ライフサイエンスコーパス: axonal growth

1 hin-mediated signaling pathways and enhanced axonal growth.

2 ctor 3 (ATF3) promotes neuronal survival and axonal growth.

3 endocannabinoid and Slit/Robo signalling in axonal growth.

4 diated knockdown of vinculin also attenuated axonal growth.

5 regulators dedicated to either dendritic or axonal growth.

6 is both necessary and sufficient to inhibit axonal growth.

7 pithelia, function in the dynamic context of axonal growth.

8 terminus to the two functions of Shot during axonal growth.

9 central nervous system is limited by lack of axonal growth.

10 f KLF7 in cortical neurons in vitro promotes axonal growth.

11 ring the processes of myelination and radial axonal growth.

12 ed have an increased ability to initiate new axonal growth.

13 odulate the functions of the NgR1 complex in axonal growth.

14 , orchestrating cytoskeletal dynamics toward axonal growth.

15 , which display defects in dendritic but not axonal growth.

16 rt of short MTs, and also limits the rate of axonal growth.

17 olonged denervation rather than a failure of axonal growth.

18 t transport to the soma, where it can impact axonal growth.

19 nating neurotrophin receptor endocytosis and axonal growth.

20 xonal conduction, in addition to stimulating axonal growth.

21 TM helices, Nogo-66, is active in preventing axonal growth.

22 ave functional consequences for dendrite and axonal growth.

23 ed molecules that facilitated contralesional axonal growth.

24 nd suppresses the ability of SnoN to promote axonal growth.

25 enhancing exogenous remyelination and neuron/axonal growth.

26 s neuronal differentiation and dendritic and axonal growth.

27 F-M KSP repeats as an essential component of axonal growth.

28 in-dependent "outside-in" trigger for radial axonal growth.

29 tional M85 peptide) is deleterious to normal axonal growth.

30 stance of axonal extension and the timing of axonal growth.

31 ared pathway with Cdh1-APC in the control of axonal growth.

32 ding genetic knock-down of Smad2, stimulates axonal growth.

33 s the ability of adult rat myelin to inhibit axonal growth.

34 ition zone may bundle these filaments during axonal growth.

35 he labile domains of microtubules and faster axonal growth.

36 and HuD affect levels of an mRNA involved in axonal growth.

37 otubule mass of the axon, thereby increasing axonal growth.

38 microtubule mass to levels more conducive to axonal growth.

39 tin dynamics in growth cones and facilitates axonal growth.

40 d promote receptor trafficking necessary for axonal growth.

41 X) complex, promote neuronal development and axonal growth.

42 T regulates mechanisms of sensory neuron and axonal growth.

43 ibose) in the cell body and axon and limited axonal growth.

44 inases prevented the NMDA receptor-dependent axonal growth acceleration, whereas AMPA/kainate-induced

45 and GAP43, which may account for the marked axonal growth across the lesion epicenter.

46 s primer will address issues in the study of axonal growth after central nervous system injury in an

47 There are multiple barriers to axonal growth after CNS injury.

48 Myelin-derived Nogo-A protein limits axonal growth after CNS injury.

49 onstrate that the ROCKII gene product limits axonal growth after CNS trauma.

50 ay hold therapeutic potential in stimulating axonal growth after injury in the CNS.

51 is not required for injury signaling or new axonal growth after injury.

52 y described that Galectin-1 (Gal-1) promotes axonal growth after spinal cord injury.

53 ning injuries have two components, increased axonal growth and a reduced response to inhibitory myeli

54 unctions autonomously in neurons to regulate axonal growth and advances a novel hypothesis that this

55 tal ARH neuronal explants to ghrelin blunted axonal growth and blocked the neurotrophic effect of the

56 Ninein in turn influences the rate of axonal growth and branching by affecting microtubule sta

57 Pum2-deficient neurons exhibited axonal growth and branching defects in vivo and impaired

58 nstrate that Nedd4-family E3 ligases promote axonal growth and branching in the developing mammalian

59 tages of neuronal differentiation, including axonal growth and branching, or dendritic development.

60 ced palmitoylation of proteins that regulate axonal growth and branching.

61 rvival or cell death, can promote or inhibit axonal growth and can facilitate or attenuate proliferat

62 oosting morphogenetic activity to facilitate axonal growth and collateral branching.

63 Appropriate axonal growth and connectivity are essential for functio

64 n about how cilia-driven signaling regulates axonal growth and connectivity.

65 cular modification was shown to be vital for axonal growth and dendritic branching.

66 r signaling of RhoA and promotes significant axonal growth and functional recovery following spinal c

67 Axonal growth and functional recovery following the sust

68 caffold-based approaches promote significant axonal growth and functional recovery in vivo in a spina

69 Several interventions promote axonal growth and functional recovery when initiated sho

70 cal environmental cues are indispensable for axonal growth and guidance during brain circuit formatio

71 that dDAAM also plays a pivotal role during axonal growth and guidance in the adult Drosophila mushr

72 ions for endothelins as general mediators of axonal growth and guidance in the developing nervous sys

73 monophosphate (cAMP) plays a pivotal role in axonal growth and guidance, but its downstream mechanism

74 kinases and among other functions regulates axonal growth and guidance.

75 derstood relative to other model systems for axonal growth and guidance.

76 Src tyrosine kinases have been implicated in axonal growth and guidance; however, the underlying cell

77 f specific Cdk5 targets, leading to aberrant axonal growth and impaired dendritic spine and synapse f

78 The triple-mutant mice exhibit greater axonal growth and improved locomotion, consistent with a

79 of Sip1 in the neocortex reveals defects in axonal growth and in ipsilateral intracortical-collatera

80 ntal switch that permits the transition from axonal growth and incipient synapse formation to synapti

81 elated KIF21B variant independently perturbs axonal growth and ipsilateral axon branching through two

82 hic factor signal directs sexually dimorphic axonal growth and maintenance, resulting in generation o

83 stathmin-2 (STMN2), an essential protein for axonal growth and maintenance.

84 ong functional links between Shot and EB1 in axonal growth and microtubule organization.

85 ed precursors (GDAs(BMP)) promotes extensive axonal growth and motor function recovery in a rodent sp

86 chanisms include phospholipid production for axonal growth and myelination, acetylcholine enhancement

87 Loss of Usp9x causes reduction in both axonal growth and neuronal cell migration.

88 Axonal growth and neuronal rewiring facilitate functiona

89 ectrical stimulation to promote regenerative axonal growth and new insights on the recovery of sensor

90 regrowth, yet signaling pathways employed in axonal growth and pathfinding are similar to those in ma

91 All treatments resulted in aberrant axonal growth and pathfinding errors, suggesting that lo

92 ediated sleep-wake regulation via control of axonal growth and PDF levels within the sLNv-encompassin

93 istances of the primate CNS, promoting local axonal growth and preventing lesion-induced neuronal deg

94 Whisker plucking induces axonal growth and pruning of horizontal projecting axons

95 t about by the formation of new circuits via axonal growth and pruning.

96 te glycosaminoglycans significantly enhances axonal growth and recovery in rodents following spinal c

97 (GAP-43) exhibits induced expression during axonal growth and reduced expression during MS progressi

98 ere, we identify KIF3C as a key regulator of axonal growth and regeneration by controlling microtubul

99 -specific kinesin that is a key regulator of axonal growth and regeneration by promoting microtubule

100 or of actin and microtubules (MTs), powering axonal growth and regeneration.

101 sent a novel therapeutic strategy to promote axonal growth and regeneration.

102 synaptic terminals, synaptic plasticity, and axonal growth and regeneration.

103 a neuron-intrinsic mechanism that regulates axonal growth and regeneration.

104 decorin as a potential therapy for promoting axonal growth and repair in the injured adult mammalian

105 herapeutic benefit appears to be mediated by axonal growth and repair, and is not attributable to cha

106 he importance of local protein synthesis for axonal growth and responses to axotomy, yet there is lit

107 trate critical roles for KIFC1 in regulating axonal growth and retraction as well as growth cone morp

108 to the lesion site secrete factors promoting axonal growth and serve as an axonal substrate, yet whet

109 ntral nervous system including neurogenesis, axonal growth and structural plasticity.

110 conditioning in adult mice can induce robust axonal growth and synapse formation in the cerebellar nu

111 n neurons and that uPA/uPAR binding triggers axonal growth and synapse formation.

112 extensively investigated, its regulation of axonal growth and target innervation are just being eluc

113 ot required for proliferation, migration, or axonal growth and targeting of developing PFN neurons.

114 l the 22q11.2 deletion, revealed deficits in axonal growth and terminal arborization, which can be pr

115 ortant implications for white matter injury, axonal growth, and axonal degeneration.

116 ion sites to provide permissive matrices for axonal growth, and brain-derived neurotrophic factor gra

117 rotrophic factors that significantly enhance axonal growth, and can inform future in vivo studies to

118 mechanical integrity of the axon, promoting axonal growth, and facilitating cargo transport.

119 trocytes inhibited GAP43 phosphorylation and axonal growth, and increased neuronal damage in cultured

120 has been implicated in synaptic plasticity, axonal growth, and neuronal survival.

121 Da Sema3A-Nrp1 signaling in the induction of axonal growth, and raise the possibility that endothelia

122 ound both local effects of growth factors on axonal growth, and remote effects of growth factors refl

123 otor neuron connectivity, column-specific on axonal growth, and subtype-specific on survival.

124 uggest a role of TDP-43 in the regulation of axonal growth, and suggest that impairment in the post-t

125 g Smad1 by RNA interference in vitro impairs axonal growth, and the continued presence of Smad1 is re

126 h the establishment of neuronal polarity and axonal growth are crucial steps in the development of th

127 us, following SCI, Ch'ase ABC may facilitate axonal growth at the spinal level, enhance adaptive feat

128 se data provide evidence that miR16 mediates axonal growth, at least in part, by regulating the local

129 Inactivation of Tsc1/Tsc2 promotes axonal growth, at least in part, via up-regulation of ne

130 lpting the nervous system through control of axonal growth, axonal and dendritic pruning, and regulat

131 This was not due to a failure of axonal growth, because injured motor axons eventually fu

132 re, we show that SRF mediates NGF signaling, axonal growth, branching, and target innervation by embr

133 ily conserved E3 ubiquitin ligase, restrains axonal growth but acts as a positive regulator for dendr

134 gnaling pathways and it functions to promote axonal growth but inhibit dendritic growth via activatio

135 nstitutively active (ca) Rit mutant promoted axonal growth but inhibited dendritic growth.

136 Rit mutant in hippocampal neurons inhibited axonal growth but potentiated dendritic growth.

137 nfluence neural progenitor proliferation and axonal growth, but its involvement in neuronal different

138 r work suggests that NOX-derived ROS promote axonal growth by regulating Rac1 activity, a molecular d

139 ex 2 (TSC2) in DRGs is sufficient to enhance axonal growth capacity in vitro and in vivo.

140 4, which activates Smad1, markedly enhances axonal growth capacity, mimicking the effect of a condit

141 owing damage and that this activity enhances axonal growth capacity.

142 s, all three USP9X variants failed to rescue axonal growth, caused reduced USP9X protein localization

143 te the initiation and further maintenance of axonal growth, challenging our currently held view of Rh

144 ich injury unlocks mature neurons' intrinsic axonal growth competence are not well understood.

145 function for p53 as a critical regulator of axonal growth cone behavior by suppressing ROCK activity

146 idance cue Semaphorin3a (Sema3a), leading to axonal growth cone collapse in vitro.

147 p53 inhibition-induced axonal growth cone collapse was significantly reduced by

148 RNAs, or by dominant-negative forms, induced axonal growth cone collapse, whereas p53 overexpression

149 tau in the organization and dynamics of the axonal growth cone cytoskeleton.

150 ss 3 semaphorins were initially described as axonal growth cone guidance molecules that signal throug

151 Recruitment of HRas to the axonal growth cone is paralleled by a decrease in HRas c

152 Whereas many molecules that promote cell and axonal growth cone migrations have been identified, few

153 In young cortical cultures, nestin regulates axonal growth cone morphology.

154 r of PI3K, markedly increases in the nascent axonal growth cone upon symmetry breaking.

155 Transplanted hMDSPCs surrounded the axonal growth cone, while hMDSPCs infiltrating the regen

156 olecular cues that activate receptors on the axonal growth cone.

157 forced by vesicular transport of HRas to the axonal growth cone.

158 is transport is essential for maintenance of axonal growth-cone dynamics and autophagosome turnover.

159 It is enriched in axonal growth cones (GCs) and has been implicated in cel

160 nctions as a cell adhesion molecule (CAM) in axonal growth cones (GCs) of the developing brain.

161 uding neural crest cells, endothelial cells, axonal growth cones and many types of adult stem cells,

162 During neural circuit assembly, axonal growth cones are exposed to multiple guidance sig

163 the nervous system, although their roles at axonal growth cones are unclear.

164 During neural development, axonal growth cones depend on rapid assembly and disasse

165 ghly and specifically expressed in axons and axonal growth cones in primary hippocampal neurons.

166 Axonal growth cones initiate and sustain directed growth

167 on from synaptic vesicle clusters present at axonal growth cones of developing neurons.

168 show that Kv3.4, the major Kv channel in the axonal growth cones of embryonic dorsal spinal neurons,

169 Membrane excitability in the axonal growth cones of embryonic neurons influences axon

170 re, we report that Kv3.4 is expressed in the axonal growth cones of embryonic spinal commissural neur

171 Kv3.4, which is transiently expressed in the axonal growth cones of many types of embryonic neurons,

172 t also restores beta-actin protein levels in axonal growth cones of SMN-deficient motor neurons.

173 ocess of chemotaxis in invasive tumor cells, axonal growth cones of Xenopus spinal neurons modulate t

174 examined NMDAR localization and function at axonal growth cones of young hippocampal neurons.

175 critical for axon branching and pruning once axonal growth cones reach their correct topographic posi

176 ecline during development, and concomitantly axonal growth cones switch their response to cAMP-depend

177 ckdown, we show for the first time in living axonal growth cones that tau is important for microtubul

178 eptor activation elicited calcium signals in axonal growth cones that were mediated by calcium influx

179 ioning neural network relies on responses of axonal growth cones to molecular guidance cues that are

180 les act in trans to modulate the response of axonal growth cones to soluble gradients to selectively

181 into the peripheral zone of differentiating axonal growth cones was decreased dramatically by antibo

182 s results in enhanced KIF21A accumulation in axonal growth cones, aberrant axon morphology, and reduc

183 caused reduced USP9X protein localization in axonal growth cones, and (in 2/3 variants) failed to res

184 to Sema3A on local protein synthesis (PS) in axonal growth cones, but a recent study has called this

185 modeling, such as retraction of neurites and axonal growth cones, elevated neuronal rigidity, and res

186 5) channels, which are present in developing axonal growth cones, suppressed CaMKK-mediated activatio

187 tial role of PTEN in chemotactic guidance of axonal growth cones.

188 pid responses that control the navigation of axonal growth cones.

189 Kif5c560-YFP, and leads to the formation of axonal growth cones.

190 ated local translation of beta-actin mRNA in axonal growth cones.

191 d expression in adult brain and are found in axonal growth cones.

192 to a few presynaptic terminals and scattered axonal growth cones.

193 edge of lamellipodia in migrating cells and axonal growth cones.

194 h general aging, there was downregulation of axonal growth, cytoskeletal assembly/transport, signalin

195 h acceleration, whereas AMPA/kainate-induced axonal growth decrease was blocked by inhibitors of calc

196 ZPR1 stimulates neurite growth and rescues axonal growth defects in SMN-deficient spinal cord neuro

197 n rescue the RNA transport deficits, but the axonal growth deficit is only rescued if the transported

198 Axonal growth deficits caused by GSK-3 inhibition could

199 ein, vinculin, is sufficient to overcome the axonal growth deficits of SRF-deficient and GSK-3-inhibi

200 conditioned medium was sufficient to enhance axonal growth, demonstrating that direct cell-cell conta

201 DD4 activation was associated with increased axonal growth driven by neuronal overexpression of SIRT1

202 -associated inhibitor that can contribute to axonal growth failure after adult spinal cord injury.

203 re is no effective treatment that stimulates axonal growth following injury.

204 Schwann cell grafts support axonal growth following spinal cord injury, but a bounda

205 lthough pulling forces have been observed in axonal growth for several decades, their underlying mech

206 actor (BDNF), which significantly stimulated axonal growth from chicken or rat dorsal root ganglia (D

207 ties of the 3D porous nanoscaffold, enhanced axonal growth from the dual-targeting therapeutic strate

208 identify transmembrane proteins that mediate axonal growth, guidance and target field innervation of

209 DM ([Formula: see text]) enhanced axonal growth in a nonmonotonic manner.

210 Thus, active GSK3 can also markedly promote axonal growth in central nerves if CRMP2 concurrently re

211 Treatment with recombinant tPA stimulated axonal growth in culture, an effect independent of its p

212 f RGS12 expression also inhibits NGF-induced axonal growth in dissociated cultures of primary dorsal

213 ing is developmentally regulated and governs axonal growth in dorsal root ganglion (DRG) neurons.

214 t on the appearance of the growth cone or on axonal growth in either type of neuron.

215 r2 controls integrin-dependent dendritic and axonal growth in mouse hippocampal neurons.

216 Nedd4-1 and Nedd4-2 are indeed required for axonal growth in murine central nervous system neurons.

217 d tensin homolog (PTEN) and thereby regulate axonal growth in neurons.

218 prenylation in sympathetic axons to promote axonal growth in response to the neurotrophin, nerve gro

219 ce of developing precise terms that describe axonal growth in terms of the inciting event, the distan

220 enerating myelin and astroglial scar prevent axonal growth in the adult brain and spinal cord.

221 e bifunctional guidance molecule netrin-1 on axonal growth in the injured adult spinal cord.

222 define a novel SnoN-Ccd1 link that promotes axonal growth in the mammalian brain, with important imp

223 the Frizzled3 (Fz3) gene leads to defects in axonal growth in the VII(th) and XII(th) cranial motor n

224 neration-associated protein that accelerates axonal growth in vitro.

225 c, is dynamic and elongates independently of axonal growth, in contrast to stretch-based mechanisms p

226 tors, Nogo, MAG, and OMgp, in injury-induced axonal growth, including compensatory sprouting of uninj

227 lso abolished the negative effects of Shh on axonal growth, including growth cone collapse and chemor

228 Thus, ephrinB3 contributes to myelin-derived axonal growth inhibition and limits recovery from adult

229 Here we show that axonal growth inhibition mediated by CSPGs requires intr

230 tracellularly, CSPG-LAR interaction mediates axonal growth inhibition of neurons partially via inacti

231 d synergistic role for all three proteins in axonal growth inhibition.

232 Nogo-A is an important axonal growth inhibitor in the adult and developing CNS.

233 are thought to mediate the action of several axonal growth inhibitors in the adult brain and spinal c

234 by the non-permissive environment, including axonal growth inhibitors such as the Nogo-A protein.

235 ation in primary cultured neurons exposed to axonal growth inhibitors.

236 Radial axonal growth initiates with myelination, and is depende

237 tively growing state, the rate of peripheral axonal growth is accelerated and the injured central axo

238 This increased axonal growth is accompanied by improved locomotor perfo

239 Directed axonal growth is essential to establish neuronal network

240 ion is beneficial for neuronal health and/or axonal growth is not entirely clear, and is likely situa

241 explanation for this is that injury-induced axonal growth is too slow.

242 of axonal morphogenesis, but how SnoN drives axonal growth is unknown.

243 ration research has been like the process of axonal growth itself: there is steady progress toward re

244 gulated by transcription factors involved in axonal growth, Kruppel-like factor (KLF) transcription f

245 ns of these motifs abolish Shot functions in axonal growth, loss of EB1 function phenocopies Shot los

246 deletion of MAG and OMgp stimulates neither axonal growth nor enhanced locomotion.

247 nterestingly, in contrast with the excessive axonal growth observed during development, mec-7 mutants

248 The increase in axonal growth occurs on both a favorable substrate and a

249 dder hyperactivity, accompanied by increased axonal growth of calcitonin gene-related peptide-labeled

250 ing physiological levels of ROS required for axonal growth of hippocampal neurons.

251 teins (CRMPs) specify axon/dendrite fate and axonal growth of neurons through protein-protein interac

252 3 GOF in postmitotic neurons not only alters axonal growth of postmitotic neurons but also impairs RG

253 re, we show that Tip60 HAT activity mediates axonal growth of the Drosophila pacemaker cells, termed

254 he distinct dependence between dendritic and axonal growth on the secretory pathway helps to establis

255 yogenesis, Nmnat2 plays an important role in axonal growth or maintenance.

256 l of AP-2 from older neurons does not impair axonal growth or signaling and synaptic function.

257 temperature adaptation, Ca(2+) homeostasis, axonal growth, (para)node of Ranvier stability and synap

258 urs and whether it can be altered to enhance axonal growth potential.

259 pically considered together, these two adult axonal growth processes are fundamentally different.

260 ore provide insights into the control of the axonal growth program.

261 This study shows that adaptive axonal growth-promoting mechanisms can substantially imp

262 Here we show that axonal growth-promoting roles of Shot require interactio

263 LCN stimulations significantly increased the axonal growth protein GAP43 in the ipsilesional somatose

264 tein 2 (CRMP2) is traditionally viewed as an axonal growth protein involved in axon/dendrite specific

265 al outcome can be improved by increasing the axonal growth rate.

266 tein ligase, NEDD4-1, a protein required for axonal growth, regeneration and proteostasis in neurodeg

267 nsists of Highwire and Wallenda and controls axonal growth, regeneration, and degeneration, is also i

268 roximately 200 diverse proteins critical for axonal growth, regeneration, and synaptic function at av

269 Regenerative axonal growth requires alterations in axonal microtubule

270 To address whether this switch in axonal growth response was mediated by distinct calcium

271 Myelin-derived inhibitors contribute to axonal growth restriction, with ephrinB3 being a develop

272 njured adult spinal cord to mount remarkable axonal growth, resulting in formation of new relay circu

273 We address definitions of axonal growth, sprouting and regeneration after injury,

274 nce of achieving functional recovery through axonal growth, substantial research effort has been, and

275 emergence of NDO, together with reduction of axonal growth, suggesting that BDNF may have a crucial r

276 in maintaining central nervous system (CNS) axonal growth, synapse formation, and neurotransmitter r

277 ism, and that FERMT2 underexpression impacts axonal growth, synaptic connectivity, and long-term pote

278 elevate the capacity of the adult brain for axonal growth, synaptic plasticity, and cognitive functi

279 h, migration, differentiation, dendritic and axonal growth, synaptogenesis, and synaptic pruning, all

280 pathway by which extrinsic signals regulate axonal growth through activation of m-calpain and p53 tr

281 Furthermore, compensatory axonal growth through collateral sprouting, normally see

282 i3 signaling pathway that ultimately affects axonal growth through the optic chiasm.

283 as OA1 to regulate melanosome biogenesis and axonal growth through the optic chiasm.

284 ng Rac1 activity, a molecular determinant of axonal growth, through a ryanodine receptor (RyR)-mediat

285 vely switch from a dormant state with little axonal growth to robust axon regeneration upon injury.

286 Here, we demonstrate that axonal growth triggered by neurotrophin-3 remotely inhib

287 ol, an endocannabinoid affecting directional axonal growth, triggers corpus callosum enlargement due

288 Although CSPGs may negatively regulate axonal growth via binding and altering activity of other

289 vel receptor mechanism whereby CSPGs inhibit axonal growth via interactions with neuronal transmembra

290 of the Nogo receptor complex, which inhibits axonal growth via RhoA.

291 Axonal growth was partially dependent on mammalian targe

292 alized, there was a significant reduction in axonal growth when incubated in HUVEC-conditioned medium

293 ) upregulated genes commonly associated with axonal growth, whereas axotomized neurons whose axons we

294 ive physical and biochemical environment for axonal growth, which may lead to functional recovery.

295 it2/Robo1 signalling to modulate directional axonal growth, which may provide a basis for understandi

296 e treatments face the challenge of restoring axonal growth within an injury environment where inhibit

297 cord can enhance astrocyte infiltration and axonal growth within the injury site, but the mechanisms

298 sm that differentially directs dendritic and axonal growth within the same neuron in vivo.

299 ion-fusion regulating proteins for improving axonal growth within the visual system, we uncover that

300 ynthesis of cytoskeletal components to allow axonal growth without marked increase in expression of g