ライフサイエンスコーパス: autotransporter

1 arity with the nontypeable H. influenzae Hia autotransporter.

2 fusion protein of a peptidase and a type IV autotransporter.

3 the gene coding for the Fap2 outer membrane autotransporter.

4 adhesin belonging to the family of trimeric autotransporters.

5 ned domain that is ubiquitous among trimeric autotransporters.

6 a member of the diffuse adherence family of autotransporters.

7 homology to YadA-like and Hia-like trimeric autotransporters.

8 one putative Type IV system and three Type V autotransporters.

9 tivity and the overall structure of trimeric autotransporters.

10 teolytic processing of two distantly related autotransporters.

11 embers of a six-member family of cohemolysin autotransporters.

12 led the translocation domain of conventional autotransporters.

13 equence that shows homology to the family of autotransporters.

14 has similarity to both acid phosphatases and autotransporters.

15 o the mechanism of translocation in trimeric autotransporters.

16 al translocator domain and known as trimeric autotransporters.

17 ions between this subfamily and conventional autotransporters.

18 id sequence showed homology to the family of autotransporters.

19 ng many novel type III secretion systems and autotransporters.

20 kely found in a broad range of other inverse autotransporters.

21 s employed for glycosylation of flagella and autotransporters.

22 factors, calling into question the moniker "autotransporter."

23 The gene identified in H10407, eatA (ETEC autotransporter A), encodes a potential serine protease

24 olved in the biogenesis of a major subset of autotransporters, a group of proteins that play key role

25 Members of the Trimeric Autotransporter Adhesin (TAA) family play a crucial role

26 Neisserial adhesin A (NadA), a trimeric autotransporter adhesin (TAA) that acts in adhesion to a

27 e analyze the biogenesis of UpaG, a trimeric autotransporter adhesin (TAA).

28 d by these genes are members of the trimeric autotransporter adhesin family.

29 the properties of SadA, a purported trimeric autotransporter adhesin of Salmonella enterica serovar T

30 Trimeric autotransporter adhesins (TAAs) are important virulence

31 Trimeric autotransporter adhesins (TAAs) are modular, highly repe

32 We identified autotransporter adhesins as the preferred protein substr

33 ng fitness benefits in vivo include trimeric autotransporter adhesins, O antigens, and type IV pili (

34 amentous hemagglutinin FhaB and two trimeric autotransporter adhesins.

35 organism, Haemophilus influenzae, possesses autotransporter adhesins.

36 uman milk removes or cleaves Hap and another autotransporter, an immunoglobulin A1 protease, from the

37 loprotease gene, genes encoding six putative autotransporters, an extension of the atf fimbrial opero

38 TibA is an autotransporter and afimbrial adhesin that is glycosylat

39 is defective in the processing of rOmpB, an autotransporter and also a major surface antigen of spot

40 brane protein D (PmpD) is a highly conserved autotransporter and the target of broadly cross-reactive

41 chitecture of Hsf and the family of trimeric autotransporters and provide insight into the structural

42 and the relationship between the assembly of autotransporters and the assembly of other classes of OM

43 m (T2SS), a type VI secretion system (T6SS), autotransporter, and outer membrane vesicles (OMVs).

44 ion of the trimeric architecture of trimeric autotransporters, and possibly other trimeric adhesins,

45 he high pathogenicity island, three putative autotransporters, and several possible insecticidal toxi

46 The autotransporters are a group of proteins that mediate th

47 The autotransporters are a group of proteins that mediate th

48 Autotransporters are a large and diverse superfamily of

49 Autotransporters are a large class of virulence proteins

50 Autotransporters are a large superfamily of cell surface

51 Autotransporters are a superfamily of bacterial virulenc

52 Autotransporters are a superfamily of virulence factors

53 Autotransporters are a superfamily of virulence factors

54 Autotransporters are a superfamily of virulence proteins

55 Autotransporters are an extensive family of large secret

56 Autotransporters are bacterial outer membrane proteins t

57 Autotransporters are bacterial virulence factors consist

58 Autotransporters are bacterial virulence factors that co

59 Autotransporters are bacterial virulence factors that co

60 translocation, the passenger domains of some autotransporters are cleaved by an unknown mechanism.

61 Bacterial autotransporters are comprised of an N-terminal 'passeng

62 Instead, chromosome-encoded autotransporters are critical for robust colonization an

63 Since autotransporters are important for virulence in many bac

64 Most autotransporters are localised to the bacterial surface

65 Autotransporters are outer membrane proteins that are wi

66 Several putative conventional autotransporters are present in the Yersinia pestis geno

67 Bacterial autotransporters are proteins that contain a small C-ter

68 Bacterial autotransporters are proteins that use a C-terminal pori

69 Autotransporters are secreted proteins produced by patho

70 Autotransporters are secreted virulence factors that com

71 Autotransporters are the largest family of outer membran

72 Although autotransporters are translocated across the inner membr

73 the beta domain is the rate-limiting step in autotransporter assembly and that passenger domain trans

74 iments using nanodiscs strongly suggest that autotransporter assembly is catalyzed by a single copy o

75 Autotransporter (AT) is a protein secretion pathway foun

76 scovery of BatB, a classical-type Bordetella autotransporter (AT) protein with an approximately 180-k

77 Autotransporter (AT) proteins are a broad class of virul

78 Autotransporter (AT) proteins are a broad class of virul

79 Autotransporter (AT) proteins are a large and diverse fa

80 Autotransporter (AT) proteins provide a diverse array of

81 Autotransporter (AT) proteins, which represent the large

82 The autotransporter (AT) secretion mechanism is the most com

83 Autotransporters (AT) are widespread in Gram-negative ba

84 annii, designated the Acinetobacter trimeric autotransporter (Ata), that contains all of the typical

85 Autotransporters (ATs) are a family of bacterial protein

86 Autotransporters (ATs) are exoproteins belonging to the

87 Autotransporters (ATs) are outer membrane proteins belon

88 One of the six predicted Proteus mirabilis autotransporters (ATs), ORF c2341, is predicted to conta

89 olding reaction and promote stability of the autotransporter barrel domain.

90 present study, we investigated one of these autotransporters, BatA, and demonstrate that it displays

91 e predicts the presence of IgA1 protease and autotransporter beta-barrel domains.

92 uences of the signal peptide (SS) and of the autotransporter beta-domain of the Neisseria gonorrhoeae

93 findings reveal far greater diversity in the autotransporter beta-helix than previously thought, and

94 All use the trimeric autotransporter BimA to facilitate actin-based motility,

95 nger domain secretion, but its exact role in autotransporter biogenesis is unclear.

96 autotransporter pathway, several aspects of autotransporter biogenesis remain poorly understood, mos

97 We also discuss insights into each stage of autotransporter biogenesis that have emerged from recent

98 n addition to leading to a detailed model of autotransporter biogenesis, our results suggest that the

99 In an attempt to understand autotransporter biogenesis, we screened the sequences of

100 to identify such factor as a pro-angiogenic autotransporter, called BafA.

101 ndicate that the proper assembly of trimeric autotransporter can occur also in a system lacking the l

102 h the large C-terminal propeptide acts as an autotransporter; certain viral coat proteins; and protei

103 xperimental support for a unique subclass of autotransporters characterized by a short trimeric trans

104 berculosis strains, we determined that these autotransporters cluster into a YapK (YPTB3285) class an

105 Bacterial autotransporters comprise a 12-stranded membrane-embedde

106 domain from another predicted M. catarrhalis autotransporter confirmed the translocation ability of t

107 Bacterial autotransporters consist of an N-terminal 'passenger dom

108 Autotransporters constitute the largest group of secrete

109 athogens, including Y. pestis, any change in autotransporter content should be considered for its imp

110 abbit ileal loop model, suggesting that this autotransporter contributes to the virulence of ETEC.

111 studies have identified a novel subfamily of autotransporters, defined by a short trimeric C-terminal

112 he temperature-sensitive hemagglutinin (Tsh) autotransporter described in avian E. coli strains (97%

113 etory signal peptide, a C-terminal predicted autotransporter domain, up to four predicted Wasp homolo

114 stance is mediated primarily by the trimeric autotransporter DsrA.

115 In contrast, another trimeric autotransporter, epithelial adhesin ApiA, was not affect

116 study, we used the Escherichia coli O157:H7 autotransporter EspP as a model protein to investigate t

117 enger domain of the Escherichia coli O157:H7 autotransporter EspP at different stages of protein biog

118 enger domain of the Escherichia coli O157:H7 autotransporter EspP effectively creates a translocation

119 enger domain of the Escherichia coli O157:H7 autotransporter EspP have been shown to cause strong sec

120 ete assembly of the Escherichia coli O157:H7 autotransporter EspP in vitro.

121 enger domain of the Escherichia coli O157:H7 autotransporter EspP is released in a novel autoproteoly

122 enger domain of the Escherichia coli O157:H7 autotransporter EspP requires the stable folding of a C-

123 uctures of three noncleavable mutants of the autotransporter EspP to examine how it promotes asparagi

124 e C terminus of the Escherichia coli O157:H7 autotransporter EspP to test this hypothesis.

125 beta domain of the Escherichia coli O157:H7 autotransporter EspP.

126 d signal peptide associated with the E. coli autotransporter EspP.

127 of mutations in the Escherichia coli O157:H7 autotransporter EspP.

128 We speculate that trimeric autotransporters evolved to enable high-affinity multiva

129 en in the presence of truncated LPS, and all autotransporters examined are polar in the cytoplasm pri

130 All of these autotransporters exhibit >96% identity in the C terminus

131 beta domain of the Escherichia coli O157:H7 autotransporter extracellular serine protease P (EspP) i

132 The Cha adhesin belongs to the trimeric autotransporter family and contains an N-terminal signal

133 bears significant homology to members of the autotransporter family of bacterial virulence factors, p

134 The autotransporter family of proteins is an important class

135 ed, including the polymorphic outer membrane autotransporter family of proteins, the putative large c

136 of H. influenzae and belongs to the trimeric autotransporter family of proteins.

137 IcsA is an outer membrane protein in the autotransporter family that is required for Shigella fle

138 hdA is a large outer membrane protein of the autotransporter family whose passenger domain binds the

139 embrane protein A [rOmpA]) and member of the autotransporter family, 660 bp from the start of transla

140 philus influenzae Hia adhesin belongs to the autotransporter family, with translocator activity resid

141 protein in Escherichia coli belonging to the autotransporter family.

142 This first stage of autotransporter folding determines whether subsequent tr

143 we hereby rename Fusobacterium phospholipase autotransporter (FplA).

144 We demonstrate that autotransporters from a wide variety of rod-shaped patho

145 Here, we demonstrate that secretion of autotransporters from several organisms requires the out

146 This 3.5-kb APEC autotransporter gene (aatA) is predicted to encode a 123

147 , and characterization of a CAMP-like factor autotransporter gene (cfa) from B. henselae.

148 rs of the polymorphic membrane protein (pmp) autotransporter gene family that corresponded to predict

149 encing, and characterization of an antigenic autotransporter gene from B. henselae.

150 the type III secreted effector EspT gene, an autotransporter gene, a hemolysin gene, and putative fim

151 In Y. pestis CO92, the autotransporter genes yapK and yapJ share a high level o

152 -forming domain to that of the H. influenzae autotransporter, Hap.

153 t studies have revealed that fully assembled autotransporters have an unusual architecture in which a

154 Numerous autotransporters have been implicated in pathogenesis, s

155 ins secreted by the type V secretion system (autotransporters) have been linked to virulence in gram-

156 rage) and that is called TleA (Tsh-like ETEC autotransporter) herein.

157 l and functional characteristics of trimeric autotransporters, highlighting the distinctions between

158 proteins are the beta-barrel portions of the autotransporter homologues.

159 eveal little similarity to any characterized autotransporters; however, two of the genes are present

160 ass of autotransporter proteins, the inverse autotransporters (IAT).

161 e-exposed adhesins, belonging to the inverse autotransporters (IATs), called Y. ruckeri invasin (YrIn

162 Like other autotransporters, the Shigella autotransporter IcsA, which is required for actin assemb

163 in vivo cytotoxicity and antigenicity of an autotransporter in P. mirabilis and its use in vaccine d

164 ructure of the enzyme fits that of a classic autotransporter in which several unique domains necessar

165 is the first report characterizing trimeric autotransporters in P. mirabilis as afimbrial surface ad

166 minus of the passenger domain of the inverse autotransporter intimin, we generated a mutant defective

167 The Haemophilus influenzae Hap autotransporter is a nonpilus adhesin that promotes adhe

168 The H. influenzae Hia autotransporter is an adhesive protein that promotes adh

169 beta-barrel appears folded; (ii) the stalled autotransporter is associated with BamA and SurA; (iii)

170 with large amounts of SurA; (iv) the stalled autotransporter is not degraded by periplasmic proteases

171 the pertactin family of Bordetella pertussis autotransporters is released from the beta domain throug

172 shs classifies the protein in a subfamily of autotransporters, known as serine protease autotransport

173 The 'autotransporter' moniker refers to early models that dep

174 Both species have numerous type Va autotransporters, most of which appear to be highly cons

175 with a model in which the secretion of large autotransporters occurs via specific conserved pathways

176 We previously identified a surface autotransporter of A. baumannii, Ata, that bound to vari

177 The Hia autotransporter of Haemophilus influenzae belongs to the

178 The Hia autotransporter of Haemophilus influenzae belongs to the

179 Moreover, NalP, an autotransporter of spherically shaped Neisseria meningit

180 ferred to as SPATE proteins (serine protease autotransporter of the Enterobacteriaceae).

181 The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secr

182 of virulence factors called serine protease autotransporters of Enterobacteriaceae (SPATEs) are secr

183 The serine protease autotransporters of Enterobacteriaceae (SPATEs) represen

184 i, is a member of the SPATE (serine protease autotransporters of Enterobacteriaceae) family and, as s

185 in EspP, a prototype of the serine protease autotransporters of enterobacteriaceae.

186 the passenger domain of the serine protease autotransporters of the Enterobacteriaceae (SPATEs) and

187 The serine protease autotransporters of the Enterobacteriaceae (SPATEs) repr

188 ce factors, particularly the serine protease autotransporters of the Enterobacteriaceae proteins.

189 f autotransporters, known as serine protease autotransporters of the Enterobacteriaceae.

190 Serine protease autotransporters of the family Enterobacteriaceae (SPATE

191 ent the passenger domain of the Hia trimeric autotransporter on the bacterial surface.

192 e serine proteases that are secreted via the autotransporter (or type V) bacterial secretion pathway.

193 report the folding behavior of pertactin, an autotransporter passenger domain from Bordetella pertuss

194 ed by periplasmic proteases; and (v) inverse autotransporter passenger domains are translocated by a

195 a-helix, a feature that is characteristic of autotransporter passenger domains but unique among known

196 ze, sequence, and functional diversity among autotransporter passenger domains, >97% are predicted to

197 al insights have expanded the utility of the autotransporter pathway for the surface display of heter

198 ri VacA, a pore-forming toxin secreted by an autotransporter pathway, causes multiple alterations in

199 Despite the apparent simplicity of the autotransporter pathway, several aspects of autotranspor

200 athogenic Gram-negative bacteria through the autotransporter pathway.

201 ase-susceptible OMPs are exported through an autotransporter pathway.

202 n line with this, biophysical studies of the autotransporter Pet show that the conserved residues sig

203 ich are highly homologous to serine protease autotransporters Pic and Tsh.

204 luster, fbpABCD (c0294 to c0297 [c0294-97]), autotransporter, picU (c0350), and RTX family exoprotein

205 EatA, an autotransporter previously identified in ETEC, possesses

206 Here we used EspP, an autotransporter produced by Escherichia coli 0157:H7, as

207 NalP complementing strains, we show that the autotransporter protease NalP cleaves C3, the central co

208 The gene encoding the autotransporter protease SepA, originally described in S

209 ermediate polypeptide that is cleaved by the autotransporter protease SphB1 to generate FHA.

210 A novel putative autotransporter protein (NMB1998) was identified in the

211 tion, including operons for type 1 fimbriae, autotransporter protein Ag43, curli production, colanic

212 yapV gene and its product, recognized as an autotransporter protein by its typical sequence, outer m

213 MisL is an autotransporter protein encoded by Salmonella pathogenic

214 The Shigella autotransporter protein IcsA, which is localized to the

215 H. influenzae Hap autotransporter protein is an adhesin composed of an out

216 The H. influenzae Hap autotransporter protein mediates adherence, invasion, an

217 This is the first 3D structure of a trimeric autotransporter protein of A. actinomycetemcomitans.

218 e characterized a novel secreted cohemolysin autotransporter protein of B. henselae.

219 Pertactin (PRN) is an autotransporter protein produced by all members of the B

220 We identified the autotransporter protein rickettsial OmpB (rOmpB) as a fa

221 perature-sensitive hemagglutinin (Tsh) is an autotransporter protein secreted by avian-pathogenic Esc

222 l ensemble are under selection for efficient autotransporter protein secretion, a necessary prerequis

223 The Rickettsia ~1800-amino-acid autotransporter protein surface cell antigen 2 (Sca2) pr

224 nalysis suggests that McaP is a conventional autotransporter protein that contains a 12-stranded beta

225 This is the first description of an autotransporter protein that expresses acid phosphatase

226 o gain further insight into the mechanism of autotransporter protein translocation, we performed a st

227 The bacterium uses an autotransporter protein UspA1 to target an important hum

228 ain 1026b is predicted to encode a classical autotransporter protein with an approximately 80-kDa pas

229 ns express a surface-exposed, outer membrane autotransporter protein, designated Aae, which has been

230 anean spotted fever, we report here that the autotransporter protein, rickettsial outer membrane prot

231 ssed with a minimal clone of EspP, a related autotransporter protein.

232 we renamed HP0289 ImaA for immunomodulatory autotransporter protein.

233 ce analysis revealed that McaP is related to autotransporter proteins and has substantial similarity

234 Autotransporter proteins are a class of cell-surface fac

235 Gram-negative bacterial autotransporter proteins are a growing group of virulenc

236 Autotransporter proteins are a large family of gram-nega

237 Autotransporter proteins are defined by the ability to d

238 Autotransporter proteins comprise a large family of viru

239 its 36 and 33% identity to the meningococcal autotransporter proteins immunoglobulin A1 (IgA1) protea

240 estigated the potential role of adhesin-like autotransporter proteins in S. flexneri biofilm formatio

241 of DnaK more generally in the chaperoning of autotransporter proteins in the bacterial cytoplasm.

242 Little is known about the fate of the autotransporter proteins in the periplasm, including whe

243 Chlamydia possess a unique family of autotransporter proteins known as the Polymorphic membra

244 redicted to encode proteins with homology to autotransporter proteins of Gram-negative bacteria.

245 Two putative autotransporter proteins, CapA and CapB, were identified

246 ane protein genes (pmpA to pmpI), resembling autotransporter proteins, has recently been discovered i

247 as an elongated shape but, unlike most other autotransporter proteins, possesses a central kink revea

248 ead representative from an emerging class of autotransporter proteins, the inverse autotransporters (

249 had similarity to passenger domains of other autotransporter proteins, whereas the C-terminal portion

250 e organism possesses multiple genes encoding autotransporter proteins, which represent important viru

251 s within Sca2, a member of a family of large autotransporter proteins.

252 antigen" (sca) genes whose products resemble autotransporter proteins.

253 d from pathogenic Gram-negative bacteria are autotransporter proteins.

254 ecessary for outer membrane translocation of autotransporter proteins.

255 as a previously unrecognized feature of all autotransporter proteins.

256 1289, S2406, and icsA, encoding adhesin-like autotransporter proteins.

257 We found that the secretion of autotransporters requires translocation and the assembly

258 Another major surface antigen and autotransporter, rOmpB, exhibits a defect in processing

259 belonging to the family of self-associating autotransporters (SAATs).

260 n surface protein and Pic, a serine protease autotransporter secreted by EAEC and Shigella flexneri,

261 esults fit with the four proposed models for autotransporter secretion and potential applications in

262 The prevailing model for autotransporter secretion comprises entry to the peripla

263 Autotransporter secretion involves the insertion of a ca

264 The final step of autotransporter secretion is C --> N-terminal threading

265 Together, these findings are consistent with autotransporter secretion occurring at the poles of rod-

266 ed by enteric Gram-negative bacteria via the autotransporter secretion pathway.

267 and RadD, which share regions homologous to autotransporter secretion systems (type Va secretion sys

268 ocation and help to clarify the mechanism of autotransporter secretion.

269 esented here suggest a general mechanism for autotransporter secretion.

270 protease is a founding member of the type V (autotransporter) secretion system and is considered a vi

271 A second Shigella autotransporter, SepA, also required DnaK for secretion,

272 The type V secreted autotransporter serine protease EspP and the enterohemol

273 erminal extension that is conserved in other autotransporter signal peptides.

274 equences of the serine protease subfamily of autotransporters (SPATEs) for conserved features indicat

275 F. nucleatum Type Vd phospholipase class A1 autotransporter (strain ATCC 25586, gene FN1704) that we

276 oth Hia and YadA are members of the trimeric-autotransporter subfamily and are characterized by an in

277 emophilus influenzae belongs to the trimeric autotransporter subfamily and mediates bacterial adheren

278 emophilus influenzae belongs to the trimeric autotransporter subfamily and mediates bacterial adhesio

279 e biogenesis of at least some members of the autotransporter superfamily.

280 we exploited the plasmid-encoded toxin (Pet) autotransporter system for accumulation of heterologous

281 ains all of the typical features of trimeric autotransporters (TA), including a long signal peptide f

282 we present the crystal structure of UpaB, an autotransporter that is known to contribute to uropathog

283 o members of the diffuse adherence family of autotransporters that are distantly related to antigen 4

284 lleles in Escherichia coli pathovars encodes autotransporters that have been implicated in biofilm fo

285 mic expansions of Type V secreted effectors (autotransporters) that are critical for host cell adhere

286 Autotransporters, the largest family of secreted protein

287 Like other autotransporters, the Shigella autotransporter IcsA, whi

288 1766a seems to secrete most of the produced autotransporter to the medium.

289 nal beta-domain is critical for targeting of autotransporters to the outer membrane and for transloca

290 The restriction of autotransporters to the pole is dependent on the presenc

291 The secreted autotransporter toxin (Sat), found predominantly in urop

292 etes the functionally well-characterized Pet autotransporter toxin that contributes to virulence thro

293 prototypical of a large family of bacterial autotransporter toxins.

294 e unfolded ensemble of pertactin, a secreted autotransporter virulence protein from Bordetella pertus

295 iched across the large and diverse family of autotransporter virulence proteins, suggesting sequence

296 -helical fold is unusual among Gram-negative autotransporters, which overwhelmingly fold as beta-sole

297 d in the genome of strain HI4320 as trimeric autotransporters with "adhesin-like" and "agglutinating

298 for two known adhesins, pH 6 antigen and the autotransporter, YapC, as well as the Caf1 capsule, whic

299 In Yersinia pestis the autotransporter YapE has adhesive properties and contrib

300 eading frames encoding putative conventional autotransporters (yaps), nine of which appear to produce