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1 vesicular autophagic vacuoles (amphisomes or autolysosomes).
2 ted degradation of the viral proteins by the autolysosome.
3 , causing lipid droplet (LD) accumulation in autolysosomes.
4 teins (mATG8s) and are unable to mature into autolysosomes.
5 ecifically regulates the transport of mature autolysosomes.
6 ases its association with autophagosomes and autolysosomes.
7 d in a sealed state in order to become lytic autolysosomes.
8 l for the progression of autophagosomes into autolysosomes.
9 critical for autophagosomal degradation into autolysosomes.
10 de and degenerating neurites that accumulate autolysosomes.
11 d lipid accumulation within greatly enlarged autolysosomes.
12 its active, GTP-locked form associates with autolysosomes.
13 ream accumulation of autophagic vacuoles and autolysosomes.
14 l-associated membrane protein 2/p62 positive autolysosomes.
15 mpanied by robust accumulation of undegraded autolysosomes.
16 lting in a time-dependent formation of giant autolysosomes.
17 in the formation of mitochondria-containing autolysosomes.
18 res and lipid droplets within giant neuronal autolysosomes.
19 les called autophagosomes and degrades it in autolysosomes.
20 o distinguish early autophagic vacuoles from autolysosomes.
21 ic four- to fivefold increase in the size of autolysosomes.
22 gy protein 5) implicated in the formation of autolysosomes.
23 lipidated LC3 protein, and the formation of autolysosomes.
24 d monodansylcadaverine staining for late AVs/autolysosomes.
25 s oncogene display late stages of autophagy, autolysosomes.
26 CTF selectively within enlarged de-acidified autolysosomes.
27 mphisomes, and do not progress to functional autolysosomes.
28 n-1 leads to a decrease in the percentage of autolysosomes, a fusion intermediate of autophagosomes a
29 mutations in FUCA1-glycan and autophagosome/autolysosome accumulation accompanies tissue destruction
30 cells, Tsc2-deficient neurons have increased autolysosome accumulation and autophagic flux despite mT
32 unctional relevance of doxorubicin-triggered autolysosome accumulation, we studied animals with dimin
33 se process resulting from autophagosomes and autolysosomes accumulation, altered expression of mitoch
34 ted as a result of a selective impairment of autolysosome acidification and cathepsin activation.
36 , which accumulate enlarged lysosomes and/or autolysosomes also but exhibit very low levels of acid h
37 lipid droplet-containing autophagosomes and autolysosomes and defective lysosomal degradation of lip
39 RHOA is sequestered via p62 (SQSTM1) within autolysosomes and fails to localize to the plasma membra
41 me elevation including more poorly acidified autolysosomes and larger-sized lipofuscin granules, refl
42 gy markedly diminished the sizes of enlarged autolysosomes and lowered their content of GM2 gangliosi
43 features, including increased autophagosomes/autolysosomes and nuclear convolution at early stages, a
44 iated localization of the oncoprotein to the autolysosomes and subsequent degradation mediated by the
45 k-/- myoblasts was characterized by enlarged autolysosomes and the persistence of hyperextended refor
46 somal tubules and vesicles that extrude from autolysosomes and ultimately mature into functional lyso
47 s, including autophagosomes, mitophagosomes, autolysosomes, and recycling endosomes, show preferentia
49 e, markedly increased autophagosomes but not autolysosomes (assessed as punctate dual fluorescent mCh
51 esults suggest that ARV induces formation of autolysosome but does not induce complete autophagic flu
52 he degradation of the autophagosome cargo in autolysosomes, but the regulation of autophagy in respon
53 Lipids are localized in autophagosomes and autolysosomes by double immunofluorescence analyses in w
54 n early Vonsattel grade brains, but impaired autolysosome clearance in late grade brains, suggesting
57 omes to lysosomes, and impaired clearance of autolysosomes, combined with reduced neuron viability an
58 king accumulation of LC3 and LAMP-1 positive autolysosomes containing undigested cytoplasmic contents
59 vacuoles in the exocrine glands are enlarged autolysosomes containing undigested cytoplasmic material
62 ion and a lower number of autophagosomes and autolysosomes during both basal and starvation-induced a
63 ic T1D leads to glucolipotoxicity inhibiting autolysosome efflux, which in turn intensifies Nrf2-driv
64 hospho-p70S6K level, lysosome depletion, and autolysosome elevation including more poorly acidified a
65 trate that lipid-protein particle release by autolysosome exocytosis protects neurons from ferroptosi
67 ermore, Cys951Ser mutation of ULK1 decreased autolysosome formation and promoted hepatic lipid accumu
68 Our study reveals a mechanism for regulating autolysosome formation by DRAM1-VAMP8 association and su
70 correlated with increased autophagosome and autolysosome formation in renal tubular epithelial cells
72 a, an autophagy protein that is critical for autolysosome function and clearance, is required for Pur
73 r via genetic inhibition of autophagosome-to-autolysosome fusion or expression of SARS-CoV-2 ORF3a, i
74 ant role in both autophagosome formation and autolysosome fusion, in induction of LC3II, a marker of
75 lutionarily conserved Wnt pathway to inhibit autolysosome generation, thereby leading to evasion of t
76 l features of early and late autophagosomes (autolysosomes), had little or no overlap with ubiquitin,
77 es, and these autophagosomes can mature into autolysosomes; however the autophagosomes are very small
78 de new evidence for the participation of the autolysosome in LD metabolism and demonstrate a novel ro
82 of autophagosomes and their maturation into autolysosomes in the absence of increased cell death.
83 ophagic flux and an accumulation of enlarged autolysosomes in the last instar larval and prepupal fat
84 cifically associated with autophagosomes and autolysosomes (in the absence of conditions stimulating
86 on of nonesterified cholesterol in lysosomes/autolysosomes, its depletion in the plasma membrane, and
87 acidification slowed the axonal transport of autolysosomes, late endosomes, and lysosomes and caused
88 ochrome c oxidase), autophagosome (p62), and autolysosome (lysosomal associated membrane protein 2) p
89 teins and other autophagic substrates within autolysosomes/lysosomes and reduced intraneuronal amyloi
90 mes while increasing numbers of normal-sized autolysosomes/lysosomes with reduced content of undigest
92 d that the LRRK2-R1441C-mediated decrease in autolysosome maturation is not dependent on LRRK2 kinase
94 Runx2 accumulation was seen in LC3 positive autolysosomes present within cells that had been treated
95 rient deprivation, active cathepsin-positive autolysosomes rather than LC3-II-positive autophagosomes
97 ipartite complex, or late stage formation of autolysosomes, rescued VP40 VLP egress back to WT levels
98 mal trafficking of EGFR and the formation of autolysosomes responsible for the degradation of interna
99 hagy and phytohormone gibberellin), lysosome/autolysosome staining, and germination experiments revea
100 usion with mature autophagosomes to generate autolysosomes that degrade autophagic materials; therefo
101 les cells to degrade pieces of themselves in autolysosomes to enable their survival in times of stres
102 tion, a matter flux of Pt(2) L escaping from autolysosomes to nucleus was observed, which represents
105 ional interconversion of PI(4)P/PI(4,5)P2 on autolysosomes was integral to lysosome replenishment and
108 and bulk ubiquitinated cytosolic proteins to autolysosomes where they were proteolytically converted
109 bstantially in the acidic environment of the autolysosomes, whereas bright RFP signals remained.
110 nstead promote the generation of degradative autolysosomes, which are the endpoint compartments of au
111 ponents and then fuse with lysosomes to form autolysosomes, which degrade their contents to regenerat
112 ion of lysosomes with autophagosomes to form autolysosomes, which is crucial for the completion of th
113 cence, and eliminates giant lipid-containing autolysosomes while increasing numbers of normal-sized a
114 biting cathepsin-mediated proteolysis within autolysosomes with cysteine- and aspartyl-protease inhib
115 te the nuclear accessibility of Pt(2) L form autolysosomes with photo-selectivity, which provides a n