ライフサイエンスコーパス: autoactivation

1 beta and C/EBPdelta and later by C/EBPalpha (autoactivation).

2 followed by accelerative allosteric feedback autoactivation.

3 llular fragmentation is largely dependent on autoactivation.

4 also holds for a one-stage scenario and for autoactivation.

5 PRSS1 in Escherichia coli and compared their autoactivation.

6 G, and p.K23R strongly stimulate trypsinogen autoactivation.

7 anisms of JNK2alpha2 autophosphorylation and autoactivation.

8 obustly activated by CTSB but cannot undergo autoactivation.

9 at is undergoing autophosphorylation through autoactivation.

10 (Tak1), and inhibits its ubiquitination and autoactivation.

11 supported tissue factor-dependent factor VII autoactivation.

12 s it is essential for maximal suppression of autoactivation.

13 as shown to contribute to the suppression of autoactivation.

14 but not other MAPKs and stimulates p38alpha autoactivation.

15 ing that TrcR is involved in transcriptional autoactivation.

16 ession, followed by Stat6-independent GATA-3 autoactivation.

17 recognition motif to allow GATA-3-dependent autoactivation.

18 ligomerizes caspase-1 zymogen, promoting its autoactivation.

19 rs to promote procaspase oligomerization and autoactivation.

20 arin for optimal inhibition by ATIII and for autoactivation.

21 e feedback loop created by Dpp diffusion and autoactivation.

22 R protein and is essential in preventing its autoactivation.

23 scuPA by cleavage at K158, a process called autoactivation.

24 hy changes in integrated domains can lead to autoactivation.

25 nderstand their impact on ligand-independent autoactivation.

26 educed trypsinogen degradation and increased autoactivation.

27 he active site in the closed form to prevent autoactivation.

28 t this binding is essential for the protease autoactivation.

29 a negatively charged surface for factor XII autoactivation.

30 ysiological conditions generates thrombin by autoactivation.

31 o unleash activity in the zymogen to produce autoactivation.

32 he autolysis loop of T8 and T9 and inhibited autoactivation.

33 was the activating protease, nor during fXI autoactivation.

34 ouse Ctrc, causing negligible stimulation of autoactivation.

35 g independent C-terminal gp175 self-cleavage autoactivation.

36 e fXI activation by thrombin and promote fXI autoactivation.

37 penetrance, exhibited a smaller increase in autoactivation.

38 and sufficient for caspase-11 induction and autoactivation.

39 nrichment of the CPC results in local kinase autoactivation, a mechanism that contributes to the spat

40 sing anti-Incenp antibodies, which stimulate autoactivation among bound complexes.

41 activation temporally coupled to matriptase autoactivation and 2) HAI-1 rapidly inhibiting not only

42 ndicate the importance of domain closure for autoactivation and activity regulation, with that event

43 gulation--one configuration further enhances autoactivation and another is essential for autorepressi

44 e cell membrane powerfully induces caspase-8 autoactivation and apoptosis.

45 n of CI bound to its operators influence the autoactivation and autorepression of P(RM) regulation.

46 on of the SP domain is critical for TMPRSS13 autoactivation and catalytic activity toward one of its

47 des cationic trypsinogen, can accelerate its autoactivation and cause hereditary or sporadic chronic

48 of the death protease CED-3, leading to its autoactivation and cell death.

49 observed, while in the presence of 1 mM EDTA autoactivation and cleavage at Lys(188) were reduced, an

50 serine protease (MASP)-2, followed by MASP-2 autoactivation and cleavage of C4 and C2 generating the

51 This results in intracellular autoactivation and constitutive low-grade secretion of a

52 activation is the main driving force of NOX2 autoactivation and contributes to generation of ~98% of

53 prominently upregulated in DC development by autoactivation and controls both DC differentiation and

54 hows complex multiattractor dynamics without autoactivation and cooperativity.

55 e of mediating RXR-dependent transcriptional autoactivation and COUP-TF-dependent repression.

56 Thus, in the presence of 5 mM Ca(2+), autoactivation and digestion of the zymogens after Arg(1

57 Here we investigate autoactivation and direct activation by BH3-only protein

58 Burial of Arg-320 prevents prothrombin autoactivation and directs prothrombinase to cleave at A

59 t into CD8alpha(+) cDCs due to decay of Irf8 autoactivation and diverted to the CD4(+) cDC lineage.

60 itions 401 and 403) that distinguish between autoactivation and effector-triggered activation.

61 In the same context, faster autoactivation and increased trypsin stability caused by

62 3-deleted form of SPC2 that does not undergo autoactivation and is not secreted.

63 The model incorporates autoactivation and lateral inhibition, which are propert

64 Results show that the combination of autoactivation and mutually antagonistic cross talk betw

65 -CatK has been speculated to accelerate CatK autoactivation and promote efficient collagen degradatio

66 r of SPAK/OSR1 activity, facilitating kinase autoactivation and promoting phosphorylation of the cotr

67 bited significantly higher stability against autoactivation and proteolysis than zymogens with Asn(21

68 together and promote their proximity-induced autoactivation and proteolytic processing.

69 In particular, both TBK1 autoactivation and substrate specificity are likely driv

70 their capacity to undergo processes such as autoactivation and to initiate enzyme cascades.

71 be dephosphorylated by RPTPbeta/zeta; thus, autoactivation and tyrosine phosphorylation of ALK rapid

72 d glycosylation in the proteolytic activity, autoactivation, and cellular localization of TMPRSS13.

73 re susceptible to chymotrypsin digestion and autoactivation, and features a shape consistent with rec

74 orylation at Thr-676, a known site of T-loop autoactivation, and interferes with Mps1-dependent phosp

75 Replacement of D169 prevents caspase-3 autoactivation, and its cleavage at D175 no longer leads

76 C1r in the fibroblast medium underwent autoactivation, and the activated form cleaved C1s.

77 ivation of FXI by factor XIIa, thrombin, and autoactivation; and inactivation of activated FXI (FXIa)

78 Autoactivation appears to be an intrinsic property of ch

79 We define in trans BAK autoactivation as the asymmetric "BH3-in-groove" trigger

80 nown to be an activator of its own promoter (autoactivation) as well as of the plasmid-located bfp op

81 regions of the NRL protein using yeast-based autoactivation assays.

82 Autoactivation at a 1:2 dilution was abnormally high in

83 hat mature, inactive enzyme generated during autoactivation at higher pH contained N-terminal extensi

84 enitors-such as BATF3, which stabilizes Irf8 autoactivation at the +32 kb Irf8 enhancer(4,6)-but the

85 ng downstream of focal adhesion kinase (FAK) autoactivation at the point of Src-mediated phosphorylat

86 ypsinogens and documented characteristics of autoactivation, autocatalytic degradation and Ca2+-depen

87 m other MAPK proteins in two major ways; its autoactivation/autophosphorylation is dependent on dimer

88 NOX2 autoactivation begins when active Rac triggers NOX2 acti

89 the propeptide latency motif did not prevent autoactivation but the autolysis rate was somewhat reduc

90 gh catalytic activity to not only facilitate autoactivation, but also carry out its in vivo functions

91 at the membrane is sufficient for caspase-8 autoactivation, but apoptosis could involve a death sign

92 GATA-3-dependent Th2 development and GATA-3 autoactivation, but not Stat6-dependent induction of GAT

93 MAPKs lack spontaneous autoactivation, but we found that converting Arg84/65 of

94 Aurora A autoactivation by autophosphorylation is promoted by spe

95 DNA binding domain, we were able to overcome autoactivation by AvrPto and identify four classes of sp

96 pose that Smo/Cos2 interactions stimulate Fu autoactivation by concentrating Fu at the membrane.

97 OAS1 can also undergo autoactivation by host RNAs, a potential trade-off to an

98 rm oligomers and may facilitate procaspase-9 autoactivation by oligomerizing its precursor molecules.

99 radoxically, CTRC also increases the rate of autoactivation by processing the trypsinogen activation

100 We demonstrate that rapid transcriptional autoactivation by the Amt1 Cu metalloregulatory transcri

101 est that generation of the active enzyme via autoactivation can be accomplished not only in vitro but

102 nterior mandibular cells, since the Deformed autoactivation circuit is normally antagonized by CncB f

103 rypsins, provides an additional mechanism of autoactivation control in the human pancreas.

104 icance of the negative charge of Asp(218) in autoactivation control.

105 an intact Asp(19-22) motif was critical for autoactivation control.

106 Finally, GATA-3 exerts Stat6-independent autoactivation, creating a feedback pathway stabilizing

107 the gatekeeper residue unexpectedly lead to autoactivation due to enhanced autophosphorylation of re

108 interplay of three generic mechanisms: local autoactivation, early long-range inhibition, and late lo

109 utations that change the affinity of a small autoactivation element for EXD protein result in corresp

110 Trypsin-mediated trypsinogen activation (autoactivation) facilitates digestive zymogen activation

111 Bistable autoactivation has been proposed as a mechanism for cell

112 R repeats are sufficient for inhibiting RPS5 autoactivation; however, the complete LRR domain was req

113 -determining transcription factor, undergoes autoactivation in cDC1 progenitors to establish cDC1 ide

114 C) is a proteolytic regulator of trypsinogen autoactivation in humans.

115 separation of CTSB-mediated activation from autoactivation in mice is possible through knocking in m

116 f-function effect, leading to erroneous IRF8 autoactivation in specified cDC2 progenitors, redirectin

117 activated efficiently by FXIIa, thrombin, or autoactivation in the presence of dextran sulfate.

118 Because autoactivation in vitro at the pH values reported for ly

119 Autoactivation in vitro requires phosphorylation of the

120 ed that although TPP I zymogen is capable of autoactivation in vitro, a serine protease that is sensi

121 Gly196Arg supported impaired factor VII autoactivation in vitro.

122 pression of dorsal markers including itself (autoactivation) in the neuroectoderm is blocked by sog.

123 bbit muscle (RM PhK), as was the hysteresis (autoactivation) in the rate of product formation at pH 6

124 FXII is converted to FXIIa through autoactivation induced by "contact" to charged surfaces.

125 Prothrombin autoactivation induced by histone H4 emerges as a mechan

126 utants of human cationic trypsinogen undergo autoactivation intracellularly, which leads to decreased

127 However, it is unclear how Irf8 autoactivation is controlled and eventually limited.

128 Zymogen autoactivation is explained by conformational selection,

129 Taken together, in DC development Irf8 autoactivation is first initiated by flanking enhancers

130 The product of autoactivation is functionally and structurally equivale

131 The kinetics of AMT1 autoactivation is greatly enhanced by homopolymeric (dA-

132 r serum-independent conditions and that this autoactivation is inhibited by PAI-1, a urokinase plasmi

133 BAK autoactivation is mechanistically similar to direct acti

134 Corroboratively, we show that otx2 autoactivation is prevented by retinoic acid.

135 f the mutants, indicating that intracellular autoactivation is responsible for the observed secretion

136 cleavage of factor XI by thrombin, FXIIa, or autoactivation, is a critical enzyme in the amplificatio

137 e Irf8 +32-kb enhancer, responsible for IRF8 autoactivation, is naturally suboptimized with low-affin

138 rmation is typically initiated by factor XII autoactivation, it is also possible to activate factor X

139 the rat proenzyme, at pH 8.0, 37 degrees C, autoactivation kinetics of Asn-21-Tg and Ile-21-Tg were

140 In this model the unusual autoactivation kinetics of tyrosinase are explained by r

141 transcription factor cooperativity, whereas autoactivation leads to a tristable system with an addit

142 YB, seen in multiple cancers, may drive this autoactivation loop and contribute to oncogenic activati

143 Thus, IFN-alpha/beta disrupts the GATA3-autoactivation loop and promotes epigenetic silencing of

144 gest that the leukemic clone can generate an autoactivation loop through S100-A9 expression, NF-kappa

145 These findings suggest an autoactivation loop whereby MYB, through enhancing SENP1

146 that these inhibitors target the matriptase autoactivation machinery rather than the intracellular s

147 substitution cause significant constitutive autoactivation mainly at lower temperature.

148 zing p53 and suggest that targeting the MDM2 autoactivation mechanism may be useful for therapeutic m

149 In this report we clarify the autoactivation mechanism of Aurora A by demonstrating th

150 utant p53 interferes with the intramolecular autoactivation mechanism of MDM2, contributing to reduce

151 The autoactivation mechanism of p38alpha has been found to b

152 lly activates USP7, mimicking the endogenous autoactivation mechanism of the enzyme.

153 states, sustained by a two-component kinase autoactivation mechanism.

154 We validate that this yeast model captures autoactivation mutations characterized in human breast c

155 ntity with PRSS1 and a strong propensity for autoactivation, mutations in PRSS2 are not found in here

156 Whether prothrombin autoactivation occurs in the wild-type under conditions

157 RstR autoactivation occurs when RstR is bound to an operator

158 Virulence is dependent on the autoactivation of a toxin cysteine protease, which is pr

159 The autoactivation of an initiating serine protease upon bin

160 tivation peptide at Phe-18 by CTRC inhibited autoactivation of anionic trypsinogen, although cationic

161 the cationic proenzyme, acidic pH inhibited autoactivation of anionic trypsinogen.

162 to ligands activates the pathway by inducing autoactivation of associated C1r, after which C1r activa

163 which in turn further led to transcriptional autoactivation of BMI1.

164 e made with EGTA Mg(2)(+) buffer, permitting autoactivation of C3.

165 learning but also represents a mechanism for autoactivation of CaMKII's multifaceted protein-docking

166 te of CARDs that leads to proximity-mediated autoactivation of caspase-1 in canonical inflammasomes.

167 Consistent with this notion, autoactivation of cationic Tg was inhibited by the cleav

168 Autoactivation of cationic trypsinogen is proteolyticall

169 es to form a tetramer, which facilitates the autoactivation of CED-3.

170 was to investigate the effect of CTRC on the autoactivation of clinically relevant trypsinogen mutant

171 tively, despite the inability to promote the autoactivation of either zymogen.

172 Autoactivation of factor VII bound to TF in suspension w

173 or, a calcium ionophore known to inhibit the autoactivation of furin.

174 PolyP70 stimulated the autoactivation of FXII and subsequent plasminogen activa

175 e LPS chemotype O26:B6 uniquely promoted the autoactivation of FXII to FXIIa and, in complex with FXI

176 tudies implied that this pathway involved an autoactivation of GATA-3 expression, since Stat6-deficie

177 we investigated the molecular basis for the autoactivation of hemolymph protease 14 (HP14), an initi

178 degradation and thereby markedly suppressed autoactivation of human anionic trypsinogen more effecti

179 Autoactivation of human cationic trypsinogen is inhibite

180 ndergo selection for LT mutations to prevent autoactivation of integrated virus replication that woul

181 hanism for oligomerization-driven allosteric autoactivation of IRAK4 that may be general to other kin

182 However, after specification of pre-CD8 DCs, autoactivation of Irf8 became Batf3 dependent at a CD8al

183 Irf8 expression in CDPs required prior autoactivation of Irf8 that was dependent on the transcr

184 Autoactivation of lineage-determining transcription fact

185 In summary, autoactivation of MASP-1 is crucial for the activation o

186 and, moreover, inhibition of MASP-1 prevents autoactivation of MASP-2.

187 Autoactivation of MASPs occurs in two steps: 1) zymogen

188 cs studies further reveal that the timing of autoactivation of matriptase, prostasin activation, and

189 study was to characterize the regulation of autoactivation of mouse trypsinogens by mouse Ctrc.

190 We conclude that autoactivation of mouse trypsinogens is under the contro

191 Autoactivation of N-terminally truncated cationic trypsi

192 emia (T-ALL), more than 50% of cases display autoactivation of Notch1 signaling, leading to oncogenic

193 that the NOX2 oxidative burst is a result of autoactivation of NOX2 coupled with the redox function o

194 The autoactivation of OXS2 may be a commensurate response to

195 this substitution causes severe constitutive autoactivation of PDGFRB regardless of temperature.

196 portance of CMD-1 for activation of Pemm and autoactivation of Pmga in the serotype M6 Mga.

197 To define the mechanisms for the autoactivation of primed Cds1 and the regulation of this

198 provide a mechanism by which Apaf-1 promotes autoactivation of pro-casp9 through Apaf-1 self-associat

199 ry that regulates proper oligomerization and autoactivation of procaspase-8 and/or procaspase-10 duri

200 influx promotes oligomerization and thereby autoactivation of Pyk2 by stimulating its interaction wi

201 ution of the RPS2 LRR domain resulted in the autoactivation of RPS5, indicating that the LRR domain m

202 the uPA receptor dimerization could promote autoactivation of scuPA on cell surfaces.

203 I24N, T50I, V152G, and D153V deregulate the autoactivation of SOS to populate their active form.

204 The p.K24R mutation increased autoactivation of T7 5-fold.

205 copper insult requires rapid transcriptional autoactivation of the AMT1 copper-metalloregulatory tran

206 ctors that are important for promoting rapid autoactivation of the AMT1 gene in response to toxic cop

207 Increased ATG8 binding led to the autoactivation of the C53 pathway and sensitization of A

208 Rapid transcriptional autoactivation of the Candida glabrata AMT1 copper metal

209 that TPX2 stimulates autophosphorylation and autoactivation of the enzyme.

210 In contrast, autoactivation of the executioner caspase-3 and -6 zymog

211 er, the molecular mechanisms responsible for autoactivation of the initiating protease remains poorly

212 s activation is indirect, being achieved via autoactivation of the per promoter which ensures suffici

213 essing of the precursor is necessary for the autoactivation of the protease domain.

214 bit an autoinflammatory disorder mediated by autoactivation of the pyrin inflammasome.

215 ess, can be initiated and accelerated by the autoactivation of the type 2 transmembrane serine protea

216 entral for ABA signaling is the ABA-mediated autoactivation of three monomeric Snf1-related kinases (

217 I prosegment fragments, and switch effective autoactivation of TPP I proenzyme toward less acidic pH

218 Increased intrapancreatic autoactivation of trypsinogen mutants has been hypothesi

219 ably, dimer TF(L)LZ efficiently promoted the autoactivation of VII to VIIa in solution in contrast to

220 Additionally, we show that trafficking and autoactivation of wild type FGFR2 is glycosylation-depen

221 cosylation led to increased contact-mediated autoactivation of zymogen FXII, resulting in excessive a

222 Temperature-dependent autoactivation offers an explanation to the strikingly d

223 effect on the levels of trypsin generated by autoactivation or by enterokinase at pH 8.0 in 1 mm Ca2+

224 be grouped into five categories: activation, autoactivation, partial inhibition, substrate inhibition

225 The autoactivation pathway may allow Abl family kinases to i

226 nt with this indication of a possible direct autoactivation pathway, we also observed that heterologo

227 e show that exd function is required for the autoactivation phase of Dfd expression in the posterior

228 ee conditions and provide evidence that this autoactivation plays a key role in regulating the intrin

229 Autoactivation primes Fu for additional CK1-dependent ph

230 We present evidence to demonstrate this autoactivation process is a trans-activation event that

231 e-switch model predicts the well-established autoactivation process, approximately 40% of the known M

232 hibition (pT305 phosphorylation) followed by autoactivation (pT286) of CaMKIIalpha in the hippocampus

233 The zymogen autoactivation rate of MASP-1 is approximately 3000-fold

234 pH values, Thr-21-Tg showed markedly higher autoactivation rates than the two other zymogens.

235 charomyces cerevisiae, we identified a novel autoactivation region in mammalian MEK1 that is involved

236 p38alpha autoactivation requires an interaction of p38alpha with

237 However, engineering can cause NLR autoactivation, resulting in constitutive defense respon

238 losteric site, thus aberrantly promoting SOS autoactivation, resulting in the population of active Ra

239 sequence resulted in a profound decrease in autoactivation, significantly greater than for any singl

240 Phosphorylation of the autoactivation site of the Src family kinases Lyn and/or

241 rs from human factor XI in that it undergoes autoactivation slowly in the presence of dextran sulfate

242 In the autoactivation stage, primed Cds1 molecules dimerize via

243 e made for MASP-2, and rate constants of the autoactivation steps as well as the possible cross-activ

244 The autoactivation steps of MASP-1 were separately quantifie

245 In addition, Nudel protease autoactivation temporally coincides with vitelline membr

246 facile production of enzymes through zymogen autoactivation that is broadly applicable to trypsin-lik

247 domains within HP14 are required for proHP14 autoactivation that is stimulated by its interaction wit

248 For activation by thrombin, or during autoactivation, the data support a cis-activation mechan

249 re generated and spread from sites of kinase autoactivation, thereby regulating cell division.

250 FXI undergoes autoactivation to FXIa in the presence of heparin.

251 ther by prekallikrein or by prekallikrein-HK autoactivation to generate kallikrein.

252 n can be activated to trypsin either through autoactivation (trypsin-mediated trypsinogen activation)

253 Instead, an increased propensity to autoactivation under acidic conditions might be relevant

254 e we demonstrate concentration-dependent BAK autoactivation under cell-free conditions and provide ev

255 ese results explain how BATF3-dependent Irf8 autoactivation underlies emergence of the cDC1-specific

256 We conclude with the suggestion that agr autoactivation, unlike classical enzyme induction, can o

257 fect was completely rescued by inhibition of autoactivation via (1) inclusion of the small molecule t

258 Instead, inhibition of autoactivation via cleavage of the autolysis loop is the

259 assays support our model of allosteric trans-autoactivation via EED, suggesting a previously unknown

260 The rate of autoactivation VII-Q10E32 with soluble tissue factor was

261 Plasma autoactivation was assessed by using a chromogenic assay

262 The rate of autoactivation was decreased substantially for A253 with

263 left unresolved the issue of whether GATA-3 autoactivation was direct or indirect.

264 To clarify the mechanism of JNK2alpha2 autoactivation, we have generated a series of chimeric c

265 To identify the mechanism of autoactivation, we have performed a series of molecular

266 cluster in the N-terminal domain also cause autoactivation when mutated.

267 ion of MASPs occurs in two steps: 1) zymogen autoactivation, when one proenzyme cleaves another proen

268 nism responsible for the deregulation of SOS autoactivation, where I24N, T50I, V152G, and D153V Ras m

269 he trypsinogen activation peptide stimulates autoactivation, whereas cleavage of the calcium binding

270 Ile mutation stabilizes the zymogen against autoactivation, whereas it has no effect on catalytic pr

271 f the active Rac trigger that initiates NOX2 autoactivation, whereas redox-mediated Rac activation is

272 ) and Asp(21) resulted in 2-3-fold increased autoactivation, whereas the Asp(22) --> Ala mutant autoa

273 d that Gln-6 and His-9 were not critical for autoactivation, whereas Val-2, Ile-5, and Met-8 were.

274 endent dysregulation of cationic trypsinogen autoactivation, which results in elevated trypsin levels

275 vation site Lys in T7 trypsinogen, abolished autoactivation while activation by CTSB was stimulated 4

276 The D226N mutant undergoes hydrolytic autoactivation with a half-life of 9.3 days at 37 degree

277 H 8.0, 37 degrees C, pure zymogens underwent autoactivation with concomitant trypsinolytic degradatio

278 supported factor X activation and factor VII autoactivation with essentially wild-type enzyme kinetic