ライフサイエンスコーパス: autoregulation

1 egree of autoregulation (1 indicates perfect autoregulation).

2 al monitoring, was used to evaluate cerebral autoregulation.

3 ssociated with Lmx1b that suggests a role in autoregulation.

4 ase is necessary but not sufficient for pilA autoregulation.

5 nctions, intracranial pressure, and cerebral autoregulation.

6 mulated NFATc1 transcription, confirming its autoregulation.

7 n-mediated scaffold phosphorylation and Fus3 autoregulation.

8 minal centre cells by avoiding BCL6-negative autoregulation.

9 enarios, stable networks had mostly positive autoregulation.

10 which can independently initiate weak Su(H) autoregulation.

11 iding in vivo evidence for mammalian kinesin autoregulation.

12 LEF-1 protein levels and LEF-1 messenger RNA autoregulation.

13 bmodule, which then sustains long-term Su(H) autoregulation.

14 % decrease) in another patient with impaired autoregulation.

15 at they result from defective bvgAS positive autoregulation.

16 edicted to be critical for achieving retinal autoregulation.

17 female developmental commitment via positive autoregulation.

18 ade fidelity, for standard models of genetic autoregulation.

19 f regulatory mechanisms in achieving retinal autoregulation.

20 sites, one of which appears to be subject to autoregulation.

21 osteoblast differentiation and negative Bmp autoregulation.

22 plays an active and unique role in cerebral autoregulation.

23 RgdR stimulation of T3S required ler and Ler autoregulation.

24 nt in FUS itself that is associated with its autoregulation.

25 ogenic tone that underpins tissue blood-flow autoregulation.

26 ific transcriptional response, including its autoregulation.

27 and identified that it is required for cIAP1 autoregulation.

28 smission, providing a novel form of synaptic autoregulation.

29 context, which could underlie translational autoregulation.

30 l perfusion and decreased the lower limit of autoregulation.

31 , which will alter RNA processing due to FUS autoregulation.

32 cating that lag-1 engages in direct positive autoregulation.

33 FR stability despite severely impaired renal autoregulation.

34 in degradation and relief of transcriptional autoregulation.

35 omised in conscious rats with impaired renal autoregulation.

36 the time and frequency responses of cerebral autoregulation.

37 nal role for perivascular nerves in cerebral autoregulation.

38 arterial pressure, lower and upper limit of autoregulation.

39 target genes HHEX and NKX3.1 as well as LMO2 autoregulation.

40 ing and repressing binding sites and examine autoregulation.

41 h acquired brain injury and loss of cerebral autoregulation.

42 d 40 mm Hg is used to indicate the degree of autoregulation (1 indicates perfect autoregulation).

43 correlation methods distinguished functional autoregulation (ABP above LLA) from dysfunctional autore

44 egulation (ABP above LLA) from dysfunctional autoregulation (ABP below the LLA).

45 ar-infrared spectroscopy-derived measures of autoregulation accurately detected loss of autoregulatio

46 tion of candidate genes involved in cerebral autoregulation after TBI provides a platform and rationa

47 e of alternative polarization, including its autoregulation and a robust, downstream TF cascade invol

48 28 mRNA targets, we found evidence for LIN28 autoregulation and also direct but differing effects on

49 is associated with worsening global cerebral autoregulation and cerebral autoregulation asymmetry, an

50 es to determine that Bcl-6 exhibits negative autoregulation and controls pleiotropic attributes of T(

51 Furthermore, Gle1(InsP6) relieves Dbp5 autoregulation and cooperates with Nup159 in stabilizing

52 n of overrepresented network motifs, such as autoregulation and coregulation of sigma and anti-sigma

53 ther, our data indicate that impaired KIF21B autoregulation and function play a critical role in the

54 rks, to investigate the relationship between autoregulation and network stability and robustness unde

55 n arterial blood pressure below the limit of autoregulation and not absolute mean arterial blood pres

56 ascent tubulin interaction abolished tubulin autoregulation and showed chromosome segregation defects

57 Sequential transcription factor autoregulation and subsequent binding to downstream prom

58 mean arterial blood pressure at the limit of autoregulation and the duration and degree to which mean

59 dentified the requirements of c-Abl in BMP-2 autoregulation and the expressions of alkaline phosphata

60 nsion explains the improved dynamic cerebral autoregulation and the reduced cerebral perfusion encoun

61 innate inflammation, disruptions in cerebral autoregulation, and acquired brain injury.

62 teral displacement, disturbances to cerebral autoregulation, and clinical outcomes in acutely comatos

63 ominance--mutations which result in stronger autoregulation, and decrease noise in homozygotes, parad

64 ed as leaderless transcripts, and subject to autoregulation, and expression of the toxin component le

65 lateral brain displacement, global cerebral autoregulation, and interhemispheric cerebral autoregula

66 the neurovascular response, cerebrovascular autoregulation, and ischaemia are critical processes to

67 nt, intracranial pressure, impaired cerebral autoregulation, and outcome remain poorly explored.

68 The structural basis of autoregulation, and whether it affects interactions of S

69 as via Smad and PI3K-AKT signaling pathways, autoregulation, and/or upregulation of Serpine1, a well-

70 ) in one patient with intact cerebrovascular autoregulation; and only inverse responses (-24% decreas

71 proximately 40%) and/or mutations disrupting autoregulation ( approximately 16%) involving the BCL6 g

72 Lateral displacement and impaired cerebral autoregulation are associated with worse outcomes follow

73 s in outflow facility and retinal blood flow autoregulation are implicated in primary open-angle glau

74 ms and the in-vivo-function of this myogenic autoregulation are poorly understood.

75 imits a diploid's ability to evolve negative autoregulation as a noise reduction mechanism.

76 ance (P<0.001), indicating impaired coronary autoregulation as its cause.

77 pressure limits of cerebrovascular pressure autoregulation (assessed with pressure reactivity index)

78 novel findings show the feasibility of renal autoregulation assessment in conscious animals with spon

79 = 0.01 septum; p = 0.05 pineal) and cerebral autoregulation asymmetry (both p < 0.001).

80 utoregulation, and interhemispheric cerebral autoregulation asymmetry were assessed using mixed rando

81 global cerebral autoregulation and cerebral autoregulation asymmetry, and poor long-term clinical ou

82 cava to identify the lower limit of cerebral autoregulation at 6 hrs postresuscitation.

83 suppress Pax6 activity and thus breaks pax6 autoregulation at defined steps during the formation of

84 5%) and explored the lower limit of cerebral autoregulation at patient and population levels.

85 lthough it is well established that cerebral autoregulation behaves as a 'high-pass' filter, recommen

86 reduced LAG-1 levels and abrogated positive autoregulation, but did not cause hallmark cell fate tra

87 a provide the only documented mechanisms for autoregulation, but these are incompatible with eukaryot

88 n receptor signaling to NF-kappaB, undergoes autoregulation by a poorly understood inhibitory domain

89 pliceosome and Srsf10, and abolishing Srsf10 autoregulation by Crispr/Cas9-mediated deletion of the a

90 Negative autoregulation by Dve maintains expression from each enh

91 Inhibition of FOXM1 transcriptional autoregulation by HSP70 leads to the suppression of FOXM

92 levels revealed DENV-vsRNA-5's role in virus autoregulation by targeting the virus nonstructural prot

93 decision-making motif, cross-antagonism with autoregulation, by synthetically constructing this netwo

94 he individual variability of static cerebral autoregulation (CA) and determined its associations with

95 Dynamic cerebral autoregulation (CA) can be expressed in the frequency do

96 Various methodologies to assess cerebral autoregulation (CA) have been developed, including model

97 Cerebral autoregulation (CA) is a key mechanism to protect brain

98 Cerebral autoregulation (CA) is a protective mechanism that maint

99 Cerebral autoregulation (CA) is an important vascular control mec

100 Dynamic cerebral autoregulation (CA) is expressed by the temporal pattern

101 Dynamic cerebral autoregulation (CA) is manifested by changes in the diam

102 Dynamic cerebral autoregulation (CA) is often expressed by the mean arter

103 t application and interpretation of cerebral autoregulation (CA) measurements in research and in clin

104 Loss of cerebral autoregulation (CA) plays a key role in secondary neurol

105 We hypothesized that knowledge of cerebral autoregulation (CA) status during recanalization therapi

106 Preventing Plk4 autoregulation causes centrosome amplification, stabiliz

107 es were used to create a color-coded maps of autoregulation - cerebral perfusion pressure relationshi

108 l blood pressure is below the lower limit of autoregulation, cerebral oximetry index approaches 1, be

109 recurrent network motifs, including negative autoregulation, combinatorial regulation, two-gene clock

110 ase in the perfusion pressure lower limit of autoregulation compared to postarrest, normothermic pigl

111 lar reactivity to CO(2) and dynamic cerebral autoregulation compared to young adults.

112 in Escherichia coli have shown that negative autoregulation confers both rapid response times and red

113 We found that autoregulation could either suppress or increase the out

114 Our work uncovers a layer of Myc autoregulation critical for lymphomagenesis yet partly d

115 fects of stimuli employed in cerebrovascular autoregulation (CVA) tests on the brain, without contact

116 Dynamic cerebral autoregulation (dCA) is impaired following stroke.

117 and hypothermia and tested novel measures of autoregulation derived from near-infrared spectroscopy.

118 f autoregulation accurately detected loss of autoregulation during hypotension.

119 opy accurately identified the lower limit of autoregulation during normothermia and hypothermia in pi

120 terlinked positive-feedback loops to control autoregulation dynamically and provides mechanistic insi

121 nvironment, we have studied the key positive autoregulation element by which the lux QS system integr

122 we show that extensive BDNF transcriptional autoregulation, encompassing all major BDNF transcripts,

123 on of critical processes, including cerebral autoregulation, endothelial-mediated signaling, and neur

124 In regard to dynamic cerebral autoregulation, endotoxemia was associated with lower mi

125 ificantly slower in states of impaired renal autoregulation, enhancing glomerular pressure exposure.

126 P could not fully explain the differences in autoregulation estimated from spontaneous vs. augmented

127 e could not fully explain the differences in autoregulation estimated from spontaneous vs. augmented

128 ery mean flow velocity, and dynamic cerebral autoregulation evaluated by transfer function analysis i

129 CO2, and metabolic responses yields the best autoregulation (factor of 1.10).

130 We conclude that transcriptional autoregulation fulfills two intrinsically linked purpose

131 Individualized autoregulation-guided cerebral perfusion pressure manage

132 he methods have focused on identifying "one" autoregulation-guided cerebral perfusion pressure target

133 e randomized research will help define which autoregulation-guided method is beneficial, safe, and mo

134 The most basic motif, autoregulation, has been associated with bistability (wh

135 d intracranial pressure or impaired cerebral autoregulation have been described as well.

136 ding depolarisations and failure of cerebral autoregulation, have all been implicated in the pathophy

137 tereochemical model of Perutz, to blood flow autoregulation (hypoxic vasodilation governing oxygen de

138 However, in rats with severe renal autoregulation impairment (3/4 nephrectomy plus amlodipi

139 Autoregulation impairment was greatest in hypoperfused a

140 Here, we report a novel mechanism for gene autoregulation in bacteria relying on small regulatory R

141 identified a novel mechanism of IGF-IR gene autoregulation in breast cancer cells.

142 However, real-time dynamics of renal autoregulation in conscious animals have not been charac

143 by constraints on the evolution of negative autoregulation in diploids.

144 ebral perfusion and improve dynamic cerebral autoregulation in healthy subjects exposed to endotoxemi

145 (5a) and Pax2 could not replace Pax6 for its autoregulation in lens induction or for neural different

146 y have focused on the importance of cerebral autoregulation in maintaining perfusion, which necessita

147 ificantly improved impaired retinal vascular autoregulation in normal tension glaucoma patients, but

148 ing progressive worsening of cerebrovascular autoregulation in one patient (Pearson coefficient 0.04,

149 arterial pressure, lower and upper limit of autoregulation in patients following cardiac arrest.

150 rent bacterial genera and is involved in its autoregulation in S. Typhimurium.

151 the importance of miRNA-mediated viral gene autoregulation in some polyomavirus life cycles.

152 We confirm previously proposed models of autoregulation in SRSF7 and U2AF1 genes and present two

153 ses support the importance of miRNA-mediated autoregulation in the life cycles of some divergent poly

154 By contrast, in placental mammals, Nkx2.5 autoregulation in the SHF functions indirectly through M

155 erate synergistically to amplify Neurogenin3 autoregulation in vitro.

156 ity and robustness positively correlate with autoregulation; in all investigated scenarios, stable ne

157 im) was determined by the break point of the autoregulation index (ARI) curve as a function of freque

158 e (Finometer) were recorded to calculate the autoregulation index (ARI, as surrogate for CA).

159 hypercapnia, which led to a reduction in the autoregulation index from 5.70 +/- 1.58 (normocapnia) to

160 ation reactivity index was the only cerebral autoregulation index predictor of Glasgow Outcome Scale.

161 on z score analysis, the best three cerebral autoregulation index predictors of mortality or Glasgow

162 ation reactivity index was the only cerebral autoregulation index that predicted patient outcome meas

163 loped, including model - based methods (e.g. autoregulation index, ARI), correlation coefficient - ba

164 at assessed the association between cerebral autoregulation indices and dichotomized or continuous ou

165 Thirty-three studies compared cerebral autoregulation indices and patient outcomes using standa

166 to assess the relationship between cerebral autoregulation indices and predictors of outcome (standa

167 To compare cerebral autoregulation indices as predictors of patient outcome

168 Several autoregulation indices were calculated using correlation

169 Three cerebral autoregulation indices, pressure reactivity index, mean

170 This autoregulation influences the temporal and/or spatial lo

171 rthermore, in addition to decreasing Neurog3 autoregulation, inhibition of Foxa2 by RNA interference

172 In addition, we show that the mechanism of autoregulation involves ubiquitin binding by a C-termina

173 Positive autoregulation is an effective mechanism for the long-te

174 Importantly, Cth2 autoregulation is critical for the appropriate recovery

175 However, cerebral autoregulation is explicitly non-linear and most prior w

176 nd mouse, we have found evidence that Nkx2.5 autoregulation is important for maintaining Nkx2.5 expre

177 We show that che-1 autoregulation is indeed required to maintain the differ

178 Our data demonstrate that cerebral autoregulation is most effective in buffering against pr

179 Cerebral autoregulation is most effective in buffering against pr

180 egulates its own expression and that ERalpha autoregulation is most likely absent.

181 A model for PknK autoregulation is proposed and discussed.

182 However, negative autoregulation is rare amongst the transcription factors

183 Localized control of tissue blood flow, or autoregulation, is a key factor in regulating tissue per

184 e flow velocity indicating impaired coronary autoregulation, is associated with a significant increas

185 l blood pressure (ABPopt) and lower limit of autoregulation (LLA).

186 Renal autoregulation maintains stable renal function despite B

187 Autoregulation may be a commonly used mechanism to contr

188 Homeostatic autoregulation may be a general mechanism to precisely c

189 a comprehensive insight about physiology of autoregulation, measurement methodologies and clinical a

190 to disease, and we show here that this novel autoregulation mechanism is altered by FUS mutations.

191 A central autoregulation mechanism observed in this unit is functi

192 esistances are controlled via the whole-body autoregulation mechanism.

193 sitive mechanisms independent of known renal autoregulation mechanisms and voltage-gated calcium chan

194 Existing cerebrovascular blood pressure autoregulation metrics have not been translated to clini

195 results suggest that dysfunctional dopamine autoregulation might precipitate psychotic relapse after

196 re calculated by bedside multimodal cerebral autoregulation monitoring using near-infrared spectrosco

197 Measures of autoregulation obtained from standard laser-Doppler flow

198 of Nus factor genes suggests that Nus factor autoregulation occurs in many bacterial species.

199 ndogenous Caz levels, demonstrating that FUS autoregulation occurs in motor neurons in vivo.

200 Repression of the autoregulation of a TF family by its only splice variant

201 , primer transfer to Polalpha, and concerted autoregulation of alternate activation/inhibition of the

202 al pressure, is critically important for the autoregulation of blood flow.

203 perimental evidence supporting this putative autoregulation of BosR has been lacking.

204 A splicing pathway, accompanied by perturbed autoregulation of canonical splicing activators (SRSF) a

205 nositol is an important cellular osmolyte in autoregulation of cell volume and fluid balance, particu

206 umans suggests a conserved mechanism for the autoregulation of CSB/ERCC6 despite the otherwise highly

207 ed disease and provides new insight into the autoregulation of DIAPH1 activity.

208 naling and the regulation of CME, leading to autoregulation of endocytosis and signaling downstream o

209 not express DAT or DBH are required for the autoregulation of GH secretion via a negative-feedback l

210 e in the Brat-mediated system, revealing how autoregulation of GSC number can arise from Brat couplin

211 Here we show that autoregulation of Hsmar1 operates during assembly of the

212 We describe here a novel mechanism of autoregulation of IGF-IR gene expression by cellular IGF

213 of Doa10, MARCH6 (TEB4), by analyzing MARCH6 autoregulation of its own degradation.

214 IL-13Ralpha2 expression, overcoming IL-13's autoregulation of its pathway and enhancing the expressi

215 This discovery of autoregulation of let-7 biogenesis establishes a new mec

216 e show that, due to stochastic fluctuations, autoregulation of mec-3 is not sufficient for TRN differ

217 in the pipette Na(+) concentration, showing autoregulation of Na(+) in beating cardiomyocytes.

218 The autoregulation of NEGAN might be a critical property to

219 ion of lateral root development and systemic autoregulation of nodulation (AON) integrated with nitro

220 of the shoot apical meristem, is involved in autoregulation of nodulation (AON), a mechanism that sys

221 Autoregulation of nodulation (AON), a systemic signaling

222 developmental processes in plants, including autoregulation of nodulation (AON), which allows legumes

223 increased expression of early nodulation and autoregulation of nodulation genes, and improved nodulat

224 We found that a functional autoregulation of nodulation pathway is required for roo

225 cell division leading to nodule development, autoregulation of nodulation, intracellular accommodatio

226 Our results together revealed that autoregulation of nodulation, root development, and the

227 ilS's phosphatase motif was required for the autoregulation of pilA transcription, suggesting that un

228 S that disrupted their interaction prevented autoregulation of pilA transcription.

229 mice, suggesting that Cav-1 plays a role in autoregulation of resistance vessels in the retina.

230 Here, we report the mechanism of the autoregulation of Rhp26, which is the homolog of CSB/ERC

231 ficantly impaired, suggesting that perturbed autoregulation of rpl10a splicing contributes to failing

232 This is because mice show autoregulation of Thap1 mRNA levels with upregulation at

233 The results shed light on the mechanism of autoregulation of the Hsp70 cycle via conserved parts of

234 STAT5a (caSTAT5a) inhibited LEF-1-dependent autoregulation of the LEF-1 gene promoter by binding to

235 idespread gene repression including feedback autoregulation of the MYC gene itself.

236 found that positive feedback resulting from autoregulation of the native spo0A promoter leads to rob

237 uitment of transcriptional machinery through autoregulation of the TAD.

238 that the ETC6 B-box sequence is involved in autoregulation of the TFC6 promoter.

239 ns, which are thought to arise from negative autoregulation of these genes.

240 ibuted to increased gene copy number and the autoregulation of YTHDF3 cap-independent translation by

241 lation-deficient mutant line, altered in the autoregulation-of-nodulation receptor kinase GmNARK, det

242 Split-root and grafting studies using an autoregulation-of-nodulation-deficient mutant line, alte

243 of transcriptional and post-transcriptional autoregulation on fluctuations in protein expression in

244 ctd15b transcription, unveiling a circuit of autoregulation operating in nephron progenitors.

245 at drive these dynamical behaviours, such as autoregulation or feedback by microRNAs, is unknown.

246 e and might be a promising tool for cerebral autoregulation oriented-therapy in neurocritical care pa

247 In 24 patients, autoregulation over the affected hemisphere was calculat

248 al perfusion pressure, and impaired cerebral autoregulation over the entire monitoring period were ca

249 vels consistent with normal retinal vascular autoregulation (P < .0001).

250 as associated with worsening global cerebral autoregulation (p = 0.01 septum; p = 0.05 pineal) and ce

251 lead to poor correlation between some of the autoregulation parameters even under well controlled sit

252 decrease) (P < 0.05) coinciding with loss of autoregulation (Pearson coefficient 0.19 --> 0.32, P < 0

253 e variety of regulatory mechanisms including autoregulation, post-translational modifications, and pr

254 Continuous assessment of cerebral autoregulation predicted outcome better than intermitten

255 The autoregulation pressure range for control and elevated l

256 evated, the model predicts a decrease in the autoregulation range toward low perfusion pressure, whic

257 igated whether a cerebral perfusion pressure autoregulation range-which uses a continuous estimation

258 ex based on cerebral perfusion pressure, and autoregulation reactivity index (z scores: 8.97, 6.01, 3

259 For patients with subarachnoid hemorrhage, autoregulation reactivity index was the only cerebral au

260 For patients with subarachnoid hemorrhage, autoregulation reactivity index was the only cerebral au

261 ex based on cerebral perfusion pressure, and autoregulation reactivity index were the best outcome pr

262 rial blood pressure below the lower limit of autoregulation (relative risk 1.02; 95% confidence inter

263 volution of RNA translation and protein-mRNA autoregulation remains an open area of research.

264 d flow but its influence on dynamic cerebral autoregulation remains unknown.

265 on of cholinergic vasodilatation to cerebral autoregulation remains unknown.

266 In Drosophila neurons, Nwk autoregulation restricts SH3a domain-dependent synaptopo

267 ase-repression of a transcriptional positive autoregulation (RPAR) loop is critical for shutting down

268 ween dynamic (dCA) and steady-state cerebral autoregulation (sCA).

269 It is generally assumed that such autoregulation serves to maintain the differentiated sta

270 frequency bands for characterizing cerebral autoregulation should be redefined Low cross-spectral co

271 intricate mechanism of BDNF transcriptional autoregulation.SIGNIFICANCE STATEMENT Deeper understandi

272 on pressure, compensatory reserve index, and autoregulation status that were physiologically plausibl

273 ressure, the compensatory reserve index, and autoregulation status was attempted using a hidden Marko

274 We propose that Nodal autoregulation substantially aided by rapid ligand trans

275 with brimonidine underwent retinal vascular autoregulation testing and visual function assessment us

276 nzyme grounded in a dynamic understanding of autoregulation that is consistent with a wealth of bioch

277 conscious rats, comparing animals with renal autoregulation that was intact versus impaired (from 3/4

278 hypoxic vasodilation that governs blood flow autoregulation, the classic physiological mechanism that

279 h mean arterial blood pressure was below the autoregulation threshold (mm Hg x min/hr of cardiopulmon

280 Plk4 autoregulation thus guards against genome instability by

281 er enough hours have passed to allow tubulin autoregulation to proceed.

282 that they have a similar dearth of negative autoregulation to that seen in S. cerevisiae.

283 prevalence of brain hypoxia, 2) characterize autoregulation using the pressure reactivity index and i

284 The lower limit of cerebral autoregulation varied substantially (mean 74.1 mmHg, SD

285 Ca(V)1.2 channels also undergo negative autoregulation via Ca(2+)-dependent inactivation (CDI),

286 An identifiable lower limit of autoregulation was ascertained in 348 patients.

287 Autoregulation was characterized via a robust non-linear

288 Disruption of cerebral autoregulation was determined using continuous bedside n

289 Autoregulation was intact during hypertension in all gro

290 The status of cerebrovascular autoregulation was monitored as a correlation between bl

291 Autoregulation was monitored during cardiopulmonary bypa

292 We showed that transcriptional autoregulation was more successful than post-transcripti

293 Investigating the mechanisms behind this autoregulation, we found that AP-1 transcription factors

294 p novel analytic methods for assessing renal autoregulation, we recorded concurrent BP and renal bloo

295 To test effectiveness of cerebral autoregulation, we refined oscillatory lower body pressu

296 l mean arterial pressure, lower and upper of autoregulation were 89 mm Hg (11), 82 mm Hg (8), and 96

297 lators, and decreases in blood pressure (CBF autoregulation) were similarly reduced in TgNotch3(R169C

298 s points toward a novel mechanism of cardiac autoregulation, whereby the previously implied increased

299 afferent arterioles and in renal blood flow autoregulation, which were rescued in Add3 transgenic ra

300 Thus, our results reveal that overriding FUS autoregulation will trigger gain-of-function toxicity vi