocardi
173 8,924) 1 to 12 months post-ACS with elevated atherogenic lipoprotein levels despite high-intensity st
175 idual larval zebrafish and collect images of atherogenic lipoprotein localization in an intact organi
176 terolemia (FH) are characterized by elevated atherogenic lipoprotein particles, predominantly low-den
177 7-fold increase in plasma cholesterol and an atherogenic lipoprotein profile with increased levels of
178 s associated with dyslipidemia, particularly atherogenic lipoprotein subparticles, the impact of thes
180 ) the association between very low levels of atherogenic lipoproteins achieved with statin therapy an
182 enetic associations between plasma levels of atherogenic lipoproteins and 25(OH)D were examined in </
183 ervationally is simply a marker for elevated atherogenic lipoproteins and question a role for vitamin
185 t a sensitive and specific approach to study atherogenic lipoproteins and their genetic and small mol
186 Among patients with recent ACS and elevated atherogenic lipoproteins despite intensive statin therap
187 n ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therap
188 ts with acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin treatm
189 isation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity s
193 locumab is an effective therapy for lowering atherogenic lipoproteins in PLHIV with high cardiovascul
196 ency of TGH in mice lowers plasma lipids and atherogenic lipoproteins without inducing hepatic steato
197 cholesterol and AF extended to several other atherogenic lipoproteins, and these associations are unl
198 )D levels are associated with high levels of atherogenic lipoproteins, but whether these 2 risk facto
199 recent acute coronary syndrome and elevated atherogenic lipoproteins, despite intensive statin thera
201 cardiometabolic biomarkers defined by lipid, atherogenic lipoproteins, inflammation and insulin resis
202 tein-B (ApoB) is the structural component of atherogenic lipoproteins, lipid-rich particles that driv
203 s, evolocumab decreased the concentration of atherogenic lipoproteins, particularly LDL, by accelerat
208 antly increased plasma total cholesterol and atherogenic low-density lipoprotein cholesterol levels i
209 one marrow from male Flna (o/fl)/ LC mice to atherogenic low-density lipoprotein receptor-deficient (
213 tin plays a role in regulating the uptake of atherogenic low-density lipoproteins in human hepatocyte
214 nol levels in the cecum, as well as elevated atherogenic lysophosphatidylcholine (LPC 18:1) and lysop
215 ders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysf
216 ectin provides clues to the inflammatory and atherogenic mechanisms associated with pathological coro
222 the potential importance of glycation as an atherogenic modification of LDL, factors determining gly
226 , leading investigators to study the role of atherogenic oxidatively modified lipids (oxylipids).
230 oprotein cholesterol (LDL-C) levels or total atherogenic particle burden (apolipoprotein B100) is les
231 ures and, for TRL-C, among subjects with low atherogenic particle concentrations (apolipoprotein B <1
232 ts provide evidence of decreased exposure to atherogenic particles in carriers of the minor SORT1 all
233 isk is more closely related to the number of atherogenic particles than to the total mass of choleste
234 in therapy, on-treatment levels of LDL-C and atherogenic particles were associated with residual risk
236 ant associations for non-HDL cholesterol and atherogenic particles: apolipoprotein B and ion mobility
237 e (GSK) 3alpha/beta in the activation of pro-atherogenic pathways and the accelerated development of
238 -seq approaches identified activation of pro-atherogenic pathways involving a complex interplay of hi
241 e activation of integrin alpha5beta1 and the atherogenic phenotype of ECs in response to OSS, and pro
242 a powerful therapeutic tool to modulate pro-atherogenic phenotypes and reduce the rate of plaque for
243 We previously showed that macrophages in the atherogenic plaque undergo RIPK3 (receptor-interacting s
245 g values, compared to SS, NASH showed a more atherogenic postprandial lipoprotein profile, an altered
246 with PPAR agonists can reduce the burden of atherogenic postprandial lipoproteins and improve vascul
247 medically important ligands, such as HIV-1, atherogenic postprandial remnant lipoproteins, and molec
248 mellitus (T2DM) impairs hepatic clearance of atherogenic postprandial triglyceride-rich lipoproteins
249 tial inflammatory response that precedes the atherogenic process by targeting different steps of the
252 cess during atherosclerosis, thereby linking atherogenic processes and pathological angiogenesis.
254 advances highlight important cell biological atherogenic processes, including mechanotransduction and
255 ment of LDL lipid subfractions toward a less atherogenic profile [decreased small LDL IIIb (-44 +/- 2
257 emonstrated that miR-155 plays a key role in atherogenic programming of macrophages to sustain and en
259 c adipocytes affects the metabolism and anti-atherogenic properties of high-density lipoproteins (HDL
261 receptors for Ccl5 and Ccl2 are important in atherogenic recruitment of neutrophils and monocytes, we
264 P = 5.5 x 10(-8)), suggesting that targeting atherogenic remnant cholesterol may reduce cardiovascula
265 hrough their metabolic activity decrease pro-atherogenic remnant lipoproteins in hyperlipidemic mice.
270 d metalloproteases (ADAMs) and stimulate pro-atherogenic responses, endothelial inflammation and perm
273 f a cohort with detailed characterization of atherogenic risk factors, including surrogate markers of
274 e results suggest that GSK3alpha plays a pro-atherogenic role, possibly by mediating the effects of e
275 cates that T helper 1 (T(H)1) cells have pro-atherogenic roles and regulatory T (T(reg)) cells have a
277 yancy from less atherogenic lb-LDL to highly atherogenic sd-LDL, restoring the percent distribution o
279 es during sleep in absence of concurrent pro-atherogenic settings (i.e., genetic propensity or dietar
281 tly by gender and, in females, a substantial atherogenic shift overlapping the time of menopausal tra
287 xidized low-density lipoprotein (ox-LDL), an atherogenic stimulus, reduced PIAS3 expression, an effec
290 n margarines should be improved by replacing atherogenic TFA and SFA with beneficial ones, in order t
292 nd apo A-I and, therefore, appear to be less atherogenic than is a low-fat, high-carbohydrate diet.
293 pro-atherogenic regions is a potential anti-atherogenic therapeutic approach, but it has been extrem
294 acid), less favorable health indices (higher atherogenic, thrombogenic and hypercholesterolemic satur
295 ue secretome from anti-inflammatory and anti-atherogenic towards a pro-inflammatory and pro-atherogen
296 deficiency elevates plasma APOC3 as well as atherogenic triglyceride-rich (TG-rich) lipoproteins (TR
298 originate through the delipidation of larger atherogenic VLDL and large LDL and from direct de novo p