ライフサイエンスコーパス: avidity

1 her Eph receptor tyrosine kinases with lower avidity.

2 ct of age at MCV1 administration on antibody avidity.

3 ell will only exist under conditions of high avidity.

4 on in the presence of lower receptor binding avidity.

5 ary disease, and no significant residual PET avidity.

6 ficiency are characterized by high (18)F-FDG avidity.

7 that bind their cognate receptors with high avidity.

8 IgGs for longevity but not for magnitude and avidity.

9 or memory CD8 T cells, regardless of epitope avidity.

10 ve and low or moderate HCMV immunoglobulin G avidity.

11 ) are essential for antibody recognition and avidity.

12 rimeric nature of hemagglutinin for improved avidity.

13 vaccine Ab responses, including blockade Ab avidity.

14 corrected for background (18)F-fluciclovine avidity.

15 se their structural complexity or functional avidity.

16 from patients with bacteremia exhibited low avidity.

17 nts with metastatic CRC to assess metastasis avidity.

18 alent interactions provide high DENV-binding avidity.

19 had solitary metastases exhibiting very low avidity.

20 oreactivity in CF patient sera exhibits high avidity.

21 uce dependence on bivalent interaction, i.e. avidity.

22 eighboring antibodies, resulting in enhanced avidity.

23 alency induces high-affinity binding through avidity.

24 umonia on CT and elevated regional (18)F-FDG avidity.

25 and immunoglobulin G (IgG), (3) anti-VP1 IgG avidity, (4) anti-VP-2 epitope type specificity (ETS), a

26 ake on SSTR PET/CT and no or minor (18)F-FDG avidity-a mismatch pattern that was associated with a be

27 e adjacent RBDs are heterotypic, provides an avidity advantage to cross-reactive B cells.

28 NCT01864083), changes in (18)F-fluciclovine avidity after neoadjuvant therapy were compared to breas

29 d saliva, and for quantifying immunoglobulin avidities against coronavirus antigens from SARS-CoV-2,

30 for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus

31 Type-specific antibody concentrations and avidity against HPV-16/18/31/33/45/52/58 were assessed.

32 mposite avidity/spatial metrics outperformed avidity alone.

33 '-MOE) bind many cellular proteins with high avidity, altering their function, localization and stabi

34 nflammatory direct cell killing and enhanced avidity, an approach that could be used to improve the a

35 standing target-cell affinity with picomolar avidities and were able to selectively identify these ce

36 The association of avidity and a high neutralizing titer (NT) were also ass

37 CHIKV-specific antibodies and their binding avidity and cross-reactivity with other alphaviruses inc

38 t there was a strong correlation between IgG avidity and days since symptom onset, and peak readings

39 Fc engineering enhances avidity and direct cell killing of cancer-targeting anti

40 LTBI, 'resisters' display enhanced antibody avidity and distinct Mtb-specific IgG Fc profiles.

41 the affinity of the individual arms, overall avidity and format valence.

42 anced functional properties due to increased avidity and improved solution behavior and stability.

43 While we did not find major differences in avidity and maturation between the pathogenic and nonpat

44 Neutralization titers and the avidity and maturation of immune responses did not diffe

45 rs for donation and the relationship between avidity and neutralizing titers is currently not well un

46 High IgG avidity and neutralizing-antibody titers >40000 to measl

47 Immunoglobulin G (IgG) avidity and plaque reduction neutralization tests distin

48 viral antigen on the cell surface with high avidity and promoted specific Fc effector functions, inc

49 w that genomes that become frustrated by low avidity and remain cytoplasmic trigger the type I interf

50 al polysaccharides revealed highly diverging avidity and selectivity for larger and more complex glyc

51 into a direct cell killing mAb with enhanced avidity and significant in vivo tumor control.

52 ctional dose increases CSP-specific antibody avidity and somatic hypermutation frequency in CSP-speci

53 88, and 192 can also modulate virus receptor avidity and that substitutions that increased or decreas

54 onship between changes in (18)F-fluciclovine avidity and the percentage of reduction of tumor on path

55 or avidity (SUVmax/mean/peak), composites of avidity and volume (including metabolic tumor volume), n

56 e all subunits simultaneously to attain high avidity and/or lock subunits together.

57 uated the magnitudes, epitope specificities, avidities, and functions of systemic and mucosal immune

58 Eight patients had lesions lacking avidity, and 2 had solitary metastases exhibiting very l

59 prefusion and postfusion proteins), antibody avidity, and binding to specific antigenic sites.

60 Anti-B19V IgM and IgG, avidity, and ETS assays were used to categorize individu

61 cell receptor affinity for antigen, antigen avidity, and other factors that can substantially alter

62 division, and CD5, a surrogate marker of TCR avidity, and produced the cytokines IFN-gamma and IL-2.

63 e from seropositive subjects, including high-avidity antibodies to viral antigens, coverage against a

64 We used low-sensitive and low-avidity antibody assays to measure the humoral response

65 rnal infection by seroconversion rather than avidity (AOR, 3.3; P = .007).

66 PBD-C06 binds with the same specificity and avidity as its murine precursor antibody and elimination

67 nkage (alpha2,6-F-SCT) has a similar binding avidity as its parent glycoform.

68 We used the antibody-avidity assay to study antibody-maturation patterns, ana

69 The IgG avidity assay used a novel label-free immunoassay techno

70 receptor-binding domain (S-RBD); and an IgG avidity assay.

71 Here, we report antibody and antibody-avidity assays, relying on near-infrared-fluorescence am

72 ivalent targets but reach a limit in binding avidity at high degrees of polymerization.

73 tively active form of PI3K-P110alpha by high-avidity autoreactive B cells of mice completely abrogate

74 at activation of the PI3K pathway leads high-avidity autoreactive B cells to breach central, but not

75 ed the mechanisms by which LNSC regulate low-avidity autoreactive cells in the NOD mouse model of typ

76 Here, we describe avidity-based fluorescent sensors that address this need

77 calization in cells, demonstrating a common, avidity-based mechanism.

78 y missing ingredient from such models is the avidity between the -35 and -10 RNA polymerase binding s

79 We used this avidity bias to devise a method to assess average CAG re

80 ane-associated CD4 (CD4-VLPs) to permit high-avidity binding of trimeric HIV-1 envelope spikes.

81 verse biological processes that require high-avidity binding to effectors and substrates.

82 tiphospholipid syndrome (APS) display higher avidity binding to FXa with greater coagulant effects co

83 cretor-positive participants maintained high avidity blockade Ab to GI.1 at day 180.

84 Development of high avidity, broadly neutralizing antibodies (Abs) is a prio

85 y of IgG antibodies can increase potency via avidity, but has never been described as essential for a

86 ated branches have the potential to increase avidity by simultaneously binding to two subunits of a s

87 Changes in FDG avidity can provide an earlier evaluation of response to

88 T cells with high functional avidity can sense and respond to low levels of cognate A

89 High-avidity CBFB-MYH11 epitope-specific T cell receptors (TC

90 as death receptor) compared with their lower-avidity CD4 counterparts.

91 High-avidity CD8+ T cell clones isolated from healthy donors

92 on-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to

93 oded tetramers to stain T cells with similar avidity compared to conventional fluorescent tetramers a

94 , we conclude that IAV balances affinity and avidity considerations in order to overcome the nuclear

95 Here we present an avidity-controlled CAR (AvidCAR) platform with inducible

96 SARS-CoV-2 antibody avidity correlated with duration of infection and higher

97 one marrow chimeras and show that higher TCR avidity correlates with higher PLZF and reduced T-bet ex

98 her factors such as HPV exposure or antibody avidity could be important.

99 ies (MAbs) and 38 Flucelvax-induced MAbs for avidity, cross-reactivity, and any selectivity toward th

100 sults delineate how heterogeneity in NK cell avidity diversifies NK cell effector function during ant

101 Their interactions are avidity driven, restricting the actions of TRIM/TRIM-lik

102 uitive, since immune escape due to increased avidity (due itself to an increase in charge) was determ

103 ree with literature values and show a strong avidity effect associated with the STV-NPs.

104 inity to m4-1BBL with an unexpectedly strong avidity effect.

105 argeting antibodies into classes, evaluating avidity effects and suggesting combinations for clinical

106 avidity, whereas targeted disruption of TCR avidity enhancement eliminated GUCY2C-specific antitumor

107 Together, TCR avidity enhancement may be leveraged by prime-boost immu

108 Ad5 maximized antitumor efficacy through TCR avidity enhancement, it produced no autoimmunity, reflec

109 Low-avidity Env antibodies have continued to decline.

110 ed incidence with the HIV-1 limiting antigen avidity enzyme immunoassay combined with viral load and

111 was determined through the limiting antigen avidity enzyme immunoassay.

112 ersely, robust and early expression of a low-avidity epitope compensated its weak intrinsic antigenic

113 In this study we tested the low-avidity epitope KCSRNRQYL, and show that a mouse CMV (MC

114 ressing a single MHC class I-restricted high-avidity epitope provided strong, T cell-dependent protec

115 n, although MCMV vectors expressing the high-avidity epitope SSIEFARL induced protective immunity irr

116 s in Ag competition, where responses to high-avidity epitopes outcompeted weaker ones expressed later

117 -bundled filaments and Ena "arms," revealing avidity facilitates enhanced processivity.

118 Similarly, HIV-1-specific antibodies and avidities fell to levels comparable to those in the Berl

119 Tumor avidity for (18)F-fluorocholine was associated with favo

120 are similarly selected on the basis of their avidity for cognate ligand is unknown.

121 a bipartite NLS in trans, which ensures high avidity for importin alpha7 while preventing non-specifi

122 context of the full length NP to confer high avidity for importin alpha7, explaining why the virus ef

123 uences of precursor frequency, affinity, and avidity for interclonal GC competition and indicate that

124 forms large plaques, and displays increased avidity for JAM-A relative to the parental virus, mimick

125 modified polyglucose nanoparticle with high avidity for macrophages.

126 the RBD on the spike and relies on antibody avidity for neutralization.

127 aling elements, which likely drive increased avidity for palatable foods.

128 +) T cells from hemizygous mice had a higher avidity for pMHCI and increased cytokine polyfunctionali

129 cell surface CD5, a surrogate marker for TCR avidity for self-pMHC, as compared with their adult coun

130 evelled, respectively, which increases their avidity for signaling effectors.

131 , although a slight increase in the mutants' avidity for synaptic vesicle-like membranes can be detec

132 re, we showed that NK cells with the highest avidity for the mouse CMV glycoprotein m157 were prefere

133 protein-lipid interactions provide critical avidity for the strong binding between the PDZ domain sc

134 ss subfamilies displayed a higher functional avidity for their cognate antigen than Vss subfamilies n

135 However, antibody avidity for these types showed noninferiority, independe

136 method to identify TCRs with high functional avidity from diverse human T cell repertoires.

137 S,S-induced NPNA-specific antibody titer and avidity have been associated with high-level protection

138 o request additional testing for IgA and IgG avidity, if both IgG and IgM are positive.

139 These data indicate that low-avidity IgG responses to BPI can arise acutely in respon

140 Notably, increased functional CD4 T cell avidity improved antiviral efficacy of CD8 T cells.

141 etween means), and higher concentrations and avidities in children than infants (p < 0.001).

142 macrophages and T cells drive [(64)Cu]-LLP2A avidity in granulomas.

143 cific memory after 4 mo, with the highest Ab avidity in mice receiving double allogeneic EV injection

144 of immunoglobulin (Ig) M and IgG and on IgG avidity in sera collected at each trimester.

145 ive B cells that bind self-antigen with high avidity in the bone marrow undergo mechanisms of central

146 (18)F-FDG avidity in the index malignancy, an advanced stage for t

147 s in the RBS 220-loop and can be buffered by avidity in viral receptor binding.

148 tive compound, CM11, dimerizes VHL with high avidity in vitro and induces potent, rapid and proteasom

149 Antibody avidity increased over duration of infection and remaine

150 with a half-life of 49 days, nAb titers and avidity increased over time for some individuals, consis

151 Preexisting antibody and high IgG avidity index (>50%) are important factors for protectio

152 4 reinfected animals showed a lower HEV-IgG avidity index (average 35.5%) than the 8 protected anima

153 primary HCMV infection, in association with avidity index and DNAemia may help to assess the risk of

154 Only immunoglobulin G avidity index was higher in nontransmitting mothers, who

155 s-protective types (HPV-16/18/31/33/45), the avidity index was noninferior for the 2-dose compared wi

156 IgG anti-HEV antibody, and the IgG anti-HEV avidity index were tested.

157 ne efficacy, vaccine effectiveness, antibody avidity index, and T-cell stimulation index.

158 mportantly, CD4 T cells of higher functional avidity induced by low-dose vaccinations showed higher c

159 lls, as is the ability of LFA-1 to form high-avidity interactions with ICAM-1.

160 onse to the Gag293 epitope with a functional avidity intermediate between that of controllers and tre

161 chnology, we demonstrate that a high binding avidity is required for infection, though the absolute v

162 DMBT1 isoform, DMBT1(S8), is the major high-avidity ligand for Siglec-8 on human airways.

163 The kinetics of IgG avidity maturation during SARS-CoV-2 infection was studi

164 of protein specificity, including functional avidity, may carry greater weight in mediating effective

165 py, our work describes the emergence of high-avidity Melan-A-specific clonotypes as a surrogate marke

166 Our tumor-targeting protein exhibits high avidity, minimal aggregation, and is easily purified at

167 hat selective enhancement of C1q binding via avidity modulation is superior to the unattended increas

168 T-cell culture and expansion) requiring high-avidity molecular interactions on the cell surface.

169 omprise the memory NK cell pool, whereas low-avidity NK cells possessed greater capacity for interfer

170 combinations negatively correlated with the avidities of F-G interactions, supporting the F/G dissoc

171 The avidities of serum antibodies as well as numbers of sple

172 1, recapitulated the direct cell killing and avidity of 88mIgG3.

173 cells correlated with both the magnitude and avidity of anti-Env serum IgG.

174 Avidity of antibody binding to cell-surface NS1 along wi

175 Glycoarray approaches demonstrated that the avidity of heparan sulfate for BDNF increased with sulfa

176 The magnitude, longevity and avidity of IgG differed significantly among mouse strain

177 The antibody titer and avidity of immunoglobulin (Ig) G specific for diphtheria

178 ther this pattern is caused by the intrinsic avidity of individual cells for FDG, the density of viab

179 of protein specificity, including functional avidity of individual responses, are also critically imp

180 The binding affinity and avidity of integrins can be regulated via inside-out sig

181 minal centers, compromised Ig switch and low avidity of lymphocytic choriomeningitis virus-specific A

182 A-CT trimer-trimer associations increase the avidity of MA-CT binding.

183 long-term decrease in the concentration and avidity of measles virus-specific neutralizing antibodie

184 nced processivity on fascin bundles and that avidity of multiple arms associating with multiple filam

185 degree of polymerization affects the binding avidity of multivalent polymers.

186 n approach that could be used to improve the avidity of other mAb with therapeutic potential.

187 Avidity of potentially neutralizing Ab may be an importa

188 TMV presentation improved titer and avidity of repeat-specific Abs compared to a nearly full

189 Indeed, functional TCR avidity of responding GUCY2C-specific CD8(+) T cells ind

190 ctivity of the parental clone, or functional avidity of selected gamma9delta2 T cell receptors (gamma

191 This reflects the increased functional avidity of the Env response over Gag, substantially more

192 earlier increases of both the magnitude and avidity of the IgG binding response than those with Env

193 requires C-terminal domains that enhance the avidity of the molecule for C3b/C4b.

194 This is because the greater the avidity of the NC-receptor interaction the more efficien

195 y unresponsive tumors and predict pTR, using avidity of the primary tumor alone.

196 m6 fusion, indicating that mim6 enhances the avidity of this fusion.

197 ed, and experiments confirmed, that the high avidity of tSH2-WT resulted in saturation of its target

198 on the kinetics, magnitude, specificity, or avidity of vaccine-elicited binding or functional antibo

199 approach to describe and compare the oxygen avidity of wines according to their basic chemical compo

200 f precursor frequency, antigen affinity, and avidity on B cell responses following immunization.

201 ated to understand the effect of valency and avidity on delivery.

202 cal studies have validated this principle of avidity optimization in the context of chimeric antigen

203 s that occupied reduced area without loss of avidity or disrupted HA/NA interactions showed significa

204 ther tracers, except in situations where low avidity or high background activity limits diagnostic pe

205 other KIR2DP1(F) residues modulate receptor avidity or signaling.

206 survival outcomes, initial (11)C-methionine avidity overlapped with recurrent tumor in 100% of cases

207 EL9 also has significantly higher functional avidity (P < 0.0001) and drives stronger selection press

208 nal infection via seroconversion rather than avidity (P=0.007, AOR=3.3).

209 igh copy number, which suggests that binding avidity plays a compensatory role during import.

210 Whether changes in (18)F-fluciclovine avidity reflect changes in tumor burden resulting from t

211 The success of our approach suggests that avidity represents a key physical principle governing th

212 sing the affinity level caused a decrease in avidity requirements for some cell types but blocked inf

213 binding site show increases and decreases in avidity, respectively.

214 infection selects for the generation of high-avidity responses, with biologic consequences for airway

215 gen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 i

216 function during antiviral immunity, and how avidity selection might serve to produce the most potent

217 Moreover, we provide evidence for avidity selection occurring in human NK cells during hum

218 This may be due to transfer of high-avidity self-specific T cells.

219 h independently predicted pTR, and composite avidity/spatial metrics outperformed avidity alone.

220 6; P < .001) than with anti-nucleocapsid IgG avidity (Spearman rho = 0.211; P = .026).

221 ger positive correlation with anti-spike IgG avidity (Spearman rho = 0.386; P < .001) than with anti-

222 s to a single Fc with low affinity, a higher avidity stable binding of two or more of C1q globular he

223 Changes in (18)F-fluciclovine avidity strongly correlated with the tumor response on p

224 lature, none of the patients exhibited tumor avidity sufficient to be considered for (177)Lu-PSMA-617

225 imaging parameters included metrics of tumor avidity (SUVmax/mean/peak), composites of avidity and vo

226 oepitopes (DeltaNPM1) and then generate high-avidity T cell clones and retrovirally transduced T cell

227 f IL-12 during in vitro expansion boosts low-avidity T cell responsiveness, tumor regression, and pre

228 Attempts to induce high-avidity T cells by low-dose in vivo vaccination failed b

229 ken together, these data illustrate that low-avidity T cells can be therapeutically beneficial if coc

230 ells provide superior tumor control, yet low-avidity T cells can promote tumor regression.

231 TCR-engineered T cells, as IL-12-primed, low-avidity T cells cause less autoimmune vitiligo.

232 expression, this defect is overcome, and low-avidity T cells control tumor growth.

233 Instead, selective induction of high-avidity T cells has required in vitro culturing of speci

234 avital imaging, we also determined that high-avidity T cells have sustained contacts with intratumora

235 s effector function to levels seen with high-avidity T cells of identical specificity.

236 R affinity will allow a large arsenal of low-avidity T cells previously thought to be therapeutically

237 Clinically, low-avidity T cells provide a safer alternative to high-avid

238 Not surprisingly, high-avidity T cells provide superior tumor control, yet low-

239 We demonstrate here that engineering of low-avidity T cells recognizing a naturally processed and pr

240 this study, we compared mouse low- and high-avidity T cells targeting the tumor Ag tyrosinase-relate

241 e and promising approach for generating high-avidity T cells through vaccination.

242 dels of ATT, PD-1:28 engineering enabled low-avidity T cells to proliferate stronger and prevented PD

243 Upgrading the function of low-avidity T cells without changing the TCR affinity will a

244 HLA/CMV tetramers selectively detecting high-avidity T cells, we observed coappearance of CMV-CTLs wi

245 ic cells and tumor targets compared with low-avidity T cells.

246 ad no effect on antibody responses, antibody avidity, T-cell responses, or B-cell responses in HIV-in

247 n be engineered to improve binding affinity, avidity, target specificities, and biodistribution.

248 Cross-arm avidity targeting of antigen double-positive cancer cell

249 T cells provide a safer alternative to high-avidity, TCR-engineered T cells, as IL-12-primed, low-av

250 The affinity of the remaining low-avidity TCRs can be improved to increase their antitumor

251 ve mimic binds to cells with a 10-fold lower avidity than the least active variant suggesting that st

252 MDM2 acidic domain with significantly higher avidity than wild-type p53.

253 A to Clec9A induced Ab responses with higher avidity that more efficiently neutralized influenza viru

254 (Fc) domain for increased stabilization and avidity, the most optimal ACE2 receptor traps neutralize

255 electively induce T cells of high functional avidity through vaccination.

256 Avidities to heterotypic genogroup I VLPs were not susta

257 Avidity to an immunologically novel GII.4 strain VLP cor

258 % confidence interval] 0.61 [0.48-0.76]) and avidity to C-terminus (0.07 [0.05-0.90]) post-vaccinatio

259 with a high oxygenation rate showed greater avidity to consume oxygen taking less time to consume th

260 analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) afte

261 ism for immune evasion consists of increased avidity to host cellular receptors, mediated by electros

262 and beta-coronaviruses, and contributions of avidity to increased binding/neutralization of IgGs over

263 expressed by B6 splenocytes, with sufficient avidity to induce a TLR-independent proliferative respon

264 Bivalent V(H), V(H)-Fc ab8, bound with high avidity to membrane-associated S glycoprotein and to mut

265 e show that longer polymers increase binding avidity to multivalent targets but reach a limit in bind

266 High IgG avidity to mumps Enders strain was detected in sera of 5

267 self-antigen-specific T cells of sufficient avidity to recognize endogenously processed antigen.

268 investigated whether T cells with sufficient avidity to recognize naturally overexpressed self-antige

269 ur experience and previous reports on VHL-HB avidity to somatostatin analogues suggested somatostatin

270 as degree of polymerization, affect binding avidity to targets have mixed results, with some finding

271 IgG avidity to the C-terminus emerges as a significant contr

272 Blockade Ab avidity to the GI.1 vaccine component peaked at day 35 (

273 Avidity to the GII.4c vaccine component peaked at day 7,

274 Simulated binding studies show that binding avidity to the receptors follows the trend: V2 > OT > V1

275 ly for immature thymocytes with intermediate avidity to the selecting ligands.

276 This mimic binds HER2 with comparable avidity to trastuzumab, has similar activity in a cell-b

277 in HA, resulted in reduced receptor-binding avidity toward both human and avian-like receptor analog

278 FcgammaRs have been associated with altered avidity toward IgG, thereby substantially impacting clin

279 We use this approach to design high-avidity trimeric proteins that bind influenza A hemagglu

280 but conferred responses of lower functional avidity upon TCR transfer.

281 rlying the direct cell killing and increased avidity via a series of constant region shuffling and su

282 Composite avidity/volume measures improve prediction.

283 sease, confirming that the (89)Zr-pertuzumab avidity was a true-positive result for HER2-positive mal

284 Tetanus toxoid (TT)-specific antibody avidity was increased in APTB cases in comparison to uni

285 Antibody avidity was investigated using surface plasmon resonance

286 Antibody avidity was investigated.

287 ional avidity, whereas CD8 T cell functional avidity was unrelated to vaccine dose in mice.

288 Increasing levels of anti-spike IgG avidity were associated with high NT (>=160) (adjusted p

289 t plasma donors, higher levels of anti-spike avidity were associated with older age, male sex, and ho

290 fic neutralizing antibody concentrations and avidity were determined up to 4 years of age.

291 Epidemiologic correlates of avidity were examined in donors by linear regression.

292 i-spike and anti-nucleocapsid IgG titers and avidity were measured in a longitudinal cohort of COVID-

293 an, metabolic tumor volume, and total lesion avidity were obtained for the primary breast tumor, axil

294 Changes in (18)F-fluciclovine avidity were strongly correlated with the percentage of

295 Ds likely use a binding mechanism similar to avidity where a minimum number of weak dynamic interacti

296 vely primes CD4 T cells of higher functional avidity, whereas CD8 T cell functional avidity was unrel

297 tumor efficacy associated with increased TCR avidity, whereas targeted disruption of TCR avidity enha

298 a conformational change to optimize receptor avidity while the P domain itself undergoes smaller conf

299 (11)C-methionine avidity within MRI-defined tumor was limited in extent,

300 sing adjunctive therapy for restoring iodide avidity within the full spectrum from RAI-refractory ded