ライフサイエンスコーパス: autopsy

1 D-19 (10 of whom were selected at random for autopsy).

2 ples before death and their bodies for rapid autopsy.

3 ally, FM was almost exclusively diagnosed at autopsy.

4 s currently exist, and diagnosis requires an autopsy.

5 majority of SCD cases diagnosed with ACM at autopsy.

6 between these CSF markers and tau burden at autopsy.

7 beta-amyloid and tau burden were measured at autopsy.

8 ociated with cerebral microinfarcts on brain autopsy.

9 odels based on vital registration and verbal autopsy.

10 nction was confirmed by echocardiography and autopsy.

11 d changes in coding practices and performing autopsy.

12 and arterial wall thickness obtained during autopsy.

13 associated multicentric Castleman disease at autopsy.

14 oners, PMCTA could be used to avoid invasive autopsy.

15 is associated with AD pathologic findings at autopsy.

16 ved xenografts at diagnosis, recurrence, and autopsy.

17 Each case was assessed by PMCTA, followed by autopsy.

18 aneurysm that was found on her grandmother's autopsy.

19 d normal brain pathologic characteristics at autopsy.

20 ations should include both PMCT and invasive autopsy.

21 , whole blood) are not retained routinely at autopsy.

22 one-quarter of MCI cases showed "pure" AD at autopsy.

23 -49 years) since January, 2008, using verbal autopsy.

24 Ocular tissue was obtained from 1 patient at autopsy.

25 rn consistent with tau pathology observed at autopsy.

26 Sixteen (5%) had an autopsy.

27 imer neuropathological change) at subsequent autopsy.

28 ng of human coronary arteries with stents at autopsy.

29 rtality among deceased children using verbal autopsy.

30 extualized by premortem AC among consecutive autopsies.

31 try-level vital registration data and verbal autopsies.

32 le derived from healthy and DM1 biopsies and autopsies.

33 focal kidney fibrin thrombi in 6 of 42 (14%) autopsies.

34 replicated in an independent data set of 369 autopsies.

35 rs560380, P=3.8 x 10(-8)) in 909 prospective autopsies.

36 omes and describe thromboembolic findings on autopsies.

37 harbor pathogens, including those performing autopsies.

38 Of 26 autopsies, 11 (42%) had thromboembolic disease not clini

39 threads but only in the patient who came to autopsy 16 years post-transplantation.

40 atients with Parkinson's disease who came to autopsy 18 months and 16 years post-transplantation.

41 m were diagnosed with Alzheimer's disease at autopsy (70%).

42 o Huntington's disease patients, who came to autopsy 9 and 12 years post-transplantation, and two pat

43 ll as other candidate SUD genes in molecular autopsy analyses.

44 Further investigation with autopsy analysis will help illuminate the binding target

45 Broad-scale systematic autopsies and long-term rhythm monitoring may clarify th

46 We reviewed light microscopy findings in all autopsies and performed immunofluorescence, electron mic

47 Of 1848 deaths, 85% had an autopsy and 99.7% were assigned a level of preventabilit

48 We analyzed archival autopsy and biopsy tissue from 21 MS patients.

49 The yield of combined molecular autopsy and clinical evaluation in 82 surviving families

50 om human cerebral cortex samples obtained at autopsy and during neurosurgical procedures.

51 hed with microscopic histopathology, both by autopsy and experimentation, to primarily originate from

52 isease Neuroimaging Initiative who underwent autopsy and for whom (18)F-FDG PET (30 AD, 6 MCI, 2 cogn

53 Participants were followed to autopsy and had a neuropathological diagnosis of FTLD-Ta

54 Maternal death was ascertained via verbal autopsy and HIV status at delivery via annual HIV survey

55 cally manifest cardiac involvement, although autopsy and imaging studies suggest a significantly high

56 g Center cohort study who died and underwent autopsy and met inclusion and exclusion criteria.

57 rom 213 patients who had been followed up to autopsy and met inclusion criteria of Lewy body disorder

58 ortem examinations (both complete diagnostic autopsy and minimally invasive tissue sampling).

59 Genetic data, as well as autopsy and neuroimaging studies in patients with AD, in

60 The frequency of autopsy and PMCTA discrepancies were not significantly d

61 Mortality was assessed by using verbal autopsy and public records.

62 ollect brain samples without performing full autopsy and show that a test currently marketed for vete

63 inical isolated cardiac amyloidosis (ICA) at autopsy and the odds of AF in these patients.

64 SADS) describes a sudden death with negative autopsy and toxicological analysis.

65 from coronial and police reports, alongside autopsy and toxicology analyses where available.

66 is that most studies are derived from human autopsy and/or organ donor samples, which lack in vivo f

67 WEMA (Whole-Exome Molecular Autopsy) and surveillance of cardiac channelopathy and c

68 tem laboratory and pathology testing, verbal autopsy, and clinical and demographic data.

69 ly, we comment on the future of the research autopsy as an integral component of precision medicine s

70 completed annual cognitive testing and were autopsied at death.

71 rain were obtained retrospectively from cats autopsied at the Iowa State College of Veterinary Medici

72 ased assessments of stillbirths using verbal autopsy at the state level in India.

73 rogressive multiple sclerosis directly after autopsy, at 3 T, using T1 and proton-density/T2-weighted

74 All patients underwent antemortem CT and autopsy between March 9 and April 30, 2020.

75 matter lesions of human progressive MS (PMS) autopsy brain tissues and iPS-derived NPCs from patients

76 ticles from three sources: consecutive rapid autopsy brains from the Adult Changes in Thought Study,

77 In DM2 autopsy brains, LPAC is found in neurons, astrocytes, an

78 tissue (FFPET) is ubiquitously collected at autopsy, but DNA quality hampers its use with traditiona

79 with multiple co-morbid neuropathologies at autopsy, but the impact of these pathologies on cognitiv

80 rtem plasma cell-free DNA sequencing (liquid autopsy) can be a novel platform for cancer research and

81 h is usually disposed of during conventional autopsies, can provide valuable data if sequenced in det

82 n this longitudinal retrospective study, 557 autopsied cases with Alzheimer's disease neuropathologic

83 n-matched samples from neurologically normal autopsy cases (n = 22).

84 Analysis of transcriptomic data from autopsy cases and animal models confirms that immunosupp

85 Between 2005 and 2012 autopsy cases of former boxers and American football pla

86 Fourteen autopsy cases with cerebral amyloid angiopathy (mean age

87 stasis pairs, and transcriptomic data from 4 autopsy cases with metastatic NSCLC and one metastatic l

88 We performed histopathologic assessment of autopsy cases, surface marker-based phenotyping of neutr

89 were present in the post-mortem plasma of 12 autopsy cases.

90 After sudden cardiac death with negative autopsy, clinical screening of relatives identifies a hi

91 re compared to SUVRs derived from young, non-autopsy, cognitively normal controls used as a standard

92 or amyloid, tau, and neurodegeneration in an autopsy cohort of 118 Alzheimer's disease patients (98 a

93 In an autopsy cohort of PPA (FTLD-TDP = 13, FTLD-Tau = 14), we

94 We therefore report the largest feline autopsy cohort to date of 32 cats ranging from 1.5 to 22

95 A practical challenge is that different autopsy cohorts are composed of disparate groups of rese

96 In community-based autopsy cohorts, ~25% of brains had sufficient burden of

97 In summary, PET-to-autopsy comparisons confirm that 18F-flortaucipir PET is

98 ral or similar), interventions (colonoscopy, autopsy), comparisons (world regions, alternative polyp

99 icantly increased in COVID-19, and pulmonary autopsies confirmed NET-containing microthrombi with neu

100 The autopsy confirmed all the above mentioned ultrasound fea

101 ifferentiate between clinically diagnosed or autopsy-confirmed AD and frontotemporal lobar degenerati

102 rt of patients with Lewy body disorders with autopsy-confirmed alpha synucleinopathy (as of Oct 1, 20

103 nclusion criteria of Lewy body disorder with autopsy-confirmed alpha synucleinopathy, we identified 4

104 rform longitudinal sampling and did not have autopsy-confirmed causes of death.

105 -0.98), and detected AD neuropathology in an autopsy-confirmed cohort.

106 campal Lewy pathology in human patients with autopsy-confirmed dementia with Lewy bodies.

107 We selected 487 patients with autopsy-confirmed diagnosis of "pure" sCJD subtype and a

108 l data from 100 consecutive patients with an autopsy-confirmed diagnosis of PD from the archives of t

109 cteristic area under the curve of 0.894) and autopsy-confirmed frontotemporal lobar degeneration (are

110 Patients had autopsy-confirmed FTLD with tauopathy (n = 31), TDP-43 p

111 Fifty-five autopsy-confirmed LBD (Parkinson disease with dementia,

112 postmortem AV-1451 binding patterns in three autopsy-confirmed non-Alzheimer tauopathy cases.

113 SUVRs in subcortical regions were higher in autopsy-confirmed progressive supranuclear palsy and cor

114 clinical data from consecutive patients with autopsy-confirmed PSP from the Queen Square Brain Bank b

115 Autopsy-confirmed samples are critical for FTLD biomarke

116 n-coding RNAs in cortical tubers compared to autopsy control brain tissue.

117 In lung specimens from autopsy (control, HF-PH, and 7 PVOD) or surgery (10 PVOD

118 (95%) in SIDS infants (n = 61) compared with autopsied controls (n = 15) [SIDS, 177.2 +/- 15.1 (mean

119 ing of vital registration and limited verbal autopsy data and generally only characterize the underly

120 Vital registration and verbal autopsy data are mainstays for the estimation of leading

121 dy has systematically collected clinical and autopsy data from subjects with SCD in Northern Finland

122 inment in most previous studies was based on autopsy data or clinical convenience samples, often with

123 d the National Alzheimer Coordinating Center autopsy data to evaluate the effect of different neurofi

124 sment and who had died and for whom complete autopsy data were available.

125 alysis because of procedural unmasking or no autopsy data, as were 24 cases with a clear diagnosis of

126 ssible clinical diagnosis, 117 had available autopsy data, including 98 with a primary pathological d

127 ically derived vital registration and verbal autopsy data.

128 were based on vital registration and verbal autopsy data.

129 t data, outpatient data, cohort studies, and autopsy data.

130 modeling predicted causes of death in verbal autopsy data.

131 -free subjects (N = 52 total): psychological autopsy-defined MDDSui and control subjects with and wit

132 rtem characteristics that can better specify autopsy-defined SAD among presumed SCDs and suggest the

133 Of 615 presumed SCDs, 348 (57%) were autopsy-defined SAD.

134 Autopsy-defined SADs had no extracardiac or acute heart

135 her premortem characteristics could identify autopsy-defined sudden arrhythmic death (SAD) among pres

136 Autopsy demonstrated a massive intrasinusoidal infiltrat

137 e.g. AMBP and AHSG) is highly specific, with autopsy-derived organ samples correctly identified as ti

138 Autopsy-derived PFC samples show elevated MMP-9 levels i

139 Disease (amyloid) and Braak (tau) scores at autopsy, even among APOE varepsilon4 noncarriers.

140 Autopsy examination in five patients (including two not

141 onse records, lifetime clinical records, and autopsy examinations.

142 an evaluation of the vascular pattern in an autopsied eye were conducted at a community retina pract

143 Even without autopsy, familial screening after sudden death in young

144 The aim of this study was to determine the autopsy findings and causes of death among women in a la

145 ogy, abstracted clinical records, and verbal autopsy findings for each case and, if applicable, also

146 This case series describes autopsy findings in 10 patients with proven severe acute

147 Translating these autopsy findings to the clinical setting, it is possible

148 gnosis from PMCTA against a gold standard of autopsy findings, modified by PMCTA findings only if add

149 Molecular autopsy for electrical disorder and cardiomyopathy genes

150 ive to the gold standard complete diagnostic autopsy for identifying specific causes of childhood dea

151 opathy genes represents the latest molecular autopsy for sudden death in the young (SDY).

152 Lack of autopsies from MERS cases has hindered understanding of

153 Myocardial Treg cells were also detected in autopsies from patients who suffered a MI.

154 e genome sequencing, 25 samples collected at autopsy from 4 patients with relapsed MM and an addition

155 uencing of 13 melanoma metastases sampled at autopsy from a treatment naive patient and by leveraging

156 ed ex vivo in pancreas sections recovered at autopsy from donors with type 1 diabetes (T1D) or T2D (9

157 ge tissues and chondrocytes were obtained at autopsy from normal knee joints and from OA-affected joi

158 d compared them with 7 lungs obtained during autopsy from patients who died from acute respiratory di

159 We examined 7 lungs obtained during autopsy from patients who died from Covid-19 and compare

160 n profiles of purified microglia isolated at autopsy from the parietal cortex of 39 human subjects wi

161 Lung tissue obtained at autopsy from three deceased Covid-19 patients was proces

162 substantial Alzheimer's disease pathology at autopsy had shown few characteristic clinical symptoms o

163 f this screening in families not selected by autopsy has never been assessed.

164 We highlight how the research autopsy has supported the identification of the clonal o

165 In fatal Covid-19, lungs at autopsy have been filled with a clear liquid jelly.

166 dies on cancer tissues obtained during rapid autopsy have provided insights into the clonal evolution

167 SCD occurred, myocyte disarray was found on autopsy heart, and tissue Doppler and cardiac magnetic r

168 Ten autopsy hearts served as controls.

169 a cohort of 42 patients dying with COVID-19, autopsy histologic evaluation revealed acute tubular inj

170 cases, the cause of death may be evident on autopsy; however, in cases of arrhythmias, standard auto

171 d the World Health Organization-defined SCDs autopsied in the POST SCD study (Postmortem Systematic I

172 Guest Editorial highlights the importance of autopsies in biomedical discovery.

173 iscuss the rationale for the use of research autopsies in cancer research and provide an evidence-bas

174 ed 2833 snakebite deaths from 611,483 verbal autopsies in the nationally representative Indian Millio

175 , and clinical syndromes from 243,000 verbal autopsies in the nationally representative Million Death

176 hological samples were ascertained following autopsy in each individual brain bank, whereas clinical

177 Neuron loss has been documented at autopsy in some cases.

178 Wales have one of the highest frequencies of autopsy in the world.

179 ld of post-mortem genetic testing (molecular autopsy) in cases of SADS and comprehensive clinical eva

180 Complete autopsy, including postmortem computed tomography and hi

181 y serve as a potential forensic biomarker in autopsied infants with SIDS with serotonergic defects.

182 IDRalpha1.7 domain from a pediatric CM brain autopsy inhibited the barrier-protective properties of E

183 s (range 34-76); eight female; median PET-to-autopsy interval of 30 months (range 4-59 months)].

184 0-17 and causes of death from 211 166 verbal autopsy interviews in the Indian Million Death Study for

185 he objective of this study was to use verbal autopsy interviews to examine factors associated with st

186 METHODS AND Verbal autopsy interviews were conducted for deaths including s

187 the placebo group were ascertained by verbal autopsy interviews.

188 A research autopsy is a post-mortem medical procedure performed on

189 In practice, rapid research autopsy is performed shortly after a patient's passing t

190 detected in bronchial epithelial cells from autopsied lung sections.

191 and morphological changes in host cells, the autopsied lung specimens from this patient were examined

192 COVID-19 autopsied lung studies identified focal disease and, con

193 I alveolar epithelial cells (AEC-IIs) within autopsied lung tissue from a patient with A/H1N1/pdm09 p

194 Autopsy lung tissue from ventilated patients showed decr

195 Studies using human autopsy material have found some sex differences in the

196 e model were confirmed in pathological human autopsy material.

197 gy is poorly defined because of a paucity of autopsy material.

198 Autopsy measures of Alzheimer's disease neuropathology h

199 When possible, minimally invasive autopsy (MIA) was performed on participants who died.

200 All patients had autopsy (n = 7) or CSF (n = 67) evidence of Alzheimer's

201 nocturnal death syndrome (SUNDS) remains an autopsy negative disorder with unclear etiology.

202 assist in the diagnosis of at least 6.3% of autopsy-negative child SUD cases and reduce risk of futu

203 e to assist in finding a diagnosis for their autopsy-negative child SUD cases.

204 are responsible for a significant portion of autopsy-negative sudden unexpected death (SUD) cases, bu

205 sis of SUDI, we sequenced >70 genes from 191 autopsy-negative SUDI victims.

206 imal models and collection of tissues during autopsies of HIV-positive individuals are 2 proposed sol

207 rence of pulmonary thrombosis in a series of autopsies of patients with COVID-19.

208 Findings from a rapid autopsy of a patient with multiple independent reversion

209 Here, we discuss how rapid research autopsy of cancer patients can elucidate heterogeneity-a

210 We describe a case, diagnosed by autopsy, of lichenoid esophagitis in which massive bleed

211 S-CoV-2 across all body organs, we performed autopsies on 22 patients with COVID-19 (18 with comorbid

212 precautions, with an emphasis on performing autopsies on COVID-19 decedents.

213 We collected brain autopsies on diseased patients with NDs, and found a dyn

214 While pathologists have performed autopsies on infected decedents for centuries, universal

215 We performed an autopsy on a single patient who died of COVID-19 after o

216 hypertension (PAH) is primarily provided by autopsy or tissue specimens.

217 Patients diagnosed at autopsy or with additional neoplastic disease were exclu

218 Patients diagnosed at autopsy or with an unknown follow-up were excluded from

219 multiple-matched metastatic tumours from ten autopsied patients to infer the evolutionary history of

220 V-2 (COVID-19) has been scarce due to sparse autopsy performance and incomplete organ sampling.

221 renal, and nonrenal tissues were obtained at autopsy performed in the Department of Pathology at the

222 atomic compartments obtained through a rapid autopsy program of individuals undergoing long-term ART.

223 Here, we leverage on a rapid autopsy programme to demonstrate that unbiased genomic c

224 Finally, the success of research autopsy programs is bolstered by collaboration across di

225 In addition, material from a range of autopsy-proven ageing-associated and primary tauopathies

226 Metrics Research Consortium shortened verbal autopsy questionnaire was used for each interview, and c

227 l services-attended cardiac arrests, with an autopsy rate of 94%.

228 es were calculated based on brain volume and autopsy reference data.

229 Although autopsy remains the gold-standard diagnostic tool, antem

230 unique post-mortem cohort wherein whole body autopsy reports and brain tissue were available for inte

231 Whole body autopsy reports were used to develop a global score of s

232 e sources, including ambulance call reports, autopsy reports, in-hospital data, and records of direct

233 In this Perspective, autopsy results and literature are presented supporting

234 d in human tissues isolated during expedited autopsies.RESULTSSMN protein expression varied broadly a

235 Autopsies revealed frequent thromboembolic disease.

236 tory epithelium obtained from human COVID-19 autopsies revealed that SARS-CoV-2 infected NRP1-positiv

237 Autopsy revealed deep venous thrombosis in 7 of 12 patie

238 ive impairment during life (N = 15) from the autopsy sample of the Baltimore Longitudinal Study of Ag

239 Rat tissue sections and myocardial autopsy samples from 6 patients with cardiac sarcoidosis

240 cs analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and e

241 y combining parallel and cone beam geometry, autopsy samples with a maximum cross section of 8 mm are

242 d increased sulfatase activity in myocardial autopsy samples.

243 lso seen in primary human COVID-19 pulmonary autopsy samples.

244 4, SE = 0.01, p = 0.007) in regions matching autopsy sampling.

245 Data were drawn from a large autopsy series (N = 1,337) of individuals followed longi

246 Although a recent autopsy series of patients who died with severe COVID-19

247 ses have been limited to patient reports and autopsy series.

248 Autopsy showed disseminated infection and midzonal hepat

249 In addition, autopsy-sourced DNA demonstrated strikingly lower whole-

250 fresh blood draw, compared with only 82% of autopsy-sourced SDY exomes.

251 show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-1

252 ng of serial cfDNA, tumor biopsies and rapid autopsy specimens elucidated substantial geographic and

253 Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS

254 gingivalis infiltration has been detected in autopsy specimens from the brains of people with AD and

255 d during life, histopathological analysis of autopsy specimens is critical to understanding the cellu

256 al specimens, the detection of SARS-CoV-2 in autopsy specimens, previous experience with the related

257 ive SARS-CoV-2 infection in kidney biopsy or autopsy specimens.

258 al PET-only studies, and comparative PET and autopsy studies are included.

259 laboration (WHO/MCEE) on the basis of verbal autopsy studies from India.

260 Rare autopsy studies have found pathology both in the striatu

261 Mechanistic insights gained from research autopsy studies of cancer patients can help identify new

262 Whole-body autopsy studies of COVID-19 patients have been sparse.

263 Systematic review of autopsy studies published in English involving PD cases

264 Although most AAOCA subtypes are benign, autopsy studies report an associated risk of sudden deat

265 The model was based on verbal autopsy studies representing more than 100 000 neonatal

266 Autopsy studies suggest that implanting stents in lipid-

267 are obtained primarily from case reports or autopsy studies, we aimed to investigate the frequency a

268 d Alzheimer's-type dementia in retrospective autopsy studies.

269 me sequencing in cases and controls from the autopsy study "Pathobiological Determinants of Atheroscl

270 RATIONALE: The objective of this autopsy study was to determine whether gastrointestinal

271 tudy using (89)Zr-labeled bevacizumab and an autopsy study, a 1-on-1 analysis of multiregional in viv

272 was based on conclusive diagnostic imaging, autopsy, surgery, or 14-day follow-up.

273 l of 1358 individuals had died and had brain autopsies that were approved by board-certified neuropat

274 stopathological appearance at lung biopsy or autopsy, they have been termed: alveolar capillary dyspl

275 althy gestational age-matched hearts, and 3) autopsy tissue from three additional human CHB hearts an

276 ented in plasma, tracheal aspirate, and lung autopsies tissues from COVID-19 patients, and their neut

277 Our findings of the deposition of (210)Po in autopsy tissues suggest that airborne radionuclides may

278 unexpected death (SUD) cases, but molecular autopsy used to identify potentially causal variants is

279 ancisco County for medical record review and autopsy via medical examiner surveillance.

280 ng trauma and haemorrhage (p=0.008), whereas autopsy was better at identifying pulmonary thromboembol

281 Complete diagnostic autopsy was done in 441 (40%) and minimally invasive tis

282 An autopsy was performed and revealed the macroscopic and m

283 static cancer tissues collected during rapid autopsy was performed, and compared their mutational sta

284 A complete autopsy was performed.

285 se-specific mortality, as assessed by verbal autopsy, was a prespecified secondary outcome.

286 including Abetao from AD brains obtained by autopsy, we directly compared the Abeta-binding capacity

287 biannual house-to-house censuses, and verbal autopsies were done between May 26, 2015, and May 17, 20

288 Verbal autopsies were done to gain information about survivors

289 Three COVID-19 lung autopsies were examined for NETs and platelet involvemen

290 Autopsies were performed blinded to PET results.

291 Autopsies were performed on 12 individuals, 10 men and 2

292 Verbal autopsies were performed.

293 ith a prior clinical diagnosis of HCM but no autopsy were considered probable HCM-related SCDs.

294 levels in spinal cord tissue as analyzed on autopsy were lower than corresponding levels in untreate

295 Metastatic subclones at autopsy were present in tissue and blood samples from ea

296 ; however, in cases of arrhythmias, standard autopsy will not reveal the cause of death.

297 Combining molecular autopsy with clinical evaluation in surviving families i

298 For routine autopsy workup of LATE-NC, an anatomically-based prelimi

299 ography (PMCTA), in adults to avoid invasive autopsy would have cultural, religious, and potential ec

300 rganization of the human brain obtained from autopsies, yielding excellent results.