ライフサイエンスコーパス: autocrine

1 source of TGFbeta -supporting Trm cells was autocrine.

2 endothelial calcium responses arise from the autocrine action of non-neuronal ACh released by the end

3 red with ATP-treated T(H)1 cells, suggesting autocrine action of T(H)17-derived IL-1beta.

4 used two CRISPR-addressable landing pads for autocrine activation of a GPCR (the somatostatin recepto

5 "spiking") at the plasma membrane because of autocrine activation of P2Y1 purinoceptors by ATP co-rel

6 Indeed, autocrine activation of PDGFRalpha induces CSC invasion

7 els at the cell surface, leading to enhanced autocrine activation of TGF-beta-responsive SMADs and ge

8 uces SDF-1 expression and secretion, and the autocrine activation of this pathway in L-CSCs.

9 identify the endothelin/Ednra pathway as an autocrine activator of Gq signalling in brown adipocytes

10 nts a novel signaling paradigm that connects autocrine and endocrine signaling modes of the same horm

11 against viral pathogens in part through the autocrine and paracrine actions of alpha/beta interferon

12 oxin-alpha (LTA) as the causative factor for autocrine and paracrine activation of canonical and nonc

13 exerts high angiogenic function through both autocrine and paracrine activities.

14 lar vesicles called exosomes affect multiple autocrine and paracrine cellular phenotypes.

15 response to environmental cues by modulating autocrine and paracrine DAF-2 ILS.

16 the anatomical HIV reservoirs can have both autocrine and paracrine effects contributing to the HIV-

17 Altogether, these data show autocrine and paracrine effects of Sfrp4 in regulating O

18 RA can function in an autocrine and paracrine fashion, and as such, the host c

19 effect disease development through possible autocrine and paracrine forms of regulation.

20 ing growth factor (TGF)-beta1 contributes to autocrine and paracrine functions in the tumor microenvi

21 an important neurotransmitter and endocrine, autocrine and paracrine hormone.

22 Blocking autocrine and paracrine IL4 signaling with the IL4Ralpha

23 nd further increased Gli1 levels, in both an autocrine and paracrine manner.

24 release type III IFNs and use these IFNs in autocrine and paracrine manners to restrict ZIKV infecti

25 bute to tumor growth and progression by both autocrine and paracrine mechanisms.

26 , stromal reaction, and angiogenesis through autocrine and paracrine PDGFRbeta signaling.

27 will be a useful tool for understanding both autocrine and paracrine roles of exosomes.

28 To understand the autocrine and paracrine roles that amino acids play in i

29 sly up-regulate GPR91, which functions as an autocrine and paracrine sensor for extracellular succina

30 RALF peptides mediate autocrine and paracrine signaling 689 IV.

31 eotides (such as ATP and ADP) and subsequent autocrine and paracrine signaling events through nucleot

32 atures of basal breast cancer: TGFbeta is an autocrine and paracrine signaling factor that drives cel

33 viral miRNA activity not only disrupts IL-1 autocrine and paracrine signaling loops that can alert e

34 esizes gamma-aminobutyric acid, an important autocrine and paracrine signaling molecule and a surviva

35 Retinoic acid (RA) is an autocrine and paracrine signaling molecule essential for

36 Secreted IFNs induce autocrine and paracrine signaling through the JAK-STAT p

37 gage in an intricate balancing act involving autocrine and paracrine signaling to maintain pollen tub

38 demonstrate that ILC2(10)s can utilize both autocrine and paracrine signaling to suppress proinflamm

39 s on cell proliferation and invasiveness via autocrine and paracrine signaling.

40 al that MDK acts as an internal modulator of autocrine and paracrine signals that maintain immune sup

41 wise released polypeptide factors that exert autocrine and/or paracrine actions, with most cytokines

42 ree peptide suggesting that it may act in an autocrine and/or paracrine manner.

43 neutrophil recruitment and activation in an autocrine and/or paracrine manner.

44 These results suggest that autocrine and/or paracrine signaling via locally generat

45 ed, ANG1 agonist activity was decreased, and autocrine ANG2 agonist activity was lost, which led to s

46 To elicit these effects, Wnts act as autocrine as well as paracrine signalling molecules betw

47 We show that BDNF acts cell autonomous and autocrine, as wildtype neurons are not capable of rescui

48 eta-catenin expression that was dependent on autocrine ATX secretion and LPA signaling.

49 An efficient autocrine-based high-throughput selection system was dev

50 venom peptide library that was formatted for autocrine-based selection.

51 -3 provides an extracellular scaffold for an autocrine BMP signal, suggesting a mechanistic framework

52 iptional requirement for activity-dependent, autocrine BMP signaling in determining synapse density,

53 omotes the function of an activity-dependent autocrine Bone Morphogenetic Protein (BMP) signaling pat

54 d class switch recombination (CSR) depend on autocrine C3a and C5a receptor (C3ar1/C5ar1) signaling i

55 lity to stimulate T cell responses, requires autocrine C3a receptor and C5a receptor (C3ar1/C5ar1) si

56 fate-mapping mice show that TLR-initiated DC autocrine C3ar1/C5ar1 signaling causes expansion of effe

57 Furthermore, WNT2 activated autocrine canonical WNT signaling in primary fibroblasts

58 ve TGF-beta1 induction of enzymes that cause autocrine cleavage/activation of PAR2, possibly through

59 ur results establish unbiased selection from autocrine combinatorial antibody libraries as a robust m

60 -15ralpha in elderly myotubes confirmed that autocrine concentrations of IL-15 also support myogenesi

61 In conclusion, inhibition of autocrine Connexin-43-dependent ATP signalling on macrop

62 These DNA extrusions convey autocrine costimulatory signals to T lymphocytes and can

63 This should prevent an autocrine development of the androgenic glands so that f

64 mediated by signaling via both paracrine and autocrine diffusible factors that induce differential ef

65 trol of salivary secretion in ticks involves autocrine dopamine activating two dopamine receptors: D1

66 MOG-restricted CD4(+) T cells were due to an autocrine effect of IL-1beta/IL-23-mediated induction of

67 Therefore, we investigated the autocrine effect of PGE2 on human adult stem cells from

68 IL26 did not have an autocrine effect on human TNBC cells, but rather its eff

69 n-stimulated DCs in vitro and in vivo due to autocrine effects on the DCs.

70 for acquired CYP19A1(amp) and promotes local autocrine estrogen signaling in AI-resistant metastatic

71 zation and observed staining consistent with autocrine expression in the tumor cells.

72 g to CNTFRalpha up-regulation, together with autocrine expression of CNTF, was involved in glioma gro

73 ng at its A2A receptor (A2AR), is a critical autocrine factor for maintenance of cartilage homeostasi

74 d rapid actions of Amh as a paracrine and/or autocrine factor in regulating hippocampal neuronal acti

75 tide that has been shown to act as paracrine/autocrine factor in various malignancies including prost

76 Erdr1 was found to function as an autocrine factor to induce apoptosis through caspase 3.

77 there is growing evidence that paracrine and autocrine factors, especially the endothelin system, are

78 ere accompanied by the repression of crucial autocrine factors, in particular, interleukin-6 (IL-6).

79 sh that the exosomal pool of LTB4 acts in an autocrine fashion to sensitize neutrophils towards the p

80 and T helper 1 (T(H)1) differentiation in an autocrine fashion.

81 ough estrogen-induced CXCR2 signalling in an autocrine fashion.

82 ediated by anaphylatoxins in a paracrine and autocrine fashion.

83 to-oncogene receptor tyrosine kinase (c-Met) autocrine feed-forward loop promoting SC proliferation.

84 We suppose that inverse signaling is an autocrine feedback and fine-tuning system in the communi

85 We propose the presence of an autocrine feedback loop in which Klotho senses the need

86 ly, beta2 adrenergic signaling reinforced an autocrine feedback loop of macrophage-derived IL-10 and

87 ized that Klotho in bone cells is part of an autocrine feedback loop that regulates FGF23 expression

88 flammation, sepsis, and cancer-disrupts this autocrine feedback mechanism, which results in defective

89 Here, we demonstrate that the autocrine FGF/FGFR axis is essential for multiple myelom

90 places circulating adiponectin downstream of autocrine FGF21 expressed by adipocytes and upstream of

91 Instead, autocrine FGFR1 and PDGFRalpha signaling, which have not

92 supports increased glutamate production and autocrine glutamatergic signaling, which can be pharmaco

93 ition (or gene silencing) interrupts stromal autocrine growth and significantly decreases secretion o

94 iculogenesis can induce GCT by activating an autocrine growth circuit program in GC.

95 Thus, apelin acted as an autocrine growth cue to sustain vascular repair and miti

96 y antigen-presenting cells, they express the autocrine growth factor IL-2 which transforms them into

97 endothelial tube formation, but also act as autocrine growth factors for GAB2-induced transformation

98 STAT4 activation to generate IFN-gamma, with autocrine IFN-gamma then signaling through STAT1.

99 was found to be independent of exogenous and autocrine IFN-gamma, or the secondary cytokines TGF-beta

100 ll stage as a major juncture where transient autocrine IFNbeta expression by developing B-cells impri

101 inase-associated activity in response to the autocrine IGF-II stimuli.

102 gradation rescue mechanism controlled by the autocrine IGF-II-insulin receptor-A specific signaling a

103 scle is attributable, in part, to diminished autocrine Igf2 production; basal tyrosine phosphorylatio

104 rs and the large adhesion phenotype required autocrine IGF2-IGF1 receptor signaling mediated by AKT2

105 y GM-triDAP-activated MDM was independent of autocrine IL-1.

106 a subset of late phase genes was mediated by autocrine IL-10, which activated STAT3 with delayed kine

107 C3a/C3aR ligations on podocytes initiate an autocrine IL-1beta/IL-1R1 signaling loop that reduces ne

108 liferative activity in activated T cells via autocrine IL-23 signaling.

109 the production of IL-9 critically depends on autocrine IL-3 acting via the sustained activation of ST

110 er, we highlight NFATc2-driven production of autocrine IL-3 as a critical and cell type-specific comp

111 ed that miR-146a inhibited the production of autocrine IL-6 and IL-21 in 2D2 T cells, which in turn r

112 This work demonstrates that autocrine IL-6 signaling in the gut epithelium regulates

113 an important molecular brake that blocks the autocrine IL-6- and IL-21-induced Th17 differentiation p

114 h a STAT3-DNMT epigenetic axis, regulated by autocrine IL6, to silence TNFalpha expression.

115 Whereas NMDAR activation is autocrine in some primary tumour types, human and mouse

116 Neutralization of this autocrine-induced EphB4-phosphorylation by IGF-II associ

117 terminals and regulates GAD65 expression via autocrine influence on sensory terminal BDNF.

118 hesion remodeling during GSIS resulting from autocrine insulin/IGF2 and AKT1 signaling.

119 ortantly, a positive feedback loop involving autocrine LIF, LIFR, and STAT4 drove sustained IL-6 tran

120 In particular, the existence of autocrine, ligand-dependent Hh signaling in SCLC has bee

121 These results provide strong support for an autocrine, ligand-dependent model of Hh signaling in SCL

122 Expression of the autocrine loop components regulating PGE2 production and

123 of neurotrophins, disruption of a CD40L/CD40 autocrine loop impaired early neurotrophin-promoted axon

124 osteosarcoma cell lines; engagement of this autocrine loop leads to tumor cell proliferation, invasi

125 r, death receptor 4, sensitizing cells to an autocrine loop of TRAIL-mediated cell death.

126 tence of BMP alterations and existence of an autocrine loop promote CML-primitive cells' TKI resistan

127 by the establishment of a TGFbeta-dependent autocrine loop that sustains EMT.

128 thermore, IL-1beta signals via a feedforward autocrine loop to promote invasion through a FAK>p130Cas

129 vitro studies revealed a Th17 cell-intrinsic autocrine loop triggered by binding of IL-17A to its rec

130 P1), a suppressor of miR-146a, suggesting an autocrine loop.

131 ss the IL11 receptor alpha, suggestive of an autocrine loop.

132 ted pathways and predict novel paracrine and autocrine loops involving cytokines, chemokines, and gro

133 NFAT1 nuclear translocation, suggesting that autocrine LPA synthesis promotes NFAT1 transcriptional a

134 in secretion and beta cell replication in an autocrine manner but also regulates peripheral insulin s

135 ells produce a source of Wnt that acts in an autocrine manner to modulate reparative dentinogenesis.

136 da1, which functions in both a paracrine and autocrine manner to protect trophoblast and non-trophobl

137 ial cell maintenance and proliferation in an autocrine manner via Notch signaling.

138 PGD(2) produced by ILC2s is, in a paracrine/autocrine manner, essential in cytokine-induced ILC2 act

139 otein kinase 2, induced K19 expression in an autocrine manner, invadopodia formation and cell invasio

140 NF-kappaB signaling axis in a paracrine and autocrine manner, leading to bromodomain protein 4 (BRD4

141 e is also the potential for ATP to act in an autocrine manner, modulating urothelial cell function.

142 in turn stimulates cell proliferation in an autocrine manner.

143 otective responses that can be boosted in an autocrine manner.

144 intracutaneously, thus acting in a para- and autocrine manner.

145 ACh-release is regulated in an autocrine manner.

146 egrin alpha6beta1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine mann

147 is complementary to the recently discovered autocrine mechanism in which lactate induces PD-L1 in tu

148 3, another member of the STAT family, via an autocrine mechanism involving interferon beta (IFNbeta)

149 creased EGFL7 expression and secretion is an autocrine mechanism supporting growth of leukemic blasts

150 prevented hypoxia-induced cell death via an autocrine mechanism through the LDL receptor-related pro

151 It operates via an autocrine mechanism to elevate STAT1 and induce internal

152 When one adds an autocrine mechanism, fine control at the level of indivi

153 dopamine themselves, suggesting a potential autocrine mechanism.

154 To explain this phenomenon, we added two autocrine mechanisms essential to achieve contraception

155 f glioma cells by non-synaptic paracrine and autocrine mechanisms.

156 axon growth that acts by target-derived and autocrine mechanisms.

157 of spontaneous metastasis, BMP4 acted as an autocrine mediator to modulate a range of known metastas

158 These results support an autocrine mode of d-serine action at synapses.

159 aptic NMDAR function and suggests a possible autocrine mode of d-serine action.SIGNIFICANCE STATEMENT

160 In line with the autocrine model, uninfected males expressed IAG from the

161 Autocrine motility factor (AMF) is a tumor-secreted cyto

162 GP78 is an autocrine motility factor (AMF) receptor (AMFR) with E3

163 gp78/AMFR, a receptor for the prometastatic autocrine motility factor (AMF), as well as an E3 ubiqui

164 ously identified the ER-polytopic gp78/AMFR (autocrine motility factor receptor) as a relevant E3 in

165 role as a novel transcriptional repressor of autocrine motility-stimulating factor Autotaxin (ATX).

166 Our results provide evidence of the autocrine neuroprotective function of VEGF on RGCs is cr

167 Thus, LTA sustains autocrine NF-kappaB activation, impacts activation of se

168 which metabolism of APP results in possible autocrine or paracrine Abeta production to drive the mic

169 also produced by immune cells and acts as an autocrine or paracrine fashion to regulate the function

170 molecule, capable of activating cells in an autocrine or paracrine fashion via specific cell surface

171 e RBP4, therefore, may have a more important autocrine or paracrine function that is confined within

172 cells and regulate cellular processes in an autocrine or paracrine manner.

173 and multicentric Castleman's disease through autocrine or paracrine mechanisms during latency or prod

174 nfluence responses to disease states through autocrine or paracrine mechanisms.

175 Autocrine or paracrine signaling by beta interferon (IFN

176 that naive hESCs secrete Wnts that activate autocrine or paracrine Wnt/beta-catenin signaling to pro

177 cal processes in multicellular organisms via autocrine, paracrine, and endocrine mechanisms.

178 ing cells can produce signals that act in an autocrine, paracrine, or endocrine manner.

179 t in papillary thyroid cancer tumors and the autocrine-paracrine conversion of SOD3 expression, which

180 TAT3 achieved the same effect, confirming an autocrine-paracrine cytokine loop as a mechanism for BCG

181 ur study uncovers an intricate IBC-initiated autocrine-paracrine signaling network between IBC cells

182 As a secreted protein, it is an autocrine/paracrine activator of canonical WNT signaling

183 The sequential cell-specific regulation of autocrine/paracrine and juxtacrine signaling accounted f

184 mmune cell-derived complement production and autocrine/paracrine C3ar1/C5ar1 signaling as crucial int

185 tive manner because of the important role of autocrine/paracrine cytokines in modulating PRR-initiate

186 regulation of the type I IFN pathway and its autocrine/paracrine effects on tumor growth.

187 efit in patients with cancers displaying SHH autocrine/paracrine expression.

188 show that galectin-3 acts as a pro-invasive autocrine/paracrine factor in trophoblast in vitro.

189 , the decreased response to and secretion of autocrine/paracrine IL-10, IL-4, IL-22 and thymic stroma

190 ine outcomes included negative feedback from autocrine/paracrine IL-10, TGF-beta, IL-4, IL-13, IL-22,

191 were particularly dependent on PRR-initiated autocrine/paracrine IL-12-induced STAT4 activation to ge

192 me assembly and IL-1 synthesis, resulting in autocrine/paracrine IL-1beta-mediated increases in EC im

193 Secreted LEP activates an autocrine/paracrine loop through binding to the LEP rece

194 ecretion of TGFbeta ligands that acted in an autocrine/paracrine loop to activate SMAD2 and suppress

195 ike growth factor 1 (IGF1) is secreted in an autocrine/paracrine manner by GCs and activates the IGF1

196 ncreased DA release and GSIS reduction in an autocrine/paracrine manner.

197 at targeting the secretion of extracellular, autocrine/paracrine mediators of glioma stem-like cell s

198 has been thought to depend on endocrine and autocrine/paracrine modulators.

199 Our findings unveil a novel autocrine/paracrine pro-homeostatic RPE cell signaling t

200 drocytes (AC) and demonstrate its role as an autocrine/paracrine pro-survival factor.

201 Autocrine/paracrine purinergic signaling is essential fo

202 ved phenotypical changes depends on enhanced autocrine/paracrine release of the EGFR ligand transform

203 on of astrocyte proliferation, supporting an autocrine/paracrine role of TNF-alpha on astrocyte proli

204 that LTB4 produced by neutrophils acts as an autocrine/paracrine signal to direct the vascular recrui

205 sulin-like growth factor-1 receptor (IGF-1R) autocrine/paracrine signaling in patients with renal cel

206 ellular vesicle release blocks LTB4-mediated autocrine/paracrine signaling required for neutrophil ar

207 with a central role for metallothioneins and autocrine/paracrine signaling via A(3)Rs.

208 rens junctions in initiating and maintaining autocrine/paracrine signaling with relevance to wound he

209 waves of oscillatory ERK activity depend on autocrine/paracrine signals produced by TACE.

210 CCA cells exchange autocrine/paracrine signals with other cancer cells and

211 ist in Mobilan-infected cells established an autocrine/paracrine TLR5 signaling loop resulting in con

212 , mediated by LPA1-, Gi-, and COX1-dependent autocrine/paracrine TXA2 release and consequent TP activ

213 Here, we have identified an autocrine pathway linking nuclear factor of activated T

214 synoviocytes, indicating the presence of an autocrine PDGFR activation loop that involved endogenous

215 e of pollen tube integrity by perceiving the autocrine peptide ligands rapid alkalinization factor 4

216 ed role of tumor cell-expressed ANGPT2 as an autocrine-positive regulator of metastatic colonization

217 Our studies reveal that cyclic autocrine presynaptic activation drives repetitive rever

218 Amnesiac release from the MB allows, via an autocrine process, the sustaining of PKA activation-medi

219 tes cAMP-dependent lipolysis in part via the autocrine production of PGI2.

220 Unexpectedly, we also observed enhanced autocrine production of prostaglandin I2 (PGI2, also cal

221 Mechanistically, autocrine production of PTX3 by melanoma cells triggered

222 ut mice, we demonstrated that keratinocytes' autocrine production of SCF activates a transient c-kit

223 hase of JNK phosphorylation was dependent on autocrine production of tumor necrosis factor alpha (TNF

224 phodiesterase 4D (PDE4D) activity to amplify autocrine prostaglandin E(2) signaling in airway smooth

225 Disruption of this autocrine PTHrP-PPR signaling in these cells leads to de

226 This identifies autocrine purinergic signaling, through Cx43 hemichannel

227 PKC signaling is thus implicated in autocrine regulation of beta cell function.

228 and studied their link to the still debated autocrine regulation of insulin secretion by insulin/ins

229 F9(+) MOLM-14 cells, in a biphasic manner by autocrine regulation, whereas it decreases that of chron

230 ceptor alpha (RORalpha) as both a target and autocrine regulator of MaR1 production.

231 Here, we report a miRNA-based autocrine regulatory pathway that controls differentiati

232 Our data provide mechanistic insight into an autocrine regulatory signaling loop that regulates beige

233 hrough a mechanosignaling loop involving the autocrine remodeling of a drug-protective ECM.

234 ion of TSG6 in TSG6(+/+) mice, suggesting an autocrine role for TSG6 in transitioning macrophages.

235 G WT control skin, we assessed the potential autocrine role of epidermal-derived eicosanoids in FLG-a

236 is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-der

237 STAT3 is required for maintaining autocrine Schwann cell survival signaling, and inactivat

238 Autocrine SDF-1/CXCR4 signaling induces L-CSC proliferat

239 (HNSCC), which is associated with increased autocrine secretion of FGF19 and poor patient outcome in

240 oted migration of a2Neu was dependent on the autocrine secretion of IL-8 from a2Neu.

241 gh the canonical pathway remained unchanged, autocrine SHH interference in colon, pancreatic, and lun

242 elopment, indicating that ILPs constitute an autocrine signal that regulates the differentiation of B

243 n several cancer types and encodes for a key autocrine signaler known to promote tumorigenic growth.

244 taining exon 6), which enhances the TGFbeta1 autocrine signaling and induces fibroblasts to transdiff

245 r results define a paradigm of intracellular autocrine signaling and may explain resistance to antago

246 We next identify a novel autocrine signaling axis in OCCC cells whereby tumor-cel

247 These cells are regulated by autocrine signaling by parathyroid hormone-related prote

248 egulatory loop caused by JNK-regulated FGF21 autocrine signaling in adipocytes that promotes increase

249 ith an increased dependency upon FGF19/FGFR4 autocrine signaling in HNSCC, revealing a therapeutic ta

250 uggested the involvement of a C3/C3 receptor autocrine signaling loop in regulating tumor growth.

251 e results suggest that 12-S-HETE might be an autocrine signaling molecule exported by ABC transporter

252 stimulated their growth through an activin A autocrine signaling pathway, a hypothesis confirmed by a

253 nthesize and secrete dopamine, suggesting an autocrine signaling process underlying these results.

254 of the VM-inhibiting miRNAs, suggesting that autocrine signaling stimulating VM is regulated by ZEB1-

255 Our findings indicate potential autocrine signaling where NF2 loss leads to secretion/ac

256 receptor complex, the latter enhancing IL-15 autocrine signaling.

257 growth of several tumor types driven by IL6 autocrine signaling.

258 intaining the stemness of stem cells through autocrine signaling.

259 r, these findings reveal a spine-autonomous, autocrine signalling mechanism involving NMDAR-CaMKII-de

260 hich they drive non-canonical, ERK-dependent autocrine signalling that is required for fibrogenic pro

261 T subsequently promotes axon regeneration by autocrine signalling through the SER-7 5-HT receptor.

262 by extracellular ATP-release and associated autocrine signalling via purinergic receptors.

263 in the tissue, is mediated by paracrine and autocrine signals mainly regulated by IL13.

264 Autocrine signals of this kind might have general and co

265 We propose that activity-dependent, autocrine signals provide neurons with continuous feedba

266 been identified as endocannabinoids and are autocrine signals that operate through cell surface G-pr

267 Our results demonstrate that autocrine STAT3 activation in IECs is mediated by the ap

268 nded on their subcellular redistribution and autocrine stimulation by cellular ATP release and was pe

269 In this study, we showed that autocrine stimulation constitutively activates the GRM1

270 ent with the plausible reduction of the VEGF autocrine stimulation of RGCs.

271 Here, we found that autocrine stimulation of the purinergic receptor P2Y11 r

272 During autocrine stimulation, the expressions of DCT and CAV1 a

273 ntial positive and negative contributions of autocrine TGF-beta signaling in insulin-responsive gene

274 may aid in the appreciation of the roles of autocrine TGF-beta signaling in normal physiological res

275 Consequently, increased autocrine TGF-beta signaling in response to insulin part

276 dissemination, we addressed to which extent autocrine TGF-beta signaling participates in insulin-ind

277 es also highlight extensive contributions of autocrine TGF-beta signaling to basal gene expression in

278 s of many genes depended on or resulted from autocrine TGF-beta signaling.

279 tructive phenotype has been shown to involve autocrine TGF-beta that triggers formation of matrix-deg

280 enefit from increased TGFbeta expression and autocrine TGFbeta signalling through effects on gene exp

281 Exogenously applied or autocrine TNC increased BTIC growth through an alpha2bet

282 eicosanoid metabolism that could serve as an autocrine trigger of inflammation and impaired late epid

283 differentiated Th1 cells to prevent abberant autocrine type I IFN and downstream signaling.

284 via 13C-labeling studies, demonstrated that autocrine type I IFN controls carbon flow through IDH in

285 Our findings have identified the autocrine type I IFN pathway as being responsible for th

286 We also demonstrate a role for autocrine type I IFN signaling in bacterial LPS-induced

287 cept that M. tuberculosis evolved to inhibit autocrine type I IFN signaling to evade host defense mec

288 unction is to transduce signals triggered by autocrine type I IFNs.

289 These results indicate an autocrine VEGF neuroprotection on RGCs.

290 Inhibition of paracrine or autocrine VEGF signaling had no effect on phospho-AKT or

291 a-derived (paracrine) and astrocyte-derived (autocrine) VEGF in controlling astrocyte proliferation a

292 ment for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the en

293 -pathway mutations, suggesting activation by autocrine Wnt ligands and/or paracrine Wnts emanating fr

294 pathway mutations, suggesting activation by autocrine Wnt ligands and/or paracrine Wnts from the BM

295 At the molecular level, blocking autocrine Wnt signaling did not affect HIFalpha-regulate

296 Our data suggest that autocrine Wnt signaling in the outer bulge maintains ste

297 ignalling in breast cancer cells, leading to autocrine Wnt signalling and CSC colony formation.

298 icient MM cells exhibited strongly decreased autocrine Wnt/beta-catenin pathway activity and reduced

299 developmental myelination by activating the autocrine Wnt/beta-catenin signaling in oligodendrocyte

300 The consequent potentiation of the autocrine Wnt/beta-catenin signalling induces the transc