ライフサイエンスコーパス: attrition

1 a (DC), a disorder characterized by telomere attrition.

2 ods of time experienced accelerated telomere attrition.

3 st telomere length and least telomere length attrition.

4 ency experience and saliva-measured telomere attrition.

5 to further define program factors affecting attrition.

6 sion and that anisotropy would be greater in attrition.

7 However, these studies are susceptible to attrition.

8 r patient load was associated with decreased attrition.

9 ured, and identified factors associated with attrition.

10 inverse probability of censoring weights for attrition.

11 l treatments for anxiety disorders with less attrition.

12 pendent factor most strongly associated with attrition.

13 iation was associated with increased 6-month attrition.

14 er versus individual trials, compliance, and attrition.

15 ll counts and death, attrition, and death or attrition.

16 itiation may be at greater risk of treatment attrition.

17 nd likely overestimated categorical resident attrition.

18 ore intensive screening were limited by high attrition.

19 ir opinions regarding resident education and attrition.

20 f TB highlight different patterns of patient attrition.

21 ematopoietic stem and progenitor cell (HSPC) attrition.

22 pine subtypes showing the greatest degree of attrition.

23 tion and protects DNA replication forks from attrition.

24 improving patient safety and preventing drug attrition.

25 kill surrounding cells, causing host tissue attrition.

26 o dissatisfaction with nursing and increased attrition.

27 type of HSC divisional memory and drives HSC attrition.

28 cancer therapies and can be a source of drug attrition.

29 order of acuity, would decrease attentional attrition.

30 ntially susceptible to fragmentation through attrition.

31 a 2-sided test with alpha=5% and 10% patient attrition.

32 cell-cycle defect in the absence of telomere attrition.

33 plication forks against spurious nucleolytic attrition.

34 art growing again after millions of years of attrition.

35 ed, orange-brown stained, and susceptible to attrition.

36 sponse (DDR) machinery resulting in telomere attrition.

37 cell division after DNA damage and telomere attrition(11-13); another two (MPL and SH2B3) encode pro

38 ), burnout (54.9% vs 35.0%), and thoughts of attrition (21.6% vs 10.8%; all P < 0.001).

39 s was additively associated with greater LTL attrition (3 herpesviruses vs none, beta = -0.07 and P =

40 ns (ie, to 95%); and the effects of coverage attrition (a 2% decrease every 5 years).

41 s with a female helper show reduced telomere attrition, a measure that reflects biological ageing in

42 The determinants of telomere attrition, a potential marker of cellular aging, are not

43 dition, these mice also had increased enamel attrition, accompanied by excessive deposition of peritu

44 liation for hypoplastic left heart syndrome, attrition after the Norwood procedure remains significan

45 lungs include defective autophagy, telomere attrition, altered proteostasis, and cell senescence.

46 ), azidothymidine (AZT) and TDF on death and attrition among HIV patients with HBV coinfection.

47 had significant effects on both of death and attrition among HIV patients with HBV coinfection.

48 For telomere attrition, amount of food and begging effort exerted add

49 concerns have been raised regarding patient attrition, an important measure of program quality.

50 cause of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-w

51 For example, a 3-year trial with 10% attrition and a treatment effect of 50% requires a total

52 Attrition and adverse events (AEs) were similar between

53 specific differences in the rate of telomere attrition and apparent radiosensitivity weaken the intra

54 ttrition prevalence) or secondary (causes of attrition and characteristics and destination of residen

55 olite1-6) by measuring AEC and resistance to attrition and compression, against natural (clinoptiloli

56 patients experience hematopoietic stem cell attrition and cytopenia during childhood, which along wi

57 o elucidate the microwear characteristics of attrition and erosion in worn natural teeth, we scanned

58 vided into 4 groups, including 2 wear types (attrition and erosion) and 2 locations (anterior and pos

59 IPT had (nonsignificantly) lower attrition and higher response rates than prolonged expos

60 treatments accelerated erythrocyte telomere attrition and increased DNA damage measured in the juven

61 obtain comparative metrics for lifelong LTL attrition and learn about the temporal association of LT

62 To confirm the association between telomere attrition and loss of LLM and ALMBMI, which are highly r

63 Norwood and S2P that both minimizes pre-S2P attrition and maximizes post-S2P survival exists and is

64 inverse probability weighting to account for attrition and missingness examined the association betwe

65 ded hippocampal volume loss, oligodendrocyte attrition and myelin loss, and impaired performance in Y

66 only sporadically, with 66% reporting animal attrition and none reporting blinded outcome assessment

67 a promising alternative to the high rates of attrition and relapse currently observed with agonist ta

68 process termed dorsal collapse that involves attrition and remodelling of pseudostratified ventricula

69 uctural integrity concomitant with increased attrition and smaller teeth.

70 ector attitudes are associated with resident attrition and to measure the categorical resident attrit

71 hibitory effects of cell-intrinsic (telomere attrition) and cell-extrinsic (chemical- or metabolism-i

72 of pre-ART CD4+ cell count levels on death, attrition, and death or attrition in HIV treated patient

73 between pre-ART CD4+ cell counts and death, attrition, and death or attrition.

74 d through 12 months, findings are limited by attrition, and further research is needed to assess long

75 rogenic diet decreases LTL and increases LTL attrition, and shortened LTL is associated with early-st

76 was the attenuation of accelerated telomere attrition, and the primary efficacy end point was a 20%

77 a cellular level, stem cell dysfunction and attrition appear to be key events, and both genetic and

78 However, further reductions in attrition are needed to maximize individual and populati

79 dhood telomere length (TL) and more rapid TL attrition are widely regarded as manifestations of stres

80 This work implicates telomere attrition as a biologically measurable consequence of ph

81 Further, the findings implicate telomere attrition as an objective biomarker to follow the pathol

82 iet and midlife plasma glucose, high rate of attrition, as well as the limited power for certain subg

83 of physician training, with the magnitude of attrition associated with workload.

84 ntained or could not be confirmed because of attrition at the age of 8 y.

85 ial network adapted to slow the rate of cell attrition at the expense of beta-cell function.

86 ty concerns remain the leading cause of drug attrition at the preclinical drug development stage, the

87 ethod to identify interns at higher risk for attrition at the start of training, and next steps would

88 3 years was then predicted and adjusted for attrition before S2P by multiplying by the estimate of T

89 pective study involvement but was subject to attrition bias caused by passive follow-up.

90 e limitations of our study include that some attrition bias towards more healthy participants was obs

91 Indication and attrition bias were controlled with propensity score mat

92 ingness from Wave 1-5 and little evidence of attrition bias.

93 All studies were at high risk for attrition bias.

94 remained on natalizumab, suggesting limited attrition bias.

95 ropout, even in studies rated at low risk of attrition bias.

96 enthood is an important mechanism of women's attrition, both women and men leave at surprisingly high

97 ied correlations between stress and telomere attrition, but no large, longitudinal studies examining

98 Telomere attrition can lead to potentially maladaptive cellular c

99 inactivation of the N-module subunits due to attrition caused by its constant activity under physiolo

100 ng TDF had significantly lower risk rates of attrition compared to those receiving the ART containing

101 plexity in erosion and greater anisotropy in attrition confirm our hypothesis.

102 ions between leukocyte telomere length (LTL) attrition, diet and cardiovascular disease (CVD) are inc

103 , Zeolite3 and 6 showed higher resistance to attrition (disintegration rate = 2.7, 4.1 NTU/h, respect

104 Of note, the mean telomere attrition during internship year was six times greater t

105 , and nutritional intervention would slow TL attrition during the first two years of life.

106 Our unexpected finding of increased telomere attrition during the first year of life in the intervent

107 Attrition during the period from HIV testing to antiretr

108 The tremendous rate of attrition during the process of metastasis implicates th

109 ervention group suggests that rapid telomere attrition during this critical period could reflect the

110 Attrition elevates fine ash production which, in turn, h

111 The evolution of homochirality via attrition-enhanced deracemization (AED) of enantiomorphi

112 vior to direct the stereochemical outcome in attrition-enhanced deracemization processes.

113 rks of ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis,

114 hrough the enigmatic process of fetal oocyte attrition (FOA).

115 Further functional attrition follows subsequent tryptophan number reduction

116 n dentine erosion for complexity and dentine attrition for anisotropy.

117 Stable or decreasing trends in attrition for ART patients were observed in most countri

118 Finally, the interaction between telomere attrition from 4 to 18 months and maternal ACEs was exam

119 Telomere attrition from 4 to 18 months interacted with maternal A

120 y of age was associated with an accelerated attrition from 4 to 5 y of age (adjusted coefficient: -5

121 ment onto ART, adherence, viral suppression, attrition from ART, and mortality.

122 A survival analysis was conducted comparing attrition from care after ART initiation between the gro

123 High rates of patient attrition from care between HIV testing and antiretrovir

124 As such, it remains unclear if early attrition from care was due to a "healthy cohort" effect

125 first 2 y of college-the window of greatest attrition from science, technology, engineering, and mat

126 hood as a mechanism of gender-differentiated attrition from STEM employment.

127 drug like properties reducing the chance of attrition from the outset.

128 early insulin independence, long-term graft attrition gradually reverts recipients to exogenous insu

129 Whether program director attitudes affect attrition has been unclear.

130 e that secondary fragmentation, specifically attrition, has in transforming primary pyroclasts upon t

131 Previous studies of resident attrition have variably included preliminary residents a

132 on assessed trends in 6- and 12-month cohort attrition (ie, the proportion of patients in each cohort

133 , to enhance reproducibility through reduced attrition, improved reporting, and adopting an approach

134 Nonignorable attrition in a longitudinal survey can lead to bias in e

135 rinatal cardiomyocyte growth, maturation and attrition in a precocial large mammal, sheep (Ovis aries

136 nd-muscle TL model shows more pronounced LTL attrition in ASCVD patients than controls.

137 decreasing order of patient acuity mitigated attrition in attentional reserves when compared with the

138 change in community-level contact coverage, attrition in AUD detection rates over time, and relative

139 AAV9-Tert treatment after telomere attrition in bone marrow cells rescues aplastic anemia a

140 We found telomere attrition in both pedigrees, but no mucocutaneous abnorm

141 onstration of investigating the influence of attrition in cohort studies using information that has b

142 drug reactions (ADRs) are a common cause of attrition in drug discovery and development and drug-ind

143 ate target exposure is a major cause of high attrition in drug discovery.

144 e during adulthood suggesting that increased attrition in early life is more likely to be a major exp

145 Our data support the hypothesis that HSC attrition in FA is the consequence of defects in the DNA

146 unt levels on death, attrition, and death or attrition in HIV treated patients.

147 h causal and potentiating roles for telomere attrition in human diseases.

148 ficient efficacy is the most common cause of attrition in late-phase drug development.

149 ey bee colonies have suffered from increased attrition in recent years, stemming from complex interac

150 and Bim (intrinsic pathway) on early T cell attrition in response to lymphocytic choriomeningitis vi

151 counting for reverse causality and selective attrition in studies of older adults.

152 es reporting on the prevalence and causes of attrition in surgical residents, as well as the characte

153 treatment TB recurrence were major points of attrition in the new smear-positive TB cascade.

154 ic damage and to mesenchymal stem cell (MSC) attrition in vivo.

155 technology-enabled interventions can reduce attrition in vulnerable populations.

156 This supports and extends the pernicious attrition/induction decay hypothesis that SR Ca(2+) rele

157 hemes were nursing workforce related ("nurse attrition," "inexperienced workforce," "limited mentorin

158 Telomere attrition is a major risk factor for end-stage liver dis

159 ing early population decline, since telomere attrition is associated with aging processes and acceler

160 Telomere attrition is closely associated with cell aging and expo

161 Hematopoietic stem cell (HSC) attrition is considered the key event underlying progres

162 experimentally produced tephra to show that attrition is likely to occur in all explosive volcanic e

163 While NPC attrition is linked to TP53-mediated cell death in sever

164 ry T lymphocytes (T(SCM)) contribute to such attrition is still unclear.

165 To further reduce ART attrition, it is imperative that patient education and h

166 ter enrollment is through interview or exam, attrition leads to missing information for nonrespondent

167 Significant attrition limits drug discovery.

168 onse to diverse triggers, including telomere attrition, macromolecular damage and signaling from acti

169 Variations in attrition may be explained by program director attitudes

170 Telomere attrition may play an important role in the pathogenesis

171 20% reduction in the annual rate of telomere attrition measured at 24 months.

172 correct for nonresponse bias under different attrition mechanisms, including weighting adjustments, m

173 Selection due to survival or attrition might bias estimates of racial disparities in

174 Dried pulps were milled into flour with attrition milling machine (0.5mm sieve size).

175 l senescence, DNA damage (including telomere attrition), mitochondrial dysfunction, a pro-inflammator

176 uce clinician-rated superior improvement and attrition more frequently than does CBT.

177 ellular aging, with the majority of lifetime attrition occurring during the first 4 y.

178 ment on the HAM-D only (odds ratio=1.67) and attrition (odds ratio=1.67) were more frequent in pharma

179 ccelerates malignancies and causes the rapid attrition of blood stem cells(5-7).

180 increased age, Wnt5a loss caused progressive attrition of dendrite arbors and spines in Cornu Ammonis

181 n systemic sclerosis (SSc) is accompanied by attrition of dermal white adipose tissue (dWAT) and redu

182 attenuated CAR T cell expansion and/or rapid attrition of functional CAR effector cells following ado

183 RWHAP-funded facilities may face attrition of highly qualified providers.

184 to these technologies result in an extensive attrition of hits during validation experiments.

185 There was also rapid attrition of Irf6-cKO molars following eruption.

186 is, VSVmIFNbeta infection is associated with attrition of murine EGFRvIII CAR T cells in a B16EGFRvII

187 The attrition of neural progenitor cells involves p53-depend

188 We found substantial attrition of new mothers: 43% of women leave full-time S

189 The attrition of novel analgesic drugs in the clinic can be

190 librium measures of block can result in high attrition of potentially low-risk drugs.

191 Attrition of residents from general surgery training pro

192 GCK-IV kinase inhibition also prevented the attrition of RGCs in developing retinal organoid culture

193 Important limitations of the study include attrition of sample from birth to assessment age and mis

194 s exclusion and discrimination that leads to attrition of scientists.

195 iological cell senescence and ageing, due to attrition of telomeric repeats and insufficient retentio

196 -CRB2TM interaction promotes the progressive attrition of the dVL without loss of overall VL integrit

197 Attrition of the immune system is associated with an inc

198 ges of postdoctoral training to prevent this attrition of underrepresented groups.

199 blasts, documenting the anticipated telomere attrition on a global telomere-by-telomere basis as well

200 .41-3.26), and a 23% decrease in the odds of attrition (OR, 0.77; 95% CI, .63-.95).

201 ticipate which residents are most at risk of attrition out.

202 s the effects of repeated burden on telomere attrition over 5 years.

203 nger telomere length or less telomere length attrition over time.

204 , and 36 months (49%/39%) showed significant attrition (P < .0001) over time.

205 t predicts sex- and age-adjusted LTL and LTL attrition (P = 0.0009 and 0.0156, respectively).

206 l treated patients were 2.63 deaths and 5.32 attritions per 100 person-years, respectively.

207 d Experience questionnaire, greater telomere attrition predicted higher externalizing problems, even

208 On the one hand, it significantly increases attrition, predicting more than a 10% chance of disappea

209 Greater overall telomere attrition predicts mortality and aging-related diseases

210 nger duration of disease, increased telomere attrition, presence of adverse prognostic mutations, and

211 The pooled estimate for the overall attrition prevalence among general surgery residents was

212 To summarize the estimate of attrition prevalence among general surgery residents.

213 Main Outcome and Measure: Attrition prevalence of general surgery residents.

214 cluded all studies reporting on the primary (attrition prevalence) or secondary (causes of attrition

215 Due to attrition, primary outcome analyses were of 550 patients

216 ering an appealing opportunity to reduce the attrition problem in drug discovery.

217 very, improved general health, and abolished attrition produced by a near maximum-tolerated dose of P

218 e more likely than their counterparts at low-attrition programs to agree with this statement: "I feel

219 ttrition programs were more likely than high-attrition programs to use resident remediation (21.0% vs

220 High- and low-attrition programs were compared.

221 Low-attrition programs were more likely than high-attrition

222 Program directors at high-attrition programs were more likely than their counterpa

223 Program directors at low-attrition programs were more likely to use resident reme

224 ptimization and screening programmes towards attrition-prone chemical matter.

225 CI: 0.40-0.79), but significantly higher ART attrition rate (AHR: 1.17, 95% CI: 1.03-1.33).

226 iated inflammation could modify the telomere attrition rate after a 5-y follow-up of a Mediterranean

227 ly life exposures, or the increased telomere attrition rate during infancy.

228 as six times greater than the typical annual attrition rate identified in a recent meta-analysis.

229 should not be surgeons." The overall 5-year attrition rate of 8.8% was significantly lower than prev

230 The attrition rate of functioning allografts beyond the firs

231 Each program had an annual attrition rate ranging from 0.73% to 6.0% (median [IQR],

232 The attrition rate was 13.7% and was balanced across the 2 g

233 The overall mortality rate and attrition rate was 2.85 (95% CI: 2.55-3.16) and 8.87 (95

234 o 12 weekly sessions of PATH or ST-CI (14.8% attrition rate).

235 cial to overcome the high expenditure, large attrition rate, and to reduce the trial-and-error settin

236 was brief, safe, and inexpensive, with a low attrition rate, it was not effective for reducing pain-r

237 tion and to measure the categorical resident attrition rate.

238 ng and costly experimental steps, has a high attrition rate.

239 Five-year attrition rates (2010-2011 to 2014-2015 academic years)

240 High attrition rates (30%-45% in all trials) were associated

241 The average mortality and ART attrition rates among all treated patients were 2.63 dea

242 Drug development is expensive, attrition rates are high, and efficacy rates are lower t

243 ch is also of concern in England where staff attrition rates are significantly higher than in physica

244 te direct treatment effects on mortality and attrition rates between first-line antiretroviral therap

245 application, matriculation, graduation, and attrition rates for general surgery residency exists for

246 netic prediction models have helped to shift attrition rates in early clinical trials from poor expos

247 nts, poor initial hit compounds and the high attrition rates in the (pre-)clinical phases.

248 pound development and address the increasing attrition rates of lead compounds within the pharmaceuti

249 Moreover, short follow-up periods and high attrition rates often impede translation of study result

250 monocultures of human hepatocytes, with high attrition rates remain major challenges.

251 Attrition rates were similar for lithium and divalproex

252 tcomes included eligibility, recruitment and attrition rates, and fidelity of the model.

253 als are hampered by small sample sizes, high attrition rates, and heterogeneity of concurrent interve

254 Given the high attrition rates, substantial costs and slow pace of new

255 ever, were not associated with different LTL attrition rates.

256 nurses' competency, level of confidence and attrition rates; others reported no impact.

257 Whether telomere attrition reducing proliferative reserve in blood-cell p

258 Additionally, attrition remained stable or decreased across both measu

259 t which has undergone significant mutational attrition rendering it without predicted function.

260 iscrepancies in the prevalence and causes of attrition reported among surgical residents in previous

261 nt associated with a lower risk of death and attrition, respectively.

262 is of T cells and prevented the early T cell attrition resulting from lymphocytic choriomeningitis vi

263 s revealed that TPMs do not prevent telomere attrition, resulting in cells with critically short and

264 ion, is introduced to quantify the degree of attrition (secondary fragmentation) from grain size data

265 -day PrEP has the potential to alleviate the attrition seen in usual care between initial evaluation

266 ) did not accelerate the rate of islet graft attrition, suggesting resistance to humoral rejection.

267 gitudinal models accounting for differential attrition, survival, and time-varying confounding, with

268 maintain consecutive openings and stochastic attrition terminates the release; 2) if the number of Ry

269 ent TB recurrence are considerable points of attrition that may contribute to ongoing TB transmission

270 The high rates of attrition that occur in drug development are widely rega

271 leukocyte TL (LTL) at birth or a faster LTL attrition thereafter.

272 ncreased DNA damage, which causes progenitor attrition through apoptosis.

273 ff morale, burden and the cyclical nature of attrition to ensure the delivery of high quality, safe a

274 ross all 9 countries, 6- and 12-month cohort attrition was 21% and 29%, respectively, with no decreas

275 This attrition was absent in age-matched mutation carriers wh

276 Attrition was associated significantly with country of b

277 Attrition was low with 55 children lost to follow up (3.

278 The difference in LTL attrition was not associated with age during adulthood s

279 Increased 12-month attrition was observed in semiurban facilities and those

280 the study was halted early, because telomere attrition was reduced in all 12 patients who could be ev

281 low and unchanged, respectively, whereas the attrition was significantly higher (3.6%, P = 0.049) whe

282 Attrition was significantly higher among female compared

283 To examine reverse causality and selective attrition, we compared rate ratios from inverse probabil

284 he link between prey availability and dental attrition, we documented dental fracture rates over deca

285 To characterize potential bias from attrition, we evaluated differences in associations betw

286 Despite racial differences in mortality and attrition, we found little evidence of selection bias in

287 cal to estimates from inverse probability of attrition weighting and survivor average causal effect.

288 mplete-case analyses, inverse probability of attrition weighting, and the survivor average causal eff

289 plement, demographic information, and annual attrition were collected from the program directors for

290 ant relationships between chronic burden and attrition were evident for those at moderate and higher

291 The most common reported causes of attrition were uncontrollable lifestyle (range, 12%-87.5

292 familiar males and also showed less telomere attrition when living next to male kin.

293 Males also had more rapid telomere attrition when living next to unfamiliar male neighbors,

294 larger samples to compensate for significant attrition when using online CBT.

295 o incomplete telomere extension and telomere attrition, which are hallmarks of these diseases.

296 eneral surgery programs have relatively high attrition, with female residents more likely to leave th

297 pendently associated with greater 3-year LTL attrition, with no association found for Epstein-Barr vi

298 Attrition within the CD4(+)T cell compartment, high vire

299 did initiate ART within 90 d, the hazard of attrition within the first 10 mo did not differ between

300 memory T cells (TRM) undergo unusually rapid attrition within the lung.