ライフサイエンスコーパス: attenuated strain

1 BL206, a high-virulence strain, and B348, an attenuated strain.

2 esis mechanisms are active in this virulence attenuated strain.

3 ve candidates for further evaluation as live attenuated strains.

4 would benefit from the availability of live attenuated strains.

5 ent in all virulent strains but deleted from attenuated strains.

6 In this study, recombinant live-attenuated (strain 17D) YF viruses were constructed to e

7 rast to previous reports of acpA function in attenuated strains, acpA had a minimal influence on caps

8 Oral immunization with this attenuated strain also produced complete, long-lasting p

9 d by the presence of a 7.5-kb plasmid in the attenuated strain and 7 nonsynonomous single-nucleotide

10 oprotein exhibiting reduced expression in an attenuated strain and plays a role in M. gallisepticum v

11 the efficacy of mucosal vaccination via this attenuated strain and will guide its further development

12 The plasmid was cured from the attenuated strain, but it remained nonlethal.

13 erferon response limits the virulence of the attenuated strain by reducing replication, protection fr

14 coprotein (G) gene, even in most recombinant attenuated strains, can still show substantial adverse o

15 were combined with the envelope genes of the attenuated strain caused milder signs of disease.

16 in were combined with the other genes of the attenuated strain caused severe rash and fever even if t

17 The attenuated strain chi10069(pYA5199) was manifested by th

18 d with 109 colony-forming units of Y. pestis attenuated strains CO99 (pCD1+/DeltaApgm) or KIM6+ (pCD1

19 Edematous peri-infarct myocardium had attenuated strain compared with remote myocardium at day

20 berculosis complex, restores virulence to an attenuated strain containing a point mutation (Arg-515--

21 Protection afforded by attenuated strains correlates in part with the ability o

22 rains, but may not be completely safe as the attenuated strain could cause AIDS in some vaccinated in

23 th altered glycogen metabolism, including an attenuated strain defective for type II secretion.

24 t neonatal mice immunized only once with the attenuated strain DeltaactA-Lm developed robust primary

25 lent strains grew more rapidly in AMphi than attenuated strains despite causing less apoptosis.

26 Live attenuated strains developed for use in animals elicit p

27 he most advanced vaccine candidates are live attenuated strains developed using a genetically modifie

28 or protection against tularemia, although an attenuated strain, dubbed the live vaccine strain (LVS),

29 ently than a virus with the H protein of the attenuated strain Edmonston, whereas cell entry efficien

30 Both attenuated strains failed to infect BALB/c mice and elic

31 effectively protect against infections with attenuated strains, for example, LVS, but not virulent s

32 We show here that immunization with live, attenuated strains generates plague-protective immunity

33 The attenuated strain grows to higher titers in CHSE cells a

34 y among four strains of M. tuberculosis: the attenuated strain H37Ra, the virulent strains H37Rv and

35 substantially less AMphi apoptosis than the attenuated strain H37Ra.

36 Such attenuated strains have the potential to be used as live

37 Vaccines combining 3 or 4 attenuated strains having different LPS serogroups were

38 rial strains elicit much less apoptosis than attenuated strains, implying that apoptosis is a defense

39 on, protection from disease conferred by the attenuated strain in immunocompetent mice can occur inde

40 r entry, which may affect the tropism of the attenuated strain in vivo.

41 Investigators are examining the attenuated strains in additional in vivo, cell culture o

42 her the plasmid-positive or plasmid-negative attenuated strain, indicating that an active process eli

43 fatal disease in pigs and wild boar, whereas attenuated strains induce infections with various levels

44 This highly attenuated strain induced long-lived protective systemic

45 This attenuated strain induces very strong protection against

46 thway is efficiently activated during NH/P68 attenuated strain infection, leading to the production o

47 cobacterium tuberculosis (M.tb) DK9897 is an attenuated strain, it was isolated from a patient with e

48 en coexpressed with N and P proteins from an attenuated strain, L proteins from two attenuated viruse

49 An attenuated strain, L. monocytogenes dal dat, produced by

50 Infection with the attenuated strain led to influx of activated macrophages

51 berculosis infections and suggests that this attenuated strain may represent a valuable vaccine candi

52 e, we show that prior infection with certain attenuated strains may elicit protective immunity.

53 sis suggests that genes absent or altered in attenuated strains may influence pathogenesis.

54 strain of vaccinia virus (VV) and the highly attenuated strain, modified vaccinia Ankara (MVA).

55 m by which virulent bacteria, in contrast to attenuated strains, modulate human cells to cause diseas

56 ed to reach this goal is the construction of attenuated strains more efficacious and safer than BCG.

57 etic variants and differing in virulence: an attenuated strain (NiggA) and a virulent strain (NiggV).

58 veloped a vaccine strategy for generating an attenuated strain of an intracellular bacterial pathogen

59 ination with a genetically engineered, live, attenuated strain of Blastomyces dermatitidis carrying a

60 -12 to control a live genetically engineered attenuated strain of Blastomyces dermatitidis given s.c.

61 e show that the genomes of a virulent and an attenuated strain of CMV are maintained in hematopoietic

62 , into the genome of CVB3/0, an artificially attenuated strain of coxsackievirus B3, at the junction

63 ro) recognition sites, into the genome of an attenuated strain of CVB type 3 (CVB3/0) at the junction

64 Following challenge with a partially attenuated strain of DENV2, all 21 subjects are protecte

65 24 h after intravaginal inoculation with an attenuated strain of herpes simplex virus type 2 (HSV-2)

66 Intravaginal inoculation of mice with an attenuated strain of herpes simplex virus type 2 (HSV-2)

67 at these individuals may be infected with an attenuated strain of HIV-1; however, a common genetic ba

68 nonprogression may include infection with an attenuated strain of human immunodeficiency virus type 1

69 ts530, a candidate live-virus vaccine, is an attenuated strain of human respiratory syncytial virus (

70 17D virus with the corresponding genes of an attenuated strain of Japanese encephalitis virus (JE), S

71 ade B NWM-GP1s and reduces infectivity of an attenuated strain of Junin virus.

72 rvive and clear high-dose challenges with an attenuated strain of L. monocytogenes that is incapable

73 We therefore have produced a highly attenuated strain of L. monocytogenes that requires D-al

74 Here, we used an attenuated strain of Listeria monocytogenes (DeltaactA,

75 In this study, we used an attenuated strain of Listeria monocytogenes as a vaccine

76 pecific CD8+ T cells after infection with an attenuated strain of Listeria monocytogenes, which was c

77 We hypothesized that an attenuated strain of Lm would be safe and induce long-la

78 titumor potential of a novel viral agent, an attenuated strain of measles virus (MV), derived from th

79 ng gene 1-/- (RAG1-/-) mice infected with an attenuated strain of MHV-JHM.

80 that received protective vaccination with an attenuated strain of Mtb.

81 Bacillus Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis (M. bovis), is

82 The attenuated strain of Mycobacterium bovis known as bacill

83 Bacille Calmette-Guerin (BCG) is an attenuated strain of Mycobacterium bovis that is used wi

84 Bacille Calmette-Guerin (BCG) is a live, attenuated strain of Mycobacterium bovis used widely for

85 Bacille Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, is widely used

86 replication, and transynaptic passage of an attenuated strain of PRV (PRV-Bartha) injected into rat

87 Intravitreal injection of the attenuated strain of pseudorabies virus (PRV Bartha) res

88 ss this question, retrograde transport of an attenuated strain of pseudorabies virus (PRV) from the n

89 question, retrograde tract tracing using an attenuated strain of pseudorabies virus (PRV-Bartha) was

90 ssessed using intracerebral injections of an attenuated strain of pseudorabies virus, a neurotropic a

91 Madrid E is an attenuated strain of R. prowazekii, while Breinl is a vi

92 the intratumoural injection of a genetically attenuated strain of Salmonella coated with antigen-adso

93 (WT) control mice were injected i.v. with an attenuated strain of Salmonella enterica Typhimurium (WB

94 ability to kill Escherichia coli (F18) or an attenuated strain of Salmonella typhimurium (sseB) in vi

95 ine was delivered by oral gavage by using an attenuated strain of Salmonella typhimurium as carrier.

96 ry have shown that infection of mice with an attenuated strain of Salmonella typhimurium causes a mar

97 e mice 3 to 7 days after inoculation with an attenuated strain of Salmonella typhimurium produced hig

98 ys after infection of C3HeB/FeJ mice with an attenuated strain of Salmonella typhimurium, there is pr

99 derived maltose-binding protein (MBP) in an attenuated strain of Salmonella typhimurium.

100 Furthermore, a unique attenuated strain of Salmonella was generated for gene d

101 In addition, a novel attenuated strain of Salmonella, which exhibited efficie

102 rom mice that had resolved infection with an attenuated strain of Salmonella.

103 in 100% of rhesus macaques infected with an attenuated strain of simian immunodeficiency virus (SIV)

104 adult rhesus macaques immunized with a live, attenuated strain of SIV (SIVmac239Deltanef).

105 Similar to the initial study, we used an attenuated strain of SIV containing a stop codon in nef.

106 RNA replicon vector system, derived from an attenuated strain of the alphavirus Venezuelan equine en

107 In summary, an attenuated strain of the Creutzfeldt-Jakob disease agent

108 Vaccination with the attenuated strain of the M. bovis pathogen, BCG, is not

109 to MHV into RAG1(-/-) mice infected with an attenuated strain of the virus results in the rapid and

110 received an intracerebral inoculation of an attenuated strain of Theiler's murine encephalomyelitis

111 herefore have endeavored to isolate a highly attenuated strain of this organism for use as a vaccine

112 at parenteral immunization with a new highly attenuated strain of this organism provided complete pro

113 ine melanoma by intratumoral injection of an attenuated strain of Toxoplasma gondii (cps) that cannot

114 MVA is an attenuated strain of vaccinia virus (VACV) that is a pop

115 Modified vaccinia virus Ankara (MVA) is an attenuated strain of vaccinia virus (VV) that has attrac

116 ed on an RNA replicon vector derived from an attenuated strain of Venezuelan equine encephalitis viru

117 A molecularly cloned attenuated strain of Venezuelan equine encephalitis viru

118 c imaging approach, was used to visualize an attenuated strain of Yersinia enterocolitica, currently

119 Infection with attenuated strains of ASFV leads to the upregulation of

120 It also may be useful in creating novel live-attenuated strains of bacteria for use as vaccine candid

121 Attenuated strains of C. trachomatis do not exist, so th

122 Thus, unlike attenuated strains of F. tularensis, Schu4 induced broad

123 st majority of work has been conducted using attenuated strains of Francisella that do not cause dise

124 well known, the possibility of infection by attenuated strains of HIV-1 has been much less studied.

125 hrough biosecurity and vaccination with live attenuated strains of ILTV and vectored vaccines based o

126 In this report, we evaluate virulence-attenuated strains of Listeria monocytogenes as vaccine

127 Both virulent and attenuated strains of M. tuberculosis could activate the

128 ion, inactivation of these genes may lead to attenuated strains of M. tuberculosis for the developmen

129 d suggest that to induce optimal protection, attenuated strains of M. tuberculosis should persist lon

130 antituberculosis drugs and for derivation of attenuated strains of M. tuberculosis.

131 g of RLORF4 and the finding that four of six attenuated strains of MDV contained deletions within RLO

132 ined through the use of eosinophil-deficient/attenuated strains of mice that have demonstrated novel

133 Mice infected with attenuated strains of mouse hepatitis virus, strain JHM,

134 viously reported that macrophage exposure to attenuated strains of pathogenic mycobacteria at multipl

135 d the direction of transport of virulent and attenuated strains of PRV, utilizing injections into the

136 r murine flank inoculation with virulent and attenuated strains of pseudorabies virus (PRV).

137 Cold-adapted, temperature-sensitive (ts), attenuated strains of respiratory syncytial virus have b

138 tes of inoculation for wild-type but not for attenuated strains of S. enterica serovar Typhimurium.

139 te the safety and protection induced by live attenuated strains of S. pneumoniae containing combinati

140 We therefore tested DeltaphoP-phoQ attenuated strains of Salmonella enterica serovar Typhim

141 Attenuated strains of simian immunodeficiency virus (SIV

142 cine/challenge experiments that utilize live attenuated strains of simian immunodeficiency virus (SIV

143 could match, or come close to matching, live attenuated strains of SIV in the degree of protection if

144 otective immunity in monkeys inoculated with attenuated strains of SIV is associated with a complex a

145 irus-specific antibody responses elicited by attenuated strains of SIV that was closely associated wi

146 monkeys experimentally infected with various attenuated strains of SIV was characterized by using a c

147 aques but not in macaques infected with live attenuated strains of SIV.

148 ease cholera have focused on the use of live attenuated strains of the causative organism, Vibrio cho

149 These vaccines are based on selected attenuated strains of the four dengue serotypes and empl

150 Attenuated strains of the naturally occurring plant path

151 Live attenuated strains of V. cholerae that have been used bo

152 rences between the ORF S/Ls of wild-type and attenuated strains of VZV.

153 ass-associated peptides from cultures of two attenuated strains of Yersinia pestis [KIM D27 (pgm-) an

154 hrough immune responses generated with live, attenuated strains or F1 subunit vaccines.

155 Utilizing this attenuated strain, our prior studies revealed that mitoc

156 ins generally are not good tracers, but some attenuated strains perform well.

157 eceiving intravenous challenge with the same attenuated strain prior to tick passage.

158 is, producing tetra-acylated lipid A, and an attenuated strain producing a Y. pseudotuberculosis-like

159 Inhalational MtbDeltasigH, a stress-response-attenuated strain, protected against lethal TB in macaqu

160 This is the first report of a defined live attenuated strain providing protection against the inhal

161 se yet, we propose to explore DPCR-defective attenuated strains (rad51DeltaDeltawss1DeltaDelta and ra

162 he smooth virulent strain 2308, in the rough attenuated strain RB51 disruption of the 14-kDa protein'

163 ating that an active process elicited by the attenuated strain reduces inflammation and disease.

164 ge also suggest that a release defect in the attenuated strain reduces the apparent rate of viral tra

165 microvascular obstruction showed especially attenuated strain results.

166 These attenuated strains retained the ability to colonize the

167 y 30 CFU of S. aureus RN6390 or the isogenic attenuated strains RN6911 (agr mutant), ALC136 (sar muta

168 ely with the level of attenuation; the least-attenuated strain, SIVmac239Delta3, gave the greatest pr

169 Therefore, highly attenuated strains such as modified vaccinia virus Ankar

170 45 was not detected in high-passage, culture-attenuated strains, suggesting that LipL45 is a virulenc

171 ture-tagged mutagenesis screen identified an attenuated strain that featured an insertional disruptio

172 ns were tested, including VNP20009, a highly attenuated strain that was previously shown to be safe i

173 this study, we examined the efficacy of new attenuated strains that are able to synthesize d-alanine

174 e theory, founded on studies with laboratory-attenuated strains, that suggests mutators are rare amon

175 o by its earlier name, Francisella novicida) attenuated strains, the DeltaiglB and DeltafopC strains,

176 With such attenuated strains, the tumor:liver ratios ranged betwee

177 The novel attenuated strains used in these studies were S. flexner

178 that administration of viable yeast of this attenuated strain vaccinates against lethal pulmonary ex

179 ur approach for production of candidate live attenuated strains was to identify mutations that did no

180 rensis Live Vaccine Strain (LVS) and related attenuated strains, we combined the control of in vitro

181 Macaques vaccinated with the attenuated strain were either solidly or partially prote

182 for a better dengue vaccine candidate, live attenuated strains were followed by non-infectious virus

183 ctors in V. cholerae; however, many of these attenuated strains were still reactogenic in human volun

184 serovar Typhi strain CVD 908-htrA is a live attenuated strain which may be useful as an improved ora

185 (CTS2 and CTS3) were disrupted to yield the attenuated strain, which was unable to endosporulate and

186 h virulence of some strains compared to more attenuated strains, which produce subclinical infections

187 l within MDM were compared for delta aroA143-attenuated strains, wild-type virulent strains, and the

188 -associated changes were demonstrated in the attenuated strain with significant downregulation of a p

189 ay serve as a viable strategy to derive live attenuated strains with potential for development as eff

190 logies can be applied to FMD virus to obtain attenuated strains with potential for further developmen

191 rulence mechanisms and the creation of other attenuated strains with vaccine potential.