ライフサイエンスコーパス: autophagy

1 nd invasion) through anti-glycolysis and pro-autophagy.

2 s restored by genetic inhibition of AMPK and autophagy.

3 tain muscle mitochondrial function and limit autophagy.

4 in skeletal muscle, but are not deficient in autophagy.

5 signaling inhibitor, suppressed IAP-induced autophagy.

6 om cell division to lysosome degradation and autophagy.

7 ptor PPARalpha to transcriptionally activate autophagy.

8 ellular senescence, mitotic catastrophe, and autophagy.

9 cids to control cell growth, metabolism, and autophagy.

10 or assembly and mTORC1 activation, promoting autophagy.

11 nistic studies of the roles of polyamines in autophagy.

12 (9)-tetrahydrocannabinol by inhibiting local autophagy.

13 However, it is not known whether IAP induces autophagy.

14 itro and in vivo with allo-antigens enhances autophagy.

15 depended on AMPK but not on its function in autophagy.

16 he down-regulation of these inflammasomes by autophagy.

17 the two systems that eventually merge during autophagy.

18 ntrols axon branching by controlling locally autophagy.

19 IV through the induction of MTOR-independent autophagy.

20 s a protective effect in GBM by upregulating autophagy.

21 E-PE, promoted LC3-I lipidation to stimulate autophagy.

22 by TRAF2, cIAP1 and cIAP2, thereby reducing autophagy.

23 tophagosome, which is the functional unit of autophagy.

24 key trafficking events and are required for autophagy.

25 ion of IgG mRNA, but rather to impairment of autophagy.

26 master regulator of lysosomal biogenesis and autophagy.

27 MPK is a central regulator of metabolism and autophagy.

28 d the role of CARM1 in nuclear regulation of autophagy.

29 spite equivalent infections through enhanced autophagy.

30 e cells into the stationary phase and induce autophagy.

31 argeted proteasomal degradation to a role in autophagy.

32 master regulator of lysosomal biogenesis and autophagy(4,5), is phosphorylated by mTORC1 via a substr

33 We show here that autophagy, a pathway allowing the lysosomal degradation

34 e type-Ia (GSD-Ia) leads to impaired hepatic autophagy, a recycling process important for cellular me

35 Autophagy-a lysosomal degradation pathway that maintains

36 and is best known for its role in regulating autophagy against intracellular pathogens.

37 tionally viewed as an autodigestive pathway, autophagy also facilitates cellular secretion; however,

38 lective breakdown of lipid droplets (LDs) by autophagy (also called lipophagy) is a key process utili

39 Autophagy, an evolutionarily conserved cellular process

40 lular stresses by maintaining high levels of autophagy, an intracellular lysosome-dependent degradati

41 Both autophagy and alphaKlotho antagonizes phosphotoxicity.

42 he role of soluble proteoglycan in affecting autophagy and angiogenesis.

43 these responses and related pathways such as autophagy and apoptosis.

44 metabolic resources via increased transport, autophagy and biomolecular condensation.

45 modulator tamoxifen as a result of increased autophagy and decreased expression of estrogen receptor-

46 Investigating the interactions between autophagy and disease pathogenesis is thus a critical ar

47 growth factor beta pathway, which activates autophagy and enhances the clearance of misfolded protei

48 Mitf/TFEB nuclear import, thereby disrupting autophagy and exacerbating proteostasis defects in C9-AL

49 on of FGF21 in obese mice improves defective autophagy and hepatosteatosis in a JMJD3-dependent manne

50 enes in M. tuberculosis resulted in enhanced autophagy and improved intracellular survival rates comp

51 AMTOR1 silencing or mTOR inhibition restores autophagy and induces apoptosis in p27(-/-) cells.

52 ally links nutrient deprivation with hepatic autophagy and lipid degradation in mammals.

53 ha agonist, fenofibrate, on liver and kidney autophagy and lipid metabolism in 5-day-old G6pc -/- mic

54 To assess the role and cross-talk between autophagy and Lkb1 in normal tissue homeostasis, we gene

55 Taken together, we demonstrated that autophagy and Lkb1 work synergistically to maintain adul

56 in proteasome system performance rather than autophagy and may provide a novel therapeutic target to

57 Lacritin monomer restores homeostasis via autophagy and mitochondrial fusion and promotes basal te

58 unifying model to inform the future study of autophagy and mTORC1 during mitosis.

59 Fenofibrate also induced autophagy and promoted beta-oxidation of fatty acids and

60 beta(2) -adrenoceptor agonists improve autophagy and re-establish proteostasis in cardiac cells

61 SCs clear myelin via autophagy and recent literature has demonstrated that ca

62 nce indicates Bcl2 mediates exercise-induced autophagy and skeletal muscle adaptions to training duri

63 with increases in the cellular activities of autophagy and some lysosomal hydrolases.

64 ation, restriction of protein degradation by autophagy and subsequent N remobilization.

65 inant-negative loss-of-function mechanism in autophagy and that UBQLN2 functions as an important regu

66 Ambra1 is considered an autophagy and trafficking protein with roles in neurogen

67 Maize rtn2 mutants display increased autophagy and up-regulation of an ER stress-responsive c

68 that control inflammation, neuronal injury, autophagy and vesicular transport genes are observed in

69 To examine the interplay between Pi, autophagy, and alphaKlotho, we used the BK/BK mouse (hom

70 and altered expression of the immune system, autophagy, and apoptosis pathway transcripts, indicating

71 ed biological processes, such as DNA repair, autophagy, and energy metabolism.

72 /kl) with impaired urinary Pi excretion, low autophagy, and premature organ dysfunction.

73 letion, global hypomethylation, induction of autophagy, and robust poly(ADP-ribose) polymerase (PARP)

74 compartments, how local machinery regulates autophagy, and the impact of coordinated regulation on n

75 rescued the activity of NHEJ-DDR proteins in autophagy- and PTEN-deficient cells.

76 In cancer, the roles of autophagy are context dependent.

77 dietary influences on protein synthesis and autophagy are critical determinants of LRRK2 neurodegene

78 We describe how the steps of autophagy are distributed across neuronal subcellular co

79 r findings demonstrate how primary cilia and autophagy are involved in the translation of mechanical

80 rivation conditions, the dominant effects on autophagy are mediated by decreased raptor acetylation c

81 Apoptosis and autophagy are two key elements involved in ischemic brai

82 asis in cardiac cells; therefore, suggesting autophagy as a downstream effector of beta(2) -adrenocep

83 This unbiased approach identified autophagy as a major HIF-1-targeted pathway in IEC.

84 Here, we explored autophagy as a mechanism to reduce tau burden in human n

85 e conclude by discussing targeting selective autophagy as an emerging therapeutic modality in NDDs.

86 Thus, our data identify AMPK and autophagy as targetable components of ADOA pathogenesis.

87 LC3 and homologs) on double membranes during autophagy as well as on single membranes during LC3-asso

88 Recent research has shown that degradative autophagy, as well as various combinations of autophagy

89 thway that requires the induction of several Autophagy (ATG) genes.

90 Unlike Atg1's role in autophagy, Atg1-mediated phosphorylation of Yorkie does

91 ults indicate that the ROS-ATM-CHK2-Beclin 1-autophagy axis serves as a physiological adaptation path

92 In strains defective for autophagy, beta5-GFP tagged proteasomes, unlike other CP

93 duce migration and invasion rates because of autophagy blockade only in BRAF(V600E)-mutant melanoma c

94 Recent findings that autophagy blocks mouse liver injury from lipopolysacchar

95 ysosomes, decreases apoptosis, and activates autophagy, but it does not rescue the defect in cystine

96 an established AMPK agonist that can promote autophagy, but its effects on the course of CKD have bee

97 ibitor p27(Kip1) promotes starvation-induced autophagy by an unknown mechanism.

98 wing pre-meiotic DNA replication, we blocked autophagy by chemical inhibition of Atg1 kinase or engin

99 n-aging H. vulgaris animals, the blockade of autophagy by knocking down WIPI2 suffices to induce agin

100 These findings indicate that HuR regulates autophagy by modulating ATG16L1 translation via interact

101 ngly suggest that the negative regulation of autophagy by sulfide is mediated by specific persulfidat

102 The most studied type of autophagy, called macroautophagy, involves membrane mobi

103 odulating functions, excessive activation of autophagy can also be detrimental.

104 Autophagy can be regulated by several energy sensing pat

105 Moreover, autophagy can play opposing roles in the tumor microenvi

106 Autophagy can protect stressed cancer cell by degradatio

107 Autophagy captures intracellular components and delivers

108 ophagy-dependent mechanism that involves the autophagy cargo receptor NBR1.

109 es tau by inhibiting self-interaction of the autophagy cargo receptor p62/SQSTM1, impeding p62 autoph

110 ed adipose atrophy and how altered adipocyte autophagy contributes to alcohol-induced liver injury re

111 Dysregulated autophagy contributes to the pathogenesis of acute kidne

112 at associates with vesicular trafficking and autophagy defects.

113 Conditional autophagy deficiency in adult mice causes liver damage,

114 s demonstrate that diabetes over time causes autophagy deficiency, which turns off Nrf2-mediated defe

115 Autophagy-deficient cells secreted increased amounts of

116 Also, autophagy-deficient ILC2s were adoptively transferred in

117 Autophagy degrades many of the toxic, aggregate-prone pr

118 ely targeted for lysosomal degradation by an autophagy-dependent mechanism that involves the autophag

119 trikingly, mice and flies lacking functional autophagy develop early onset progressive neurodegenerat

120 ion polymerase chain reaction for markers of autophagy, DNA damage, cell proliferation, and inflammat

121 s one of the first reports showing a role of autophagy during early neural circuit development and su

122 to our understanding of the requirements for autophagy during flavivirus infection.IMPORTANCE Flavivi

123 tive approaches for monitoring intracellular autophagy dynamics, as a comprehensive account of method

124 Macroautophagy and selective autophagy (e.g., mitophagy, aggrephagy) can influence ce

125 Inhibition of autophagy, either genetically or pharmacologically with

126 Boosting autophagy, either pharmacologically (with temsirolimus)

127 where we can conditionally delete Stk11 and autophagy essential gene, Atg7, respectively or simultan

128 ein receptor-mediated clustering of upstream autophagy factors drives continued autophagosome formati

129 es restored the Abeta-induced impairments on autophagy flux and apoptosis in a calcium-dependent mann

130 Autophagy flux assays revealed that NUB1 affected the au

131 t alpha-synuclein preformed fibrils impaired autophagy flux by upregulating PELI1, which in turn, res

132 hagy cargo receptor p62/SQSTM1, impeding p62 autophagy flux.

133 proteolysis, calcium homeostasis, and normal autophagy flux.

134 o its negative regulator BCL2, which impairs autophagy flux.

135 chronic ethanol consumption on apoptosis and autophagy following transient focal cerebral ischemia.

136 ic flux in TNBC cells that were dependent on autophagy for survival and displayed synergistic cytotox

137 The beneficial effects of heightened autophagy from Becn1(F121A) was abolished by chronic hig

138 ion-specific programs influenced by the core autophagy gene Atg16L1 and its T300A coding polymorphism

139 Using conditional mice models lacking the autophagy gene Atg7 specifically in all intestinal epith

140 autophagy regulation, epigenetic control of autophagy gene transcription remains unclear.

141 Deletion of essential autophagy genes increased the sensitivity of mouse mamma

142 can work in the distal regions and activate autophagy genes through enhancer activation.

143 Thus, select autophagy genes, but not all genes essential for degrada

144 utophagy, as well as various combinations of autophagy genes, regulate immunity and inflammation(5-12

145 Finally, a genetic signature of autophagy had negative prognostic value in patients with

146 However, questions remain about whether autophagy has a protective or a pathological role in kid

147 Autophagy has been implicated in acute kidney injury, wh

148 in various neurodegenerative disorders where autophagy has been studied using hiPSC models.

149 ranscriptional and epigenetic regulations of autophagy have emerged as essential mechanisms for maint

150 but not all genes essential for degradative autophagy, have a key function in maintaining immune qui

151 and PPAR-alpha signaling are responsible for autophagy impairment but mTOR is involved minimally.

152 Taken together, these data show that hepatic autophagy impairment in GSD-Ia is mediated by downregula

153 at both pre-tumor and tumor stages, hepatic autophagy impairment was attributed to downregulation of

154 Recent efforts to target autophagy in cancer have focused on kinase inhibition, w

155 a mechanistic basis for reports of selective autophagy in cells lacking the lipidation machinery, whe

156 r RNAs (mRNAs) encoding proteins involved in autophagy in colonic mucosal tissues from patients with

157 However, the role of autophagy in epidermal proliferation, particularly under

158 Interference with autophagy in experimental models, but also during the pa

159 neural circuit development and suggests that autophagy in general plays a much more prominent role du

160 gress in understanding the roles of neuronal autophagy in homeostatic maintenance of synaptic functio

161 Basal autophagy in kidney cells is essential for the maintenan

162 It then examines the extended role of autophagy in neuronal function, plasticity, and memory.

163 w, we focus on the cell biological course of autophagy in neurons, from biogenesis at the synapse to

164 The primary drivers of autophagy in states of nutrient and oxygen deprivation-s

165 CC)-derived perivascular cells in the brain, autophagy in the retina, viral gene delivery, and chemic

166 PRRSV-induced autophagy in thymic epithelial cells modulates the devel

167 scle insulin sensitivity along with enhanced autophagy (increased LC3 and LC3-II/I ratio, and decreas

168 p) has been implicated in maintenance of the autophagy-inflammasome axis in innate murine immune cell

169 Indeed, survival of autophagy-inhibited HCMV-infected monocytes was rescued

170 d provide a rationale for the combination of autophagy inhibition and dual ICB therapy as a therapeut

171 Here we demonstrate that systemic autophagy inhibition induces the premature acquisition o

172 mour sites and are thus promising agents for autophagy inhibition-based combination therapy.

173 As clinically useful autophagy inhibitors are elusive, our findings suggest t

174 e 8, which was maintained in the presence of autophagy inhibitors.

175 sting an evolutionary similarity between the autophagy-initiating TBK1 kinase and the ULK1 kinase com

176 ings in the context of its role in selective autophagy initiation and autophagosome formation.

177 In pancreatic cancer, selective autophagy instead reroutes MHC-I to lysosomes, using the

178 Autophagy is a cellular homeostatic program for the turn

179 Autophagy is a cellular process that preserves cellular

180 Autophagy is a highly conserved intracellular clearance

181 Autophagy is an evolutionarily conserved process that pl

182 Autophagy is an intracellular degradation pathway crucia

183 Disruption of autophagy is associated with neuronal dysfunction and ne

184 Dysregulation of autophagy is associated with several ocular diseases inc

185 Although autophagy is being pursued as a therapeutic target in cl

186 Additionally, as autophagy is enhanced and inhibited by these effectors,

187 specific removal of organelles via selective autophagy is important to maintain neuronal homeostasis.

188 Autophagy is inhibited during NMDAR-LTD to decrease endo

189 duced markers of DNA repair, indicating that autophagy is required for bacteria-induced DNA damage re

190 Here, we show that autophagy is specifically induced in vaccine-induced ant

191 Autophagy is traditionally depicted as a signaling casca

192 Macroautophagy (referred to hereafter as autophagy) is an intracellular degradation pathway in wh

193 tional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage respo

194 that the DAP1 risk allele mediates enhanced autophagy, leading to the survival of autoreactive lymph

195 s enhanced and inhibited by these effectors, autophagy likely has different functions throughout infe

196 mitigates lethal intestine degeneration upon autophagy loss.

197 flux assays revealed that NUB1 affected the autophagy-lysosomal pathway primarily via the UBA domain

198 ated with deficient ubiquitin-proteasome and autophagy-lysosomal systems), neuroinflammation and oxid

199 Importantly, the autophagy-lysosome pathway contributes to the loss of SI

200 The autophagy-lysosome system has been identified as a main

201 ly, we show that, somewhat unexpectedly, the autophagy machinery is necessary for the normal formatio

202 assing the requirement of canonical upstream autophagy machinery.

203 hown that Vps13 acts after Atg40 engages the autophagy machinery.

204 ve autophagy receptors but requires the core autophagy machinery.

205 t/mTOR pathways, and increased expression of autophagy markers, leading to an increased apoptosis rat

206 the framework for investigating how IAP and autophagy may act together to control inflammatory condi

207 While it has been suggested that autophagy may elicit cardioprotective and pro-survival m

208 ynamics of individual dendrites and that the autophagy mechanism may be leveraged by delta-catenin an

209 h among individual dendrites and engages the autophagy mechanism to sculpt the developing dendritic a

210 n that reveals a main role in the control of autophagy mediated by the autophagy-related (ATG) Cys pr

211 y crisis and renewal of energy resources via autophagy-mediated catabolism.

212 hat maize Rtn1 and Rtn2 act as receptors for autophagy-mediated ER turnover, and thus are critical fo

213 thylation of histone H3K27-me3, resulting in autophagy-mediated lipid degradation.

214 The effects of these autophagy-modifying agents and azithromycin in neutrophi

215 ckout mouse models and viral vector-mediated autophagy-modulating strategies in vivo showed that cann

216 ing, JMJD3 epigenetically upregulates global autophagy-network genes, including Tfeb, Atg7, Atgl, and

217 Autophagy of the ER (ER-phagy) is implicated in human ne

218 models, reducing proliferation and inducing autophagy of the tumor cells.

219 Our findings demonstrate a role for enhanced autophagy or lysosome function in immune evasion by sele

220 operties are necessary for an Ede1-dependent autophagy pathway for endocytic proteins, which differs

221 Moreover, the caspase-autophagy pathway is engaged by fear conditioning to fac

222 is now recognised that perturbations of the autophagy pathway itself can also lead to neurodegenerat

223 Targeting the autophagy pathway may have therapeutic benefit in the tr

224 ic disorders of key proteins involved in the autophagy pathway, and disorders within pathways that cr

225 NbP3IP degraded p3 through the autophagy pathway, thereby affecting the silencing suppr

226 results identify an mTOR-responsive neuronal autophagy pathway, wherein RILP integrates the processes

227 aching consequences for a range of selective autophagy pathways critical for the normal functioning o

228 sing apart at what stages of differentiation autophagy plays a critical role.

229 As one of the major degradation pathways, autophagy plays a pivotal role in maintaining effective

230 Collectively, autophagy plays a positive role in epidermal proliferati

231 However, whether autophagy plays a role in alcohol-induced adipose atroph

232 omeostatic link between oxidative stress and autophagy plays an important role in cellular responses

233 Autophagy plays an important role in myogenesis, but the

234 Autophagy plays critical roles in the maintenance of end

235 hways and cellular organelles underlying the autophagy process, be it as signaling platforms or throu

236 ate mechanisms by which decreased hepatocyte autophagy promotes IL-1beta/TNF-induced necrosis from im

237 itochondrial RNA or DNA depletion; moreover, autophagy promotes survival in this condition.

238 We previously showed that the autophagy protein ATG16L1 is necessary for protection ag

239 at AP-4 mediates export of the transmembrane autophagy protein ATG9A from the TGN to preautophagosoma

240 )-is upregulated during exercise, and a core autophagy protein, beclin 1, is required for AMPK activa

241 serve as scaffolds for binding of other core autophagy proteins and various effector proteins involve

242 oxicity and co-aggregation of proteasome and autophagy proteins to GA aggregates.

243 ch leads to phosphorylation of the major pro-autophagy proteins ULK1 and Beclin-1 (BECN1), increased

244 ophagy, specifically on cargo recognition by autophagy receptor proteins p62 and NBR1 (neighbour of B

245 lly expressed in the brain compared to other autophagy receptor proteins.

246 We compared the requirements for autophagy receptor proteins: OPTN, NBR1, p62, NDP52, and

247 n of TRIM2 (an E3 ligase) and optineurin (an autophagy receptor), which mediate the selective regulat

248 ocytic protein Ede1 functions as a selective autophagy receptor.

249 A number of selective autophagy receptors (SARs) have been characterized that

250 s and does not involve other known selective autophagy receptors but requires the core autophagy mach

251 roautophagy (hereafter called ER-phagy) uses autophagy receptors to selectively degrade ER domains in

252 e findings define a novel mechanism by which autophagy regulates neuronal activity: control of intrin

253 ting transcription factor YAP/Yorkie and the autophagy-regulating kinase Ulk1/Atg1.

254 the emerging importance of nuclear events in autophagy regulation, epigenetic control of autophagy ge

255 hat mammalian Atg8 proteins (mAtg8s) and the autophagy regulator IRGM control TFEB, a transcriptional

256 cancer models to temporally delete essential autophagy regulators during carcinoma progression.

257 rather than by altered acetylation of other autophagy regulators.

258 er90/Ser93, thereby impairing Beclin 1-Bcl-2 autophagy-regulatory complex formation in a ROS-dependen

259 in the control of autophagy mediated by the autophagy-related (ATG) Cys protease AtATG4a.

260 We found significant downregulation of autophagy-related genes particularly, autophagosome comp

261 LK1 and ULK2 have major differences in their autophagy-related interactors and their post-translation

262 between the LD surface protein (NoLDSP) and AUTOPHAGY-RELATED8 (NoATG8) protein and show a role of m

263 nisms and signalling pathways underlying the autophagy response in different types of kidney cells an

264 is a critical regulator of inflammatory and autophagy responses in HD.

265 nscriptomic analyses, we identified numerous autophagy-responsive proteins, which revealed processes

266 Remarkably, autophagy restoration provides a near complete recovery

267 Importantly autophagy-restored mice still succumb earlier due to an

268 xpression in G6pc-/- mice corrects defective autophagy, restores SIRT1/FoxO3a/AMPK/PPAR-alpha signali

269 atic SIRT1 overexpression corrects defective autophagy, restores the expression of FoxO3a and liver k

270 strated that the promotive effect of RSK2 on autophagy resulted from directly binding of AMPKalpha2 i

271 lipopolysaccharide led to an examination of autophagy's function in hepatotoxicity from proinflammat

272 sychoactive ingredient of cannabis, disrupts autophagy selectively in the striatum, a brain area that

273 Autophagy, self-eating, is a pivotal catabolic mechanism

274 However, whether autophagy should be inhibited or activated for cancer th

275 s a key serine/threonine kinase activated by autophagy stimuli and that it catalyzes phosphorylation

276 However, we find that a subset of autophagy substrates remains robustly targeted to the ly

277 surface are needed for assembly of selective autophagy substrates.

278 Therefore, deciphering the mechanisms of how autophagy supports tumor cell metabolism is essential.

279 /FTD etiology, including the proteasomal and autophagy systems.

280 autophagosomes for degradation via selective autophagy (termed synucleinphagy).

281 evels of mRNAs encoding proteins involved in autophagy than colonic mucosa without these bacteria.

282 bition of MTOR has modulatory effects beyond autophagy that might affect viral replication.

283 unction as signaling molecules that regulate autophagy through ataxia-telangiectasia mutated (ATM) an

284 ders within pathways that critically control autophagy through monitoring of the supply of nutrients

285 ng of axon branches by spatially controlling autophagy, thus directly controlling formation of neural

286 TORC1 and mTORC2, which negatively regulates autophagy to facilitate ZIKV replication.IMPORTANCE The

287 ether, these data indicate that HCMV induces autophagy to prevent necroptotic cell death in order to

288 We explored the potential for autophagy to regulate budding yeast meiosis.

289 wever, the role of host factors in mediating autophagy to suppress viruses is poorly understood.

290 n of the intracellular replication of HIV by autophagy, trehalose decreased viral entry in human prim

291 y effects of the MTOR-independent inducer of autophagy, trehalose.

292 Our findings demonstrate that ATG5-dependent autophagy uncouples T-cell proliferation from its effect

293 SP55 in unconventional protein secretion and autophagy under stress or pathological conditions.

294 ing results in many disease models, in which autophagy upregulation is able to reduce the levels of t

295 au, and others, raising the possibility that autophagy upregulation may help to reduce levels of toxi

296 Sustained pharmacological inhibition of autophagy using Chloroquine (50 mg kg(-1) day(-1) ) abol

297 Here we find that p27 controls autophagy via an mTORC1-dependent mechanism in amino aci

298 s demonstrated that calcineurin can regulate autophagy via dephosphorylation of transcription factor

299 n most cell types we examined, Leu regulates autophagy via the impact of its metabolite AcCoA on mTOR

300 We tested the hypothesis that IAP may induce autophagy which may mediate the anti-inflammatory effect