ライフサイエンスコーパス: axon guidance

1 igand-receptor pair that is central to motor axon guidance.

2 ion, cooperate with glia to mediate follower-axon guidance.

3 elopmental steps such as differentiation and axon guidance.

4 n the growth cone plays an important role in axon guidance.

5 ion of contralateral RGC differentiation and axon guidance.

6 on dendritic elaboration, but not inhibitory axon guidance.

7 laboration but is dispensable for inhibitory axon guidance.

8 red to be soluble can promote LAD-2-mediated axon guidance.

9 es a role for the C. elegans ephrin EFN-4 in axon guidance.

10 g molecule, is important for thalamocortical axon guidance.

11 ediate a specific aspect of neuronal growth: axon guidance.

12 ntially acting downstream of Frizzled to aid axon guidance.

13 anonical ephrin receptor to EFN-4 to promote axon guidance.

14 olved in cell migration, cell signaling, and axon guidance.

15 e in neuronal migration, axon outgrowth, and axon guidance.

16 highly enriched for mRNA targets related to axon guidance.

17 ct effect of MYO9A on neuronal branching and axon guidance.

18 ects both cortical neuronal migration and CT axon guidance.

19 o ADAM10 substrates previously implicated in axon guidance.

20 specific neuronal connections via selective axon guidance.

21 ed forms of LON-2/glypican are functional in axon guidance.

22 have complementary roles during commissural axon guidance.

23 rning and adhesion distinct from its role in axon guidance.

24 of VASP dynamics, filopodial stability, and axon guidance.

25 a previously unidentified effector of Shh in axon guidance.

26 filopodial stability during netrin-dependent axon guidance.

27 trusion' pathway shares common features with axon guidance.

28 n cytoskeletons in growth cones (GCs) during axon guidance.

29 n)cell-autonomous roles for Frizzled3 in MSN axon guidance.

30 adhesive molecules direct eve-dependent dMN axon guidance.

31 is known of its importance in the control of axon guidance.

32 ulation limits endocannabinoid modulation of axon guidance.

33 axon populations during reciprocal cortical axon guidance.

34 py-18 acts from multiple tissues to regulate axon guidance.

35 ilitates Sema-1a-PlexA/Gyc76C-mediated motor axon guidance.

36 y identifies a novel role of this pathway in axon guidance.

37 ins are key regulators of cell migration and axon guidance.

38 e mechanistic link between Fz3 and Celsr3 in axon guidance.

39 ng neurite outgrowth, neuronal polarity, and axon guidance.

40 roles in axonogenesis, dendritogenesis, and axon guidance.

41 ings suggest a tiered mechanism for reliable axon guidance.

42 pport directional growth, a process known as axon guidance.

43 esponse to Sema3a, particularly during early axon guidance.

44 ng in neuronal growth cones is essential for axon guidance.

45 p190RhoGAP as a critical regulator of motor axon guidance.

46 ues, and transmembrane receptors to regulate axon guidance.

47 assembly, cellular remodeling, and repulsive axon guidance.

48 isease (AD), as a potential key modulator of axon guidance, a neuronal process that depends on the re

49 DPY-18 regulates ephrin expression to direct axon guidance, a role for P4Hs that may be conserved in

50 nstrate an instructive role for serotonin in axon guidance acting through ephrinB2a and reveal a nove

51 rated a hypermethylated profile in pathways; axon-guidance, adherens-junction and calcium-signaling,

52 The involvement of PPFIA4 and SH3PXD2A in axon guidance also suggested a role in disease pathogene

53 leton dynamics and appear necessary for some axon guidance, also mediate interactions with membrane a

54 ay roles in cell adhesion, ion transport and axon guidance, among other biological pathways, suggesti

55 Our results reveal a developmental switch in axon guidance and a mechanism of circuit integration of

56 the microarray dataset showed enrichment in axon guidance and actin cytoskeleton signalling pathways

57 o link between semaphorin-mediated repulsive axon guidance and alteration of intracellular neuronal c

58 ne receptors that regulate processes such as axon guidance and angiogenesis.

59 ular endothelial growth factors, involved in axon guidance and angiogenesis.

60 rocesses, including cell fate specification, axon guidance and anteroposterior neuronal polarization.

61 he p75 neurotrophin receptor causes dramatic axon guidance and branching deficits, leading to a loss

62 ns to be enriched in PDA pathways, including axon guidance and cell adhesion, and newly identified pr

63 showed that overexpression of this repulsive axon guidance and cell patterning cue models the behavio

64 ment, including neural crest cell migration, axon guidance and cerebellar development.

65 ification of the core genes that orchestrate axon guidance and circadian rhythms in the 1990s.

66 pathway genes, but also in genes involved in axon guidance and cytoskeletal remodeling.

67 y in multiple model systems, with a focus on axon guidance and dendrite morphogenesis.

68 shed light on how the disparate functions of axon guidance and dendritic morphogenesis are accomplish

69 dance.SIGNIFICANCE STATEMENT Defects in both axon guidance and endoplasmic reticulum (ER) function ar

70 ditional mechanism for ephrins in regulating axon guidance and expands the repertoire of receptors by

71 d repulsive guidance molecule (RGM)-mediated axon guidance and in bone morphogenetic protein (BMP) si

72 twork was enriched for genes associated with axon guidance and interneuron differentiation, consisten

73 Filopodia-inducing Myo10 is implicated in axon guidance and mice lacking the Myo10 cargo protein D

74 tion on the role of miRNAs in the control of axon guidance and more broadly in nervous system develop

75 ages to the discrete nervous niche may exert axon guidance and nerve regeneration and thus contribute

76 e observations might be broadly relevant for axon guidance and neural circuit formation.

77 o a family of cytosolic proteins involved in axon guidance and neurite outgrowth signaling during neu

78 tem development and plasticity, ranging from axon guidance and neuron migration to synaptic organizat

79 Netrins are secreted proteins that regulate axon guidance and neuronal migration.

80 ment, semaphorin-plexin signalling instructs axon guidance and neuronal morphogenesis.

81 what they have taught us about mechanisms of axon guidance and selective vulnerability.

82 oligomerization-induced Robo activation for axon guidance and shed light on Robo family member ligan

83 ngs identify a dual function of NRP1 in both axon guidance and subcellular target recognition in the

84 g Notch signaling, neuronal differentiation, axon guidance and synapse formation.

85 dentities to neurons, and physically mediate axon guidance and synapse targeting.

86 erse neurodevelopmental functions, including axon guidance and synaptic adhesion, as well as self-rec

87 ment, local mRNA translation is required for axon guidance and synaptogenesis, and dysregulation of t

88 rent understanding of the factors regulating axon guidance and target engagement in regenerating axon

89 tes growth cone-growth cone communication in axon guidance and that both loss-of-function mutation an

90 Ps) are trans-membrane receptors involved in axon guidance and vascular development.

91 developmental genes that regulate apoptosis, axon guidance and vesicle transport.

92 F-beta and notch signaling), rap1-signaling, axon-guidance and hippo-signalling.

93 l development function in synapse formation, axon guidance, and axon termination.

94 pecific human pathways, such as cell growth, axon guidance, and cell differentiation.

95 he precise regulation of neuronal migration, axon guidance, and dendritic arborization.

96 glycan is critical for the proper migration, axon guidance, and dendritic stratification of neurons i

97 pression of genes involved in cell adhesion, axon guidance, and gliogenesis upon silencing of FoxO6 W

98 M degeneration leads to defective migration, axon guidance, and mosaic spacing of neurons and a loss

99 neuronal factors implicated in axonogenesis, axon guidance, and neuroblast migration.

100 psychosis, including synaptic cell adhesion, axon guidance, and neurogenesis.

101 ent, insect coagulation and innate immunity, axon guidance, and signaling in extracellular matrices.

102 lated factors are involved in cell adhesion, axon guidance, and signaling of Notch and GABA receptor

103 tor of neuronal migration, axonal outgrowth, axon guidance, and synaptogenesis by activating the GTPa

104 otentiation, PKA, immune response signaling, axon guidance, and synaptogenesis that significantly inf

105 ocesses, including survival, axon outgrowth, axon guidance, and synaptogenesis.

106 cells during the early stages of commissural axon guidance, and that over-expression of Robo2 can res

107 e, suggesting they cooperate in longitudinal axon guidance, and through biochemical approaches, we fo

108 However, the inability to control axon guidance, and thus neuronal network architecture, h

109 egulatory roles in diverse processes such as axon guidance, angiogenesis, and immune responses.

110 In particular, genes involved in axon guidance are enriched among the genes with altered

111 at modulate the strength of Wnt signaling in axon guidance are largely unknown.

112 ch as cell division, neuronal migration, and axon guidance are still prominent at P5, their expressio

113 Although the basic principles of axon guidance are well established, it remains unclear h

114 Fc gamma receptor-mediated phagocytosis and axon guidance AS genes were also highly represented.

115 neural differentiation processes, including axon guidance as supported by in vivo functional studies

116 served Ret receptor, known to play a role in axon guidance, as an important regulator of dendrite dev

117 rimarily as an extracellular scaffold during axon guidance, as it functions non-cell autonomously and

118 odevelopment and highlighted genes linked to axon guidance (associated with SEMA6D), synapse formatio

119 The mechanisms regulating PMN axon guidance at the MPs are not fully understood.

120 issural neurons suggested a receptor role in axon guidance at the spinal cord midline.

121 r mechanisms that control cell migration and axon guidance at the vertebrate CNS-PNS border.

122 elated to cardiomyopathy, calcium signaling, axon guidance, cell adhesion, and extracellular matrix s

123 uding signaling, transcriptional regulation, axon guidance, cell adhesion, cellular stress responses,

124 in conjunction with Slit ligands to mediate axon guidance, cell migration, and cell positioning in d

125 leased guidance molecule that is involved in axon guidance, cell patterning, and cell survival.

126 evelopment defects in stereotyped left/right axon guidance choices within the GABAergic motor neuron

127 ions in zebrafish embryos induced defects in axon guidance, confirming a dominant-negative mode of ac

128 endent angiogenesis and semaphorin-dependent axon guidance, controlling signaling and cross-talk betw

129 These findings identify NELL2 as an axon guidance cue and establish Robo3 as a multifunction

130 netrin-1 is both an attractive and repulsive axon guidance cue and mediates its attractive function t

131 (deleted in colorectal cancer), serves as an axon guidance cue during neural development and also con

132 terfering with the function of this specific axon guidance cue may be beneficial to the survival of D

133 Here, we identified the axon guidance cue netrin-1 as an essential factor requir

134 Here we show that the axon guidance cue Netrin-1 promotes naive pluripotency b

135 mpal neurons and fidelitous responses to the axon guidance cue netrin-1.

136 that Neuropilin 2 (Nrp2), a receptor for the axon guidance cue semaphorin 3F, has important and previ

137 UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and r

138 Netrin is a key axon guidance cue that orients axon growth during neural

139 Although Ntn1 is best known for acting as an axon guidance cue through Dcc and neogenin receptors, it

140 ns in hypodermal seam cells that secrete the axon guidance cue UNC-129/BMP, and our data revealed tha

141 Netrin is a prototypical axon guidance cue.

142 hich interactions between limited numbers of axon guidance cues can multiply the responses in develop

143 Semaphorins, originally discovered as axon guidance cues in neural development, have been show

144 cal endocytic events involving receptors for axon guidance cues play a central role in controlling gr

145 h the precise spatiotemporal effects of most axon guidance cues remain poorly characterized, a prevai

146 at locally regulate synapse formation, or by axon guidance cues restricting access to one of several

147 Although domain-specific axon guidance cues that discriminate contralateral and i

148 ated with chemoattractive and chemorepulsive axon guidance cues that influence point contact adhesion

149 Axon guidance cues that stimulate cytoskeletal reorganiz

150 uronal cdk5/p35 kinase, affects responses to axon guidance cues upstream of cdk5, specifically, to Se

151 We conclude that axon guidance cues, not molecularly distinct dendritic a

152 Following their description as axon guidance cues, semaphorins have been implicated in

153 racellular matrix (ECM) proteins and soluble axon guidance cues, suggesting that it may regulate axon

154 In addition to the archetypal axon guidance cues, the extracellular matrix provides lo

155 iphery have long been considered sensors for axon guidance cues, yet how they respond to extracellula

156 axon guidance on ECM proteins downstream of axon guidance cues.

157 nge can map to neural circuit patterning and axon guidance decisions during development.

158 This pathway may also be important in axon guidance decisions since asymmetric inhibition of M

159 rin signaling is required for key oculomotor axon guidance decisions, and provide a zebrafish model f

160 Notably, genetic axon guidance defects can be rescued, restoring function

161 development of corneal axons and that early axon guidance defects have long-term consequences on cor

162 d a gain-of-function mutation (G2019S) cause axon guidance defects in development.

163 PVD 1 degrees dendrites mimic ALA axon guidance defects in loss-of-function mutants for th

164 Trim9 deletion induces axon guidance defects in vitro and in vivo, whereas a gr

165 Slit-mediated repulsion and produces severe axon guidance defects in vivo.

166 olymicrogyria, pachygyria, microcephaly, and axon guidance defects.

167 for axon growth, and reveal the aetiology of axon-guidance defects in sax-3/Robo and vab-1/EphR mutan

168 ic neurons in the intestines, and have motor axon guidance deficits, similar to Gfralpha1(-/-) mice.

169 e brain at developmental stages relevant for axon guidance, dendrite formation, and synaptogenesis.

170 Commissural axon guidance depends on a myriad of cues expressed by i

171 Although commissural axon guidance during development has been studied in gre

172 Ligand receptor interactions instruct axon guidance during development.

173 Axon-axon interactions are essential for axon guidance during nervous system wiring.

174 lpain regulation of growth cone motility and axon guidance during neuronal development.

175 proliferation, neuronal migration, neuronal axon guidance during the infancy in rats in response to

176 o in mouse and chick resulted in commissural axon guidance errors.

177 es to date, and deepens our understanding of axon guidance events both in vitro and in vivo.

178 at this interaction is critical for specific axon guidance events in vivo.

179 With emerging evidence that axon guidance factors can regulate myeloid recruitment a

180 ap is unclear, as is the impact of embryonic axon guidance fidelity on adult nervous system function.

181 A prevailing concept that has emerged in the axon guidance field is the importance of repulsion as a

182 An important concept to have emerged in the axon guidance field is the importance of repulsion as a

183 both biologically active cues with distinct axon guidance functions in vivo Slit signaling is used i

184 metastatic tumours induced expression of the axon-guidance gene Slit2 in endothelium, establishing di

185 according to expression of neurotrophic and axon guidance genes also separated cancers according to

186 on start sites of upregulated genes, notably axon guidance genes and ion channel genes.

187 contain guidance receptors and contribute to axon guidance; however, the mechanism by which the guida

188 trate that ZBP1 is required for Shh-mediated axon guidance, identifying a new member of the noncanoni

189 tify a gene that provides anterior-posterior axon guidance in a large brain nucleus and link Frizzled

190 lt stem cell maintenance, cell migration and axon guidance in a wide range of organisms.

191 o, demonstrating that zSTIM1 is required for axon guidance in actively navigating zebrafish motor neu

192 fibroblasts and drive neurite outgrowth and axon guidance in neurons.

193 ed as a complementary mechanism to classical axon guidance in regulating axon track formation, axon o

194 rates suggests that Nogo-A may contribute to axon guidance in the lizard visual system.

195 CXCL12 levels, is an important regulator of axon guidance in the oculomotor system; complete loss ca

196 During commissural axon guidance in the spinal cord, chemorepulsion by Sema

197 pathway formation (i.e., anterior-posterior axon guidance in the striatum and axon entry into the gl

198 idance cues, suggesting that it may regulate axon guidance in vivo.

199 egulating Gyc76C activity in vitro and motor axon guidance in vivo.

200 ly, the absence of FLRT3 produces defects in axon guidance in vivo.

201 we identified several oncogenes involved in axon guidance, including Sema4d and Sema6d, which we fun

202 wn as RNA regulons - that drive axon growth, axon guidance, injury responses, axon survival and even

203 lly synthesized for functional roles such as axon guidance, injury signaling and regeneration.

204 nd included membrane receptors important for axon guidance, innate immunity, synapse development, and

205 o contains glutamatergic interneurons, whose axon guidance involves the EphA4 receptor.

206 lt, indicating that accurate embryonic motor axon guidance is critical for optimal neuromuscular func

207 repulsion is still present but longitudinal axon guidance is disrupted, particularly across segment

208 Axon guidance is driven by changes in the growth cone in

209 However, longitudinal axon guidance is highly disrupted in tok mutants and can

210 e demonstrate that this novel role of Mud in axon guidance is independent of its previously described

211 Appropriate axon guidance is necessary to form accurate neuronal con

212 Axon guidance is proposed to act through a combination o

213 Semaphorin family proteins are well-known axon guidance ligands.

214 pattern also extended to associated cues of axon guidance like neuropilin-1 and F-actin.

215 as a sympathetic guidance cue, and show how axon guidance mechanisms are coordinated with endorgan m

216 surprising regional diversity in commissural axon guidance mechanisms.

217 ing on juxtacrine signaling systems, such as axon guidance mediated by Ephrins and developmental patt

218 yelination in the central nervous system and axon guidance might be significant contributors to the g

219 the demonstration that null mutation in the axon guidance molecule EphA4 gene impairs the ability of

220 In mice lacking the axon guidance molecule EphA4, axonal misrouting of the c

221 unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum.

222 arteries is facilitated by secretion of the axon guidance molecule netrin-1 by arterial VSMCs.

223 Recently identified mutations of the axon guidance molecule receptor gene, DCC, present an op

224 that was first identified 20 years ago as an axon guidance molecule that regulates midline crossing i

225 odel of C2 hemisection SCI, we expressed the axon guidance molecule, brain-derived neurotrophic facto

226 hown that semaphorin3A (Sema3A), a repulsive axon guidance molecule, localizes to the PNNs and is rem

227 An axon guidance molecule, Neuropilin 2 (Nrp2), is known to

228 Of interest, we found that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among

229 Axon guidance molecules and neuronal activity have been

230 axon elimination.SIGNIFICANCE STATEMENT Both axon guidance molecules and neuronal activity regulate a

231 that high levels of nerve growth factor and axon guidance molecules are recorded in the presence of

232 Here, we investigate the axon guidance molecules downstream of Satb2 and Ctip2 th

233 factors' produced by neurons themselves, and axon guidance molecules have also been implicated in dev

234 articipation of one of the major families of axon guidance molecules in this process, the Semaphorins

235 e-pass transmembrane receptors that bind the axon guidance molecules semaphorins.

236 Semaphorins are a large family of axon guidance molecules that are known primarily as liga

237 the retinotopic map depends on the action of axon guidance molecules, activity-dependent mechanisms a

238 Myelin-associated molecules, repulsive axon guidance molecules, and extracellular matrix molecu

239 ts is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive

240 the other side of the cord is controlled by axon guidance molecules, such as Netrin-1 and DCC.

241 ucleus (dLGN) is established by gradients of axon guidance molecules, to allow initial coarse connect

242 ssion of extracellular matrix components and axon guidance molecules, with these transcripts being en

243 nd cell adhesion that predates their role as axon guidance molecules.

244 cell-derived neurotrophic factor and release axon-guidance molecules such as ephrin B1 to promote axo

245 n factors Lmx1a, Lmx1b, and Otx2 control the axon guidance of mDAs and the segregation of mesolimbic

246 P1) and promotes the migration, survival and axon guidance of subsets of neurons, whereas VEGF121 can

247 ggest that local clutching of RF can control axon guidance on ECM proteins downstream of axon guidanc

248 different isoforms, like an association with axon guidance or neuron differentiation during early dev

249 to other steps in circuit formation such as axon guidance, our knowledge of how synaptic partner sel

250 components in cortical, brainstem and spinal axon guidance/outgrowth pathways during neural different

251 By using the Slit-Robo axon guidance pathway to target neuronal midline crossin

252 udy suggested that glutamatergic synapse and axon guidance pathways were specifically enriched and ma

253 icroglia and macrophages (IAMs) that engages axon guidance pathways.

254 tion of these two functions well explain the axon guidance phenotype observed in Sfrp1 and Sfrp2 sing

255 -124 regulates Smed-slit-1, which encodes an axon guidance protein, either by targeting slit-1 mRNA o

256 SRGAP2 and other axon guidance proteins likely play a role in osteosarcom

257 chondroitin sulfate derivatives bound to the axon guidance proteins, protein tyrosine phosphatase sig

258 and pathways associated with chemotaxis and axon guidance, providing new insights into the mechanism

259 Humans with heterozygous mutations in the axon guidance receptor DCC display such mirror movements

260 In addition, we identify the axon guidance receptor EphB1 as a target of Fezf2 necess

261 deployed downstream of molecularly distinct axon guidance receptor families, but the scope of this o

262 ify novel (non)cell-autonomous roles for the axon guidance receptor Frizzled3 in uncharacterized aspe

263 late axons display reduced expression of the axon guidance receptor NRP1 and form aberrant axonal bun

264 Here we find that the developmental axon guidance receptor Roundabout 2 (Robo2) is critical

265 s revealed that the expression of Plxnc1, an axon guidance receptor, is repressed by Lmx1a/b and enha

266 -function mutations in the gene encoding the axon-guidance receptor 'deleted in colorectal carcinoma'

267 g integrator downstream of growth factor and axon guidance receptors.

268 anism for preventing premature activation of axon guidance receptors.

269 nuclear signaling may be a common output of axon guidance receptors.

270 xpression of specific motor pool markers and axon guidance receptors.

271 n coupled receptor (GPCR) signaling pathway, axon guidance, reelin signaling in neurons, and ERK/MAPK

272 s alternative splicing events of a series of axon guidance related genes during cortical development.

273 pression of differentiation-, apoptosis- and axon guidance-related genes was changed in BDNF mutant m

274 P2, show that it interacts with a network of axon guidance-related mRNAs, and reveal that it is requi

275 Upregulation of an axon-guidance-related gene signature was the most signif

276 Axon guidance requires interactions between extracellula

277 trin and Semaphorin in pioneer- and follower-axon guidance, respectively, and for glial and pioneer-n

278 oss of function and subsequent disruption of axon guidance, resulting in abnormal decussation of the

279 Axon guidance signaling and many other pathway genes are

280 or decussation of RGC axons, with a focus on axon guidance signaling at the optic chiasm and ipsi- an

281 netic manipulation of a critical mediator of axon guidance signaling, Abelson (Abl) tyrosine kinase,

282 tem requires temporal and spatial control of axon guidance signaling.

283 e often preprogrammed to respond to multiple axon guidance signals because they use sequential guidep

284 ulates spatiotemporal calcium signals during axon guidance.SIGNIFICANCE STATEMENT Defects in both axo

285 ew mediator of noncanonical Shh signaling in axon guidance.SIGNIFICANCE STATEMENT Sonic hedgehog (Shh

286 se, we focused on Sema5a, a gene involved in axon guidance, spine dynamics, Parkinson's disease and a

287 reviously undescribed glial roles in pioneer-axon guidance, suggesting conserved principles of brain

288 collicular development and in hindlimb motor axon guidance, suggesting that chick and mouse PTPRO hav

289 ination of a multiple-step program including axon guidance, target recognition, and synaptogenesis.

290 calcium (Ca(2+)) is an essential signal for axon guidance that mediates opposing effects on growth c

291 Like axon guidance, the tuning of vascular tip cells during a

292 Second-order axon guidance therefore multiplexes a smaller number of

293 s within growth cone filopodia that regulate axon guidance through activation of the protease calpain

294 vadosomes to target protease activity during axon guidance through tissues.

295 trin-1 is dispensable for commissural neuron axon guidance to the CNS midline during development.

296 maphorin 3E (Sema3E) plays a crucial role in axon guidance, vascular patterning, and immune regulatio

297 ing earlier developmental processes, such as axon guidance, we conditionally knocked out Celsr3 in th

298 , neuron differentiation, cell adhesion, and axon guidance, whereas CHD8-bound genes are strongly ass

299 0.05], such as KEGG FOCAL ADHESION and KEGG AXON GUIDANCE, which had been demonstrated to be involve

300 ment through highly constrained processes of axon guidance, which have been extensively studied.