ライフサイエンスコーパス: autosome

1 er selective pressure (p = 0.006, for the 22 autosomes).

2 ale germline expression when relocated to an autosome.

3 on the X chromosome, whereas spe-5 is on an autosome.

4 ng its potential status as a non-recombining autosome.

5 A single linkage group spans each autosome.

6 provides single linkage groups spanning each autosome.

7 oci for coronary artery disease (CAD) on the autosome.

8 ers 100% female lethality when placed on the autosomes.

9 hree times lower on the X chromosome than on autosomes.

10 -specific spatial conformation distinct from autosomes.

11 e removal of ATR-mediated DDR signaling from autosomes.

12 X than seen for X-to-autosome retrogenes on autosomes.

13 e topology of X to a conformation resembling autosomes.

14 boundaries and more regular spacing than on autosomes.

15 d onto the X chromosome as compared with the autosomes.

16 ctor into permissive expression sites on all autosomes.

17 iversity-reducing selection on X than on the autosomes.

18 bers are largely consistent across all human autosomes.

19 the sex chromosome but also in trans of all autosomes.

20 Sex chromosomes originate from autosomes.

21 me tracing to map the trajectories of entire autosomes.

22 IM-5 protein localizes preferentially to the autosomes.

23 on patterns compared to paralogous copies on autosomes.

24 in crossover distribution on both the X and autosomes.

25 vement of genes from the X chromosome to the autosomes.

26 ted to the evolution of the X chromosome and autosomes.

27 the X chromosome, with lesser effects on the autosomes.

28 prisingly also to relocalization to sites on autosomes.

29 tation patterns on both the X chromosome and autosomes.

30 ysis of haplotype blocks across all 38 canid autosomes.

31 the Bogota X chromosome and one locus on the autosomes.

32 somes have many unusual features relative to autosomes.

33 mical features that differ between the X and autosomes.

34 d the enrichment of the male-biased genes on autosomes.

35 the X chromosome are equalized with those of autosomes.

36 ecurrent duplication of retrogenes from X to autosomes.

37 fixation of male beneficial mutations on the autosomes.

38 y retroposition from the X chromosome to the autosomes.

39 context of pairing, both of the X and of the autosomes.

40 complex distinguishes the X chromosome from autosomes.

41 Sex chromosomes evolved from autosomes.

42 igher rate of evolution on the Y relative to autosomes.

43 n assigned to linkage groups on the cat's 18 autosomes.

44 ift than is expected from the pattern on the autosomes.

45 involve distinguishing the X chromosome from autosomes.

46 X chromosome and dominant-acting loci on the autosomes.

47 on both samples for 338 markers covering all autosomes.

48 omes replicating at a distinct time from the autosomes.

49 lved in eye development as that found on the autosomes.

50 elative to the ploidy, the number of sets of autosomes.

51 ence of its small size relative to the giant autosomes.

52 chromosome was more differentiated than the autosomes.

53 s variation among inbred strains than do the autosomes.

54 ctive bottleneck times compared to gene-poor autosomes.

55 ments on the autosomes and between the X and autosomes.

56 en sexes and between the sex chromosomes and autosomes.

57 s and genetic polymorphisms located on human autosomes.

58 e, gnomAD) of 13,860 human X chromosomes and autosomes.

59 mCH similar to the male X chromosome and the autosomes.

60 but instead were recruited secondarily from autosomes.

61 tic interaction between the X Chromosome and autosomes.

62 ely reported at the non-imprinted regions on autosomes.

63 .45% in 75-year olds), as reported for Y and autosomes.

64 ding comparison between the X Chromosome and autosomes.

65 panied the evolution of sex chromosomes from autosomes.

66 d number of genes due to transpositions from autosomes.

67 enes nor sufficient to repress transgenes on autosomes.

68 ee with experimental results for all GM12878 autosomes.

69 an ensemble of 3D structures for all GM12878 autosomes.

70 ng their evolution from an ancestral pair of autosomes [1-4].

71 essive lethal in Jersey cattle on Bos taurus autosome 15.

72 When inserted on an autosome, a newly identified site can direct local MSL s

73 opied from sex chromosomes and inserted into autosomes, a process termed 'gene traffic'.

74 ng sex chromosome fuses to an autosome or an autosome acquires a new sex-determining locus/allele.

75 s that sex differences in DNA methylation of autosomes act as a primary driver of sex differences tha

76 ibed X chromosomes to one per diploid set of autosomes, allowing for dosage equality between the sexe

77 g, transcriptionally inactive regions on the autosomes also replicated in an unstructured manner, sim

78 ssed in somatic cells, Ant4 is encoded by an autosome and selectively expressed in testicular germ ce

79 use genome sequence, was 7.1-fold across the autosomes and 6.6-fold across the X chromosome.

80 ntly enriched on the X chromosome versus the autosomes and also occur at higher densities around X-li

81 erences in chromatin composition between the autosomes and between chromosome arms and centers.

82 trum in multiple genomic compartments on the autosomes and between the X and autosomes.

83 n the X chromosome, creation of new genes on autosomes and changed genomic location of existing genes

84 Y chromosomes originate from ordinary autosomes and degenerate by accumulating deleterious mut

85 contents in comparison with both metatherian autosomes and eutherian chromosomes.

86 igh number of retrogenes that are located on autosomes and exhibit male-biased expression patterns [6

87 ago, Bridges proposed that male genes on the autosomes and female genes on the X chromosome compete t

88 s and compound heterozygous rare variants in autosomes and hemizygous rare variants in the X chromoso

89 veal that karyotype is a key factor: Smaller autosomes and heteromorphic sex chromosomes become weak

90 ted by their location on sex chromosomes vs. autosomes and inside vs. outside of Alu repeats, the for

91 Heterozygosity is restricted to autosomes and its retention is accompanied by substantia

92 enes located on the sex chromosomes than the autosomes and led to feminization of the X chromosome an

93 trogression from G. fortis to G. scandens on autosomes and mitochondria but not on the Z chromosome.

94 ecies boundaries as they diverge faster than autosomes and often have reduced diversity.

95 .3, 5q13-q22, and 11p15) have been mapped to autosomes and one gene (SOS1) has been associated with t

96 required in males for proper segregation of autosomes and provides a genetic tool for understanding

97 al problem of gene dosage imbalances between autosomes and sex chromosomes and also between males and

98 es' sex chromosomes are derived from ancient autosomes and show few signatures of their origins.

99 y in the chimpanzee X chromosome relative to autosomes and stronger purifying selection than for the

100 , Kind et al. show that MOF is also found on autosomes and that it has two modes of binding: one in m

101 sing a saturated linkage map spanning all 12 autosomes and the mitochondrion.

102 dual chromosomes and among chromosome types (autosomes and the two sex chromosomes).

103 Moreover, genes moving between the autosomes and the X chromosome experience change in seve

104 ective population size was estimated for all autosomes and the X chromosome from estimated LD between

105 Additionally, contrasting the autosomes and the X chromosome holds information on the

106 alyses 24 candidate genome regions within 14 autosomes and the X chromosome were revealed, in which 1

107 The resulting sex-averaged map covers 16 fox autosomes and the X chromosome with an average inter-mar

108 chanism for random monoallelic expression on autosomes and the X chromosome, and implicate Eed in est

109 g on regions of low marker density on feline autosomes and the X chromosome, in addition to regions f

110 were analysed using 46,171 SNPs covering all autosomes and the X chromosome.

111 with similarly prominent differences between autosomes and the X chromosome.

112 genes paralogous to single-copy genes on 18 autosomes and the Z chromosome, and is enriched in genes

113 of 40 independent intergenic regions on the autosomes and X chromosome comprising ~210 kb from each

114 e Y chromosome and the genetic background of autosomes and X chromosome.

115 te a persistent dosage imbalance between the autosomes and X chromosome.

116 Yet condensin I binds to autosomes and X chromosomes in both sexes to promote chr

117 ed the positions of TADs in human interphase autosomes and X chromosomes.

118 The Y chromosome evolved from an autosome, and its evolution has been characterized by ma

119 n of an ancestral sex-determining gene to an autosome, and the maintenance of multiple sex-determinin

120 loci (QTL) have been developed primarily for autosomes, and comparable methods for X-linked QTL have

121 ent with our reconstruction of the ancestral autosomes, and followed the evolutionary trajectory of a

122 k repair was delayed or failed in unsynapsed autosomes, and misexpression of chromosome X and chromos

123 genes, defined as those conserved on chicken autosomes, and newly acquired X-linked genes are upregul

124 approximately 20-Mb intervals across the 19 autosomes, and three markers on the X chromosome.

125 rmed repeatedly across Diptera from ordinary autosomes, and X-chromosomes mostly conserve their ances

126 n X and Y chromosomes evolved from a pair of autosomes approximately 180 million years ago.

127 DEGs on the X chromosome and the autosomes are coexpressed in both syndromes, indicating

128 r chromatids of X and Y chromosomes, but not autosomes, are segregated nonrandomly during asymmetric

129 one H3S10 kinase activity was able to rescue autosome as well as partially rescue male X polytene chr

130 ty and higher FST for Z-linked loci than for autosomes, as expected.

131 ion and lower evolutionary rates relative to autosome associated genes.

132 d nuclear elements (LINE)-1 (L1) along mouse autosomes at a 1-Mb scale, and found a unique combinatio

133 cusing on highly recombining portions of the autosomes, at a spatial scale appropriate to the study o

134 on to identify a gene affected by a balanced autosome;autosome translocation.

135 elay in assembling DSB-promoting proteins on autosome axes and loss of a specialized PAR-axis domain

136 hromosomes may have originated from the same autosomes bearing the X allelic form that still exist in

137 an X and Y chromosomes evolved from ordinary autosomes beginning at least 180 million years ago.

138 s much more strongly differentiated than the autosomes between North American and African populations

139 ysis identified a putative SNP on Bos taurus autosomes (BTA) 2 associated with phenotype 1, and anoth

140 completion, is less gene-dense than chicken autosomes but contains a massive tandem array containing

141 d, spermatogenesis genes are enriched on the autosomes but depleted on the X Chromosome (demasculiniz

142 Sex chromosomes originated from autosomes but have evolved a highly specialized chromati

143 The repeat is also present on autosomes but not on chromosome Y in other hominoid spec

144 (UBCS) are common near the telomeres of all autosomes but not the sex chromosomes.

145 fficient for correct chromosome targeting to autosomes but that both COOH- and NH(2)-terminal sequenc

146 Remarkably, the DCC binds to autosomes, but at far fewer sites and rarely at consensu

147 more pronounced on the X chromosome than the autosomes, but autosomal loci are also affected, possibl

148 X chromosomes evolve differently from autosomes, but general governing principles have not eme

149 osomes have evolved repeatedly from ordinary autosomes, but little is known about the processes that

150 chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravag

151 Gene order is conserved on the autosomes, but noticeably less so on the Z chromosome, a

152 between the sexes, to a level equivalent to autosomes, by reducing Pol II recruitment to promoters o

153 though ectopic high-level Xist expression on autosomes can be compatible with viability, transgenic a

154 Comparisons of chromosome X and the autosomes can illuminate differences in the histories of

155 Autosomes carrying ectopic X-inactivation center sequenc

156 ; low divergence states cover inner parts of autosomes; chromosome X forms its own state with lowest

157 ther, these observations indicate that human autosomes contain discrete cis-acting loci that control

158 ion between an ancestral Z chromosome and an autosome corresponding to chromosome 15 in the Bombyx mo

159 higher than the rates of the paternal PAR or autosomes, culminating in an elevated chromosome-wide ra

160 The localization of HIM-5 to the autosomes depends on the activities of both xnd-1 and hi

161 Available demographic models of X and autosome descent cannot account for the increased diverg

162 er reveal that the ratio of X chromosomes to autosomes dictates methylation levels, with female hybri

163 ive levels of neutral diversity on the X and autosomes differ markedly from each other and from the n

164 X-autosome differences are reflective of germline sex diff

165 ome rearrangements involving eight different autosomes display delayed replication timing, and that c

166 We show that the difference between X and autosomes does not depend on the somatic dosage compensa

167 gene for lamin B1) have been shown to cause autosome-dominant leukodystrophy.

168 le mice remain healthy despite significant X-autosome dosage imbalance.

169 Here we showed that the autosome dose is communicated by a set of autosomal sign

170 chromosomes evolved from an ordinary pair of autosomes during the past 200-300 million years.

171 differences between the X chromosome and the autosomes either in the relative frequencies of mutation

172 animals (fem-3), a single pair of asynapsed autosomes elicits a checkpoint response, yet an unpaired

173 s diverged from mammals, different ancestral autosomes evolved into sex chromosomes in each lineage.

174 aptive evolution is barely detectable on the autosomes except for a few striking cases of recent sele

175 ial DNA rearrangements ensures that only one autosome expresses a functional T or B cell receptor.

176 chanism balances transcription between X and autosomes: expression of compensated hermaphrodite X-lin

177 mosome is evolving significantly faster than autosomes for nonsynonymous and most noncoding DNA sites

178 thereby marking somatic/progenitor genes on autosomes for repression.

179 structure and gene content of the ancestral autosome from which the sex chromosomes evolved.

180 These features were not present on the autosomes from which the Z and X chromosomes originated

181 The Z-autosome fusion brought two major genes conferring insec

182 is enhanced by rex site binding in cis in X-autosome fusion chromosomes.

183 [1]) and is very rapid after sex chromosome-autosome fusions in Drosophila [2-4].

184 retains only three percent of the ancestral autosomes' genes owing to genetic decay.

185 uggests that material from several different autosomes has been recently transferred to the sex chrom

186 diversity of the human X chromosome (X) and autosomes has facilitated understanding historical diffe

187 for the sex chromosomes variation within the autosomes has not been recognised.

188 Y-linked gene loss through transposition to autosomes has previously been reported for a single isol

189 High density linkage maps for the porcine autosomes have been constructed exploiting the high dens

190 dures for Hardy-Weinberg equilibrium for the autosomes have been described, but Bayesian work on the

191 This suggests that gene-dense autosomes have been subject to increased purifying selec

192 n MSL complex is ectopically localized to an autosome, histone H3K36 trimethylation (H3K36me3) is a s

193 e human Y chromosome began to evolve from an autosome hundreds of millions of years ago, acquiring a

194 Integration of an Rsx transgene on an autosome in mouse embryonic stem cells leads to gene sil

195 that an ancient X chromosome reverted to an autosome in the lineage leading to Drosophila.

196 specifically-inherited X chromosome with the autosomes in 20 early Neolithic and 16 late Neolithic/Br

197 ements results in many dysregulated genes on autosomes in an organ-specific manner.

198 sity is about three-quarters of that for the autosomes in both species.

199 is stronger on the X chromosome than on the autosomes in chimpanzees.

200 We find that fewer than half of the autosomes in each genome harbor all detectable introgres

201 ed duplicates generated from X chromosome to autosomes in flies and mammals.

202 e are higher on the X chromosome compared to autosomes in humans.

203 chromosomal copy number variations (CNVs) of autosomes in male subjects, whereas somatic loss of chro

204 eight cases of genes that have relocated to autosomes in mammalian lineages where the corresponding

205 ntified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult

206 novel pathway that distinguishes the X from autosomes in the germ line, and further show that xnd-1

207 omes differentiated from different ancestral autosomes in various vertebrate lineages.

208 usual evolutionary stability of lepidopteran autosomes; in contrast, higher rates of intrachromosomal

209 -biased for all sex-linked genes relative to autosomes, including those in the pseudoautosomal region

210 Many X-autosome incompatibilities in natural populations may be

211 ther F1 male sterility is caused by X-Y or X-autosome incompatibilities or a combination of both.

212 e sterility appears to be caused mainly by X-autosome incompatibilities, X-Y incompatibilities contri

213 male-beneficial duplicates are biased toward autosomes, independent of the dominance parameters of se

214 -mediated regulation may contribute to the X-autosome interaction.

215 sults imply a significant role for Y/X and Y/autosome interactions in maintaining proper expression o

216 In order to detect Y chromosome-autosome interactions, which may go unnoticed in a singl

217 t gene transposition from sex chromosomes to autosomes is a conserved phenomenon across mammalian spe

218 Random monoallelic expression on the mouse autosomes is broadly similar to that in human cells: it

219 e exception to the UBCS pattern found in all autosomes is chromosome 2, which shows a UBCS peak midch

220 The other set of autosomes is discarded into a residual body.

221 Instead, movement of autosomes is largely driven by distance change between c

222 tic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and dem

223 times from the least to the most gene-dense autosomes is ~17-21% for Sub-Saharan African populations

224 n the typically CO-deprived center region of autosomes leads to premature loss of sister chromatid co

225 transgenes inserted into X chromosome versus autosome locations.

226 this approach was able to produce a targeted autosome loss in aneuploid mouse embryonic stem cells wi

227 single X, unlike asynapsed X chromosomes or autosomes, maintains repressive chromatin marks and rema

228 Sex chromosomes evolved from autosomes many times across the eukaryote phylogeny.

229 This is important because the translocated autosome may be influenced by the evolution of the recip

230 ting forces between the X chromosome and the autosomes may be associated with various pathologies cau

231 The bias of X-to-autosome movement was significantly stronger for RNA-bas

232 mentation, including the X-chromosome and an autosome (Muller Element C/E).

233 ired DSBs and pairing failures-stochastic on autosomes, nearly absolute on X and Y-cause meiotic arre

234 enes--EIF1AX/Y and RPS4X/Y--transposition to autosomes occurred independently in three distinct linea

235 ved papaya sex chromosomes with a homologous autosome of a close relative, the monoecious Vasconcelle

236 up and were probably inherited from a single autosome of an ancestor.

237 Here we show that an autosome of Drosophila, the dot chromosome, was ancestra

238 omosome of F. virginiana and the homeologous autosome of hermaphroditic diploid species.

239 pophylla and S. otites each correspond to an autosome of the other species, and both differ from the

240 ORI-29 library has an average depth over the autosomes of 5.0-fold and 2.8-fold coverage of the X chr

241 loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell

242 A1 deposition are largely similar across the autosomes of both cell lines.

243 Unexpectedly, DPY-21 also associates with autosomes of germ cells in a DCC-independent manner to e

244 ed genes is much lower than that of genes on autosomes: on average, maximal expression is three times

245 se if an existing sex chromosome fuses to an autosome or an autosome acquires a new sex-determining l

246 ly homomorphic and evolved from an ancestral autosome pair in association with a shift from hermaphro

247 in a way that is different from that of the autosomes, potentially resulting in accelerated evolutio

248 lity of XIST to dosage compensate a trisomic autosome presents unique experimental opportunities and

249 rrent models invoke a dependency on the X-to-autosome ratio (X:A), but molecular factors remain poorl

250 selection can account for the observed X to autosome ratio of variability in the ancestral populatio

251 servations: notably, the puzzlingly low X-to-autosome ratios of substitution rates in humans and chim

252 on of retrogenes on the X than seen for X-to-autosome retrogenes on autosomes.

253 as well as differences in sex chromosome vs. autosome segregation.

254 reas two subpopulations were observed in the autosomes separating gynodioecy and dioecy and three sub

255 ster chromatids, which co-segregate with the autosome set to generate a functional haplo-X sperm.

256 In all cases, insertions on the autosomes showed significantly higher expression than th

257 individual Y genes inserted as transgenes on autosomes shows that expression of the Zfy 1/2 paralogs

258 ore likely to produce male sterility than on autosome (so-called large-X theory); second, spermatogen

259 essions show a significant enrichment on the autosomes, supporting an epistatic interaction between t

260 allele (Mybl1(repro9)) had subtle defects in autosome synapsis in pachynema, a high incidence of unsy

261 mutation-selection balance conditions for X-autosome synthetic lethals and steriles.

262 Second, we analyze sex chromosome versus autosome TE densities corrected for regional genomic eff

263 eterious mutations) is more effective on the autosomes than on the X chromosome, because of the lack

264 that there are more genes subject to RMAE on autosomes than the number of genes on the X chromosome w

265 o random monoallelic expression on mammalian autosomes than there are on the X chromosome and that th

266 al gene expression, but rather in changes on autosomes that can be rescued by expression of transgeni

267 nly 2% of the MSY derives from the ancestral autosomes that gave rise to the mammalian sex chromosome

268 tic interaction between the X Chromosome and autosomes that is essential for male fertility.

269 X or Z-linked divergence exceeds that on the autosomes (the so-called 'faster-X effect').

270 by the ratio of X chromosomes to the sets of autosomes, the X:A signal.

271 es share features that distinguish them from autosomes: the acquisition and amplification of testis-e

272 Y chromosomes evolved from a single pair of autosomes, they are highly differentiated: the Y chromos

273 s often thought that the translocation of an autosome to a sex chromosome may share a common origin a

274 bank dataset and estimate its runtime on the autosomes to be 3.3 days parallelized across 128 cores.

275 ormation, X-added regions, and conversion of autosomes to sex chromosomes from which we propose a mod

276 itiation of MSCI sequesters DDR factors from autosomes to the sex chromosomes at the onset of the pac

277 Similarly, autosome-to-X retroposition events are associated with l

278 e Y-linked genes have autosomal paralogs, so autosome-to-Y transposition must be the main source of D

279 NA methylation profiling in six unbalanced X;autosome translocations.

280 TEX11-deficient spermatocytes with asynapsed autosomes undergo apoptosis at the pachytene stage, whil

281 eparately on the Bogota X chromosome and USA autosomes using a combination of different mapping strat

282 l, X and Y chromosomes evolve from a pair of autosomes via a series of inversions leading to stepwise

283 ith polymorphic markers across the 19 murine autosomes was performed on the N2 mice.

284 nd that monoallelic DNA accessibility across autosomes was pervasive, developmentally programmed and

285 e nuclear-nuclear (specifically X chromosome-autosome), we found the strongest deleterious interactio

286 unnoticed in a single-species background of autosomes, we constructed hybrid genotypes involving thr

287 nearly always involved in tangles, and small autosomes were involved more often than large ones.

288 new version, analyses for GM12878 individual autosomes were performed and compared to earlier studies

289 somes have evolved from a pair of homologous autosomes which differentiated into sex determination sy

290 s undergo mosaic events more frequently than autosomes, which could have implications for understandi

291 es have unequal ratios of sex chromosomes to autosomes, which has resulted in the invention of divers

292 aches we detect 199 peaks spread over all 19 autosomes, which potentially contribute to trait variati

293 methods designed to investigate gene flow in autosome-wide genotype data from 3,528 unrelated individ

294 d Ware culture show high similarity in their autosomes with European hunter-gatherers, Steppe Eneolit

295 e levels of variability on X chromosomes and autosomes with selection at linked sites are discussed,

296 The assembly comprises 26 autosomes with sizes ranging from 12.4 to 33.1 Mb and a

297 ian ZW pair is believed to have evolved from autosomes, with most change occurring in the chromosomes

298 Also, for X chromosome-to-autosome (X-->A) movement, we observed high testis expre

299 d to have had multiple effects on human X-to-autosome (X:A) diversity ratios, as a result of male-bia

300 s of development, and in strains harboring X;autosome (X;A) fusions.

301 nicate the ratio of X chromosomes to sets of autosomes (X:A signal).