ライフサイエンスコーパス: aversive

1 many cases define dominance, can be socially aversive.

2 avoidance of places that mice find innately aversive.

3 nal signals arrive in the CeA eliciting both aversive and appetitive behaviors, our understanding of

4 a/+;octbeta1r/+ flies perform poorly in both aversive and appetitive conditioning, while individual h

5 pamine-Octbeta1R-cAMP pathway processes both aversive and appetitive learning in distinct neural site

6 votal functions of the D(1) receptor dDA1 in aversive and appetitive learning, and the alpha1 adrener

7 tically interacts with dumb (dDA1 mutant) in aversive and appetitive learning, but it interacts with

8 nd dopamine-dDA1 signals together drive both aversive and appetitive learning, whereas the octopamine

9 ions of dopamine and octopamine signaling to aversive and appetitive learning.

10 ta-adrenergic-like receptor Octbeta1R drives aversive and appetitive learning: Octbeta1R in the mushr

11 d that DANs compare convergent feedback from aversive and appetitive systems, which enables the compu

12 AV construct and assessed their necessity in aversive and appetitive taste learning.

13 ut neurons and link distinct memory systems (aversive and appetitive).

14 indexed as the activation difference between aversive and neutral trials.

15 nucleus accumbens (NAc) subnuclei during an aversive and reward conditioning task.

16 in beta2(-/-) mice to double-dissociate the aversive and rewarding conditioned responses to nicotine

17 EMENT Acute stress influences learning about aversive and rewarding outcomes.

18 accumbens (NAc) shell, which integrates the aversive and rewarding valence of stimuli, exhibits plas

19 Aversive and safety learning provide translational parad

20 Having complementary aversive and safety memories augments LTM performance af

21 Co-existence of aversive and safety memories is evident as depression of

22 ior insula, regions previously implicated in aversive and social-emotional processing.

23 eipt of these signals, these neurons produce aversive and sustained appetite-suppressing signals, whi

24 BAergic RMTg terminals in the VTA in vivo is aversive, and low-frequency stimulation induces long-ter

25 ( c) Dehydration is aversive, and median preoptic nucleus (MnPO) neuron acti

26 Cognitive effort is described as aversive, and people will generally avoid it when possib

27 We conclude that mice find waste products aversive, and that housing mice in a way that facilitate

28 competing action alternatives is considered aversive, as recruiting cognitive control to overcome co

29 few days of abstinence, primarily due to the aversive aspects of the nicotine withdrawal syndrome (NW

30 may therefore affect both the rewarding and aversive aspects of withdrawal.

31 While sodium is attractive at low and aversive at high concentrations in most studied species,

32 al habituation to two sets of similar mildly aversive auditory and tactile stimuli in 42 high-functio

33 alamus, in the arbitration of appetitive and aversive behavior during motivational conflict.

34 l aversive taste memory, resulting in strong aversive behavior upon retrieval.

35 sensory receptors in the oral cavity trigger aversive behaviors in response to acid stimuli.

36 tuned taste neurons in the brain to trigger aversive behaviors.

37 , the CS controls conflicting appetitive and aversive behaviors.

38 einforcing properties of rewards and induces aversive behaviors.

39 ive sugar pathway as well as suppressing the aversive bitter pathway.

40 that DEET repels on contact by activating an aversive bitter taste pathway [10].

41 In contrast to flies, geosmin is not aversive but mediates egg-laying site selection.

42 within 1 min after the first encounter of an aversive but not neutral stimulus.

43 or cingulate cortex underlies the affective (aversive), but not the sensory-discriminative features (

44 interacts with owner personality and use of aversive communication to influence the likelihood of be

45 adjuvants to alleviate the emotional, tonic-aversive component of chronic pain, which is argued to b

46 that KORs are sufficient to drive the tonic-aversive component of chronic pain; the emotional compon

47 ut not glutamatergic neurons, may encode the aversive component of itch.

48 vation that can drive ingestion of high, yet aversive concentrations of sodium in animals that are de

49 taste stimuli quinine and cycloheximide, and aversive concentrations of sodium, cofired to agonists o

50 We conclude that abnormalities in social aversive conditioning are present across the psychosis s

51 s. neutral) in neural circuitry underpinning aversive conditioning of social stimuli characterizes th

52 3T fMRI utilized a passive aversive conditioning paradigm, with neutral faces as co

53 Young children underwent an aversive conditioning procedure either in the parent's p

54 wo-day experimental protocol using pavlovian aversive conditioning, evaluating acquisition and extinc

55 Unexpectedly, amygdala did not show aversive conditioning; its activation trended greater fo

56 a learning signal during both appetitive and aversive conditions.

57 bens shell (Acb) circuit plays a role in the aversive consequences of alcohol withdrawal.

58 ational context but suppress movements in an aversive context.

59 in instigating versus suppressing actions in aversive contexts remains to be clarified.

60 ress inappropriate actions in appetitive and aversive contexts.

61 imental to the subsequent rapid retrieval of aversive contextual associations.SIGNIFICANCE STATEMENT

62 pen their orientation tuning as humans learn aversive contingencies.

63 activation trended greater for neutral than aversive CS, and did not differ significantly based on g

64 rontal cortex activated more to neutral than aversive CS; this "safety effect" was driven by HC and r

65 l and neural mechanisms by which emotionally aversive cues disrupt learning in socially anxious human

66 promoting learned responses to appetitive or aversive cues in distinct, intermingled sets of BA excit

67 t drive triply dissociable RMTg responses to aversive cues, outcomes, and prediction errors, respecti

68 parent, regardless of valence (rewarding or aversive), despite the diversity of parenting styles(2).

69 heir projections to the PVT elicits a flavor aversive effect, and selective optogenetic stimulation o

70 Cocaine produces strong aversive effects after rewarding effects wear off, accom

71 its projections to the LHb in processing the aversive effects of cocaine, which could serve as a nove

72 We use the optoPAD to induce appetitive and aversive effects on feeding by activating or inhibiting

73 well-known rewarding effects but also strong aversive effects that influence addiction propensity, bu

74 though not exclusive, rEPN role in cocaine's aversive effects, and shed light on the development of a

75 ated by cocaine and contributes to cocaine's aversive effects, and the current findings show that the

76 amine neurons mediate nicotine's conditioned aversive effects, while beta2* nAChRs on VTA GABA neuron

77 ors-those governing nicotine's rewarding and aversive effects.

78 he subsequent unconditioned stimulus (US; an aversive electric shock).

79 ions of sucrose solution, floral scents, and aversive electric shock.

80 hat visual fear learning (the acquisition of aversive emotion associated with a visual stimulus) affe

81 w different neuromodulatory systems regulate aversive emotional processing and reveal fundamental pri

82 S2) auditory stimuli immediately prior to an aversive event (US) produces freezing and flight respons

83 y stimulus that reliably signals an upcoming aversive event can be conditioned to elicit locomotion t

84 r overexpected, but less so when an expected aversive event is omitted.

85 procedure in which, after acquiring fear of aversive events (fear learning), subjects were exposed t

86 an significantly reduced learning rates from aversive events (losses) when participants were first ex

87 were exposed to fear-eliciting cues without aversive events (safety learning), leading to suppressio

88 Encoding and predicting aversive events are critical functions of circuits that

89 onmental stimuli that become associated with aversive events are experienced on other occasions witho

90 g fear when novel predictions about upcoming aversive events are generated, such as when fear is infl

91 ar reduction that depends on the omission of aversive events but not on overexpectation.

92 tion, we provide evidence that fear-inducing aversive events elevate MN activity.

93 um dynamics in response to appetitive versus aversive events in conditioning paradigms.

94 nitiation or suppression of actions to avoid aversive events is crucial for survival.

95 ons in a context-appropriate manner to avoid aversive events or obtain other goals is a critical surv

96 Foraging exposes organisms to rewarding and aversive events, providing a selective advantage for max

97 ects insensitive to punishment are afraid of aversive events, they are simply unable to change their

98 responded to mild foot shocks and predicted aversive events.

99 However, over the course of the aversive experience, neural activation in RBN relative t

100 l habenula (LHb) processes information about aversive experiences that contributes to the symptoms of

101 apt their behavior by generalizing from past aversive experiences, allowing to avoid harm in novel si

102 ate environmental stimuli with appetitive or aversive experiences, forming preferences for scents, lo

103 on of cognitive effort against other primary aversive experiences, however, remains relatively unexpl

104 e selective effect on their behavior towards aversive facial expressions.

105 ic projections has an impact on sound-driven aversive/fear behavior.

106 as been shown to be involved in sound-driven aversive/fear behavior.

107 een name cues and rewarding (happy faces) or aversive (fearful faces) social outcomes.

108 ossible mechanism for the intensification of aversive feelings after withdrawal that involves the glu

109 ) and why people are motivated to reduce the aversive feelings generated by uncertainty.

110 h maximizes preference for high quality, non-aversive floral sites.

111 ate diacetyl learning and thus integrate the aversive food context with the diacetyl odor, FLP-34 is

112 This was not the case under aversive foraging conditions, suggesting an adaptive tun

113 ses to modulate the inhibitory drive on the "aversive" glutamatergic neurons.

114 re is growing evidence that, compared to non-aversive handling methods (i.e. tunnel and cup), tail ha

115 for effective familiarisation with these non-aversive handling methods, and test whether this is suff

116 and an abnormally decreasing response during aversive homeostatic perturbations may promote hallmark

117 A novel, pleasant taste stimulus becomes aversive if associated with gastric malaise, a form of l

118 ior colliculus activation during emotionally aversive image viewing blocks was greater than that duri

119 cleus accumbens shell (NAcSh) suppresses the aversive impact of sucrose devalued using the conditione

120 the mouse brain during brief stimulation of aversive inputs.

121 sed the activation during anticipation of an aversive interoceptive event in the anterior cingulate a

122 ody sensations and BN symptoms suggests that aversive interoceptive experiences may be particularly r

123 ory of BN show aberrant neural processing of aversive interoceptive stimuli.

124 h cognitive effort is generally perceived as aversive, its investment is inevitable when navigating a

125 ory, with different compartments controlling aversive learning (heel) vs. appetitive learning (medial

126 res to isolate sensory-specific processes in aversive learning and behavior and to assess the possibl

127 uced anxiety-like behaviors and enhanced the aversive learning and memory index in sham animals, alth

128 Highlighting aversive learning as the cognitive process mediating thi

129 aptive flexibility depends on a mechanism of aversive learning based on memory traces of recently enc

130 inosa, regulates both pathogen avoidance and aversive learning by modulating not only the DAF-7/TGF-b

131 Aversive learning changed scanning patterns selectively

132 n excessive avoidance.SIGNIFICANCE STATEMENT Aversive learning evolved early in evolution to promote

133 negative reinforcement and is essential for aversive learning in mice.

134 igra (SNL) that contribute to appetitive and aversive learning in mice.

135 These results suggest that aversive learning increases peripheral olfactory inputs

136 Aversive learning is fundamental for animals to increase

137 Our findings implicate aversive learning processes in the expression of psychia

138 er how computational mechanisms that support aversive learning relate to specific psychiatric symptom

139 understanding of stress conditions in which aversive learning results in excessive avoidance.SIGNIFI

140 wer this question using an online game-based aversive learning task together with measures of common

141 he lPBN is required for escape behaviors and aversive learning to noxious stimulation.

142 ) plays a central role in the acquisition of aversive learning via actions in the lateral nucleus of

143 ear how visual attention is recruited during aversive learning, particularly when learning about mult

144 he mushroom body alphabeta neurons processes aversive learning, whereas Octbeta1R in the projection n

145 , which simultaneously probes appetitive and aversive learning.

146 stinct domains of the lPBN, are required for aversive learning.

147 discovered that it is required for olfactory aversive learning.

148 hways jointly facilitate appetitive, but not aversive, learning.

149 neuroanatomical basis for the impairment in aversive limbic memory observed during withdrawal in alc

150 Following an aversive mechanical or blue light stimulus, worms respon

151 Aversive memories are at the heart of psychiatric disord

152 how such an interplay between appetitive and aversive memories might be implemented in insect neural

153 y during recall of reconsolidation-resistant aversive memories renders them liable to the amnesic eff

154 ditis elegans demonstrates that retrieval of aversive memories, stored within sensory neurons, is suf

155 al approach in rats that robustly attenuates aversive memories.

156 ggested as a therapeutic target for unwanted aversive memories.

157 europeptide Y (NPY) is well known to promote aversive memory acquisition in mammals.

158 tion and puncture mice exhibited spatial and aversive memory deficits and anxiety-like behavior.

159 s acquire additional information and form an aversive memory for the shock-paired odor and a slowly e

160 BNST) or central amygdala (CEA) generates an aversive memory.

161 trates a broader neural network to calibrate aversive memory.

162 tes in outcome value, but similar results in aversive motivation are difficult to interpret due to a

163 luation tools, the same cannot be said about aversive motivation.

164 ars to be connected with other regulators of aversive motivational states, including the lateral habe

165 nduce either rewarding (positive valence) or aversive (negative valence) brain activity.

166 Activation to aversive nociceptive stimuli in gustatory cells was asso

167 orientation (CS+) that reliably predicts an aversive noise (unconditioned stimulus: US) is selective

168 owever, H2A.Z cKO improved memory on the non-aversive object-in-place task in both sexes, suggesting

169 An aversive odor does not reverse object aversion.

170 x were elevated 7 days after exposure to the aversive odorant.

171 al components interact synergistically, with aversive odors triggering otherwise hidden aversions to

172 We show that it is required for aversive olfactory learning after pairing diacetyl with

173 Here, we show that aversive olfactory learning in adult flies requires type

174 Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training,

175 peptide required in the MB for two phases of aversive olfactory memory.

176 or on ASH nociceptive neurons to modulate an aversive olfactory response.

177 umans, approach attractive stimuli and avoid aversive ones.

178 and holds regardless of whether outcomes are aversive or involve reward gain or loss.

179 e motivated and oriented by a need to reduce aversive orexin cell activity, and suggest a hypothalami

180 cit locomotion to a safe location before the aversive outcome ensues.

181 ard through extinction training in which the aversive outcome is omitted.

182 by the association between a stimulus and an aversive outcome is suppressed by a new association with

183 rate a contribution of the basal amygdala to aversive outcome-dependent motivational processes.SIGNIF

184 events (e.g., being in a subway station) and aversive outcomes (e.g., footage or verbal reports from

185 al shell (vNAcMed) are excited by unexpected aversive outcomes and to cues that predict them, whereas

186 Learning to avoid aversive outcomes is an adaptive strategy to limit one's

187 nhibiting actions in the service of avoiding aversive outcomes or obtaining rewarding ones.

188 king requires the consideration of potential aversive outcomes.

189 o stimuli that predict salient appetitive or aversive outcomes.

190 ugments learning from appetitive relative to aversive outcomes.

191 llustrate how after abstinence from cocaine, aversive pathways change in a manner that may contribute

192 oning to excitation during cocaine's delayed aversive phase.

193 ty rapidly reduced upon exiting the innately aversive places.

194 ial for pain perception, which suggests that aversive prediction error-associated regions, such as th

195 These findings suggest that aversive prediction-error-related regions interact with

196 ators traditionally linked to appetitive and aversive processes, are also involved in sensory inferen

197 ediction errors (ventral striatum), but also aversive processing (insular cortex and cerebellum).

198 The aversive properties associated with drugs of abuse influ

199 ch reflects a selective insensitivity to the aversive properties of alcohol intoxication.

200 g associated with both the rewarding and the aversive properties of ethanol in mice.

201 gions involved in processing the hedonic and aversive properties of taste.SIGNIFICANCE STATEMENT The

202 fter TBI results in neutral stimuli adopting aversive properties with a corresponding impact on facil

203 We now show that the ability of an aversive punisher to inhibit reward seeking depends on c

204 n's affective neural circuits attribute this aversive quality to nociceptive information remains unkn

205 n extracts from yellow frogs provoked higher aversive reactions by birds than white frogs in the labo

206 esumably separating its established roles in aversive reinforcement and appetitive motivation [5, 6].

207 n mammals, transgenic TRPV1 worms exhibit an aversive response to capsaicin.

208 determined to elicit an innate appetitive or aversive response, ensuring that animals consume nutriti

209 s accumbens shell pathway attenuates learned aversive responses in male but not female rats, indicati

210 otyped outputs to initiate both positive and aversive responses through populations of immune and neu

211 ulation of this S1->ACC projection regulates aversive responses to pain.

212 Pain affects both sensory and emotional aversive responses, often provoking anxiety-related dise

213 han force per se, is the main determinant of aversive rolling responses to noxious mechanical stimuli

214 blocks in which they were at risk of hearing aversive screams at any time vs. blocks in which they we

215 Itch is a distinct aversive sensation that elicits a strong urge to scratch

216 Itch is an aversive sensation that evokes a desire to scratch.

217 ng' characterized by increased tolerance for aversive sensations and decreased awareness of non-avers

218 ve sensations and decreased awareness of non-aversive sensations.

219 ubset of vCA1 neurons were responsive to the aversive shock during context conditioning, their activi

220 on can be induced by the presentation of two aversive shocks to the animal's tail.

221 ronic pain, but are limited by dysphoric and aversive side effects.

222 t the MFC registers cognitive conflict as an aversive signal, but no study directly tested this idea.

223 ch regions respond similarly to conflict and aversive signals.

224 of sodium even from rock salt, while evoking aversive signals.

225 ts), as well as increased responses to learn aversive situations (in the passive avoidance and fear c

226 However, in aversive social contexts, additional pathways play criti

227 ediating the effects of OT in appetitive and aversive social contexts.

228 ring with altered tactile sensitivity in two aversive somatosensory behavioural tasks, but no overt d

229 peated exposure to (i.e., habituation of) an aversive sound (klaxon-horn) reduced freezing to conditi

230 llowing repeated learning trials in a weakly aversive spatial task.

231 ity is proportional to the intensity of this aversive state.

232 cre in KOR(loxP) mice prevented pain-induced aversive states as measured by place aversion assays.

233 we show that activation of KORs drives pain aversive states in male but not female mice.

234 ays an important role in suppressing learned aversive states selectively in males but spares hedonic

235 l cortex, has been implicated in suppressing aversive states.

236 d amygdala, is engaged by both rewarding and aversive stimuli and plays a role in ethanol-seeking beh

237 of basal amygdala in discriminating between aversive stimuli conveying different degrees of threat.

238 t the firing of ACC neurons was modulated by aversive stimuli delivered to the recording rat and thei

239 reclinical mouse models present rewarding or aversive stimuli in isolation, ignoring that ethological

240 ence on ventral tegmental (VTA) responses to aversive stimuli is untested.

241 und that RMTg neurons are broadly excited by aversive stimuli of different sensory modalities and inh

242 ences on avoidance behaviour as more primary aversive stimuli such as physical pain.

243 By contrast, repeated aversive stimuli that lead to prolonged periods of vigil

244 riant of outcome devaluation procedures with aversive stimuli to study the role of basal amygdala in

245 CeA->SNL neural responses to appetitive and aversive stimuli were modulated by expectation and magni

246 spatially defined, differentially engaged by aversive stimuli, and had distinct electrophysiological

247 visual, auditory, somatosensory and chemical aversive stimuli, as well as "opponent" motivational sta

248 ions to the basal amygdala (BA), paired with aversive stimuli, contributes to encoding conditioned fe

249 opamine system, is specifically activated by aversive stimuli, such as foot shock.

250 tion, generalized to learning about multiple aversive stimuli, were not due to changes in stimulus se

251 al variation in sensitivity to rewarding and aversive stimuli, which can be modulated by pharmacologi

252 ion derived from these data that emotionally aversive stimuli, which recruit the noradrenergic system

253 involved in regulating anxious responses to aversive stimuli.

254 iring conditioned place aversion to multiple aversive stimuli.

255 to emotion, predict impending appetitive and aversive stimuli.

256 induced by removal of sustained rewarding or aversive stimuli.

257 rons are activated immediately by a range of aversive stimuli.

258 mine neurons and are excited by a variety of aversive stimuli.

259 A mild aversive stimulus activated cholinergic inputs and evoke

260 learn to associate a neutral context with an aversive stimulus and display fear responses to a contex

261 als learn to associate a neutral cue with an aversive stimulus despite their separation in time by a

262 esponses to a neutral stimulus preceding the aversive stimulus within a few instances of their pairin

263 ew sensory stimulus was paired with the same aversive stimulus, about half of these neurons generaliz

264 oned stimulus), comes to predict an innately aversive stimulus, such as a mild footshock (the uncondi

265 ditioned stimulus predicts the arrival of an aversive stimulus, the animal encodes the time interval

266 ith a history of partial association with an aversive stimulus, with potential implications for under

267 and excitotoxic RMTg lesions greatly reduce aversive stimulus-induced inhibitions in VTA neurons, pa

268 in naive mice and those exposed to an acute aversive stimulus.

269 g stimulus was repeatedly associated with an aversive stimulus.

270 Interestingly, aversive STM requires PDF but not PDFR, suggesting that

271 used computational modelling to examine the aversive subjective value of effort and its effects on r

272 duced a significant postprandial increase in aversive symptom scores (fullness, distention, bloating,

273 al driver for relapse events is the negative aversive symptoms experienced by addicts during withdraw

274 A better understanding of the etiology of aversive symptoms in CD will facilitate identification o

275 fore be part of the mechanism underlying the aversive symptoms seen after withdrawal.SIGNIFICANCE STA

276 's disease (CD) patients suffer postprandial aversive symptoms, which can lead to anorexia and malnut

277 ceptors (KORs) have been characterized as an aversive system in the brain and implicated in social be

278 so that, after abstinence, their synapses on aversive targets are strengthened, whereas the synapses

279 these neurons are most strongly connected to aversive targets, such as the lateral habenula, but also

280 iming of stereotyped, orofacial reactions to aversive tastants during consumption.

281 es but spares hedonic processing of innately aversive tastants.

282 Aversive taste learning and retrieval require neuronal a

283 aIC-to-BLA projection is necessary for both aversive taste memory acquisition and retrieval, but not

284 learning per se, but effectively suppressed aversive taste memory retrieval when applied either duri

285 omfort, was sufficient to form an artificial aversive taste memory, resulting in strong aversive beha

286 ecessary and sufficient to form and retrieve aversive taste memory.

287 no significant differences in appetitive or aversive taste reactivity (TR) to sucrose was observed i

288 Skelhorn introduces the innate responses to aversive tastes.

289 cs in the environment induced cues that were aversive to other flies, modulated physiology, and impai

290 (TMT), a volatile chemical that is innately aversive to some rodent species, produced in male rats a

291 Thus, higher doses of lidocaine are aversive to uninjured animals, but disbudded calves are

292 , indicating that suppression of conditioned aversive TR can be dissociable from the effects of uncon

293 aoral infusion of devalued sucrose inhibited aversive TR in male but not female rats.

294 imuli (CSs) that poorly predict the onset of aversive unconditioned stimuli (USs) in rats.

295 We showed that despite disliking the aversive unconditioned stimulus, children exhibited a be

296 Protonated nicotine is less aversive upon inhalation than free-base nicotine, and ma

297 fied basal forebrain neurons that encode the aversive US scaled up responses to the CS and increased

298 Finally, despite having no aversive valence of its own, NS9283 enhanced ethanol-con

299 othesis that reduced differential responses (aversive vs. neutral) in neural circuitry underpinning a

300 uits and multiple cognitive domains in a non-aversive way, here we exposed 6-month-old C57BL/6J male