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1 nt in rogue B cells producing the pathogenic autoantibody.
2 ic mutations leading to an iconic pathogenic autoantibody.
3 sed in abundance before appearance of either autoantibody.
4 of immunohistopathology and normal levels of autoantibody.
5 al of autoreactive lymphocytes and increased autoantibody.
6 of FPIR over time in children with multiple autoantibodies.
7 lation-based screening of children for islet autoantibodies.
8 ntigenic proteins targeted by these maternal autoantibodies.
9 tide candidates triggering anti-Desmoglein-1 autoantibodies.
10 art failure who have positive for beta(1)-AR autoantibodies.
11 those DQB1*06:02 (+) individuals with islet autoantibodies.
12 licating a role in stimulation of pathogenic autoantibodies.
13 e complexes induced glycan-specific anti-IgE autoantibodies.
14 tment for patients who have beta(1) receptor autoantibodies.
15 rs IFN-I in pDCs and is target of pathogenic autoantibodies.
16 obalt (Co(III)) and exposed to anti-ADAMTS13 autoantibodies.
17 id tissues and the pancreas while inhibiting autoantibodies.
18 ineage leads to production of the pathogenic autoantibodies.
19 known circulating G-protein coupled receptor autoantibodies.
20 eloped autoimmunity associated with elevated autoantibodies.
21 pecifically target and neutralize beta(1)-AR autoantibodies.
22 ownregulated by glycan-specific IgG anti-IgE autoantibodies.
23 ti-thymocyte globulin (after absorption), or autoantibodies.
24 presence of autoimmune disease and positive autoantibodies.
25 count for the intrathecal synthesis of these autoantibodies.
26 study in children with and without multiple autoantibodies.
27 eatment, suggesting a role for anti-ADAMTS13 autoantibodies.
28 pared with mothers of children without islet autoantibodies (2 [1-4]) (P = .002), but declined after
30 and IGF2 levels were significantly lower in autoantibody (AAb)(+) compared with AAb(-) relatives of
32 of acetylcholine receptor (AChR) function by autoantibodies (Abs) is considered a rare pathogenic mec
33 The developed method of characterization of autoantibody activity by recording the kinetics of their
34 susceptible children with the development of autoantibodies against (pro)insulin in early childhood.
36 dings show a weak link between the levels of autoantibodies against AGEs and diabetes mellitus (DM 44
39 Within the CNS autoimmunity control cohort, autoantibodies against aquaporin 4 and high-titer Abs ag
41 to assess serum levels of IgG, IgM, and IgA autoantibodies against FceRIalpha and investigated wheth
43 is a neurological disorder characterized by autoantibodies against IgLON5 and pathological evidence
46 ration of exogenous sialic acids, leading to autoantibodies against N-glycolylneuraminic acid in huma
47 The aim of this study was to test whether autoantibodies against neurologic surface Ags are found
49 B cell tolerance, resulting in production of autoantibodies against nucleic acids and other cellular
50 e patients showed high levels of IgG and IgM autoantibodies against numerous autoantigens, and some a
51 ns decades, beginning with the production of autoantibodies against post-translationally modified pro
59 n and native kinetic parameters that reflect autoantibody aggressiveness to the organism's tissues.
62 antibodies (AHAs) and anti-intercalated disk autoantibodies (AIDAs) are autoimmune markers in myocard
63 terpretation is difficult or impossible when autoantibodies, alloantibodies, or therapeutic antibodie
66 findings, aid the identification of surface autoantibodies among unselected people with new-onset fo
68 anti-U1 small nuclear ribonucleoprotein 70k autoantibodies and a high incidence of life-threatening
70 asma cells that secrete disease-causing AChR autoantibodies and although thymectomy improves clinical
71 ovarian insufficiency, and between anti-RFX6 autoantibodies and diarrheal-type intestinal dysfunction
72 are the major source of pathogenic allo- and autoantibodies and have historically demonstrated resist
73 , transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented w
74 is study aimed to characterise both neuronal autoantibodies and levels of interferon alpha, two propo
75 notyping, we find novel associations between autoantibodies and organ-restricted autoimmunity, includ
76 munity, including a link between anti-KHDC3L autoantibodies and premature ovarian insufficiency, and
77 secrete high titers of germline-encoded IgM autoantibody and hypermutating germinal center B cells.
78 atients with the DAP1 genotype have distinct autoantibody and transcription profiles, supporting the
79 suggest a possible link between HLA alleles, autoantibodies, and environmental triggers in the pathog
80 ell burden, decreased serum and tissue-bound autoantibodies, and increased DSG3-CAART engraftment.
81 lasma revealed both known disease-associated autoantibodies (anti-La) and novel candidates that recog
82 work investigated the detection of anti-p53 autoantibodies (anti-p53aAbs) using nanomagnetic beads c
83 istence subgroup, the prevalence of positive autoantibodies (antinuclear or ACPA) was significantly h
85 ether, these findings demonstrate that NMDAR autoantibodies are detectable in a subgroup of CHR subje
88 n many autoimmune diseases, disease-specific autoantibodies are produced by B cells in response to so
91 nt work supports further evaluation of NMDAR autoantibodies as a possible prognostic biomarker and ae
92 stinfectious GN by identifying anti-factor B autoantibodies as contributing factors in alternative co
93 activity >50% and undetectable anti-ADAMTS13 autoantibodies, as well as after rituximab treatment, su
94 history of anti-interferon-gamma (IFN-gamma) autoantibody-associated immunodeficiency syndrome is not
96 tial data for 4 patients with anti-IFN-gamma autoantibodies at the US National Institutes of Health w
98 onia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-omega (IFN-
99 new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed
100 ine a general mechanism of autoimmunity with autoantibodies being produced by ignorant B cells on pro
101 sponses against pathogenic DSG3 epitopes and autoantibody binding to epithelial tissues, leading to c
102 mic lupus erythematosus because they secrete autoantibodies, but they are unresponsive to standard im
105 subsets to induce desmoglein (Dsg)-specific autoantibodies by memory B cells was evaluated in cocult
106 18 (78%) samples, proving that anti-ADAMTS13 autoantibodies can induce an open ADAMTS13 conformation.
107 e screened a panel of anticomplement protein autoantibodies, carried out related functional character
108 e growth factor 1 receptor (IGF1R) with TSHR autoantibodies, causing retro-orbital tissue expansion a
109 human serum both critical characteristics of autoantibody: concentration and native kinetic parameter
111 for immunopathologic confirmation of MMP by autoantibody detection is inappropriate for DIF- ocular-
112 Understanding the mechanisms underlying autoantibody development will accelerate therapeutic tar
113 disease characterized by mutually exclusive autoantibodies directed against distinct nuclear antigen
115 es and long-lived plasma cells as sources of autoantibodies, discuss data that indicate migration of
116 enerally decreased with time, anti-IFN-gamma autoantibody disease had a chronic clinical course with
120 upus pathology by reducing serum antinuclear autoantibodies, dsDNA titers, and the number of circulat
121 of the lung in the generation of RA-related autoantibodies during a period of disease development te
122 arises only under pathological conditions in autoantibodies endowed with stereospecific binding sites
125 This effect is associated with impaired autoantibody formation, and mitigates experimental autoi
126 ine monolayer, replicating a key activity of autoantibodies found in patients with antiphospholipid s
127 T cells increased the serum concentration of autoantibodies, frequency of germinal center (GC) B cell
128 conclusion, we have shown that anti-ADAMTS13 autoantibodies from iTTP patients induce an open ADAMTS1
129 z and Wong et al. assessed the prevalence of autoantibodies from the sera of 51 adult ICL patients (o
130 Two risk associations were related to GAD65 autoantibody (GADA) and IA-2 autoantibody (IA-2A) but in
132 dherins, including human and mouse pemphigus autoantibodies, had no effect on monolayer integrity and
133 orefront of this effort is the modulation of autoantibody half-life and blocking access of autoantibo
135 ividuals were positive for one or more islet autoantibodies; however, there was a greater proportion
136 children having early onset of each initial autoantibody, i.e., IAA-first by 12 months and GADA-firs
140 rocarriers to selectively capture anti-dsDNA autoantibodies (IgG, IgA and IgM AAbs) present in the se
141 vidence strongly supports the involvement of autoantibodies in arrhythmogenesis, a large-panel autoan
142 pecific tyrosine kinase (MuSK)-specific IgG4 autoantibodies in autoimmune myasthenia gravis (MG) are
144 PAD2 and PAD4 are additionally targeted by autoantibodies in distinct clinical subsets of patients
145 The generation of MAR-ASD-specific epitope autoantibodies in female mice prior to breeding created
147 r data demonstrate that a high prevalence of autoantibodies in ICL, some of which are specific for CD
150 eases; our data confirms the presence of AGE-autoantibodies in patients with CAD and that in parallel
153 0, a ring-shaped protein that is a target of autoantibodies in patients with systemic lupus erythemat
155 f an FO-SPR immunoassay for the detection of autoantibodies in plasma samples from immune-mediated th
156 mmunologic study revealed high titers of IgG autoantibodies in serum and cerebrospinal fluid directed
157 The finding of mildly increased neurologic autoantibodies in SLE may be consistent with a broader l
159 ion and activity characterization of several autoantibodies in the same serum sample have been demons
161 ution series of a cloned human anti-ADAMTS13 autoantibody in ADAMTS13-depleted plasma resulting in an
162 d LAMP3 expression and the presence of serum autoantibodies including anti-Ro/SSA, anti-La/SSB, anti-
163 hages and suggest a therapeutic strategy for autoantibody-induced inflammation, including lupus nephr
164 in barrier (BBB) breakdown, extravasation of autoantibodies into the CNS, and loss of excitatory syna
165 ssociated with positivity for multiple islet autoantibodies, irrespective of class II HLA DR-DQ genot
168 unotherapy-responsive seizure syndromes with autoantibodies largely fall under the umbrella of autoim
170 t is also associated with lower anti-insulin autoantibody levels in part by inhibition of T follicula
172 arthritis model without reducing circulating autoantibody levels, providing support for FcRn's direct
175 T cell functions and reduce serum anti-dsDNA autoantibody levels; 2) differentially regulate autophag
176 ) and the pathogenic, GD-specific monoclonal autoantibody, M22, robustly induce IL-23 in human fibroc
178 We examined MG patient-derived monoclonal autoantibodies (mAbs), their corresponding germline-enco
185 spontaneous arthritis depended on SAP in the autoantibody-mediated K/BxN model, organized insulitis a
187 the Sle1 interval leading to anti-chromatin autoantibodies; Mfge8(-/-) , leading to defective cleara
188 he majority of patients under 50 y with AChR autoantibody MG have thymic lymphofollicular hyperplasia
189 herefore critical for selective CNS entry of autoantibodies, microglial activation, and neural circui
190 s.RESULTSAll ICL patients had a multitude of autoantibodies mostly directed against private (not shar
191 here was a greater proportion who were islet autoantibody negative compared with those T1D DQB1*06:02
192 rapy, patients with these neuroglial surface autoantibody (NSAb)-mediated diseases often experience c
196 oming tolerized and repressed from secreting autoantibody, Pik3cd gain-of-function B cells are activa
198 ed from whole genome sequencing of 160 islet autoantibody positive subjects, including 87 who had pro
199 cestry; T1D (n = 262 clinically defined, 200 autoantibody positive), T2D (n = 345) and controls (n =
200 ellent immunotherapy-independent outcomes of autoantibody-positive patients without encephalitis sugg
202 ysis identified six features which predicted autoantibody positivity (area under the curve=0.83): age
205 Families of children with multiple islet autoantibodies (presymptomatic type 1 diabetes) were inv
208 e that ASD-specific antigen-induced maternal autoantibodies produced alterations in a constellation o
209 deletion of alphav from B cells accelerates autoantibody production and autoimmune kidney disease in
210 c impact on B cells extends to inhibition of autoantibody production and autoimmunity in mouse lupus
211 precipitated fatal autoimmunity with intense autoantibody production and dysregulated T follicular he
213 over, female ALX/FPR2 KO mice show increased autoantibody production and loss of salivary gland funct
214 lls led to hyperactivation of B and T cells, autoantibody production and lupus-like disease in mice.
215 that c-Rel overexpression in B cells caused autoantibody production and renal immune complex deposit
216 geting BAFF specifically for attenuating the autoantibody production associated with cholestatic live
223 such that monovalent IgG4 Fab-arm-exchanged autoantibodies reach a high-affinity threshold required
224 nd their families, including the presence of autoantibodies reactive to fetal brain proteins in nearl
225 ertoire with immunodominant clones and serum autoantibodies reactive to oncogenic signaling pathway p
231 in the formation of public rheumatoid factor autoantibodies responsible for mixed cryoglobulinemic va
232 primary hippocampal neurons to anti-Drebrin autoantibodies resulted in aberrant synapse composition
233 ay lead to antibodies against self-antigens (autoantibodies), resulting in organ-specific or systemic
234 ntibodies in arrhythmogenesis, a large-panel autoantibody screening was performed in patients with ca
235 nresolved etiology and equivalent results in autoantibody screening were subjected to epitope identif
236 itro functional studies confirmed that these autoantibodies selectively blocked M(3) receptor activat
241 We examined HLA associations in SSc and its autoantibody subsets in a large, newly recruited African
245 However, newborn serum contains abundant autoantibodies, suggesting that B cell tolerance during
246 patient sera with elevated levels of TRIM72 autoantibodies suppress sarcolemmal resealing in healthy
248 n Drebrin as a pathophysiologically relevant autoantibody target in patients with recurrent seizures
250 t inflammatory pathways, genetic influences, autoantibodies targeting brain proteins, and exposure to
256 ot more frequently seropositive for neuronal autoantibodies than controls (8.3% vs. 5.2%; OR = 1.50;
257 oup of CNS diseases are caused by pathogenic autoantibodies that target neuroglial surface proteins.
258 neuromuscular, autoimmune disease caused by autoantibodies that target postsynaptic proteins, primar
260 ive to immunoadsorption is neutralization of autoantibodies through the intravenous application of sm
261 t ensures a constant exposure to the salient autoantibodies throughout gestation in C57BL/6J mice.
263 ation in the pancreas, decreased circulating autoantibody titers against citrullinated glucose-regula
264 AP1 risk allele exhibit significantly higher autoantibody titers and altered expression of the immune
266 both TM strains had significant increases in autoantibody titers, Ag spread, and IgG deposition in th
267 s have generally resulted in reduced thyroid autoantibody titre without apparent improvements in the
268 nts, NMO is caused by pathogenetic serum IgG autoantibodies to aquaporin 4 (AQP4), the most abundant
272 utoantibody half-life and blocking access of autoantibodies to fragment cystallizable gamma receptors
273 n to acquired immunodeficiencies like HIV or autoantibodies to IFN, variants in specific genes have b
274 ew-onset focal epilepsy had detectable serum autoantibodies to known or novel cell surface antigenic
275 and are characterized by the development of autoantibodies to the neutrophil proteins leukocyte prot
279 d pathogenicity by causing the antigen-bound autoantibodies to undergo phase transition to insoluble
280 tage (presence of anti citrullinated-peptide autoantibody) to diagnosis of rheumatoid arthritis (RA),
282 function, immune responses to transgenes and autoantibodies, vector copy number, and integration were
283 TTING, AND PARTICIPANTS: Screening for islet autoantibodies was offered to children aged 1.75 to 5.99
284 up (p < 0.05) and the presence of a neuronal autoantibody was associated with larger amygdala volumes
289 circulating B lymphocytes making pathogenic autoantibodies were found to comprise clonal trees accum
294 In acute postinfectious GN, anti-factor B autoantibodies were transient and correlated with plasma
295 Respiratory allergy and the presence of autoantibodies were unrelated (12% concurrence versus th
297 sts such as nerve ultrasound and testing for autoantibodies, which are not yet part of the guidelines
298 n, associated with a higher frequency of IgG autoantibodies with an agalactosylated, proinflammatory
300 type 1 diabetes, defined by 2 or more islet autoantibodies, with categorization into stages 1 (normo