ライフサイエンスコーパス: autoinhibitory

1 On the other hand, both local and autoinhibitory 5-HT(1A) binding inversely modulated the

2 in autoregulatory elements of PDZRhoGEF, the autoinhibitory "activation box" and the "GEF switch," wh

3 This autoinhibitory activity contrasts GRF-ZF domains of othe

4 a directly past the ICL is attributed to its autoinhibitory activity, caused by elongation of the sho

5 suggest the C-terminal domain may contain an autoinhibitory activity.

6 elices at the base of the active site and an autoinhibitory (AI) segment in the regulatory M domain a

7 ins characterized by an intrinsic N-terminal autoinhibitory alpha-helix.

8 on complex, the CTD transforms back into the autoinhibitory alpha-state, resetting the cycle.

9 vation, through a putative disruption of the autoinhibitory alphaL-helix on the C terminus of RSK2, u

10 r biochemical and structural analyses reveal autoinhibitory and activation mechanisms of mitochondria

11 that, similar to BRAGs, its PH domain is not autoinhibitory and strongly potentiates nucleotide excha

12 m with their catalytic Sec7 domain, which is autoinhibitory and supports a positive feedback loop in

13 Other classes of formins lack the autoinhibitory and/or Rho-binding domains and thus are l

14 e kinases is also a crucial component of the autoinhibitory apparatus.

15 Our data indicate that WASP displaces the autoinhibitory Arp3 C-terminal tail from a hydrophobic g

16 The removal of an autoinhibitory beta-hairpin loop from genotype 2a HCV NS

17 ts suggest that the role of AIM2(PYD) is not autoinhibitory, but generating a structural template by

18 itionally, we found that Mpk1 binds near the autoinhibitory C terminus of Swi4, suggesting an activat

19 via caspase-3-mediated cleavage of the Panx1 autoinhibitory C-terminal domain.

20 (PH) domain of Cdc24p, which functions in an autoinhibitory capacity, and was required, along with ot

21 We show that RIG-I uses its autoinhibitory CARD2-Hel2i (second CARD-helicase inserti

22 of the NRR, suggesting that it releases the autoinhibitory clamp on the heterodimerization domain im

23 This unfolding event enables an autoinhibitory compact H-NS conformation that blocks DNA

24 This autoinhibitory complex, with A-kinase anchoring protein-

25 preexisting plexin dimers that could act as autoinhibitory complexes.

26 This autoinhibitory configuration of RIAM can be released by

27 data provide a more complete picture of the autoinhibitory conformation adopted by full-length TEC k

28 ncement (PRE) NMR data reveal an alternative autoinhibitory conformation for the alphaN region of fre

29 ntral stalk's epsilon subunit in an extended autoinhibitory conformation in all three states.

30 In its native state, vinculin is in an autoinhibitory conformation in which domain 1 prevents i

31 The autoinhibitory conformation is common to three Neks and

32 us BTK activity by destabilizing the compact autoinhibitory conformation of full-length BTK, shifting

33 ndicates that this mutation destabilizes the autoinhibitory conformation of MET and abrogates an impo

34 g the allosteric site and in stabilizing the autoinhibitory conformation of the DH-PH unit.

35 ap70 mutation, W131A, which destabilizes the autoinhibitory conformation of Zap70, rendering the kina

36 loop segment of Csm(crRNA) adopt a proposed autoinhibitory conformation suggestive of DNase activity

37 al data suggest that alpha-catenin adopts an autoinhibitory conformation, in the absence of junctiona

38 Strikingly, the MTase domain adopts an autoinhibitory conformation, with a self-occluded cataly

39 ructural determinant of the stability of the autoinhibitory conformation.

40 ts in the chaperones and to counteract their autoinhibitory conformation.

41 inase domain and latches the protein into an autoinhibitory conformation.

42 kinase domain fragment (deltaKD) freed from autoinhibitory constraints imposed by the regulatory dom

43 sting that Thr(141) phosphorylation relieves autoinhibitory constraints that limit PKCdelta activity.

44 purified kinase domain of aPKC and relieved autoinhibitory constraints, thereby activating the kinas

45 These changes relieve autoinhibitory contacts between the N- and C-termini and

46 indicate that the N-terminal peptide exerts autoinhibitory control over rat GTPCH and is required fo

47 re-engagement of the active site zinc by the autoinhibitory Csn5 glutamate-104 diminish affinity for

48 All of the disease mutations map to the autoinhibitory diaphanous inhibitory domain.

49 Unlike TnrA, GlnR sensors mediate an autoinhibitory dimer-destabilizing interaction alleviate

50 erminus contains two regulatory domains, the autoinhibitory domain (AID) and calmodulin-binding domai

51 ng a conformational change that displaces an autoinhibitory domain (AID) from the active site, result

52 exon 4A, and the other is equivalent to the autoinhibitory domain (AID) of L-WNK1.

53 th minor changes in the glycine loop and the autoinhibitory domain (AID).

54 nucleation was identified for the Diaphanous autoinhibitory domain (DAD), which is C-terminal to the

55 An autoinhibitory domain (ID) at the extreme C terminus int

56 inactivation (VDI) due to the presence of an autoinhibitory domain (inhibitor of CDI) in the distal C

57 phorylation at Ser-617 and Ser-635 within an autoinhibitory domain (residues 595-639) in bovine endot

58 tiple Lysine residues including those in its autoinhibitory domain (SAID), leading to endocytosis and

59 Deletion of the autoinhibitory domain also doubles the maximum calmoduli

60 s the intramolecular interaction between the autoinhibitory domain and a not well defined region of t

61 challenge the previous identification of an autoinhibitory domain and show instead that Hsl1p activa

62 amino acid sequence similarity to the CaMKII autoinhibitory domain and to a CaMKII binding domain in

63 addition of phosphomimetic mutations in the autoinhibitory domain and was more sensitive to inhibiti

64 f a construct of S6K1 lacking the C-terminal autoinhibitory domain as well as full-length S6K1, revea

65 n a trans-inhibited conformation, where each autoinhibitory domain covers the kinase domain of the ot

66 Our results suggest that an autoinhibitory domain ensures the motor activity of Mfd

67 However, we found that removal of the autoinhibitory domain from Toxoplasma gondii CDPK1 is no

68 2-7 recruitment by ORC/Cdc6 is blocked by an autoinhibitory domain in the C terminus of Mcm6.

69 tion is not conserved; instead, a C-terminal autoinhibitory domain is responsible for dimerization of

70 on Tiam1, which is homologous to the CaMKII autoinhibitory domain itself.

71 ugh a direct interaction with the regulatory autoinhibitory domain of AMPK.

72 Lysine 609 in the calmodulin autoinhibitory domain of bovine eNOS mediates aspirin-st

73 he amino-terminal SAM domain functions as an autoinhibitory domain of intrinsic RhoGAP activity.

74 n mechanical pulling forces that disrupt the autoinhibitory domain of Notch, we hypothesized that, in

75 We show that Yck2p binds to the autoinhibitory domain of Sec2p, adjacent to the PI(4)P b

76 eneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamyc

77 we report the solution NMR structure of the autoinhibitory domain of WNK1 (WNK1-AI), a small regulat

78 This interaction is mediated by a pseudo-autoinhibitory domain on Tiam1, which is homologous to t

79 of activated JNK as well as enhanced p70S6K1 autoinhibitory domain phosphorylation.

80 C-terminal region that is different from the autoinhibitory domain present in all other CnA isoforms.

81 gest a conserved mechanism by which the Set2 autoinhibitory domain requires multiple Set2 interaction

82 ID mutations in DLBCL and reveal an unusual autoinhibitory domain structure and strategy for prevent

83 deletion mutants, we show that the HD is an autoinhibitory domain that blocks productive NAD(+) bind

84 the region immediately upstream of CBD is an autoinhibitory domain that maintains the closed state th

85 ated, this N-terminal region functions as an autoinhibitory domain that places DLC1 in a closed, inac

86 hat the C-terminal region of GlnR acts as an autoinhibitory domain that prevents GlnR dimerization an

87 inal domain in the wild-type enzyme being an autoinhibitory domain that upon binding the effector HPA

88 initiation factor 4G (eIF4G) functions as an autoinhibitory domain to modulate its ability to stimula

89 se domain and partial loss of the N-terminal autoinhibitory domain was identified in fibroblasts from

90 of Arg114 [me-Arg114]) within an N-terminal autoinhibitory domain were important for Ras-induced C/E

91 re the Mre11 RBD and linker domain act as an autoinhibitory domain when not in complex with Rad50.

92 ons in BTK (Cys481) and/or PLCG2 (within the autoinhibitory domain) were found in 9 patients (10.7%),

93 ing of beta-catenin exon 3, which encodes an autoinhibitory domain, induces partial skipping of the i

94 letions, located within a region encoding an autoinhibitory domain, result in protein products with c

95 Thus, rather than being an autoinhibitory domain, the C-terminus of Chk1 also conta

96 mimicking the sequence of the phosphatase's autoinhibitory domain-interfere with normal CDI.

97 promoting phosphorylation of the C-terminal autoinhibitory domain.

98 horylation of S344 in the calmodulin-binding/autoinhibitory domain.

99 rminal amino acids of NBCe1-B function as an autoinhibitory domain.

100 and motifs, or this domain together with the autoinhibitory domain.

101 ermeable peptide corresponding to the CaMKII autoinhibitory domain.

102 ts N-terminal C2 domain that functions as an autoinhibitory domain.

103 er-617 partially reverses suppression by the autoinhibitory domain.

104 nsistent with its lack of the NH(2)-terminal autoinhibitory domain.

105 p mutations) in a region encoding a proposed autoinhibitory domain.

106 Capu does not contain conserved autoinhibitory domains and can be regulated by a second

107 l unfolding and tension-dependent removal of autoinhibitory domains are common features in force-sens

108 st, N-terminal truncated CRAF (CatC) lacking autoinhibitory domains forms constitutive dimers and occ

109 is allosteric Ras-binding site is blocked by autoinhibitory domains of SOS.

110 ese data indicate that JAK pseudokinases are autoinhibitory domains that hold the kinase domain inact

111 everal classes of signaling proteins contain autoinhibitory domains that prevent unwarranted signalin

112 thermore, CEP290 activity was regulated by 2 autoinhibitory domains within its N and C termini, both

113 imited to Purkinje cells, it lacks classical autoinhibitory domains, and its FH1 domain has minimal p

114 at the post-translation level by cis-acting autoinhibitory domains, which can be relieved by protein

115 thin its negative regulatory DNA-binding and autoinhibitory domains.

116 e disparate Drp1 isoforms and alleviates the autoinhibitory effect imposed by these sequences on Drp1

117 enes induced by Treg cells that bolstered an autoinhibitory effect in Teff cells, and this induction

118 This autoinhibitory effect may play an important role in prev

119 In the context of ABL, these domains have an autoinhibitory effect on kinase activity, and mutations

120 biquitin-associated domain revealed a modest autoinhibitory effect.

121 tes from 96 to 120 hpf was investigated, and autoinhibitory effects of fluoxetine on phase I biotrans

122 activated state of CDC42, EspF(U) mimics an autoinhibitory element found within N-WASP.

123 t more complex and may involve an additional autoinhibitory element in the form of a molten globule r

124 cal and cellular analyses of the five-domain autoinhibitory element of Vav1.

125 The Ct-extension is therefore an autoinhibitory element that must re-orient during cataly

126 ding to an allosteric site that includes the autoinhibitory elements in addition to the PH domain.

127 relieved by competitive sequestration of the autoinhibitory elements in grooves at the Arf6/PH domain

128 l evidence has revealed regulatory roles for autoinhibitory elements within PLCbeta, Gbetagamma, smal

129 cardiac-specific amino terminus acted in an autoinhibitory fashion to bind MYOCD via specific negati

130 ; SA biosynthesis is negatively regulated by autoinhibitory feedback at ICS1.

131 These results are consistent with CDI as an autoinhibitory feedback mechanism against excessive Ca(2

132 ffect of ex9-39 on PYY secretion supports an autoinhibitory feedback mechanism that controls L cell s

133 This particular mechanism for autoinhibitory feedback reveals strategies and challenge

134 roplast and inhibits its own accumulation by autoinhibitory feedback.

135 ll contained MAP3K8 exons 1-8 but lacked the autoinhibitory final exon.

136 We identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbeta1, (462)L

137 Thus, this pathogen has used a simple autoinhibitory fragment as a component to build a highly

138 We show that the disordered region has an autoinhibitory function and a dimerization interface, wh

139 by promoting a closed conformation, plays an autoinhibitory function and decreases SNARE complex form

140 ease NADP(+) production through relief of an autoinhibitory function inherent to its amino terminus.

141 nylalanine residues known to be critical for autoinhibitory function of AID abolish the ability of th

142 .3 CT strongly suppresses VDF, signifying an autoinhibitory function of this part of the channel.

143 factor regulatory region, serve an essential autoinhibitory function.

144 the release of this domain and relief of its autoinhibitory function.

145 Here we show that EspF(U) binds to the autoinhibitory GTPase binding domain (GBD) in WASP prote

146 nally linked to the interactions between the autoinhibitory helix and the DH domain.

147 E280del, a single amino acid deletion in the autoinhibitory helix increased the constitutive (lipid-i

148 upted by mutation of Tyr633 within the Mint1 autoinhibitory helix leading to enhanced APP binding and

149 hat RIM binding C2A releases UNC-13L from an autoinhibitory homodimeric complex to become fusion-comp

150 homodimerization, and that RIM disrupts the autoinhibitory homodimerization forming monomeric primin

151 rystal structure of EspG in complex with the autoinhibitory Ialpha3-helix of PAK2 defines a previousl

152 tric-oxide synthase (nNOS) contains a unique autoinhibitory insert (AI) in its FMN subdomain that rep

153 SMURF2, is antagonized by an intramolecular, autoinhibitory interaction between its C2 and Hect domai

154 ral and biochemical data indicating that the autoinhibitory interaction between the N-SH2 and protein

155 tic actin nucleation factors regulated by an autoinhibitory interaction between the N-terminal RhoGTP

156 is missing in cten, and thereby releases an autoinhibitory interaction between the sterile alpha mot

157 lipid transport by releasing a charge-based autoinhibitory interaction between this domain and the S

158 ulation of FAK activity is an intramolecular autoinhibitory interaction between two of its domains--t

159 mmalian myosin V suggest that a head-to-tail autoinhibitory interaction is a primary means of regulat

160 Altogether, the results suggest that the autoinhibitory interaction of the extreme C-terminal seg

161 2-DAD is also predicted to participate in an autoinhibitory interaction with the N-terminal diaphanou

162 ough two levels of regulation, an allosteric autoinhibitory interaction, in which the VCA is sequeste

163 riphosphatases to the IS domain disrupts the autoinhibitory interactions and exposes the IS domain bi

164 main interacts with its stalk and that these autoinhibitory interactions are released upon binding of

165 utively active, truncated myoV, in which the autoinhibitory interactions between the globular tail an

166 ysin/Rvs167 (F-BAR) proteins is regulated by autoinhibitory interactions between their SRC homology 3

167 ar juxtamembrane (JM) region participates in autoinhibitory interactions that must be disrupted for t

168 nduces a conformational change that relieves autoinhibitory interactions with the ATPase motor, which

169 The tail domain of vinculin (Vt) forms tight autoinhibitory interactions with the head domain and dow

170 In the absence of stress, autoinhibitory interactions, mediated by the L3 loop, st

171 To understand these autoinhibitory interactions, we generated mutations at t

172 al rearrangement of the loop and breaking of autoinhibitory interactions.

173 talytic activity by relieving intramolecular autoinhibitory interactions.

174 However, PI(4,5)P2 does not release autoinhibitory interactions; rather, Src phosphorylation

175 substrate these activities are repressed by autoinhibitory interdomain contacts.

176 Instead, a distinct set of autoinhibitory interdomain interactions hold unliganded

177 Here we validate the significance of this autoinhibitory interface for the regulation of ZAP-70 ca

178 tations that disrupted the predicted p30-p20 autoinhibitory interface resulted in GSDMD aggregation,

179 ults directly correlate the stability of the autoinhibitory interface with the activation of these ke

180 All our PlxnA ectodomain structures show autoinhibitory, intermolecular "head-to-stalk" (domain 1

181 with phosphorylation of Ser-33 relieving an autoinhibitory intramolecular interaction within PfCRT,

182 nition motif (RRM) domains of U2AF2 mediates autoinhibitory intramolecular interactions to reduce non

183 red to a calmodulin-like domain (CLD) via an autoinhibitory junction (J).

184 orter platform for live-cell measurements of autoinhibitory kinase activity states.

185 Deleting the autoinhibitory L(1)-alpha(2) motif (or just the loop L(1

186 C-terminal 86 residues of Zuo1 fold into an autoinhibitory left-handed four-helix bundle.

187 ears to activate the enzyme by displacing an autoinhibitory loop from the iodothyronine binding site.

188 f CDC20 to APC/C is normally prevented by an autoinhibitory loop in APC1 and that its mitotic phospho

189 CS1 and SOCS3 in pDCs, indicating a possible autoinhibitory loop that impedes IFN production by pDCs.

190 ll-like receptor (TLR) agonists, creating an autoinhibitory loop that may contribute to the pathogene

191 gnaling dynamics relied on a dose-dependent, autoinhibitory loop that rendered cells refractory to fu

192 number of structural features, including an autoinhibitory loop, the C-terminal tail of the enzyme,

193 ng that IL-1beta might be involved in a like autoinhibitory loop, we determined that (1) TLR activati

194 Interestingly, NTD functions in an autoinhibitory manner during initiation, and its partial

195 al hydrophobic domain 1 (HD1) of GDAP1 in an autoinhibitory manner.

196 This reveals an autoinhibitory mechanism aimed at reducing dopamine cell

197 us to re-evaluate the current model for the autoinhibitory mechanism and the structural basis for co

198 full activation of the enzyme, suggesting an autoinhibitory mechanism for self-preservation.

199 region of MyoGEF to its DH domain acts as an autoinhibitory mechanism for the regulation of MyoGEF ac

200 Moreover, sequence analyses suggested the autoinhibitory mechanism has been evolutionarily maintai

201 Here we identified an autoinhibitory mechanism in alpha2-chimaerin that restri

202 Our findings suggest that an autoinhibitory mechanism in Mint1 is important for regul

203 mplex formation may represent an alternative autoinhibitory mechanism in the ETS family at the protei

204 ceptors and reduce further entry, through an autoinhibitory mechanism known as Ca(2+) -dependent inac

205 ks, Plk4 possesses a previously unidentified autoinhibitory mechanism mediated by a linker (L1) near

206 The structure reveals that the autoinhibitory mechanism mediated by the importin-beta b

207 h is inconsistent with a previously proposed autoinhibitory mechanism of regulation.

208 This autoinhibitory mechanism presumably evolved to prevent b

209 Our findings suggest that an autoinhibitory mechanism prevents clathrin recruitment b

210 ino acid pairing interactions are part of an autoinhibitory mechanism that holds the structure in an

211 that is unable to bind DNA, suggestive of an autoinhibitory mechanism that prevents premature activat

212 hange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like

213 This phosphorylation also releases an autoinhibitory mechanism that results in the coil-coil (

214 c interactions and regulated by an intrinsic autoinhibitory mechanism through conformational changes.

215 Our studies identify an autoinhibitory mechanism, in which unmethylated CpG dinu

216 N lobe of the catalytic domain disrupted an autoinhibitory mechanism, producing a weakly hyperactive

217 as limited our further understanding of this autoinhibitory mechanism.

218 tly binding and disrupting an intramolecular autoinhibitory mechanism.

219 ta establish how a combination of active and autoinhibitory mechanisms ensures the high fidelity of D

220 s known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biolog

221 iven the widespread regulation of kinases by autoinhibitory mechanisms, the approach described herein

222 tes the simultaneous suppression of multiple autoinhibitory mechanisms, which in turn confers added s

223 suggest that LIS1 may have coevolved with an autoinhibitory mode of cytoplasmic dynein regulation.

224 h regulatory mechanism is the presence of an autoinhibitory module, which in Ets-1 allosterically inh

225 phosphorylated pathogenic mutants reveals an autoinhibitory "molecular brake" mediated by a triad of

226 ent microtubule-binding sequence and the IAK autoinhibitory motif - are essential for development and

227 ngly, there were no indications that the IAK autoinhibitory motif acts as a general downregulator of

228 An autoinhibitory motif restrains Hsl1p activity when it is

229 bl kinase via displacement of the N-terminal autoinhibitory "myristoyl latch", may lead to an increas

230 identify a physical interaction between the autoinhibitory N terminus and the TIR domain of SARM1, r

231 t mechanism that could serve to override the autoinhibitory negative feedback regulation of ARF2 on i

232 ow that BRAF(D594G):CRAF heterodimers bypass autoinhibitory P-loop phosphorylation, which might contr

233 R from IL-6R and downregulation of the SOCS3 autoinhibitory pathway.

234 application of okadaic acid (10 nM) and CaN-autoinhibitory peptide (50 microM) did not potentiate th

235 al inner-membrane protease, PARL, removes an autoinhibitory peptide from Skd3 to greatly enhance disa

236 Displacement of the autoinhibitory peptide provides a molecular mechanism fo

237 vents that remove the C1 domain (but not the autoinhibitory PH domain) limit maximal PKD1 activity to

238 m in which the tyrosine is released from its autoinhibitory position.

239 in which the latency is maintained by their autoinhibitory pro-domains.

240 e than full-length vti1a, suggesting that an autoinhibitory process regulates vti1a function.

241 letes the removal and the degradation of the autoinhibitory prodomain and the liberation of the funct

242 ALIX activation requires dissociation of the autoinhibitory PRR and opening of the V domain arms.

243 A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical

244 type II PAKs are regulated by an N-terminal autoinhibitory pseudosubstrate motif centered on a criti

245 We have previously shown that the autoinhibitory pseudosubstrate must be removed from the

246 H-bonds that link the C-terminal tail to the autoinhibitory region (AIR) and the tandem Src homology

247 Our data suggest that dismantling this autoinhibitory region via deletion or proteolysis is the

248 stepwise fashion, first an unwinding of the autoinhibitory region, followed by a two-step unfolding

249 nlike other IRF members, IRF4 has a flexible autoinhibitory region.

250 n demonstrated that the FLAP is a functional autoinhibitory region.

251 in the cA(4) CARF-binding pocket involved in autoinhibitory regulation of RNase activity.

252 Here, we show that autoinhibitory regulation of the integrin-associated ada

253 We propose that SCF may be subject to autoinhibitory regulation, in which Nedd8 conjugation ac

254 in-frame FAM73A-BRAF fusion lacking the BRAF autoinhibitory regulatory domain but retaining an intact

255 The autoinhibitory regulatory domain of AHA2 reduced the int

256 urring between the kinase catalytic core and autoinhibitory/regulatory region.

257 action is rendered TCR-inducible by the four autoinhibitory repressive elements in the CARD11 inhibit

258 in, but was critically dependent on a single autoinhibitory residue (Leu-919) upstream of the C-termi

259 miRNA processing through the formation of an autoinhibitory RNA conformation.

260 stream of vesicle priming, revealing a novel autoinhibitory role for the C2B.

261 The large RecA2 insert played an autoinhibitory role in suppressing DHX29's intrinsic NTP

262 of Rpn11, due in part to alleviation of the autoinhibitory role of its C terminus.

263 ased platelet binding, corroborating the key autoinhibitory role of the A2 domain within VWF multimer

264 Consistent with the postulated autoinhibitory role of the JMD Tyr-559 and its relief by

265 Consistent with an autoinhibitory role of the VD, we identified Arg-376 in

266 describe biochemical evidence suggesting an autoinhibitory role played by the human CUL1 ECTD (extre

267 In contrast, Gln-316 has an autoinhibitory role, and its mutation to lysine resulted

268 hat instead plays an activating--rather than autoinhibitory--role.

269 ructural components, including an N-terminal autoinhibitory segment (AIS), four predicted cyclic nucl

270 We found that the autoinhibitory segment (AIS), located within the CBD, is

271 vation segment similar in conformation to an autoinhibitory segment observed in the hepatocyte growth

272 e similarity with other MLCKs but lacking an autoinhibitory segment.

273 its catalytic core structure rather than an autoinhibitory segment.

274 PlxnA ectodomains: imposing a pre-signaling autoinhibitory separation for the cytoplasmic domains vi

275 Here we identify a GEF-H1 autoinhibitory sequence and exploit it to produce an act

276 Binding requires deletion of an apparently autoinhibitory sequence in the Gga2p hinge.

277 nteraction with SCPL-1 required the putative autoinhibitory sequence, and immunoglobulin (Ig) and fib

278 Ca(2+)-calmodulin to the calmodulin-binding autoinhibitory sequence, which in the human PMCA is loca

279 ous mutation (R707Q) in the highly conserved autoinhibitory SH2 domain in three of 10 cases.

280 he p.Ser707Tyr substitution is located in an autoinhibitory SH2 domain that is crucial for PLCgamma2

281 Pin1 increases Raf-1 phosphorylation on the autoinhibitory site Ser259, leading to reduced MEK activ

282 This is mediated by disruption of an autoinhibitory Smurf1 homodimer and is independent of AP

283 st majority of Cb splice variants contain an autoinhibitory src homology 3 domain, and several synapt

284 rase, RfaH exists in a structurally distinct autoinhibitory state in which the RNA polymerase-binding

285 metric complex that relieves a UBA-regulated autoinhibitory state of TDP2.

286 However, the mechanism(s) that maintains the autoinhibitory state of the DDR1 dimers is unknown.

287 NSD enzymes exhibit an autoinhibitory state that is relieved by binding to nucl

288 Formation of the autoinhibitory state, and thus sequence-specific recruit

289 Free PPP5C assumes an autoinhibitory state, which has low "basal" catalytic ac

290 o adopt a conformation that destabilizes the autoinhibitory state.

291 This autoinhibitory strategy makes CARD11 highly susceptible

292 ed that the variant probably destabilizes an autoinhibitory subunit interaction, sensitizing mast cel

293 The autoinhibitory surface on the PHTH domain has been previ

294 variants are located within or close to the autoinhibitory switch domain that is necessary for trans

295 eptidyl-prolyl cis-trans isomerization as an autoinhibitory switch in the adaptor protein Crk, sugges

296 totic protein Bcl-xL and a BH3 peptide as an autoinhibitory switch that can be controlled with a smal

297 Here, we show that EB1 and the KIF17 autoinhibitory tail domain (KIF17-Tail) interacted compe

298 Thus, PHLPP, Akt, and Mst1 constitute an autoinhibitory triangle that controls the fine balance o

299 back-to-back dimerization that releases the autoinhibitory tyrosine residue, a mechanism conserved i

300 In contrast, removal of the autoinhibitory X/Y-linker region of the catalytic core o