ライフサイエンスコーパス: atrophic

1 arrest, fail to redifferentiate, and become atrophic.

2 , although some nerves lost axons and became atrophic.

3 agina of the MOER female mice were extremely atrophic.

4 ixels without increased FAF would not become atrophic.

5 undergo premature growth arrest, and become atrophic.

6 0.59%-1.55%) of nonindigenous participants (atrophic, 0.72%; neovascular, 0.24%).

7 Mesh herniorrhaphy more completely reverses atrophic abdominal wall changes than primary herniorrhap

8 RNFL is partially spared in atrophic advanced AMD.

9 Atrophic age-related and juvenile macular degeneration a

10 ular dystrophy (age >18 years) and nine with atrophic age-related macular degeneration (age >55 years

11 ipofuscin is associated with pathogenesis of atrophic age-related macular degeneration (AMD) and Star

12 ic lipofuscin bisretinoids may contribute to atrophic age-related macular degeneration (AMD) pathogen

13 receptor degenerative conditions like RP and atrophic age-related macular degeneration (AMD).

14 rophy (GA) is the end-stage manifestation of atrophic age-related macular degeneration (AMD).

15 ardt disease, retinitis pigmentosa (RP), and atrophic age-related macular degeneration (AMD).

16 ) transplantation is a promising therapy for atrophic age-related macular degeneration (AMD); however

17 onths after transplantation in patients with atrophic age-related macular degeneration and 8-20 point

18 he retina is associated with pathogenesis of atrophic age-related macular degeneration and Stargardt

19 Loss of photoreceptors in atrophic age-related macular degeneration results in sev

20 f the prosthesis in patients affected by dry atrophic age-related macular degeneration.

21 seases such as retinitis pigmentosa (RP) and atrophic age-related macular degeneration.

22 ases including retinitis pigmentosa (RP) and atrophic age-related macular degeneration.

23 atients with exudative AMD, 46 patients with atrophic AMD and 111 healthy controls.

24 Patients with advanced atrophic AMD carried these rare variants more frequently

25 progressively thinner up to neovascular and atrophic AMD groups (P < .0001).

26 cantly vary among AREDS category 2 and 3 and atrophic AMD groups, compared to controls.

27 ed similarly for predicting the end point of atrophic AMD only (AUC, 0.83, 0.84, 0.85, and 0.88 for m

28 mpared with healthy controls (P < 0.001) and atrophic AMD patients (P < 0.001).

29 ictive models for progression to late AMD or atrophic AMD were only developed (each including age) ba

30 e eye from each of 42 patients with early or atrophic AMD) were divided into four groups: 14 with dru

31 category 3, 26 for neovascular AMD, 26 with atrophic AMD, and 26 controls.

32 In advanced atrophic AMD, FIAF is found mostly adjacent to drusen an

33 neration (AMD) are limited, particularly for atrophic AMD, the identification of predisposing genetic

34 category 2 and 3, naive neovascular AMD, and atrophic AMD.

35 rove understanding of the pathophysiology of atrophic AMD.

36 cytotoxic functions for endogenous dsRNAs in atrophic AMD.

37 n of RPC survival in future cell therapy for atrophic AMD.

38 4%-0.63%]) indigenous participants had late (atrophic) AMD.

39 ormal at 20 weeks, but by 30 weeks, 56% were atrophic and 25% of glomeruli were atubular; glomerulotu

40 Regions of interest (ROIs) including all atrophic and border regions were selected manually on th

41 (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, respec

42 During aging, skeletal muscles become atrophic and lose contractile force.

43 H. felis-infected wild-type mice had severe atrophic and metaplastic mucosal changes.

44 This study has demonstrated progressive atrophic and microstructural changes across the sensory

45 Extensive upstream atrophic and microstructural changes of corticospinal ax

46 to the RPE in order to protect against both atrophic and neovascular AMD.

47 e in rates of ripple discharge between local atrophic and nonatrophic areas.

48 generated, and in each line the pancreas was atrophic and occasionally showed dilation of pancreatic

49 ilitate both proliferation and DNA damage in atrophic and PIN cells.

50 number of small fibers corresponding to both atrophic and regenerating fibers were observed.

51 within the collapsed OPL, although both are atrophic and the spatial distribution of the pedicles is

52 biopsies showed a focal increase of TIA1 in atrophic and vacuolated fibers.

53 On examination, he was severely atrophic and weak in his shoulder girdle and the entire

54 th diabetes mellitus, Schwann tubes appeared atrophic and were limited to the mid-dermis.

55 onfluent PPA patients, the posterior IFC was atrophic and, unlike controls, showed an equivalent leve

56 vitelliform, pseudohypopyon, vitelliruptive, atrophic, and cicatricial) identified no pattern as stag

57 ior, inferior, and middle temporal gyri were atrophic, and subjacent white matter was gliotic.

58 s reduced, the ducts of the VP and MG became atrophic, and, in the VP, there was massive immune infil

59 Two patients showed an atrophic-appearing macular lesion.

60 Atrophic AQM myofibers showed coexpression of TGF-beta r

61 rames, FA displayed hyperfluorescence in the atrophic area in 100% (n = 20) of eyes affected by GA an

62 ied above the Bruch membrane line within the atrophic area in the SD-OCT images.

63 The mean atrophic area increased by 0.37 mm(2) in the hyper-FAF s

64 The atrophic area of the retinal pigment epithelium assessed

65 the hyporeflective band, already within the atrophic area.

66 standard deviation) rate of increase in pure atrophic areas (no subretinal material) was 0.7 +/- 0.8

67 IL expression was restricted to regenerating/atrophic areas of muscle fascicles, blood vessels, and i

68 3% of perfluorodecalin-treated eyes; retinal atrophic areas were found in 41.7% of PFO and in none of

69 Central atrophic areas were larger in NIR-AF images than in blue

70 d loss of outer retinal structure within the atrophic areas.

71 st and most variable immediately adjacent to atrophic areas.

72 tions and treatment changes; those that were atrophic at the final visit (30.8%) had a worse initial

73 malities are the result of a morphologically atrophic AV node.

74 al detection thresholds were measured at the atrophic border in 12 patients.

75 gnificantly increased Akt phosphorylation in atrophic C2C12 cells, corresponding to significantly dec

76 assays showed high fat-fed mice had greater atrophic capillaries, pericyte ghosts, and permeability

77 lular localization of critical RPE proteins, atrophic cell extrusions into the subretinal space, and

78 e further demonstrate that the p53 gene from atrophic cells expressing TAg is wild type, whereas tumo

79 uggesting that TAg may inactivate p53 in the atrophic cells.

80 s characterized by keratotic lesions with an atrophic center encircled by a prominent peripheral ridg

81 without polymicrogyria or heterotopia; (ii) atrophic cerebellar hemispheres with stunted folia, prof

82 Axonal degeneration of the CST in the atrophic cervical cord, proximal to the site of injury,

83 We examined how atrophic change in the cerebellum impacts functional con

84 We hypothesize that these atrophic changes decrease muscle elastic properties and

85 submacular lesions resulted in outer retinal atrophic changes in all 3 eyes.

86 Pathophysiological and atrophic changes in the cerebellum are documented in Par

87 All tested agents partially prevented atrophic changes in the Rdh8(-/-)Abca4(-/-) retina with

88 Atrophic changes in the retinal vasculature are also obs

89 e excess motoneurons remained viable without atrophic changes in the ZPK/DLK-deficient mice surviving

90 These data indicate that profound atrophic changes occur in cholinergic systems of the LDT

91 ociated with a greater visual gain and fewer atrophic changes over a 12-month follow-up.

92 evealed perivascular pigmentary clumping and atrophic changes radiating from the optic disks.

93 of axonal elongation during regeneration and atrophic changes that occur in denervated Schwann cells

94 specific changes across the neuroaxis (i.e., atrophic changes versus increases in volume) and may pro

95 evident in 38%, whilst multifocal, focal, or atrophic changes were seen in 7%, 33% and 9% respectivel

96 cular choroidal inflammatory infiltrate, and atrophic changes within the optic nerve were consistentl

97 y (SCI) has been shown to trigger structural atrophic changes within the spinal cord and brain.

98 aded skeletal muscles undergo characteristic atrophic changes, including change in fiber type composi

99 nd disease progression, while sd-OCT reveals atrophic changes.

100 plasmosis syndrome classically presents with atrophic choroidal scars, which are thought to progress

101 er TRB3 regulates skeletal muscle mass under atrophic conditions.

102 The C3KO mice were atrophic containing small foci of muscular necrosis.

103 ncreas-specific disruption of Atg5 developed atrophic CP, independent of beta-cell function; a greate

104 se may thus serve as a model for age-related atrophic degeneration of the RPE, including the dry type

105 ds, in Crxp-Nrl transgenic mice, produces an atrophic dendritic field yet leaves the axon terminal sy

106 boundary of CNV defined at baseline, termed "atrophic disciform scars," developed in 5 eyes (6%), all

107 drusen-associated lipofuscin is a marker of atrophic disease progression.

108 These include early, intermediate, and atrophic disease stages.

109 iant appears to play a role in exudative and atrophic disease, whereas the ELOVL4 variant may play a

110 al therapeutic applications in children with atrophic disorders such as lipoatrophy and morphea.

111 These temporal regions were not atrophic, displayed normal evoked magnetic and electrica

112 get, was increased and accumulated in highly atrophic DM2 muscle fibers.

113 d the clinical heart failure field, and anti-atrophic drugs have been used to enhance the cardiac rec

114 l cell compartment did not expand and became atrophic during uterine development in these mice.

115 ng transforming growth factor-beta1-mediated atrophic effects in inflammation-induced atrophy.

116 eared not to contribute to the repair of the atrophic epithelium.

117 ing muscle mass by controlling expression of atrophic factors like Mstn and activin.

118 These changes were not detected in non-atrophic fast-twitch extensor digitorum longus muscle.

119 ts appeared smaller at 10 weeks; by 12 weeks atrophic fibers were more prevalent than in age-matched

120 llary and transverse vessel densities in non-atrophic fibre regions were not significantly different

121 s, a variation in myofibre size and/or small atrophic fibres.

122 Sex, age, and number of atrophic foci predicted future progression rates with a

123 Gastric premalignant conditions, atrophic gastritis (AG) and intestinal metaplasia (IM) a

124 biopsy specimens from 74 patients, including atrophic gastritis (AG) cases without aspirin use (contr

125 s are associated with autoimmune metaplastic atrophic gastritis (AMAG).

126 on host biology-the transition from chronic atrophic gastritis (ChAG) to gastric adenocarcinoma-and

127 er, a subset of individuals develops chronic atrophic gastritis (ChAG), a condition characterized in

128 Chronic atrophic gastritis (ChAG), a Helicobacter pylori-associa

129 hat develop an antecedent condition, chronic atrophic gastritis (ChAG).

130 ive once preneoplastic lesions of multifocal atrophic gastritis (MAG) and intestinal metaplasia (IM)

131 ces gastric cancer risk in patients with non-atrophic gastritis (NAG), and is ineffective once preneo

132 as an efficient model for the development of atrophic gastritis after infection and to determine the

133 e associated with hypergastrinaemia, chronic atrophic gastritis and achlorhydria.

134 NS-GAS and B6 wild-type mice had both severe atrophic gastritis and corpus dysplasia, while GAS-KO mi

135 d characteristictly found in assciation with atrophic gastritis and gastric cancer consistent with Bh

136 The high incidence of atrophic gastritis and gastric cancer suggest the phylog

137 ze the human stomach and have been linked to atrophic gastritis and gastric carcinoma.

138 ting gastrin levels, and develop spontaneous atrophic gastritis and gastrointestinal intraepithelial

139 Decreased Bcl-2 gene expression signified atrophic gastritis and IM in presence of cancer, as well

140 how helminth coinfection may protect against atrophic gastritis and T helper type 1 responses.

141 Chronic atrophic gastritis can lead to gastric metaplasia and in

142 ; 2) gastric IM adjacent to a GU but with no atrophic gastritis changes; 3) patients receiving H. pyl

143 sia (SPEM) develops in patients with chronic atrophic gastritis due to infection with Helicobacter py

144 rent study tests the hypothesis that chronic atrophic gastritis from hypochlorhydria in the gastrin-d

145 The atrophic gastritis in the infected wild-type mice, parti

146 gastric cancer (GC) and adjacent mucosa with atrophic gastritis or intestinal metaplasia (AG/IM GC+),

147 stinal metaplasia (AG/IM GC+), as well as in atrophic gastritis or intestinal metaplasia mucosa of pa

148 otic transgenic mouse model of human chronic atrophic gastritis, a preneoplastic condition.

149 We evaluated 19 superficial gastritis, 18 atrophic gastritis, and 18 intestinal metaplasia from ca

150 duces acute gastritis, peptic ulcer disease, atrophic gastritis, and gastric adenocarcinoma.

151 er pylori infection in patients with chronic atrophic gastritis, can cause metaplasia, characterized

152 included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia.

153 postulated to initiate a progression through atrophic gastritis, metaplasia and dysplasia to cancer,

154 gnificantly increases the risk of developing atrophic gastritis, peptic ulcer disease, and gastric ad

155 otential concern in patients with autoimmune atrophic gastritis.

156 circumvent the pH alteration resulting from atrophic gastritis.

157 redominantly in tissues showing gastritis or atrophic gastritis.

158 strains isolated from patients with chronic atrophic gastritis.

159 to determine this balance by activating pro-atrophic gene transcription when present in muscle fiber

160 Atrophic glands also showed evidence of epithelial plugg

161 Her final diagnoses were atrophic glossitis and glossodynia secondary to vitamin

162 hogenic mechanisms of nutrient deficiency in atrophic glossitis are discussed.

163 ound in only 14 of 166 eyes of the early and atrophic groups.

164 n and the LOXL protein in the heart, dermis, atrophic hair follicles, and sebaceous glands.

165 geal arches (PA2s) and is associated with an atrophic heart.

166 Unlike skeletal muscle cachexia, atrophic hearts do not upregulate the ubiquitin-proteaso

167 repsilon4 carrier status was associated with atrophic hippocampal volume (pooled SMD: -0.47; 95% CI -

168 APOE varepsilon4 was associated with atrophic hippocampal volume in MRI markers, increased ce

169 ndings included lattice in 196 eyes (54.0%), atrophic holes in 126 eyes (34.7%), retinal tears in 111

170 Contributing factors to RDs included atrophic holes within peripheral avascular retina, visib

171 mantic dementia did not extend caudal to the atrophic/hypometabolic zone.

172 cortical atrophy, brain regions known to be atrophic in patients with autopsy-proved FTD.

173 Sebaceous glands were markedly atrophic in PP versus nonlesional psoriatic skin (91% av

174 The atrophic injury seems to result from increased oxidative

175 steophytes and joint space narrowing [JSN]), atrophic (JSN without osteophytes), or osteophytic (femo

176 In contrast, atrophic kidneys beyond totally occluded renal arteries

177 yze the electrophysiologic remodeling of the atrophic left ventricle (LV) in right ventricular (RV) f

178 Atrophic lesion areas were measured by FAF and CFP to as

179 enotypic features observed in choroideremia: atrophic lesion borders and outer retinal tubulations (O

180 tor in 7 eyes and localized to a punched-out atrophic lesion in 1 eye.

181 gradable fundus autofluorescence images with atrophic lesion(s) present in at least 1 eye.

182 Incidence of atrophic lesions as determined by fundus autofluorescenc

183 er of 300 microm, with the total area of all atrophic lesions being less than or equal to 12 mm2 in a

184 The effective radius growth rate of atrophic lesions could serve as a reliable outcome measu

185 To describe the yearly progression rate of atrophic lesions in the retrospective Progression of Sta

186 arly rate of progression using the growth of atrophic lesions measured by fundus autofluorescence.

187 efined by the presence of sharply demarcated atrophic lesions of the outer retina, resulting from los

188 To examine the incidence of atrophic lesions of the retinal pigment epithelium in pa

189 We manually delineated atrophic lesions on color fundus photographs of 318 eyes

190 onset of symptoms, 21.9 [13.3] years) showed atrophic lesions present on at least 2 visits and were g

191 peripheral pigmentary changes and clustered atrophic lesions resembling grouped congenital albinotic

192 exists regarding the progression pattern of atrophic lesions secondary to STGD1, and the reported gr

193 factors by measuring the enlargement of the atrophic lesions using fundus autofluorescence (FAF) and

194 Atrophic lesions with a diffuse (mean 0.95 mm(2)) or ban

195 tions in ESCS include (1) torpedo-like, deep atrophic lesions with a small hyperpigmented rim, variab

196 ment epithelial changes; 2 (5%) had multiple atrophic lesions, extending beyond the arcades; and 1 (2

197 underwent the same light treatment developed atrophic lesions.

198 h fatty livers nor PARP-1-deficient mice had atrophic livers.

199 ere staining occurred primarily in basal and atrophic luminal epithelial cells.

200 ed with electrophysiologic remodeling of the atrophic LV.

201 demyelination, high MOG antibody titers and atrophic lymphoid organs.

202 Nevertheless, because of severe atrophic macular changes and subfoveal fibrosis, no impr

203 ion of MFRP and to study the pathogenesis of atrophic macular degeneration.

204 Bilateral coloboma-like atrophic macular lesions were observed in 1 patient (6%)

205 ndus features of pigmentary retinopathy with atrophic macular lesions.

206 Zone 1 (atrophic margin) sensitivity was significantly lower tha

207 re further classified as complete edentulous atrophic maxilla (CEM) and partial edentulous atrophic m

208 trophic maxilla (CEM) and partial edentulous atrophic maxilla (PEM).

209 etic rehabilitation of 10 totally edentulous atrophic maxillae after bone reconstruction with a titan

210 considered a valid option in reconstructing atrophic maxillae to allow for implant-borne prosthetic

211 Ten atrophic maxillae were reconstructed with 19 titanium me

212 Reconstruction and rehabilitation of atrophic maxillae with bone grafts is a lengthy and dema

213 Atrophic maxillary ridges present a challenge in the fie

214 ents and HCs, to detect Abeta plaques in the atrophic mesial temporal cortex, and potentially to eval

215 lterations in precancerous conditions, i.e., atrophic mucosa (AM) and intestinal metaplasia (IM), in

216 gastric mucosa with and without GC, i.e., in atrophic mucosal glands without intestinal metaplasia (n

217 We hypothesized that nNOS expression in atrophic muscle is regulated by DNA methylation of the n

218 the mechanisms regulating nNOS expression in atrophic muscle remain unclear.

219 the regulating mechanism of Akt activity in atrophic muscle remains unclear.

220 iption of these atrogenes is synchronized in atrophic muscle.

221 ncreased p63 protein levels in the fibers of atrophic muscles via denervation-dependent and -independ

222 Perifascicular atrophic myofibers in DM were deficient in a number of s

223 wed deficiency of titin in DM perifascicular atrophic myofibers.

224 ith moderate and advanced POAG, 19 eyes with atrophic NAION, and 40 eyes of normal subjects were imag

225 e cells may have a role in the prevention of atrophic non-union and could enable a paradigm shift in

226 the fracture gap to prevent the formation of atrophic non-union in a rat model.

227 Atrophic non-union is attributed to biological failure o

228 ignificant bone regeneration potential in an atrophic non-union model.

229 .0001) in callus were significantly lower in atrophic-nonunion patients than in healed-fracture patie

230 patients (41 mumol/L; P < 0.001) but not in atrophic-nonunion patients.

231 plasma and callus were measured with HPLC in atrophic nonunions (n = 12) and compared with those in h

232 Atrophic nonunions had lower concentrations of all amino

233 end-stage age-related macular degeneration (atrophic or disciform scar age-related macular degenerat

234 The atrophic pancreas contained small numbers of islets, whi

235 MDCT of the abdomen was done which revealed atrophic pancreas with organized collection in the sub-c

236 The malignant form of atrophic papulosis (Kohlmeier-Degos disease) is a rare t

237 old male who first presented with cutaneous atrophic papulosis but became critically ill from small

238 and laparotomy in our patient with malignant atrophic papulosis were compared to those in the literat

239 copic and laparoscopic findings in malignant atrophic papulosis which suggest laparoscopy is the more

240 terature search using the keywords malignant atrophic papulosis, Degos disease, endoscopy, laparoscop

241 of suspicion for gastrointestinal malignant atrophic papulosis, even if endoscopic examination is no

242 anching reticular pigmentation) (22.7%), and atrophic patches (16.8%).

243 iated skin manifestations, including unusual atrophic patches with abnormal elastic fibers that can s

244 However, daily dosing activated atrophic pathways, including F-box protein 32 (Fbxo32),

245 relation to radiographic OA status, with the atrophic phenotype being defined as knees with absent or

246 A minority of knees exhibited the atrophic phenotype, which also included knees without ra

247 Twenty-one knees (1.3%) showed an atrophic phenotype.

248 phytic and composite phenotypes, but not the atrophic phenotype.

249 Most lesions presented as 2- to 15-mm, round atrophic plaques.

250 techniques are most effective for restoring atrophic posterior areas of the mandible with dental imp

251 Our objective was to determine whether the atrophic posterior IFC is differentially recruited for t

252 ne the sinus lateral wall thickness (LWT) of atrophic posterior maxilla (<10 mm) of patients with com

253 as either free of atrophy or involved in the atrophic process, and the impact on reading was assessed

254 In 27 eyes, the M3R was involved in the atrophic process.

255 unction for p63 as a contributor to muscular atrophic processes via the regulation of multiple genes,

256 anabolic (or hypertrophic) and catabolic (or atrophic) processes.

257 many distinct pathways that make it a unique atrophic program.

258 (iii) In an infant with atrophic putaminal lesions, striatal flow was normal but

259 y with the severity of damage in these local atrophic regions.

260 ow the normal reference range, suggesting no atrophic remodeling after prolonged LVAD unloading.

261 dine receptor were not indicative of ongoing atrophic remodeling during LVAD unloading.

262 egulators of protein synthesis in a model of atrophic remodeling induced by heterotopic transplantati

263 nderlying increased protein synthesis during atrophic remodeling is not known.

264 ional regulators of protein synthesis during atrophic remodeling of the heart.

265 in mass, and altered gene expression, due to atrophic remodeling.

266 lated with increased muscle adipogenesis and atrophic remodeling.

267 d muscle recovery from injury while limiting atrophic remodeling.

268 nt vaginal opening, persistent diestrus, and atrophic reproductive tracts with absent corpora lutea.

269 Histopathology revealed severely atrophic retina.

270 Two patients developed an atrophic retinal hole in a nonfunctioning macular area w

271 ions, including canine kennel cough, porcine atrophic rhinitis, and a whooping cough-like disease in

272 No significant geometric associations with atrophic RHOA were found.

273 presence of teeth adjacent to the edentulous atrophic ridge, and age were shown to influence maxillar

274 erimental ridge defects were created to form atrophic ridges.

275 Atrophic RPE changes included RPE thinning, RPE porosity

276 y; the other 22 patients had foveal atrophy, atrophic RPE lesions, and/or irregular yellow-white fund

277 ar histoplasmosis from the development of an atrophic scar at the fovea or following choroidal neovas

278 Fibrotic or atrophic scar present in the lesion, but not under the c

279 tion showed that the testes were composed of atrophic seminiferous tubules, whereas germ cells were f

280 opose a model whereby Dex- and Mstn-mediated atrophic signals are integrated through miR1, which then

281 We studied a patient referred for unusual atrophic skin patches on the buttocks.

282 ls and downregulated nNOS gene expression in atrophic slow-twitch soleus muscle from the mouse leg.

283 ith a protein-free, elemental diet led to an atrophic small intestine with low numbers of activated T

284 with the increased DNA methylation levels in atrophic Sol, the gene expression levels of total nNOS a

285 Ia fibre) immunoreactivity also decreased in atrophic Sol.

286 in participants who had eyes with multifocal atrophic spots compared with those with unifocal spots (

287 re was centrifugal expansion of disseminated atrophic spots, which progressed to the eventual profoun

288 nding that some tumor cells can remain in an atrophic state even in completely regressed lesions sugg

289 etal muscle atrophy in response to different atrophic stimuli in cells and in mouse models.

290 Atrophic testes and testicular degeneration were observe

291 CreERT2 lines) resulted in male infertility, atrophic testes with vacuolation, azoospermia, and sperm

292 loading of the superolateral cortex leads to atrophic thinning.

293 mination through structural connections from atrophic to unaffected cortical regions.

294 titial myofibroblasts from perivascular into atrophic tubular spaces rather than via epithelial-mesen

295 Epithelium of atrophic tubules containing TR-dextran remained confined

296 The atrophic tubules display pathologically persistent signa

297 0% of glomeruli were atubular or attached to atrophic tubules; in advanced disease, 100% were abnorma

298 It typically manifests as atrophic white plaques, which may be accompanied by purp

299 ed, and remaining PC soma and dendrites were atrophic, with almost complete disappearance of spiny br

300 sa (RP) and in the transitional zone (TZ) of atrophic zones (AZ), which characterize geographic atrop