ライフサイエンスコーパス: auditory nerve

1 formation to the brain via synapses with the auditory nerve.

2 neration of the spiral ganglion cells of the auditory nerve.

3 which forms the spike initiation site of the auditory nerve.

4 us neurotrophins prevent degeneration of the auditory nerve.

5 -deaf people to electrically stimulate their auditory nerve.

6 it may contribute to spike adaptation at the auditory nerve.

7 ceive sounds by electrically stimulating the auditory nerve.

8 responses with a sophisticated model of the auditory nerve.

9 n, a procedure that requires survival of the auditory nerve.

10 diameter and neurofilament regulation in the auditory nerve.

11 precise stimulus-driven spike timing in the auditory nerve.

12 cess most likely underlies adaptation in the auditory nerve.

13 ng and chronic electrical stimulation of the auditory nerve.

14 annel's ability to effectively stimulate the auditory nerve.

15 unction of terminal unmyelinated portions of auditory nerve.

16 ost always higher than those observed in the auditory nerve.

17 and processes first-order afferents from the auditory nerve.

18 e and sets the stage for cell replacement of auditory nerve.

19 enting the main source for adaptation in the auditory nerve.

20 ere it is localized to ganglion cells in the auditory nerve.

21 vities <1.2 kHz was enhanced relative to the auditory nerve.

22 bnormal synaptic structure in endings of the auditory nerve.

23 lely on the relative timing of spikes in the auditory nerve.

24 e development of spontaneous activity in the auditory nerve.

25 om the outer ear, through the cochlea to the auditory nerve.

26 bon synapse and spike rate adaptation in the auditory nerve.

27 cking precision compared with input from the auditory nerve.

28 anscranial electric stimulation reaching the auditory nerve, a deep intercranial target located in th

29 e abnormalities persist after restoration of auditory nerve activity by a cochlear implant, the proce

30 This had the benefit that BCs relayed auditory nerve activity even when synapses showed signif

31 ent of a neuronal correlate of tinnitus when auditory nerve activity is reduced due to the earplug.

32 Examination of the sural nerve and the auditory nerve adjacent to the brainstem showed marked l

33 x in adult mice with a near-complete loss of auditory nerve afferent synapses in the contralateral ea

34 cochlear nucleus (VCN) is from glutamatergic auditory nerve afferents, but the VCN is also innervated

35 tory synapses formed by two distinct inputs, auditory nerve (AN) and parallel fibers (PF), on differe

36 ceives direct tonotopic projections from the auditory nerve (AN) as well as secondary and descending

37 ed this in the mouse cochlear nucleus, where auditory nerve (AN) fibers contact bushy cells (BCs) at

38 onstructed in 3D the trajectories of labeled auditory nerve (AN) fibers following multiunit recording

39 e of sound levels over which firing rates of auditory nerve (AN) fibers grows rapidly with level shif

40 Here, we compared peripheral-processing in auditory nerve (AN) fibers of male chinchillas between t

41 convergent inputs from high-spontaneous rate auditory nerve (AN) fibers, with no special currents and

42 fect neurotransmitter release by presynaptic auditory nerve (AN) fibers.

43 also induce changes in myelin sheaths of the auditory nerve (AN) is an important issue particularly b

44 nological model of the inner hair cell (IHC)-auditory nerve (AN) synapse successfully explained neura

45 Loss of auditory-nerve (AN) afferent cochlear innervation is a p

46 aused by SNHL.SIGNIFICANCE STATEMENT Loss of auditory-nerve (AN) cochlear innervation is a common pro

47 It abbreviated signaling between IHC and the auditory nerve and also balanced differences in decay ki

48 ate in auditory cortex despite nearly absent auditory nerve and brainstem responses, suggesting an im

49 auditory brainstem implants that bypass the auditory nerve and directly stimulate auditory processin

50 putatively reflecting decreased inputs from auditory nerve and increased inputs from nonauditory str

51 ributed to a return of spike activity in the auditory nerve and may help explain cochlear implant ben

52 onotopic axis, has been characterized in the auditory nerve and primary auditory cortex, but little i

53 ribbons, followed by reduced activity of the auditory nerve and reduced centrally generated wave II a

54 of anemia disrupts normal development of the auditory nerve and results in altered conduction velocit

55 d VGLUT2, are differentially associated with auditory nerve and somatosensory inputs to the CN, respe

56 t occurs in the cochlear nucleus (CN), where auditory nerve and somatosensory pathways converge.

57 They were activated by auditory nerve and T-stellate cells, and made local inhi

58 lcium-binding proteins were expressed in the auditory nerve, and CR immunoreactivity labeled the firs

59 potential initiation and propagation in the auditory nerve, and suggest that modulation of these cha

60 atch response properties of the cochlea, the auditory nerve, and the auditory cortex.

61 ons based on neural population responses for auditory nerve (ANF) input and SBC output to assess the

62 otion of mammalian cochlear function is that auditory nerves are tuned to respond best to different s

63 cochlear turns and a reduced activity of the auditory nerve (auditory brainstem response wave I).

64 gan of Corti initiate electrical activity in auditory nerves before hearing, pointing to an essential

65 ntitative differences between trigeminal and auditory nerve boutons in terms of their localization on

66 coustic emissions, summating potentials) and auditory nerve/brainstem activity (auditory brainstem re

67 constrained by temporal phase locking in the auditory nerve but may instead stem from higher-level co

68 ar implants deliver electrical pulses to the auditory nerve by relying on sophisticated signal proces

69 ending mammalian auditory pathway beyond the auditory nerve can be predicted based on coding principl

70 Sound-evoked spikes in the auditory nerve can phase-lock with submillisecond precis

71 Production of neurospheres from auditory nerve cells was stimulated by acute neuronal in

72 pamine agonist that reduces the sound evoked auditory nerve compound action potential and/or Memantin

73 suprathreshold amplitude of the sound-evoked auditory nerve compound action potential.

74 Solution effects on inner hair cells reduced auditory nerve compound action potentials (CAPs) and pro

75 ed low amplitude negative potentials without auditory nerve compound action potentials.

76 urosphere formation assays showed that adult auditory nerves contain neural stem/progenitor cells (NS

77 eriod surrounding either moderate or massive auditory nerve damage.

78 ostsynaptic disorders affecting unmyelinated auditory nerve dendrites; (iii) postsynaptic disorders a

79 n is a standard clinical tool for diagnosing auditory nerve disorders due to acoustic neuromas.

80 it possible to distinguish both synaptic and auditory nerve disorders from sensory receptor loss.

81 Subjects with auditory nerve disorders had normal loudness adaptation

82 greater magnitude in ribbon synapse than in auditory nerve disorders.

83 tween the cochlea's inner hair cells and the auditory nerve, effectively severing part of the connect

84 ode of auditory prosthesis using penetrating auditory-nerve electrodes that permit frequency-specific

85 em, from pulse trains presented with various auditory-nerve electrodes to phase-locked activity of ne

86 ether structural and molecular substrates at auditory nerve (endbulb of Held) synapses in the cochlea

87 The large endings of the auditory nerve, endbulbs of Held, were studied because t

88 lobular bushy cells of the AVCN receive huge auditory nerve endings specialized for high fidelity neu

89 eafness results in synaptic abnormalities in auditory nerve endings.

90 Auditory nerve excitation and thus hearing depend on spi

91 n T-stellate cells could enhance the gain of auditory nerve excitation in proportion to the excitatio

92 te that a subset of glial cells in the adult auditory nerve exhibit several characteristics of NSPs a

93 antly inherited neuropathy of both optic and auditory nerves expressed by impaired visual acuity, mod

94 The inner hair cell (IHC)/auditory nerve fiber (ANF) synapse is the first synapse

95 ng approximations of the three categories of auditory nerve fiber in these simple models can substant

96 t the characteristic frequency (CF) of their auditory nerve fiber inputs.

97 encoding of spectral peaks relative to their auditory nerve fiber inputs.

98 Single-unit auditory nerve fiber recordings were obtained from 41 Mo

99 explain many observations made from in vivo auditory nerve fiber recordings.

100 ells, which cannot be restored by increasing auditory nerve fiber recruitment.

101 hermore, comparison between SFOAE delays and auditory nerve fiber responses for the barn owl strength

102 ation (Wiener kernel) analyses of chinchilla auditory nerve fiber responses to Gaussian noise to reve

103 innovative system-identification analyses of auditory nerve fiber responses to Gaussian noise to unco

104 s of presynaptic Ca(2+) channels and smaller auditory nerve fiber terminals contacting cochlear nucle

105 s from mammalian inner hair cells (IHCs) and auditory nerve fiber terminals that typically receive in

106 echanical gains are excellent surrogates for auditory nerve fiber thresholds at the base of the cochl

107 Here we report that several basic auditory nerve fiber tuning properties can be accounted

108 acteristics of each primary afferent (type I auditory-nerve fiber; ANF) are mainly determined by a si

109 Phase locking of auditory-nerve-fiber (ANF) responses to the fine structu

110 Phase locking of auditory-nerve-fiber (ANF) responses to the temporal fin

111 muli.SIGNIFICANCE STATEMENT Phase locking of auditory-nerve-fiber responses to the temporal fine stru

112 ANFs.SIGNIFICANCE STATEMENT Phase locking of auditory-nerve-fiber responses to the temporal fine stru

113 Auditory nerve fibers (ANFs) exhibit a range of spontane

114 ule cell domains (GCD) of CN, whereas type I auditory nerve fibers (ANFs) project to the magnocellula

115 nnels and their placement along the axons of auditory nerve fibers (ANFs).

116 ectrophonic responses) from responses of the auditory nerve fibers (electroneural responses), with se

117 se more centrally, possibly due to a loss of auditory nerve fibers (or their peripheral synapses) but

118 xtract different features from the firing of auditory nerve fibers and convey that information along

119 NA and NM receive input from bifurcating auditory nerve fibers and initiate processing pathways s

120 in synaptic transmission in synapses between auditory nerve fibers and spherical bushy cells (BCs) in

121 tense noise can destroy the synapses between auditory nerve fibers and their hair cell targets withou

122 ing in SGN, assessed by recordings of single auditory nerve fibers and their population responses in

123 term depression (LTD), whereas those between auditory nerve fibers and their targets do not.

124 octopus cells detect coincident firing among auditory nerve fibers and transmit signals along monaura

125 zation in the cochlea and hypomyelination of auditory nerve fibers as predominant neuropathological s

126 or initiating bursts of action potentials in auditory nerve fibers before the onset of hearing.

127 sholds, but normal frequency tuning, of aged auditory nerve fibers can be explained by the well known

128 These results suggest that auditory nerve fibers encode a broad set of natural soun

129 Auditory nerve fibers encode sounds in the precise timin

130 Auditory nerve fibers exhibited a recovery of normal syn

131 Auditory nerve fibers from mutants had normal threshold,

132 n by maintaining the functional integrity of auditory nerve fibers in early life rather than at old a

133 racterized the response properties of single auditory nerve fibers in mice lacking Bassoon, a scaffol

134 Terminals of auditory nerve fibers in the multipolar cell area includ

135 ically by recording spike times from chicken auditory nerve fibers in vivo while stimulating with rep

136 Auditory nerve fibers innervate narrow, topographically

137 A reduction in the number of myelinated auditory nerve fibers leads to a reduced maximal firing

138 ontaneous activity, we hypothesized that the auditory nerve fibers might initially form topographical

139 owed that temporal coding was not altered in auditory nerve fibers of aging gerbils.

140 are not apparent in responses of single-unit auditory nerve fibers of quiet-aged gerbils.

141 endbulb of Held synapse, which is formed by auditory nerve fibers onto bushy cells (BCs) in the ante

142 ndbulb of Held synapses, which are formed by auditory nerve fibers onto bushy cells in the cochlear n

143 Auditory nerve fibers reflect this tonotopy and encode t

144 Activity of auditory nerve fibers reflects this frequency-specific t

145 spiral ganglion, to study the projections of auditory nerve fibers representing a narrow band of freq

146 In the CN, espin-positive auditory nerve fibers showed a projection pattern typica

147 This wave evokes firing in auditory nerve fibers that are tuned to high frequencies

148 rites of fusiform cells in the deep layer by auditory nerve fibers through synapses that do not show

149 cochlea, release glutamate onto the afferent auditory nerve fibers to encode sound stimulation.

150 ceive their primary excitatory input through auditory nerve fibers via large, axosomatic synaptic ter

151 ure tone thresholds, the frequency tuning of auditory nerve fibers was not affected.

152 A model combining damage to high-threshold auditory nerve fibers with increased response gain of ce

153 can cause a selective loss of high-threshold auditory nerve fibers without affecting absolute sensiti

154 f the wave I potential (generated by primary auditory nerve fibers) but normal amplitudes of the more

155 In whole-cell recordings from targets of auditory nerve fibers, octopus and T stellate cells, min

156 ular to the tonotopically organized array of auditory nerve fibers, placing the earliest arriving inp

157 ssibly due to a reduced population of active auditory nerve fibers, which will be of importance for t

158 very similar to that reported for individual auditory nerve fibers.

159 t noise exposure, is associated with loss of auditory nerve fibers.

160 e and timing of the postsynaptic response in auditory nerve fibers.

161 a their ribbon synapses into firing rates in auditory nerve fibers.

162 may underlie fundamental characteristics of auditory nerve fibers.

163 cells is converted into a firing pattern in auditory nerve fibers.

164 ing of midbrain neurons approximated that of auditory nerve fibers.

165 tative changes in the responses of remaining auditory nerve fibers.

166 into release of glutamate onto postsynaptic auditory nerve fibers.

167 d, reliable, and precise spike generation in auditory nerve fibers.

168 connections between cochlear hair cells and auditory nerve fibers; however, there is no clinical tes

169 illa cochlea were inferred from responses of auditory-nerve fibers (ANFs) to threshold- and moderate-

170 shape changes of threshold tuning curves of auditory-nerve fibers along the cochlea.

171 The responses to sound of auditory-nerve fibers are well known in many animals but

172 ear implants cannot activate selectively the auditory-nerve fibers having low characteristic frequenc

173 otential tuning curves against the tuning of auditory-nerve fibers in experimental animals and use co

174 Some investigators have claimed that the auditory-nerve fibers of humans are more sharply tuned t

175 from existing records of cat and chinchilla auditory-nerve fibers on the basis of their characterist

176 e brainstem back to the outer hair cells and auditory-nerve fibers, respectively.

177 etect the coincident activation of groups of auditory nerve fibres by broadband transient sounds, com

178 es the frequency response of the innervating auditory nerve fibres However, the data supporting these

179 ry ganglion cells and central and peripheral auditory nerve fibres within the cochlea.

180 ency-bandwidth dependence similar to that of auditory nerve fibres, and yield significantly greater c

181 a gives rise to V-shaped tuning functions in auditory nerve fibres, but by the level of the inferior

182 emperature-sensitive auditory neuropathy) or auditory nerve fibres.

183 kely to induce neurotransmitter release onto auditory nerve fibres.

184 r, the mechanisms responsible for initiating auditory nerve firing in the absence of sound have not b

185 abnormally high levels during high rates of auditory nerve firing, or that calcium-dependent process

186 noninvasive electrophysiological measure of auditory nerve function and has been validated in the an

187 ts in the ongoing timing of responses in the auditory nerve, generally but not always resulting in sh

188 As sound-evoked responses from the auditory nerve grew progressively weaker following dener

189 electrode array that directly stimulates the auditory nerve, has greatly benefited many individuals w

190 with animal models, computational modeling, auditory nerve imaging, and human temporal bone histolog

191 e examined the regenerative potential of the auditory nerve in a mouse model of auditory neuropathy.

192 ansmit phase-locked action potentials of the auditory nerve in a pathway that contributes to sound lo

193 Synapses of the contralateral auditory nerve in early implanted cats also exhibited sy

194 de from neurophysiological recordings of the auditory nerve in response to pure-tone stimuli played f

195 mass potentials recorded on the cochlea and auditory nerve in the cat.

196 receptors while unilaterally stimulating the auditory nerve in vitro.

197 can be bypassed by directly stimulating the auditory nerve; in agreement with the stereausis hypothe

198 pathy were probably related to a decrease of auditory nerve input accompanying axonal disease.

199 ns in the central auditory system to reduced auditory nerve input in the absence of elevated hearing

200 Deprivation of auditory nerve input in young mice results in dramatic n

201 The dorsal cochlear nucleus (DCN) integrates auditory nerve input with a diverse array of sensory and

202 CN) where principal cells integrate primary, auditory nerve input with modulatory, parallel fiber inp

203 ider range of intensities than many of their auditory nerve inputs (Blackburn and Sachs, 1990; May et

204 in the parallel fiber inputs, but not in the auditory nerve inputs innervating the same DCN principal

205 n of intensity selectivity from nonselective auditory nerve inputs remain largely unclear.

206 r ultrastructural characteristics of primary auditory nerve inputs were similar across the rostral an

207 gnocellular ventral CN (VCN), which receives auditory nerve inputs.

208 al and thus lowers the response threshold to auditory nerve inputs.

209 ve phase-locking precision relative to their auditory nerve inputs.

210 l tonotopically based representations in the auditory nerve, into perceptually distinct auditory-obje

211 It has been believed that loss of the auditory nerve is irreversible in the adult mammalian ea

212 ange adaptation observed at the level of the auditory nerve is located peripheral to the spike genera

213 Damage to the auditory nerve is postulated to trigger compensatory lon

214 The auditory nerve is the primary conveyor of hearing inform

215 of the current investigation was to generate auditory nerve-like glutamatergic neurons from ES cells.

216 brainstem response wave-V in noise reflects auditory nerve loss.

217 (pancreatic beta-cell, hematopoietic cells, auditory nerve) maintained normal function but pachytene

218 Deaf patients without an intact auditory nerve may be helped by the next generation of a

219 Comparisons with data from auditory nerve, midbrain, thalamus and cortex reveals th

220 eural coding, predicted from a computational auditory nerve model, with perception of vocoded speech

221 A phenomenological auditory-nerve model was used to verify that the interau

222 otentials." Ribbon synapses between IHCs and auditory nerve neurons are responsible for converting re

223 itory system is very immature at birth, with auditory nerve neurons initially exhibiting very low or

224 and after deafferentation of the excitatory auditory nerve (nVIII) inputs.

225 ificity of the primary afferent axons of the auditory nerve occurs in late gestation or early postnat

226 of the spiral ganglion neurons (SGNs) of the auditory nerve occurs with age and in response to acoust

227 wave, we recorded from single fibers in the auditory nerve of anesthetized cat in response to harmon

228 ith disruption of the first heminodes at the auditory nerve peripheral terminal.

229 ing deficits may develop more central to the auditory nerve, possibly due to a reduced population of

230 NF application induced significant growth of auditory nerve presynaptic boutons that convey the condi

231 postnatal maturation of the primary afferent auditory nerve projections from the cat cochlear spiral

232 re therefore potential targets for promoting auditory nerve regeneration.

233 Toward the eventual goal of auditory nerve replacement, the aim of the current inves

234 nd 85% from injections of the trigeminal and auditory nerves, respectively) were apposed to somata or

235 y, NO-GC stimulation exacerbated the loss of auditory nerve response in aged animals but attenuated t

236 luated the effects of contralateral noise on auditory nerve responses as a measure of the individual

237 s to pairs of stimuli, based on single-fiber auditory nerve responses at 70 and 50 dB sound pressure

238 rm treatment with a NO-GC stimulator altered auditory nerve responses but did not affect OHC function

239 e examined the trial-to-trial variability of auditory nerve responses during short-term rate-adaptati

240 shift in BF that characterizes maturation of auditory nerve responses during the same period.

241 s will enable multicompartmental modeling of auditory nerve responses elicited by afferent chemical n

242 Tympanal vibrations and auditory nerve responses reveal that localization errors

243 Yet inner hair cell (IHC) ribbons and auditory nerve responses showed significantly less deter

244 The characteristics of auditory nerve responses to sound have been described ex

245 easurements of basilar membrane velocity and auditory nerve responses to sound, has demonstrated sign

246 normal media, unilateral stimulation of the auditory nerve resulted in darker Y10B immunolabeling of

247 s on the temperature dependence of spikes in auditory nerves.SIGNIFICANCE STATEMENT The vertebrate in

248 sly published basilar membrane vibration and auditory nerve single unit data.

249 We report the developmental profile of the auditory nerve spike generator with a focus on NaV1.1, N

250 n thought to rely on precise stimulus-driven auditory-nerve spike timing (time code), whereas a coars

251 on from the turtle by pairing trigeminal and auditory nerve stimulation.

252 macaques using a stimulus design employed in auditory nerve studies of pitch encoding.

253 he influence of neurotrophin gene therapy on auditory nerve survival and peripheral sprouting in Pou4

254 ynaptic components at the level of the first auditory nerve synapse in the auditory brainstem.

255 o constant, nondamaging noise and found that auditory nerve synapses changed to facilitating, reflect

256 port describes the morphologic plasticity of auditory nerve synapses in response to ototoxic deafenin

257 High reliability at specialized auditory nerve synapses in the cochlear nucleus results

258 lopment of synaptic function was examined at auditory nerve synapses in the rostromedial region of th

259 In accordance, auditory nerve synapses in the VCN are functional at E15

260 However, receptors at auditory nerve synapses on cells that also receive paral

261 To address this issue, we studied auditory nerve synapses onto bushy cells in the cochlear

262 We examined the effects of CHL at auditory nerve synapses onto bushy cells in the mouse an

263 Both juvenile and mature auditory nerve synapses onto bushy cells modify short-te

264 Thus, auditory nerve synapses regulate excitability through an

265 However, high Pr also causes auditory nerve synapses to depress strongly when activat

266 reflect a homeostatic, adaptive response of auditory nerve synapses to reduced activity.

267 This is particularly important at auditory nerve synapses, where the presence and timing o

268 MPA receptor by increasing GluR4 subunits in auditory nerve synapses.

269 only transient threshold shifts can destroy auditory-nerve synapses without damaging hair cells.

270 from noise-induced loss of Inner Hair Cell - Auditory Nerve synaptic connections.

271 ns associated with loss of Inner Hair Cell - Auditory Nerve synaptic connections.

272 The results show that trigeminal and auditory nerve terminal fields occupy primarily the soma

273 Thus, elimination of auditory nerve terminals and pruning of axonal branches

274 c auditory nerve terminals, although rostral auditory nerve terminals contained a greater concentrati

275 ansmission at the end-bulb synapse formed by auditory nerve terminals onto the soma of neurons in the

276 The percentage of primary auditory nerve terminals was larger in caudal AVCN, wher

277 volume fraction were similar for axosomatic auditory nerve terminals, although rostral auditory nerv

278 ormal positions at the basolateral pole, and auditory-nerve terminals extend towards the hair cell's

279 eak conditioned stimulus (CS) applied to the auditory nerve that immediately precedes an unconditione

280 In auditory nerve, this form of adaptation is likely mediat

281 timing information from neural spikes in the auditory nerve (time code) and the spatial distribution

282 riven spike timing, or phase locking, in the auditory nerve (time code), and the spatial distribution

283 amine the timing of action potentials in cat auditory nerve to broadband noise presented at different

284 rease in adaptation to sound statistics from auditory nerve to midbrain to cortex is an important sta

285 ea activated proximal myelinated portions of auditory nerve to restore hearing.

286 d biophysical simulations of the cochlea and auditory nerve to simple spectrogram-like approximations

287 tion potential that is transmitted along the auditory nerve to the cochlear nucleus in the brainstem

288 Axons are extended from the bundle of auditory nerve toward some of the new hair cells, sugges

289 echanical tuning was broad and did not match auditory nerve tuning characteristics.

290 sounds through electrical stimulation of the auditory nerve using a cochlear implant (CI).

291 i in a three-neuron activation loop from the auditory nerve via an intermediate neuron in the cochlea

292 Auditory nerves were similarly small but increased in fi

293 refining precise timing information from the auditory nerve, whereas SCs discard precise timing infor

294 h reduces fidelity at central targets of the auditory nerve, which could affect perception.

295 s an intrinsic regulation of output from the auditory nerve, which could be targeted for therapeutic

296 mally ~1% of the transcranial current to the auditory nerve, which was sufficient to produce sound se

297 e findings demonstrate that treatment of the auditory nerve with neurotrophic factors may be relevant

298 (tINs) in the hindbrain, at the level of the auditory nerve, with long, ipsilateral, descending axons

299 cer molecules were delivered into the locust auditory nerve without destroying its function, simultan

300 responding to different vowel sounds akin to auditory nerves, without amplifying the amplitude of the