ライフサイエンスコーパス: axis formation

1 naling pathway that specifies Xenopus laevis axis formation.

2 ny organisms, this signaling pathway directs axis formation.

3 ycan provides a spatial cue for dorsoventral axis formation.

4 yos and partially inhibits endogenous dorsal axis formation.

5 tern in the morphogenetic movements of early axis formation.

6 , we have examined the role of CK2 in dorsal axis formation.

7 results in abnormalities of head and dorsal axis formation.

8 unction in mesoderm induction during primary axis formation.

9 iate time and place to participate in dorsal axis formation.

10 of processes in development, including early axis formation.

11 ventral marginal zone results in a secondary axis formation.

12 for noncanonical Wnt function in vertebrate axis formation.

13 n chromosome 3R that disrupt anteroposterior axis formation.

14 ning, providing new insights into left/right axis formation.

15 f all four micromeres prevented dorsoventral axis formation.

16 ages governs asymmetric expression during LR axis formation.

17 enin during cell proliferation and embryonic axis formation.

18 is required for Xenopus laevis embryo dorsal axis formation.

19 atenin(-) embryos would rescue organizer and axis formation.

20 n the chemical machinery required for dorsal axis formation.

21 s PAR-3 from the posterior pole early in a-p axis formation.

22 ribute to the body itself, it is involved in axis formation.

23 division and hence controls proximal-distal axis formation.

24 gnaling gradients are sufficient to initiate axis formation.

25 eviously described role late in oogenesis in axis formation.

26 e of differential cortical MT nucleation for axis formation.

27 hin the posterior follicle cells to initiate axis formation.

28 pecifying genes, indicating a role in dorsal axis formation.

29 n the lateral plate that is critical for L/R axis formation.

30 have not supported a role for Dsh in primary axis formation.

31 negative (kinase dead) mutants cause ectopic axis formation.

32 and asymmetric expression during left-right axis formation.

33 vents in Drosophila embryonic dorsal-ventral axis formation.

34 f cell adhesion, we find a role for XRhoA in axis formation.

35 factor that mediates Xenopus dorsal-ventral axis formation.

36 n the follicle cells with potential roles in axis formation.

37 mice that is required for normal vertebrate axis formation.

38 nfluence caudal vertebrae number during body axis formation.

39 tically increases the incidence of secondary axis formation.

40 ell-autonomous induction of secondary neural axis formation.

41 uned to accommodate feather regeneration and axis formation.

42 n early Xenopus embryos is required for body axis formation.

43 earch for other T-box genes participating in axis formation.

44 ZIC3 functions in the earliest stages of LR-axis formation.

45 hord precursor cells during gastrulation and axis formation.

46 us null mutants nevertheless spares anterior axis formation.

47 en implicated in the regulation of embryonic axis formation.

48 is both necessary and sufficient for dorsal axis formation.

49 lack of one or more Wnt-5A receptors during axis formation.

50 the regulation of CYP26A1 during vertebrate axis formation.

51 of the beta-catenin-cadherin interaction in axis formation.

52 /forerunner cell cluster may play in teleost axis formation.

53 soanterior development, initiates left-right axis formation.

54 of forces in tissue patterning and embryonic axis formation.

55 s, demonstrating that Ser168 is essential to axis formation.

56 to Bilateria, and is important in bilaterian axis formation.

57 brane trafficking, lysosomes, and vertebrate axis formation.

58 nd a novel requirement in anterior-posterior axis formation.

59 long-hypothesized GPCR regulating vertebrate axis formation.

60 rsely, Ccr7 or Ccl19.1 overexpression limits axis formation.

61 is and are independent of anterior-posterior axis formation.

62 h is essential for germ layer patterning and axis formation.

63 center in Xenopus germ layer patterning and axis formation.

64 -H but not abnormalities in left-right (L-R) axis formation.

65 are required for the initiation of embryonic axis formation.

66 ct involvement of somatic myosin activity in axis formation.

67 Tubifex tubifex are essential for embryonic axis formation.

68 ion, demonstrating that Baz is essential for axis formation.

69 at both 2d and 4d are required for secondary axis formation.

70 embryonic development, including left-right axis formation.

71 n during cortical rotation, and subsequently axis formation.

72 s specifically required in KV for proper L-R axis formation.

73 ork, which is known to be crucial for dorsal axis formation.

74 e streak and tail-bud regression during body axis formation.

75 enerating signals for embryonic mesoderm and axis formation.

76 ith failure of both mesoderm development and axis formation.

77 riably penetrant role in the later stages of axis formation.

78 signal emitted by the oocyte to control body axis formation.

79 timing mechanism for controlling the dorsal axis formation.

80 d is also essential for anteroposterior (AP) axis formation.

81 oxD3 protein resulted in a complete block to axis formation, a loss of mesodermal gene expression, an

82 embryos also display defects in dorsoventral axis formation accompanied by a disorganized cortical mi

83 ing protein (GBP), known to be essential for axis formation, also induces depletion of GSK3beta.

84 os have a defect in anterior-posterior (A-P) axis formation and are developmentally retarded, resulti

85 on at the 2- and 4-cell stages blocks dorsal axis formation and at the 8-cell stage blocks head forma

86 dult hydra, these three elements controlling axis formation and axial patterning are in a steady stat

87 erebrospinal fluid (CSF) contributes to body axis formation and brain development.

88 in ventral cells leads to complete secondary axis formation and can synergize with Xwnt-8 while an in

89 MZdicer mutants undergo axis formation and differentiate multiple cell types but

90 11b is maternally required for robust dorsal axis formation and for timely gastrulation, and zygotica

91 l-related signaling factors are required for axis formation and germ layer specification from sea urc

92 n regulatory complex in vivo is critical for axis formation and GSK-3beta activity.

93 example, mutations in the nodal gene disrupt axis formation and head development while mutations in t

94 enopus embryos, MTG family members inhibited axis formation and impaired the ability of beta-catenin

95 Axis formation and its maintenance is controlled by the

96 tal processes, including zebrafish posterior axis formation and kidney tubule formation.

97 rior of young oocytes for anterior-posterior axis formation and later in the dorsal anterior region f

98 Dorsal axis formation and mesoderm patterning are accepted effe

99 oxD5a acts as a transcriptional repressor in axis formation and neural plate expansion.Deletion const

100 ology has revealed deep similarities in body-axis formation and organization across deuterostomes, at

101 Dorsoventral axis formation and patterning is then mediated by matern

102 sin proteins, especially STAG3, perturb both axis formation and recombination in the mouse, prompting

103 In the mutants, axis formation and recombination initiation are normal,

104 G1/S transition coordinate key regulators of axis formation and sex determination with cell cycle pro

105 nizing the morphogenetic machinery to enable axis formation and stabilization.

106 key aspects of meiosis, including chromosome axis formation and synapsis in live human cells.

107 se-1 (TPST-1) is required for Xenopus dorsal axis formation and that O-sulfation of specific tyrosine

108 oth required for the initiation of embryonic axis formation and that the two proteins physically inte

109 They also reveal a link between DNA repair, axis formation and the COP9 signalosome, a protein compl

110 red for the establishment of anteroposterior axis formation and the formation of head structures duri

111 o separable processes acting with respect to axis formation and tissue specification in the early Xen

112 showed that Hox13 genes help to support body axis formation and to maintain the autoregulatory loop,

113 of LRRFIP2 in Xenopus embryos induced double axis formation and Wnt target gene expression; a dominan

114 f recombination, pairing, meiotic chromosome axis formation, and assembly of the synaptonemal complex

115 n pattern is linked to symmetry breaking and axis formation, and current theoretical models of Hydra

116 yos, Gdf3 misexpression results in secondary axis formation, and induces morphogenetic elongation and

117 sses, including neural differentiation, body axis formation, and organogenesis.

118 r species is required for ciliogenesis, body axis formation, and renal function.

119 We show that Pitx2 is essential for axis formation, and that it acts as a direct regulator o

120 die at mid-gestation, but surprisingly early axis formation, anterior patterning and neural crest for

121 lthough the mechanisms of anterior-posterior axis formation are well understood in Drosophila, both e

122 xperiments reveal that Ccr7 functions during axis formation as a GPCR to inhibit beta-catenin, likely

123 to other gene products known to be active in axis formation, beta-catenin is placed.

124 volution of spiral cleavage, anteroposterior axis formation, body axis segmentation, and head versus

125 that Star is involved in anterior-posterior axis formation both in the female germline cells and in

126 nds was proposed to inhibit beta-catenin and axis formation, but mechanisms remain unclear.

127 Activin/Nodal/Smad2/3 signalling and Xenopus axis formation, but not BMP/Smad1 signalling.

128 ting G proteins and intracellular calcium in axis formation, but such GPCRs have not been identified.

129 an essential role for beta-catenin in dorsal axis formation, but the maternal-effect mutation ichabod

130 rant micromeres have the ability to organize axis formation, but they lack the ability to induce neur

131 Hwa) acts as a dorsal determinant, dictating axis formation by activating beta-catenin signaling in z

132 like the spindle-class genes, CSN5 regulates axis formation by checkpoint-dependent, translational co

133 plays a key role in anterior-posterior (A-P) axis formation by inducing the anterior visceral endoder

134 in mRNA into Xenopus embryos inhibits dorsal axis formation by interfering with signaling through the

135 Xenopus laevis, beta-catenin-mediated dorsal axis formation can be suppressed by overexpression of th

136 anation for the defect in anterior-posterior axis formation caused by Notch and Delta mutants.

137 f Rho-kinase prevents proper proximal-distal axis formation, causes segments to develop abnormally, a

138 lopmental processes in eukaryotes, including axis formation, cell fate determination, spindle pole re

139 s (paraxial mesoderm) and spinal cord during axis formation challenged these notions.

140 rganizer gene expression and a disruption of axis formation, consistent with a redundant role for Sia

141 During embryonic axis formation, deep cells migrate and converge toward t

142 This explains the axis formation defects in Notch mutants, which arise bec

143 sion of early mesodermal markers and inhibit axis formation, demonstrating that FAST-1 is a necessary

144 Vertebrate body axis formation depends on a population of bipotential ne

145 he role of the foot in the initiation of new axis formation during budding by manipulating the foot a

146 ctors Dorsal and Twist regulate dorsoventral axis formation during Drosophila embryogenesis.

147 ific developmental role in dorsoventral (DV) axis formation during Drosophila oogenesis by localizing

148 ogaster have helped elucidate the process of axis formation during early embryogenesis.

149 orks underlying germ layer specification and axis formation during embryogenesis.

150 (e.g., Y14, staufen, mago nashi) needed for axis formation during oogenesis.

151 es have implicated Wnt signalling in primary axis formation during vertebrate embryogenesis, yet no W

152 continuous cell division, cell density, and axis formation early in metazoan evolution.

153 Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endoderm specificatio

154 ld-type Raf-1 exhibited defects in posterior axis formation exemplified by bent trunk and tail struct

155 the PMZ is removed, the embryo can initiate axis formation from another part of the remaining margin

156 PAM-1 in both cell cycle progression and AP axis formation, further implicating proteolytic regulati

157 age that comprises profound events including axis formation, gastrulation and the emergence of haemat

158 ernally derived Ndr1 for dorsal and anterior axis formation has also been documented.

159 enzymes responsible for RA abundance during axis formation has yet to be elucidated.

160 he same cell lineages during neurulation and axis formation, however, during the tailbud stage, MocuF

161 ing departure from established mechanisms of axis formation: Huluwa-mediated prepatterning is dispens

162 genetic and molecular pathways that lead to axis formation, I conducted a large-scale genetic screen

163 signaling and blocked Wnt-induced secondary axis formation in a dose-dependent manner, but did not b

164 threonine kinase that has been implicated in axis formation in a step downstream of Wnt.

165 Deciphering the mechanisms of axis formation in amphioxus is a key step to understandi

166 ne the effects of epimorphin on crypt-villus axis formation in an in vivo model, rat gut endoderm was

167 inhibition of sirtuins interferes with body axis formation in Arabidopsis.

168 f inhibiting MocuFH1 expression on embryonic axis formation in ascidians are similar to those reporte

169 intriguing parallel with anterior-posterior axis formation in C. elegans, where MyoII also acts upst

170 Axis formation in Drosophila depends on correct patterni

171 een oocyte selection, oocyte positioning and axis formation in Drosophila, leading us to propose that

172 -1 kinase is required for anterior-posterior axis formation in Drosophila.

173 Axis formation in fish and amphibians typically begins w

174 herefore function in a conserved pathway for axis formation in flies and worms.

175 direct molecular evidence of events driving axis formation in humans.

176 ead plays a critical role in head as well as axis formation in hydra.

177 ing and regulates an early step in embryonic axis formation in mammals and amphibians.

178 While mechanisms of axis formation in mammals could, in principle, be unique

179 morphogens play critical roles in embryonic axis formation in many organisms.

180 fundamental processes such as dorso-ventral axis formation in metazoans.

181 these genes support and refine our views of axis formation in plants.

182 usly shown to regulate the cell cycle and AP axis formation in the C. elegans zygote.

183 e results show that cVg1 can mediate ectopic axis formation in the chick by inducing new cell fates a

184 Axis formation in the D. melanogaster embryo involves th

185 alyzing enhancers during dorsal-ventral (DV) axis formation in the Drosophila embryo, we find that th

186 encoded by the gene jing is critical for PD axis formation in the Drosophila legs.

187 Anterior-posterior axis formation in the Drosophila oocyte requires activat

188 Dorso-ventral axis formation in the Drosophila wing requires the local

189 d the hypothesis that CamKII participates in axis formation in the early embryo.

190 Anterior-posterior axis formation in the mouse embryo requires the active m

191 proof for the requirement of Wnt3 in primary axis formation in the mouse.

192 ts may cooperate with each other to regulate axis formation in the normal embryo.

193 ain cell-signaling pathways is necessary for axis formation in the oocyte.

194 The mechanism of animal-vegetal (AV) axis formation in the sea urchin embryo is incompletely

195 rns anteroposterior (AP) and left-right (LR) axis formation in the vertebrate embryo.

196 and BMP pathways) involved in organizer and axis formation in the Xenopus embryo are now characteriz

197 lity to explain the preservation of anterior axis formation in these mutants would be the existence o

198 but the extent to which each contributes to axis formation in this paradigm remains unclear.

199 ation of Wnt-beta-catenin signaling disrupts axis formation in vertebrate embryos and underlies multi

200 ty and convergent extension movements during axis formation in vertebrates by activation of Rho and R

201 Embryonic axis formation in vertebrates is initiated by the establ

202 Axin is a negative regulator of embryonic axis formation in vertebrates, which acts through a Wnt

203 entres in the early embryo are essential for axis formation in vertebrates.

204 Elucidating the molecular framework of axis formation in vivo is fundamental for our understand

205 mal region supports a role for ski in neural axis formation in vivo.

206 Dorsal axis formation in Xenopus embryos is dependent upon asym

207 ates Wnt/beta-catenin signaling, and induces axis formation in Xenopus embryos.

208 activity and beta-catenin-induced secondary axis formation in Xenopus embryos.

209 1 in reducing beta-catenin-induced secondary axis formation in Xenopus laevis embryos in vivo.

210 In contrast, GBP, which is required for axis formation in Xenopus, binds and inhibits GSK-3.

211 , as negative regulators of beta-catenin and axis formation in zebrafish.

212 aises an intriguing parallel with C. elegans axis formation, in which PAR-2 excludes the anterior PAR

213 a spectrum of defects related to left-right axis formation, including visceral situs inversus, right

214 mportant in anteroposterior and dorsoventral axis formation, including wingless (wg) and decapentaple

215 ive siamois, a VP16 activator fusion induced axis formation, indicating that siamois functions as a t

216 Ectopic axis formation induced by Siamois is repressed by inject

217 mutant of CK2alpha was able to block ectopic axis formation induced by XWnt8 and beta-catenin and was

218 embryo and undergo subsequent movements, and axis formation is abnormal.

219 Insect axis formation is best understood in Drosophila melanoga

220 Asymmetric body axis formation is central to metazoan development.

221 CFC genes and Nodal signalling in left-right axis formation is conserved from fish to humans.

222 Embryonic axis formation is essential for patterning and morphogen

223 Within the Drosophila retina, D/V axis formation is essential to ensure that each unit eye

224 Axis formation is important for the regional specificati

225 paper, we report that the site of embryonic axis formation is marked earlier at the late-blastula st

226 at distinct tissue sites during A-P and L-R axis formation is potentially controlled by common trans

227 gene plays two essential roles in Drosophila axis formation: it is required downstream of the signal

228 Vg1 gene is a candidate for the initiator of axis formation: its RNA and protein are broadly but appr

229 la or Spemann-Mangold organizer orchestrates axis formation largely by limiting the ventralizing and

230 data are then used to ask whether aspects of axis formation might be derived or ancestral.

231 s indicate that previous and future work on "axis formation" must be interpreted in the context of th

232 uring early embryogenesis, including primary axis formation, neural crest induction, and A-P patterni

233 We describe principles of crypt-villus axis formation; neural, vascular, mesenchymal morphogene

234 s and is required for proper anteroposterior axis formation, neuroectoderm patterning, and somitogene

235 extending Brachyury function in the anterior axis (formation of the head process, prechordal plate).

236 BPTF is required for anterior-posterior axis formation of the mouse embryo and was shown to prom

237 Moreover, KLF4 inhibits the axis formation of Xenopus embryos and inhibits xenograft

238 hase kinase-3beta has been shown to initiate axis formation or axial patterning processes in many bil

239 t its role during hypothalamo-pituitary (HP) axis formation or involvement in human CH remains elusiv

240 In AP axis formation, Orb is required for the translation of o

241 In DV axis formation, Orb protein is required to localize and

242 erens junction (P = 0.03134), dorsal-ventral axis formation (P = 0.03695), proteasome (P = 0.04327),

243 LPP3 also mediates gastrulation and axis formation, probably by influencing the canonical Wn

244 entification of Drosophila genes involved in axis formation provides a launch-pad for comparative stu

245 This CSN5 phenotype - defective axis formation, reduced Gurken accumulation and modifica

246 chanisms of posterior neural development and axis formation regulated by eve1.

247 of the follicle cells in anterior-posterior axis formation remains enigmatic.

248 gote and coordinates cell cycle changes with axis formation remains unclear.

249 Defects in embryonic left-right axis formation represent a significant portion of congen

250 Drosophila axis formation requires a series of inductive interactio

251 together, these data indicate that wild-type axis formation requires CKII-catalyzed phosphorylation o

252 Abnormal left-right-axis formation results in heterotaxy, a multiple-malform

253 ic embryos, strongly suggest that during A/P axis formation, SPC4 acts primarily in the foregut.

254 ventral mesoderm resulting in ectopic dorsal axis formation, suggesting a role for this large evoluti

255 etic background, VML is not essential for DV axis formation, suggesting that there is redundancy in t

256 -posterior polarity and subsequent embryonic axis formation, the Drosophila par-1 gene is required ve

257 (DP) which controls feather regeneration and axis formation, the pulp mesenchyme (Pp) which is derive

258 Nuclear migration and DV axis formation therefore depend on centrosome positionin

259 examine whether 2d and 4d are sufficient for axis formation they were transplanted to an ectopic posi

260 e embryonic shield is sufficient for ectopic axis formation, they also raise questions concerning the

261 d signaling molecules that play key roles in axis formation, tissue differentiation, mesenchymalepith

262 The genetic systems controlling body axis formation trace back as far as the ancestor of dipl

263 Furthermore, SE strongly blocks axis formation triggered by beta-catenin but not by the

264 ke ligand Gurken (GRK), a crucial ligand for axis formation, underlies EGFR activation and DR formati

265 canonical Wnt pathway for the initiation of axis formation was established early in metazoan evoluti

266 getal alignment zone during gastrulation and axis formation, we have inhibited its formation by disru

267 ction of endogeneous Siamois in dorsoventral axis formation, we made a dominant repressor construct (

268 sophila limbs and can initiate proximodistal axis formation when expressed ectopically.

269 in and was capable of suppressing endogenous axis formation when overexpressed dorsally.