ライフサイエンスコーパス: avascular

1 The lens and central cornea are avascular.

2 t at 1-month posttransplantation were almost avascular.

3 Because cartilage is generally avascular, all nutrients, oxygen, signaling molecules, a

4 that sflt-1 is essential for preserving the avascular ambit of the cornea can rationally guide its u

5 to inflammation using the cornea, a normally avascular and densely innervated ocular tissue, as a mod

6 Early cancers are avascular and hence, profoundly acidic.

7 C.HA might explain why AM is developmentally avascular and how AM might exert an antiangiogenic actio

8 d tubular-like compartments that are largely avascular and immature in static culture.

9 15-LOX and ALX are highly expressed in the avascular and immune-privileged cornea.

10 Regenerated cartilage was avascular and integrated with regenerated subchondral bo

11 conducted to measure the retinal function in avascular and isolated perfused retinas to separate vasc

12 Stage 1 metastases were avascular and lacked mitotic activity.

13 lar areas where TAMs promote metastasis, and avascular and perinecrotic areas where hypoxic TAMs stim

14 The avascular and transparent cornea serves as a good in viv

15 enotypic markers and chondrogenic potency of avascular and vascular meniscal cells and chondrocytes f

16 t change the Po(2) at the border between the avascular and vascularized retina; hyperoxia significant

17 ion, defined as a completely epithelialized, avascular, and clinically stable corneal surface.

18 66%) maintained a completely epithelialized, avascular, and clinically stable corneal surface.

19 9 distinct pulmonary lesion types (vascular, avascular, and mixed) obtained from 15 hard-to-treat TB

20 ic features of osseous sclerosis, sequestra, avascular, and radiopaque alveolar bone in the jaw that

21 gns (successful: restoration of transparent, avascular, and stable corneal epithelium without neovasc

22 (46.7%) achieved completely epithelialized, avascular, and stable ocular surfaces.

23 Total extrafoveal avascular area (tEAA) was based on the area of absent ca

24 Avascular area analysis with an automated algorithm usin

25 wed greater revascularization of the central avascular area and developed equal or fewer neovascular

26 Total avascular area and foveal avascular zone area were great

27 The central avascular area and neovascular tufts were measured after

28 ndary measures included the agreement of the avascular area between the OCT angiogram and FA.

29 atistically significant reduction of retinal avascular area compared with control eyes.

30 Total avascular area in the central 5.5-mm-diameter area disti

31 ls by dietary or genetic means decreased the avascular area of the retina by increasing vessel regrow

32 a statistically significant decrease in the avascular area of the retinas.

33 Moreover, vessel regrowth into the avascular area was reduced in TIMP3-injected mice, but n

34 o have abnormalities at the periphery (large avascular area, abnormal branching, shunt) or the poster

35 afoveal and perifoveal vessel density, total avascular area, and foveal avascular zone as detected wi

36 ing neovascular tuft formation and increased avascular area, in a dose-dependent manner.

37 ss and quantitatively for measures of foveal avascular area, parafoveal flow, and vascular density.

38 , all showed abnormalities at the periphery (avascular area, vessel leakage, shunts, abnormal vessel

39 Documentation of peripheral avascular areas on intravenous fluorescein angiography w

40 Although larger avascular areas or higher severity scores were associate

41 Neovascularization (NV) and avascular areas were assessed on retinal flat-mounts by

42 , Ntn-4(-/-) mice initially displayed larger avascular areas which recovered faster to revascularizat

43 In only 1 of the 40 eyes did a cystic avascular bleb develop, with all the other eyes being no

44 Six (30%) cystic thin avascular blebs without oozing were recorded in the MMC

45 Limbus-based procedures produce higher, more avascular blebs, with a greater risk of infection.

46 from E10.5 to E13.5 revealed the presence of avascular blood islands of primitive erythroid cells exp

47 The cornea is avascular but the tumour promotes vascularisation from t

48 dogenous cells, as exemplified by stratified avascular cartilage and vascularised bone.

49 initially inhibit angiogenesis to allow for avascular cartilage formation.

50 penetration and distribution of TAA into the avascular cartilage is not well understood.

51 slow diffusive transport through the dense, avascular cartilage matrix comprised of negatively charg

52 Endochondral ossification depends on an avascular cartilage template that completely remodels in

53 cal step in bone formation is to replace the avascular cartilage template with vascularized bone.

54 c agents to the resident chondrocytes in the avascular cartilage.

55 fferentiate in the perichondrium surrounding avascular cartilaginous rudiments; the source of trabecu

56 We demonstrate here that in the avascular chicken retina, vascular endothelial growth fa

57 e images were generated using the "retina," "avascular," "choriocapillaris," and "outer retina to cho

58 Molecular transport in avascular collagenous tissues such as articular cartilag

59 HRM, OCTA distinguished between vascular and avascular components.

60 neal micropocket angiogenesis assay uses the avascular cornea as a canvas to study angiogenesis in vi

61 genesis of lymphatic vessels in the normally avascular cornea in response to HSV-1 infection.

62 The avascular cornea is a uniquely-isolated organ, with its

63 Angiogenesis into the normally avascular cornea is incompatible with good vision and, t

64 enesis is neovascularization of the normally avascular cornea, a process that involves the vascular e

65 tecture at the limbal border of the normally avascular cornea, a quantitative trait under strong gene

66 In the normally avascular cornea, however, pathological lymphangiogenesi

67 lood and lymphatic vessels into the normally avascular cornea.

68 y of peripheral nerves after injury using an avascular corneal nerve injury model.

69 l emigration through limbal vessels into the avascular corneal stroma, peaking within 12 to 18 hours

70 ion of a completely epithelized, stable, and avascular corneal surface.

71 corneas, do not express sflt-1, whereas the avascular corneas of dugongs, also members of the order

72 Limited nutrient supply in the avascular disc environment restricts the production of A

73 changes that decrease nutrient supply to the avascular disc.

74 e, we demonstrated efficient regeneration of avascular elastic cartilage from in vitro-grown mesenchy

75 rgy-dependent anabolic processes occur in an avascular environment(1,2).

76 e in vitro, but glomeruli do not form in the avascular environment.

77 study is to evaluate the reliability of the avascular exposed root surface area (AERSA) as a prognos

78 ion and end up with encapsulation by a dense avascular fibrous layer enriched in extracellular matrix

79 In the avascular fibrous stromal core of all specimens, the pre

80 more likely to be graded as higher and to be avascular (GEE model, both P < 0.0001).

81 uires rapid restoration of blood flow to the avascular graft.

82 tion before gonadotoxic chemotherapy and its avascular grafting after cancer healing permitted fertil

83 mour growth, linking the relatively harmless avascular growth phase and the potentially fatal vascula

84 ug therapy in ACH is targeting agents to the avascular growth plate.

85 These studies suggest that the normal avascular human cornea contains and synthesizes the comp

86 , and differentiation of chondrocytes in the avascular hypoxic fetal growth plate, which is rich in e

87 Avascular, hypoxic retina has been postulated to be a so

88 Sema6A expression increases in avascular inner retina and colocalizes with Nrf2 in huma

89 istochemistry showed deposition of HP in the avascular inner retina but not in areas underlying prere

90 In addition, avascular isolated cells expressing primitive erythroid,

91 M showed an anatomic preference for vascular-avascular junctions.

92 ounding the retina and were separated by the avascular layer in between.

93 iary body as a source of immune cells to the avascular lens.

94 Avascular lesions were defined as benign.

95 fatty acids, and thus adapts the cells to an avascular life.

96 Transformation of small avascular masses of tumor cells into rapidly progressive

97 Although tumors may arise as avascular masses, there is increasing evidence that some

98 nd pathologic angiogenesis into the normally avascular, mature (secondary) vitreous.

99 In contrast, the avascular media is often spared by immune-mediated disor

100 expressed at a significantly higher level on avascular meniscal cells derived from tissues with a mor

101 le for the generation and maintenance of the avascular midline and that BMP antagonists expressed by

102 hesive aortic vessels because of loss of the avascular midline, yet maintain lateral avascular zones.

103 nched aortic plexus with a markedly narrowed avascular midline.

104 and continues to be broadly used as a unique avascular model, the isolation of the cloche gene has be

105 Because cartilage is avascular, molecular transport occurs primarily via diff

106 egions far from blood vessels, they exhibit 'avascular motility', defined by high speed and less conf

107 The avascular nature and the dense matrix of this tissue mak

108 The avascular nature of cartilage makes it a unique tissue(1

109 ould be involved in the establishment of the avascular nature of seminiferous tubules and after puber

110 Owing to the avascular nature of the IVD and lack of understanding th

111 Avascular necrosis (AVN) after renal transplantation has

112 xperience a high rate of fracturing and some avascular necrosis (AVN), but little is known about the

113 as well as other bone complications, such as avascular necrosis (AVN).

114 n syndromes are associated with or accompany avascular necrosis and leg ulcers.

115 Avascular necrosis of femoral head (AVNFH) is a debilita

116 both have led to a reduction in the rate of avascular necrosis of the femoral head.

117 Avascular necrosis of the femur head (AVNFH) is a debili

118 ered from long bone fractures (n = 4) and/or avascular necrosis of the hip (n = 4).

119 Avascular necrosis of the lunate bone (Kienbock's diseas

120 gesics and physical therapy for treatment of avascular necrosis, and use of angiotensin-converting en

121 cluded chronic osteomyelitis, growth arrest, avascular necrosis, chronic dislocation, and pathologic

122 recipients had significantly lower rates of avascular necrosis, cytomegalovirus, cataracts, new-onse

123 d HIV act as common risk factors for stroke, avascular necrosis, severe splenic dysfunction, pulmonar

124 yslipidemia to 8.3 (95% CI, 4.6 to 14.9) for avascular necrosis.

125 ditionally, possible confounders specific to avascular organ culture were investigated.

126 The eye lens is an encapsulated avascular organ whose function is to focus light on the

127 sient bone marrow edema syndrome (TBMES) and avascular osteonecrosis.

128 plus the embedded retinal vessels, (ii) the avascular outer nuclear (photoreceptor) layer and its ph

129 ular layers bounding the retina, but not the avascular outer nuclear layer and the vitreous.

130 h or without treatment with Mn2+, 1/T1rho of avascular outer retina (64% to 72% depth) was significan

131 in mistargeting of the HSCs to the normally avascular outer retina.

132 in a single patient showed a subepithelial, avascular pannus.

133 nd increasing nanoparticle concentrations in avascular peritoneal tumors, little is known about the m

134 But the molecular underpinnings of the avascular phenotype have until now remained obscure and

135 ntrols blood vessel growth into the normally avascular photoreceptor layer through the inflammatory s

136 logical neovessels growing into the normally avascular photoreceptors cause vision loss in many eye d

137 he Vldlr(-/-) retinas, which invade normally avascular photoreceptors, are reminiscent of the vascula

138 tional characterization of UAS homologs from avascular plants (mosses, liverwort, and hornwort), from

139 kweed cell walls but not in the walls of the avascular plants and algae.

140 m Api distinguishes vascular plants from the avascular plants and green algae.

141 n characterized; however, it is not known if avascular plants or green algae produce this enzyme.

142 sform into epithelial-like cells to form the avascular primary decidual zone (PDZ) around the implant

143 ich these signals regulate the disruption of avascular privilege in photoreceptors are unknown.

144 he immune cells that populate this typically avascular region after wounding closely associate with t

145 topoietic lineage cells were observed in the avascular region around the dorsal midline of the develo

146 ntained at the inner and outer border of the avascular region during hyperoxia, Q(av) was not restore

147 improved the morphology of astrocytes in the avascular region of the retina.

148 ArntDeltaEC mice had a significant volume of avascular region.

149 ts, EECs in the vascularized, but not in the avascular, region efficiently produce and secrete lipopr

150 derived myeloid progenitor cells migrated to avascular regions of the retina, differentiated into mic

151 from intact blood vessels quickly infiltrate avascular regions via vascular sprouting.

152 cally evident, subdividing the gonad into 10 avascular regions where testis cords form.

153 ing cancer cell hypoxia and death in distant avascular regions.

154 vessel, demonstrating the ability to target avascular regions.

155 lial tubes form in a region that is normally avascular, resulting in aberrant connections.

156 ent intravitreous neovascularization (IVNV), avascular retina (AVA), and retinal detachment in preter

157 as DMOG-treated wild-type mice have 50% less avascular retina (P < 0.0001).

158 Inhibition of STAT3 reduced avascular retina and increased retinal erythropoietin (E

159 Areas of avascular retina and neovascular tufts in injected (trea

160 w that increased retinal VEGF contributes to avascular retina by regulating retinal Epo expression th

161 k of MMP-12 accelerated revascularization of avascular retina in OIR.

162 Epo administered exogenously also reduced avascular retina in the model.

163 orable outcome was achieved with lasering of avascular retina in the right eye.

164 F has on other factors in the development of avascular retina is important to prevent aberrant angiog

165 Laser treatment of the avascular retina may have helped prevent complications f

166 retinal neovascularization and/or peripheral avascular retina on fluorescein angiography and were tre

167 e evolved from destruction of the peripheral avascular retina to inhibit angiogenic stimuli to anti-V

168 ice are returned to room air and the hypoxic avascular retina triggers both normal vessel regrowth an

169 Avascular retina was identified on dilated fundus examin

170 ed for clock hours of NV, percent peripheral avascular retina, capillary density, apoptosis, and VEGF

171 Ds included atrophic holes within peripheral avascular retina, visible vitreous condensation ridge-li

172 facilitate vascularization of the previously avascular retina, which include supporting neural and va

173 for neuronal Nrf2 in vascular regrowth into avascular retina.

174 IOH to the junction between vascularized and avascular retina.

175 this model, inhibition of creatine kinase in avascular retinas blocks synaptic transmission without i

176 In avascular retinas, aerobic production of energy occurs o

177 ) and to compare the predictive value of the avascular root surface area calculation and Miller class

178 al portion naturally created to survive over avascular root surfaces.

179 hy angiography can distinguish vascular from avascular SHRM components.

180 OCTA artifacts may distinguish certain avascular SHRM components.

181 al role for lymphangiogenesis in a primarily avascular site such as the cornea has not been described

182 l lymphangiogenesis also occurs in primarily avascular sites.

183 3%), followed by the "retina" slab (22.0%), "avascular" slab (17.1%), and "choriocapillaris" slab (14

184 4% for "ORCC" and 100% for the "retina" and "avascular" slabs.

185 ot directly injure the limbal vessels or the avascular stroma of the cornea.

186 vessels are permitted to grow into normally avascular structures, such as the articular cartilage an

187 P > .05) when considering total vascular and avascular surfaces.

188 ne (FAZ) features and the total vascular and avascular surfaces.

189 By being avascular, those zones lack endogenous retinoids as indi

190 nd penetration of therapeutic agents through avascular tissue are critically important processes if s

191 Mammalian articular cartilage is an avascular tissue with poor capacity for spontaneous repa

192 Articular cartilage is an avascular tissue with precise polarity and organization

193 Articular cartilage is an avascular tissue with precise polarity and organization

194 mounts were analyzed for percent of areas of avascular/total retina (AVA) and of intravitreal neovasc

195 es were intravitreous neovascularization and avascular/total retinal areas, vascular endothelial grow

196 viral infection and LN reconstruction after avascular transplantation.

197 tigated the signals attracting leukocytes to avascular transplanted pancreatic islets and leukocyte a

198 ic stages of a solid tumor, starting with an avascular tumor and progressing through angiogenesis and

199 tumor-associated macrophage (TAM) entry into avascular tumor areas is regulated by Semaphorin 3A/Neur

200 We present a new mathematical model for avascular tumor growth and development that spans three

201 st paper, we present simulations of unstable avascular tumor growth in two and three dimensions and d

202 rlier biomechanical changes occurring during avascular tumor growth within the peri-tumoral ECM remai

203 ltiscale, multicellular approach to simulate avascular tumor growth, applied to pancreatic cancer.

204 on of such molecules into poorly perfused or avascular tumor regions remains problematic.

205 luster of tumor cells, the model produces an avascular tumor that quantitatively and qualitatively mi

206 a single tumor cell, this model produces an avascular tumor that quantitatively mimics experimental

207 role of hypoxia in incipient angiogenesis in avascular tumors during their early stages of growth.

208 ctor (VEGF) expression and resulted in small avascular tumors in mice.

209 ule and antibody therapies into microscopic, avascular tumors typical of patients with ascites.

210 or progression, particularly in slow-growing avascular tumors.

211 ading to dormancy of a substantial number of avascular tumors.

212 mature DC population than respective dormant avascular tumors.

213 Whilst an avascular tumour always proceeds to a benign steady stat

214 Both vascular and avascular tumour dynamics are investigated, and a number

215 The outcome of the avascular tumour growth model suggested that tumour micr

216 mour implants, or whether this characterises avascular tumour growth more generally.

217 The model is based upon a growing avascular tumour spheroid, in which volume is filled by

218 lular automaton model to mimic the growth of avascular tumours, including the infusion of a bioreduct

219 by loss of endothelial cells leaving behind avascular type IV collagen-positive empty sleeves with r

220 uded extensive fibrinoid deposits, fibrosis, avascular villi, and edema, which could impair placental

221 tion of the placenta leads to development of avascular villi, edema, and hypoxia associated with symp

222 Large fibrinoids with avascular villi, edema, and inflammation were significan

223 owed visualization of the architecture of an avascular vitreous veil with localized retinal traction.

224 ivilege is integral in maintaining the clear avascular window to the foreign world.

225 Analyses of the foveal avascular zone (FAZ) and vasculature surrounding the FAZ

226 Five OCTA biomarkers, including foveal avascular zone (FAZ) area (FAZ-A), FAZ contour irregular

227 To quantify foveal avascular zone (FAZ) area and macular vascular density o

228 alyzed for multiple metrics including foveal avascular zone (FAZ) area and perimeter, nonperfusion ar

229 cular complex (DVC) were analyzed for foveal avascular zone (FAZ) area and superficial and deep vesse

230 The foveal avascular zone (FAZ) area and the vessel density of the

231 Foveal avascular zone (FAZ) area was measured manually; vessel

232 complex vessel density (mSVC_VD), and foveal avascular zone (FAZ) area were calculated.

233 Foveal avascular zone (FAZ) area, central subfield thickness (C

234 Foveal avascular zone (FAZ) area, nonflow area, superficial and

235 afoveal, and full macular regions and foveal avascular zone (FAZ) area, perimeter, and circularity.

236 Parameters quantified include the foveal avascular zone (FAZ) area, peripheral ischemic index, pe

237 Foveal avascular zone (FAZ) area, vessel densities, and perfusi

238 custom software used to quantify the foveal avascular zone (FAZ) area.

239 hickness (CT), temporal and nasal CT, foveal avascular zone (FAZ) diameter, and vessel densities of s

240 d to provide quantitative data on the foveal avascular zone (FAZ) features and the total vascular and

241 anges in perfusion density and in the foveal avascular zone (FAZ) in eyes with idiopathic vitreomacul

242 ity (VD), fractal dimension (FD), and foveal avascular zone (FAZ) of superficial and deep capillary p

243 ty (VLD), perfusion density (PD), and foveal avascular zone (FAZ) parameters were measured on average

244 ceptor density, foveal pit shape, and foveal avascular zone (FAZ) size in children.

245 plexus (DCP) vessel density (VD), and foveal avascular zone (FAZ) size were measured and compared bet

246 The foveal avascular zone (FAZ) was more clearly delineated using t

247 The capillary network and foveal avascular zone (FAZ) were extracted using video and imag

248 l collateral vessels, the size of the foveal avascular zone (FAZ), and degree of vessel branching wer

249 Following manual delineation of the foveal avascular zone (FAZ), FAZ area, perimeter, and acircular

250 Foveal avascular zone (FAZ)-related metrics consisted of FAZ ar

251 ation of a perfusion network with the foveal avascular zone (FAZ).

252 years) with three preselected with no foveal avascular zone (FAZ).

253 ique for use in quantification of the foveal avascular zone (FAZ).

254 FD), vessel diameter index (VDI), and foveal avascular zone (FAZ).

255 es on SS-OCTA, including an irregular foveal avascular zone and flow loss within the deep capillary p

256 While foveal avascular zone and foveal pit metrics did not significan

257 alized to areas of enlargement of the foveal avascular zone and macular capillary nonperfusion.

258 ROP, sEH-/- mice developed a larger central avascular zone and peripheral pathological vascular tuft

259 he SRL (0.794 [95% CI, 0.707-0.881]), foveal avascular zone area (0.472 [95% CI, 0.356-0.588]), and v

260 Parameters included: (1) foveal avascular zone area and macular leakage, (2) peripheral

261 Visual acuity correlated with foveal avascular zone area and parafoveal vascular density in t

262 Total avascular area and foveal avascular zone area were greater in eyes with DR by 0.82

263 el density, total avascular area, and foveal avascular zone as detected with 6 x 6-mm OCT angiography

264 ds tended to incorrectly binarize the foveal avascular zone as white (i.e., wrongly indicating flow).

265 ibitory role of the notochord in defining an avascular zone at the embryonic midline, in part via BMP

266 rounding the implantation chamber forming an avascular zone called the primary decidual zone (PDZ).

267 For foveal avascular zone grading, agreement was good for the 3 x 3

268 erior temporal vein and splitting the foveal avascular zone horizontally.

269 The area of the foveal avascular zone in the superficial retinal vessel layer i

270 operative increase in the size of the foveal avascular zone in the superficial retinal vessel layer,

271 y (n = 1 eyes), and disruption of the foveal avascular zone including fovea plana (n = 3 eyes).

272 detected between vascular density or foveal avascular zone metrics and hemoglobin A1C or duration of

273 Quantitative parameters, including foveal avascular zone metrics, parafoveal vessel length density

274 he area of capillary nonperfusion and foveal avascular zone morphology in patients with RVO.

275 OCT, and diameters and circuit of the foveal avascular zone on OCTA.

276 ity was independently associated with foveal avascular zone size and central macular thickness (R(2)-

277 01), there was no association between foveal avascular zone size and peripheral ischemia (r = 0.114,

278 Foveal avascular zone size was not associated with DR severity

279 Foveal avascular zone size was predictive for logarithm of the

280 quantifying cone density and spacing, foveal avascular zone size, and foveal pit morphometry to inves

281 The size of the foveal avascular zone was also calculated automatically, and so

282 An avascular zone was not identified in the subjects with R

283 Asymmetry and distorsion of the foveal avascular zone were also noticed.

284 o form at Fd 135 in the center of the foveal avascular zone which is surrounded by a ring of blood ve

285 The nonflow area (foveal avascular zone) was significantly larger in sickle cell

286 (hyperfluorescent lesion, absence of foveal avascular zone).

287 (hyperfluorescent lesions, absence of foveal avascular zone).

288 of the posterior tumor border to the foveal avascular zone, and poorer baseline visual acuity in the

289 hat co-localized to areas of enlarged foveal avascular zone, areas of no flow between capillaries, an

290 greatest linear dimension and area of foveal avascular zone, perifoveal capillary dropout grade, and

291 h particularly slower flow around the foveal avascular zone.

292 ss, and proximity of the tumor to the foveal avascular zone.

293 s of 2 patients had irregularities in foveal avascular zones and poor vision.

294 e findings demonstrate that Sema3E-generated avascular zones are critical regulators of mammalian car

295 We demonstrate that lateral avascular zones are directly generated by the lateral pl

296 ulpted through the generation of stereotyped avascular zones by EC-repulsive cues.

297 Four fellow eyes with normal foveal avascular zones did not show any retinal changes on SD-O

298 erning and normal revascularization into the avascular zones of the retina were augmented.

299 irculations and irregularities of the foveal avascular zones.

300 the avascular midline, yet maintain lateral avascular zones.