ライフサイエンスコーパス: autism spectrum

1 tial component of care for all people on the autism spectrum and should be integrated into clinical p

2 Past research has linked autism spectrum (AS) traits to person perception deficit

3 y expressed in the brain and associated with autism spectrum (ASD) and attention deficit hyperactivit

4 xplain (1) evidence regarding a key role for autism spectrum cognition in human technology; (2) trade

5 with four major neuropsychiatric disorders: autism spectrum condition (ASC), bipolar disorder (BD),

6 development and behavior in 96 children with autism spectrum disorder (ASD) [45 with neurodevelopment

7 Autism spectrum disorder (ASD) affects 1 in 59 children,

8 Autism spectrum disorder (ASD) affects an estimated 1.85

9 lied to neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyp

10 s investigated neuroradiological findings in autism spectrum disorder (ASD) and attention-deficit hyp

11 isorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Pr

12 nal week 10-as a key point of convergence in autism spectrum disorder (ASD) and epilepsy.

13 nitial link between DIP2A gene variations in autism spectrum disorder (ASD) and highlight the contrib

14 We ascertained autism spectrum disorder (ASD) and intellectual disabili

15 AP1 have been identified in individuals with autism spectrum disorder (ASD) and intellectual disabili

16 eral neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disabili

17 been noted consistently in individuals with autism spectrum disorder (ASD) and their families, inclu

18 genomes from 1,902 individuals affected with autism spectrum disorder (ASD) and their unaffected sibl

19 riched for genes implicated in non-syndromic autism spectrum disorder (ASD) and were differentially e

20 quences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit

21 The second spectrum manifested with autism spectrum disorder (ASD) and/or ID and epilepsy.

22 Sleep patterns in children with autism spectrum disorder (ASD) appear to diverge from ty

23 Several genes implicated in autism spectrum disorder (ASD) are chromatin regulators,

24 al motion (BM) and its putative anomalies in autism spectrum disorder (ASD) are not completely clarif

25 s of sociality in individuals diagnosed with autism spectrum disorder (ASD) are standardly explained

26 f the brain have been previously reported in autism spectrum disorder (ASD) but these alterations are

27 studying a missense variant in a well-known autism spectrum disorder (ASD) causing gene SHANK3.

28 n in neural suppression in young adults with autism spectrum disorder (ASD) compared to neurotypical

29 Individuals with an autism spectrum disorder (ASD) diagnosis are often descr

30 Autism spectrum disorder (ASD) does not have a distinct

31 Autism spectrum disorder (ASD) encompasses wide-ranging

32 ASD.SIGNIFICANCE STATEMENT Individuals with autism spectrum disorder (ASD) exhibit atypical attentio

33 mic studies have led to striking advances in autism spectrum disorder (ASD) genetics.

34 e hypothesized link between gut bacteria and autism spectrum disorder (ASD) has been explored through

35 Autism spectrum disorder (ASD) has been hypothesized to

36 Autism spectrum disorder (ASD) has been mostly associate

37 Autism spectrum disorder (ASD) has captured the attentio

38 Heterogeneity in autism spectrum disorder (ASD) has hindered the developm

39 range of dysregulation of gene expression in autism spectrum disorder (ASD) have been reported, the r

40 xposure to asthma medications with offspring autism spectrum disorder (ASD) have been reported.

41 r ex vivo histological postmortem studies of autism spectrum disorder (ASD) have shown gray matter mi

42 ting has been hypothesized to play a role in autism spectrum disorder (ASD) in an attempt to explain

43 olate were associated with increased risk of autism spectrum disorder (ASD) in children.

44 ombined previously distinct subcategories of autism spectrum disorder (ASD) into a single diagnostic

45 Autism spectrum disorder (ASD) is a brain disorder chara

46 Autism Spectrum Disorder (ASD) is a common neurodevelopm

47 Autism spectrum disorder (ASD) is a complex disorder wit

48 Autism spectrum disorder (ASD) is a complex neurodevelop

49 Autism spectrum disorder (ASD) is a constellation of neu

50 Autism spectrum disorder (ASD) is a continuum of neurode

51 Autism spectrum disorder (ASD) is a highly heritable and

52 Autism spectrum disorder (ASD) is a largely heritable, m

53 Autism spectrum disorder (ASD) is a multifactorial neuro

54 Autism spectrum disorder (ASD) is a neurodevelopmental c

55 Autism spectrum disorder (ASD) is a neurodevelopmental d

56 Autism spectrum disorder (ASD) is a neurodevelopmental d

57 and treatment of ASD.SIGNIFICANCE STATEMENT Autism spectrum disorder (ASD) is a neurodevelopmental p

58 Autism spectrum disorder (ASD) is a phenotypically and g

59 Autism spectrum disorder (ASD) is associated with noise

60 Autism spectrum disorder (ASD) is behaviorally and biolo

61 Autism spectrum disorder (ASD) is characterized by dysfu

62 Autism Spectrum Disorder (ASD) is characterized by early

63 Autism spectrum disorder (ASD) is characterized by impai

64 Autism spectrum disorder (ASD) is characterized by neuro

65 Autism spectrum disorder (ASD) is characterized partly b

66 Autism spectrum disorder (ASD) is consistently diagnosed

67 Autism spectrum disorder (ASD) is genetically heterogene

68 Autism spectrum disorder (ASD) is highly familial, with

69 The genetic architecture of autism spectrum disorder (ASD) is itself a diverse allel

70 Autism spectrum disorder (ASD) is more prevalent in male

71 Autism spectrum disorder (ASD) is often grouped with oth

72 Autism Spectrum Disorder (ASD) is one of the most common

73 g technology to evaluate the degree to which autism spectrum disorder (ASD) is related to reduced res

74 The complex etiology of autism spectrum disorder (ASD) is still unresolved.

75 Autism spectrum disorder (ASD) is strongly associated wi

76 Autism Spectrum Disorder (ASD) is the most prevalent neu

77 Autism spectrum disorder (ASD) manifests as alterations

78 It has been estimated that autism spectrum disorder (ASD) now affects 1 in 59 child

79 nditions with etiological heterogeneity like Autism Spectrum Disorder (ASD) often pose a challenge fo

80 Children with autism spectrum disorder (ASD) or attention deficit hype

81 seen in minimally-verbal (MV) children with Autism Spectrum Disorder (ASD) relates to deficits in co

82 Some children with autism spectrum disorder (ASD) show behavioral improveme

83 aracterize their diagnoses, individuals with autism spectrum disorder (ASD) show enhanced performance

84 Applying this framework to 1,790 autism spectrum disorder (ASD) simplex families reveals

85 The association between macrocephaly and autism spectrum disorder (ASD) suggests that the mechani

86 ection neurons (CPNs), has been linked to an autism spectrum disorder (ASD) syndrome.

87 are core features in schizophrenia (SZ) and autism spectrum disorder (ASD) that have been linked to

88 The syndromic autism spectrum disorder (ASD) Timothy syndrome (TS) is

89 resent the largest exome sequencing study of autism spectrum disorder (ASD) to date (n = 35,584 total

90 All patients had autistic features, and autism spectrum disorder (ASD) was diagnosed in 5 of 11

91 esents particular challenges for youths with autism spectrum disorder (ASD) who often struggle to beh

92 tations in PTEN account for ~10% of cases of autism spectrum disorder (ASD) with coincident macroceph

93 The identification of an early biomarker for autism spectrum disorder (ASD) would improve the determi

94 omes of families containing individuals with autism spectrum disorder (ASD)(2,3) and population contr

95 ability, is the leading monogenetic cause of autism spectrum disorder (ASD), a neurodevelopmental con

96 ion in neuropsychiatric conditions including autism spectrum disorder (ASD), a neurodevelopmental syn

97 m birth (PTB), term low birth weight (TLBW), autism spectrum disorder (ASD), and asthma.

98 b are associated with X-linked macrocephaly, autism spectrum disorder (ASD), and intellectual disabil

99 key phenotypes in individuals diagnosed with autism spectrum disorder (ASD), and may potentially cont

100 ntion deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive

101 s frequently disrupted in male subjects with autism spectrum disorder (ASD), but the functional conse

102 Hundreds of genes are implicated in autism spectrum disorder (ASD), but the mechanisms throu

103 urrently known about sleep in the context of autism spectrum disorder (ASD), including ASD-related co

104 ifferent neuropsychiatric diseases including Autism Spectrum Disorder (ASD), intellectual disabilitie

105 oduplications of 16p11.2 are associated with autism spectrum disorder (ASD), intellectual disability

106 Despite rising prevalence of autism spectrum disorder (ASD), its brain bases remain u

107 he effects of oxytocin on social deficits in autism spectrum disorder (ASD), no large-scale study has

108 Autism spectrum disorder (ASD), obsessive-compulsive dis

109 SIB) is among the most dangerous concerns in autism spectrum disorder (ASD), often requiring detailed

110 d neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like featu

111 Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and

112 aling, are prone to developing macrocephaly, autism spectrum disorder (ASD), seizures and intellectua

113 al environmental risk factor contributing to autism spectrum disorder (ASD), which compromises fetal

114 rived neurons are increasingly used to model Autism Spectrum Disorder (ASD), which is clinically and

115 Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confe

116 Heredity has a major role in autism spectrum disorder (ASD), yet underlying causal ge

117 For a set of 13 autism spectrum disorder (ASD)-associated genes, we show

118 rotransmission system has been implicated in autism spectrum disorder (ASD).

119 he most powerful windows into the biology of autism spectrum disorder (ASD).

120 e Multisensory Integration (MSI) deficits in Autism Spectrum Disorder (ASD).

121 types have been observed in individuals with autism spectrum disorder (ASD).

122 fspring neurodevelopmental disorders such as autism spectrum disorder (ASD).

123 essions-is often altered in individuals with autism spectrum disorder (ASD).

124 ypothesized to contribute to the etiology of autism spectrum disorder (ASD).

125 in restricted, repetitive behaviors (RRB) in autism spectrum disorder (ASD).

126 on-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).

127 ic disorders such as schizophrenia (SCZ) and autism spectrum disorder (ASD).

128 cy may be associated with increased risk for autism spectrum disorder (ASD).

129 s among the most frequently mutated genes in autism spectrum disorder (ASD).

130 ted and studied social behaviors affected by autism spectrum disorder (ASD).

131 ked to neurodevelopmental disorders, such as autism spectrum disorder (ASD).

132 c scaffold protein, play a causative role in autism spectrum disorder (ASD).

133 netic and environmental factors relevant for autism spectrum disorder (ASD).

134 activity disorder (ADHD) and, more recently, Autism Spectrum Disorder (ASD).

135 egulated oxytocin signaling is implicated in autism spectrum disorder (ASD).

136 l disorders including epilepsy, dementia and Autism Spectrum Disorder (ASD).

137 yroid, and other cancers and, in one subset, autism spectrum disorder (ASD).

138 th and neurodevelopmental disorders, such as autism spectrum disorder (ASD).

139 ated with several brain disorders, including autism spectrum disorder (ASD).

140 sfunction have been repeatedly implicated in autism spectrum disorder (ASD).

141 on deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).

142 f the earliest observations in children with autism spectrum disorder (ASD).

143 heterogeneity underlies the neurobiology of autism spectrum disorder (ASD).

144 pathway has become a point of convergence in autism spectrum disorder (ASD).

145 on mutations revealed by exome sequencing in autism spectrum disorder (ASD).

146 ders, including schizophrenia, epilepsy, and autism spectrum disorder (ASD).

147 reported in children but not in adults with autism spectrum disorder (ASD).

148 ed, confer risk that is largely specific for autism spectrum disorder (ASD).

149 eages and associated with phenotypes such as autism spectrum disorder (ASD).

150 riants to identify 102 genes associated with autism spectrum disorder (ASD).

151 obustness of brain networks in children with autism spectrum disorder (ASD).

152 mechanism in many brain disorders including autism spectrum disorder (ASD).

153 renia (N = 696), bipolar disorder (N = 211), autism spectrum disorder (N = 126), or major depressive

154 sessions of videogame play in 39 youth with autism spectrum disorder and 23 age-matched youth with t

155 rts dimensional, nonbinary classification in autism spectrum disorder and ADHD.

156 unced for childhood-onset disorders, such as autism spectrum disorder and attention-deficit/hyperacti

157 Autism spectrum disorder and attention-deficit/hyperacti

158 from two related neuropsychiatric disorders-autism spectrum disorder and bipolar disorder-to show th

159 y gamma oscillations, was equivalent between autism spectrum disorder and control groups, but importa

160 nalysis of de novo variants in patients with autism spectrum disorder and intellectual disability or

161 re repeatedly identified as risk factors for autism spectrum disorder and intellectual disability, bu

162 enuated by missense variants associated with autism spectrum disorder and intellectual disability.

163 tent of brain tissue in Alzheimer's disease, autism spectrum disorder and multiple sclerosis is signi

164 mer's disease, familial Alzheimer's disease, autism spectrum disorder and multiple sclerosis.

165 r diverse developmental phenotypes including autism spectrum disorder and other neurodevelopmental di

166 he behavioural phenotypes, that characterize autism spectrum disorder and Phelan-McDermid syndrome.

167 and exhibits reduced cortical expression in autism spectrum disorder and Rett Syndrome.

168 their formal diagnostic criteria, including autism spectrum disorder and schizophrenia.

169 s many neuropsychiatric illnesses, including autism spectrum disorder and schizophrenia.

170 severe neuropsychiatric disorders including autism spectrum disorder and schizophrenia.

171 1.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia.

172 body movement is a distinguishing feature in autism spectrum disorder and that movement atypicalities

173 A subset of children with autism spectrum disorder appear to show an improvement i

174 2-week clinical phase 2 study in adults with autism spectrum disorder balovaptan demonstrated improve

175 pothesis that aberrant sensory processing in autism spectrum disorder could be linked to atypical int

176 dy movement may distinguish individuals with autism spectrum disorder from individuals with typical d

177 cillations, was significantly reduced in the autism spectrum disorder group.

178 Autism spectrum disorder has been characterized by atypi

179 and repeated administration of oxytocin for autism spectrum disorder have led researchers to hypothe

180 surrogates of social behavior in adults with autism spectrum disorder in an exploratory proof-of-mech

181 ncy and increased risks of schizophrenia and autism spectrum disorder in the offspring.

182 lted in a behavioral phenotype suggestive of autism spectrum disorder in the xCT(-/-) mice; in tests

183 ndary microcephaly in two other children and autism spectrum disorder in three previously healthy chi

184 Autism spectrum disorder involves persistent difficultie

185 Autism spectrum disorder is a construct used to describe

186 Autism Spectrum Disorder is a neuropsychiatric condition

187 The etiology of autism spectrum disorder is poorly understood.

188 e features of fragile X syndrome and related autism spectrum disorder models.

189 A pre-emptive intervention for the autism spectrum disorder prodrome had no immediate treat

190 nd that schizophrenia, bipolar disorder, and autism spectrum disorder share similar white matter micr

191 Individuals with autism spectrum disorder struggle with motor difficultie

192 e had no immediate treatment effect on early autism spectrum disorder symptoms, the quality of parent

193 any anxiety disorder (OR 2.9, 1.2-6.7), and autism spectrum disorder traits (OR 44.1, 15.3-127.5) wa

194 dividuals with autism spectrum disorder, and autism spectrum disorder traits in individuals with ADHD

195 pplication to heterogenous disorders such as autism spectrum disorder will require individual-subject

196 , objective, and quantitative measurement of autism spectrum disorder's core symptoms are lacking, ma

197 s that ADHD traits occur in individuals with autism spectrum disorder, and autism spectrum disorder t

198 evelopmental delay, intellectual disability, autism spectrum disorder, and behavioral abnormalities a

199 such as schizophrenia, Alzheimer's disease, autism spectrum disorder, and bipolar disorder.

200 s, including those associated with language, autism spectrum disorder, and drug addiction.

201 risk factor for global developmental delay, autism spectrum disorder, and epileptic encephalopathy.

202 risk factor for global developmental delay, autism spectrum disorder, and epileptic encephalopathy.

203 highly penetrant, monogenic risk factor for autism spectrum disorder, and is a cause of Phelan-McDer

204 intellectual disability/developmental delay, autism spectrum disorder, and multiple medical comorbidi

205 disorders such as Phelan-McDermid syndrome, autism spectrum disorder, and schizophrenia.

206 a, attention-deficit hyperactivity disorder, autism spectrum disorder, anxiety disorders, seizures an

207 he central nervous system or associated with autism spectrum disorder, as well as 773 genes under unu

208 neuropsychiatric disorders [e.g., increased autism spectrum disorder, attention deficit hyperactivit

209 ntion deficit hyperactivity disorder (ADHD), autism spectrum disorder, bipolar disorder, major depres

210 athology of psychiatric disorders, including autism spectrum disorder, bipolar disorder, major depres

211 ng the inherited intellectual disability and autism spectrum disorder, fragile X syndrome (FXS).

212 Neurodevelopmental disorders, including autism spectrum disorder, have complex polygenic etiolog

213 xiety and mood disorders, schizophrenia, and autism spectrum disorder, in which they have been identi

214 e of neurodevelopmental disorders, including autism spectrum disorder, intellectual disability, and e

215 r, attention-deficit/hyperactivity disorder, autism spectrum disorder, intelligence, and educational

216 or depressive disorder, depressive symptoms, autism spectrum disorder, psychosis, and alcohol use dis

217 ric, and neurodegenerative disorders such as autism spectrum disorder, schizophrenia, and Huntington'

218 erived from RNA-sequencing studies including autism spectrum disorder, schizophrenia, and Zika virus

219 in our cohort were intellectual disability, autism spectrum disorder, seizures, variable brain malfo

220 smembrane transporter activity pathways, and autism spectrum disorder-associated gene sets.

221 nction variants in TMPRSS9 are related to an autism spectrum disorder.

222 attention-deficit/hyperactivity disorder and autism spectrum disorder.

223 iatric disorders including schizophrenia and autism spectrum disorder.

224 nt, and also to some degree with findings in autism spectrum disorder.

225 ly implicated in intellectual disability and autism spectrum disorder.

226 attention deficit hyperactivity disorder and autism spectrum disorder.

227 Pten mutations are associated with autism spectrum disorder.

228 well as neurodevelopmental disorders such as autism spectrum disorder.

229 ed potential risk factors and biomarkers for autism spectrum disorder.

230 its and sociability in three mouse models of autism spectrum disorder.

231 ity, delayed speech and motor milestones and autism spectrum disorder.

232 e model for both intellectual disability and autism spectrum disorder.

233 of 2:1 in intellectual disability and 4:1 in autism spectrum disorder.

234 ures early behavioural signs associated with autism spectrum disorder.

235 environmental risk factors or biomarkers of autism spectrum disorder.

236 of oxytocin (48 IU/day) in adult males with autism spectrum disorder.

237 did not find a significant relationship with Autism Spectrum Disorder.

238 n group of participants, including some with autism spectrum disorder.

239 d candidate therapeutics in a mouse model of autism spectrum disorder.

240 57 subjects have a diagnosis of Autism Spectrum Disorder.

241 brain differences between men and women with autism spectrum disorder.

242 orders, particularly Tourette's disorder and autism spectrum disorder.

243 morbidity maps of a cohort of children with autism spectrum disorder/intellectual disability versus

244 ivo Perturb-Seq, to functionally evaluate 35 autism spectrum disorder/neurodevelopmental delay (ASD/N

245 Autism spectrum disorders (ASD) are a group of neurodeve

246 Autism spectrum disorders (ASD) are a group of related n

247 Autism spectrum disorders (ASD) are strongly associated

248 Genes that are mutated in Autism Spectrum Disorders (ASD) can be classified broadl

249 antibodies contributes to the development of autism spectrum disorders (ASD) has been entertained for

250 Diagnosing autism spectrum disorders (ASD) is a complicated, time-c

251 re found in intellectual disability (ID) and autism spectrum disorders (ASD) patients.

252 on to identify the functional variants among autism spectrum disorders (ASD) patients.

253 adsorption, is one of the possible causes of autism spectrum disorders (ASD) predominantly in patient

254 Autism spectrum disorders (ASD) refer to a range of neur

255 and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis un

256 tivate negative translation regulators cause autism spectrum disorders (ASD), which predominantly aff

257 ial symptoms following oxytocin treatment in autism spectrum disorders (ASD), while others point to e

258 ome) in the recent increase in prevalence of autism spectrum disorders (ASD).

259 l vitamin D concentrations influence risk of autism spectrum disorders (ASD).

260 , including intellectual disability (ID) and autism spectrum disorders (ASD).

261 uli were presented to adult individuals with autism spectrum disorders (ASD; n = 24, mean age 23 year

262 at PLR response was altered in children with autism spectrum disorders (ASDs) and other neurological

263 Autism spectrum disorders (ASDs) are developmental neuro

264 Taok2-dependent ASDs.SIGNIFICANCE STATEMENT Autism spectrum disorders (ASDs) are linked to abnormal

265 Autism spectrum disorders (ASDs) are pervasive neurodeve

266 cation of genetic biomarkers associated with autism spectrum disorders (ASDs) could improve recurrenc

267 Subjects with autism spectrum disorders (ASDs) have difficulty identif

268 Individuals with autism spectrum disorders (ASDs) imitate observed behavi

269 A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and growin

270 major hallmark of fragile X syndrome (FXS), autism spectrum disorders (ASDs), and other intellectual

271 elopmental defects.SIGNIFICANCE STATEMENT In autism spectrum disorders (ASDs), prenatal infection or

272 d to neurodevelopmental disorders, including autism spectrum disorders (ASDs).

273 ebellar dysfunction has been demonstrated in autism spectrum disorders (ASDs); however, the circuits

274 ng variants in MINT2 have been identified in autism spectrum disorders (ASDs); however, these rare va

275 ocial interaction (SI) are a core symptom of autism spectrum disorders (ASDs); however, treatments fo

276 Participants aged 7.5-18 years with autism spectrum disorders and a total score of 6 or high

277 chizophrenia, obsessive-compulsive disorder, autism spectrum disorders and even personality disorders

278 tions in Shank3 are strongly associated with autism spectrum disorders and neural circuit changes in

279 other neurodevelopmental disorders, such as autism spectrum disorders and schizophrenia.

280 Autism spectrum disorders are associated with some degre

281 Autism spectrum disorders are often associated with atyp

282 Such altered sensory perception in autism spectrum disorders could arise from disruptions i

283 Affective and autism spectrum disorders exhibited a SNP heritability o

284 The recurrence risk for autism spectrum disorders is substantial, leading many f

285 ental challenge in developing treatments for autism spectrum disorders is the heterogeneity of the co

286 d that mosaicism quantification can stratify autism spectrum disorders recurrence risk due to de novo

287 s of neurodevelopmental disorders, including autism spectrum disorders, intellectual disabilities, an

288 a model of synaptic dysfunction relevant to autism spectrum disorders, were highly replicable across

289 th social deficits typically associated with autism spectrum disorders.

290 communication is a common characteristic in autism spectrum disorders.

291 nce, spine dynamics, Parkinson's disease and autism spectrum disorders.

292 uR1 as potential target for the treatment of autism spectrum disorders.

293 unity or neurodevelopmental issues including autism spectrum disorders.

294 neurons is associated with both epilepsy and autism spectrum disorders.

295 ty, macrocephaly, and psychiatric disorders (autism spectrum disorders/attention deficit hyperactivit

296 The youth on the autism spectrum exhibited more variability and more entr

297 Furthermore, the genetic interaction with autism-spectrum genes, such as ASH1L, DYRK1A, MED13, and

298 gender and thalamic GABA/Water in predicting Autism-Spectrum Quotient (AQ) and Ritvo Autism Asperger'

299 ts were selected based on their score on the Autism-Spectrum Quotient (AQ), and AQ scores were assess

300 ted the level of autistic traits measured by Autism-spectrum Quotient (AQ).