ライフサイエンスコーパス: axonal outgrowth

1 uidance defects and proteins that promote DA axonal outgrowth.

2 neurotransmission, synaptic plasticity, and axonal outgrowth.

3 amino acids does not alter cell spreading or axonal outgrowth.

4 delay and/or increasing the initial rate of axonal outgrowth.

5 se it is involved in synaptic plasticity and axonal outgrowth.

6 dramatic defects in neuronal development and axonal outgrowth.

7 ates neuronal differentiation, migration and axonal outgrowth.

8 teins initiate signaling cascades that repel axonal outgrowth.

9 to neurotrophins or netrin-1 with efficient axonal outgrowth.

10 ing is unnecessary for retinal ganglion cell axonal outgrowth.

11 rons, reduction of SPRR1A function restricts axonal outgrowth.

12 S white matter is selectively inhibitory for axonal outgrowth.

13 s play a special role during early phases of axonal outgrowth.

14 hese components function together to control axonal outgrowth.

15 y regulate target genes that are involved in axonal outgrowth.

16 oping motor neurons when these cells undergo axonal outgrowth.

17 hat potentially mediates signals involved in axonal outgrowth.

18 in permissiveness of dorsal myotome for CaP axonal outgrowth.

19 8-mutated MAG retains the ability to inhibit axonal outgrowth.

20 generated but exhibits patterns of abnormal axonal outgrowth.

21 ns, suggesting that it, like UNC-76, acts in axonal outgrowth.

22 s (but not laminin 1) may promote peripheral axonal outgrowth.

23 e of its target mRNAs, Gap43, is involved in axonal outgrowth.

24 tic fibers and that it functions to regulate axonal outgrowth.

25 em processes, such as synaptic formation and axonal outgrowth.

26 es which are important for neural repair and axonal outgrowth.

27 y neurons lacking OGT also exhibit decreased axonal outgrowth.

28 tween the integrity of the Golgi complex and axonal outgrowth.

29 second messenger cAMP overcomes this blocked axonal outgrowth.

30 genesis, neurotransmitter specification, and axonal outgrowth.

31 n, which affects both neuronal migration and axonal outgrowth.

32 that this regulation is required for normal axonal outgrowth.

33 with the miRNA hairpin inhibitor suppressed axonal outgrowth.

34 levels by miR-19a likely contributes to the axonal outgrowth.

35 he establishment of dendritic complexity and axonal outgrowth.

36 cilitating a more permissive environment for axonal outgrowth.

37 ing functions in both neuronal migration and axonal outgrowth.

38 arity of neurons, as well as ensuring proper axonal outgrowth.

39 o differ with respect to the timing of their axonal outgrowth.

40 ntrosomal localization, leading to misplaced axonal outgrowth.

41 expression of GAP-43, a crucial component of axonal outgrowth.

42 eover, been demonstrated to regulate neurite/axonal outgrowth.

43 is critical for neuronal differentiation and axonal outgrowth.

44 urface targeting, synaptic transmission, and axonal outgrowth.

45 trin-1, but most DCC-mutant samples lack VCN axonal outgrowth.

46 for their role in patterning can also direct axonal outgrowth.

47 nes and regulates growth cone morphology and axonal outgrowth.

48 oneurons express scn8a and displayed delayed axonal outgrowth.

49 binds to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth.

50 otubules converging into the laminin-induced axonal outgrowths.

51 monstrated that S-220 significantly enhanced axonal outgrowth across the lesion gaps in the organotyp

52 rain injury and into potential mechanisms of axonal outgrowth after injury.

53 thesized that Epac2 activation would enhance axonal outgrowth after SCI.

54 Wnt proteins regulate axonal outgrowth along the anterior-posterior axis, but

55 n (Crmp-2), a neuronal protein implicated in axonal outgrowth and a component of the semaphorin 3A pa

56 eurons results in a substantial reduction in axonal outgrowth and arborization.

57 uring development and suggest that it limits axonal outgrowth and branching in a DRG-autonomous manne

58 II or nuclear CaMKIV, dramatically decreases axonal outgrowth and branching in cultured neonatal hipp

59 tured PTPRO(-/-) TG neurons display enhanced axonal outgrowth and branching in response to BDNF and G

60 knockdown is sufficient to redrive defective axonal outgrowth and branching related to Tau-P301L expr

61 hereas a second domain, Amino-Nogo, inhibits axonal outgrowth and cell adhesion through unknown mecha

62 domain of NogoA, called amino-Nogo, inhibits axonal outgrowth and cell spreading via a largely unknow

63 VGluT2 expression in dopamine neurons drives axonal outgrowth and contributes to dopamine neuron axon

64 tracellular signaling proteins that regulate axonal outgrowth and extension, most were conducted in t

65 ed on embryonic axons and may play a role in axonal outgrowth and fasciculation.

66 Overexpression of sAC results in axonal outgrowth and growth cone elaboration, whereas in

67 of secreted molecules that are important for axonal outgrowth and guidance in the developing nervous

68 ggesting that Cdk5 has no obvious effects on axonal outgrowth and guidance mechanisms of these two ne

69 anterograde syd vesicles may play a role in axonal outgrowth and guidance.

70 ing those linked to amyloid-beta processing, axonal outgrowth and lipid metabolism.

71 We show that kbp is required for axonal outgrowth and maintenance.

72 d that specific activation of Epac2 enhances axonal outgrowth and minimizes glial activation in an ex

73 factor (EGF) ligand neuregulin required for axonal outgrowth and myelination, are indeed posttransla

74 ny aspects of neuronal development including axonal outgrowth and neuronal migration.

75 RP promotes mRNA entry to axons and enhances axonal outgrowth and neurotransmitter release from presy

76 variety of developmental processes, such as axonal outgrowth and pathfinding, synaptogenesis, and th

77 eurons are studied intensively as a model of axonal outgrowth and pathfinding, yet the neurotransmitt

78 dies have revealed many molecules underlying axonal outgrowth and pathfinding.

79 de have identified many molecules underlying axonal outgrowth and pathfinding.

80 Remarkably, NMN deamidase also rescues axonal outgrowth and perinatal lethality in a dose-depen

81 e protein Nogo-A is known as an inhibitor of axonal outgrowth and regeneration in the CNS.

82 nt, as we show STMN2 is necessary for normal axonal outgrowth and regeneration.

83 ced VGluT2 expression in DA neurons promotes axonal outgrowth and reinnervation in the postlesional b

84 upregulation of Tuj1 and SV2 is required for axonal outgrowth and search for appropriate targets, whe

85 monstrate that G protein activation inhibits axonal outgrowth and suggest that there may be a G prote

86 retinal ganglion cell (RGC) differentiation, axonal outgrowth and survival.

87 Thy-1 has been implicated in regulating axonal outgrowth and synaptic function, but little is kn

88 were found to be highest during periods when axonal outgrowth and synaptogenesis predominate.

89 cell bodies to synaptic terminals following axonal outgrowth and synaptogenesis.

90 ation through postmitotic differentiation to axonal outgrowth and synaptogenesis.

91 After termination of axonal outgrowth and target recognition, axons in the ve

92 ting that there is an increased capacity for axonal outgrowth and targeting, and increased support fo

93 ing 5-HT axons, is necessary for normal 5-HT axonal outgrowth and terminal arborization during the pe

94 on of miR-17-92 cluster expression regulates axonal outgrowth and that local modulation of PTEN prote

95 -sensitive signaling mechanism that controls axonal outgrowth and the expression of multiple growth-a

96 opmental steps, culminating in dendritic and axonal outgrowth and the formation and maturation of syn

97 Initial experiments characterized axonal outgrowth and the specific segregation of axons a

98 f the quaternary CRMP2 complex that controls axonal outgrowth and thus neuronal development.

99 Previous work has identified axonal outgrowth and/or guidance defects in the brain an

100 Many of these regions are known to display axonal outgrowth and/or synaptic rearrangement in adulth

101 We measured GC adhesion, initial axonal outgrowth, and substrate preference on alternatin

102 including neuronal migration, dendritic and axonal outgrowth, and synaptogenesis.

103 rial traffic in axons responds to changes in axonal outgrowth, and that the mechanism by which sortin

104 ts as a key regulator of neuronal migration, axonal outgrowth, axon guidance, and synaptogenesis by a

105 l potential of Epac2 activation in promoting axonal outgrowth by an ex vivo rat model of SCI mimickin

106 Collapsin-1 or semaphorin III(D) inhibits axonal outgrowth by collapsing the lamellipodial and fil

107 that Vangl2 acts as a negative regulator of axonal outgrowth by regulating the strength of the molec

108 the C-terminal tail of the protein, displays axonal outgrowth defects similar to those observed in nu

109 ice had agenesis of the corpus callosum, and axonal outgrowth defects specific to ventral motoneuron

110 loproteinases (MMPs) have been implicated in axonal outgrowth during CNS development and show increas

111 hem (i.e., class II) correlates closely with axonal outgrowth during development and regeneration.

112 critical requirement for spastin to promote axonal outgrowth during embryonic development, and they

113 Axonal outgrowth during peripheral nerve regeneration re

114 oneuron survival up to 45 weeks and improved axonal outgrowth, electrophysiological recovery, and mus

115 , or rapamycin, an mTOR inhibitor, abolished axonal outgrowth enhanced by overexpression of the miR-1

116 tand how leptin could simultaneously promote axonal outgrowth from and inhibit the activity of NAG ne

117 l development in the rodent, leptin promotes axonal outgrowth from ARH neurons, and preautonomic NAG

118 In addition, axonal outgrowth from cerebellar granule neurons is incr

119 n this study, the time course and pattern of axonal outgrowth from different populations of pregangli

120 utralizing antibodies to BDNF eliminated the axonal outgrowth from spinal organotypics observed with

121 gh apical constriction, which is followed by axonal outgrowth from the opposite basal side of the cel

122 I nIF protein expression and early phases of axonal outgrowth has changed during evolution, the autho

123 survival of motoneurons, but its effects on axonal outgrowth have not been examined in detail.

124 related strongly with the earliest phases of axonal outgrowth in fishes but less so in mammals.

125 ormation of inhibitory synapses, and promote axonal outgrowth in inhibitory interneurons.

126 o laminin and APP-binding peptide as well as axonal outgrowth in Itgb1- independent manner; and APP d

127 d impairment of FAT in squid axoplasm and of axonal outgrowth in mammalian primary motor neurons invo

128 T STXBP5L, but not variant STXBP5L, promoted axonal outgrowth in manipulated mouse primary hippocampa

129 V kinases in dissociating the cell death and axonal outgrowth in neurons and their druggability provi

130 irements for plasticity and stability during axonal outgrowth in neurons that project long axons.

131 Proteoglycans influence axonal outgrowth in several experimental paradigms, and

132 eir role in limiting synaptic plasticity and axonal outgrowth in the adult CNS has been described pre

133 Collagen type V(SC) blocked axonal outgrowth in the presence of otherwise active sub

134 Moreover, C3 increases axonal outgrowth in the rat hippocampus, raising the pos

135 or KIF3C gene knock-out, display an impaired axonal outgrowth in vitro and a delayed regeneration aft

136 neuronal cell spreading and strongly inhibit axonal outgrowth in vitro and in vivo.

137 CNS myelin inhibits axonal outgrowth in vitro and is one of several obstacle

138 GDF10 promotes axonal outgrowth in vitro in mouse, rat and human neuron

139 h necessary and sufficient for NGF-dependent axonal outgrowth in vitro, and NGF regulates SRF-depende

140 ) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediat

141 bind to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth in vitro.

142 g that NgR mediates a significant portion of axonal outgrowth inhibition by myelin.

143 Axonal outgrowth is generally thought to be controlled b

144 al development shows that the speed of early axonal outgrowth is reduced in both the peripheral and c

145 bryonic day (E) 11.5, when sensory and motor axonal outgrowth is underway.

146 fundamental processes including mitosis and axonal outgrowth, its mechanism of action is poorly unde

147 axonal proteins that have been implicated in axonal outgrowth, microtubule spacing, and microtubule b

148 NMJ chip' enables real-time, live imaging of axonal outgrowth, NMJ formation and muscle maturation, a

149 It was found that during the period of axonal outgrowth, Npr2 and cGKIalpha were strongly label

150 eages, and reveals L/R asymmetric control of axonal outgrowth of bilaterally symmetric neurons.

151 These results implicate 20E in enhancing axonal outgrowth of Kenyon cells to support MB remodelin

152 ERK/MAPK signaling was dispensable for axonal outgrowth of layer 2/3 callosal neurons.

153 ene, mutations in which cause defects in the axonal outgrowth of motor neurons, as well as defects in

154 ding astrocyte-neuron metabolic coupling and axonal outgrowth of neurons.

155 ervous systems where they support continuous axonal outgrowth of olfactory sensory neurons to their t

156 on of Rac1 in VZ progenitors did not prevent axonal outgrowth of telencephalic neurons.

157 iscernible effect on either the migration or axonal outgrowth of the EP cells.

158 ith F-actin in membrane ruffles and augments axonal outgrowth on a range of substrates.

159 response because it occurs without affecting axonal outgrowth or cell survival, and it is not observe

160 ting a potential role for the DAN protein in axonal outgrowth or guidance.

161 analysis addressed the role of FGF-2 in mDA axonal outgrowth, pathway formation, and innervation of

162 a crucial role in axon guidance, but not in axonal outgrowth per se.

163 uggests that ADAM21 is involved in the final axonal outgrowth phase and/or synapse formation.

164 cetylcholinesterase (AChE) during periods of axonal outgrowth prior to synaptogenesis, suggesting tha

165 Here, we demonstrate fabrication, rapid axonal outgrowth, reproducible cytoarchitecture, and sim

166 ent and inhibitory effects of the miR-19a on axonal outgrowth, respectively.

167 Timeline analysis of axonal outgrowth reveals that leg motoneurons reach thei

168 neurons and glia after injury to facilitate axonal outgrowth.SIGNIFICANCE STATEMENT During developme

169 ogenous 5-HT and blunting of endogenous 5-HT axonal outgrowth specifically within the fetal forebrain

170 n DNA repair, cell cycle, cell survival, and axonal outgrowth, suggesting p53 as key modifier of axon

171 neural precursors produce grafts with richer axonal outgrowth than primary foetal grafts, and that th

172 suppressor factor, p53, in the regulation of axonal outgrowth through a nontranscriptional effect inv

173 regulates SRF-dependent gene expression and axonal outgrowth through activation of both MEK/ERK and

174 surface of oligodendrocytes and can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR

175 regulate these events, inducing and guiding axonal outgrowth through the processes they extend.

176 jury-conditioned neurons by siRNA attenuated axonal outgrowth to 48% of control injured neurons and w

177 eurons, to examine their distribution during axonal outgrowth, to determine the reliance of this dist

178 Sensory neuron formation and axonal outgrowth, two early metamorphic events, also occ

179 ssociation between XIF3 expression and early axonal outgrowth was especially strong.

180 were observed at C7, while only one surge of axonal outgrowth was found at the L4 level.

181 However, by 8 days, differences in axonal outgrowth were observed with respect to target ty

182 ain binds to the Nogo-66 receptor to inhibit axonal outgrowth, whereas a second domain, Amino-Nogo, i

183 rtical neurons, LMNB1 overexpression reduces axonal outgrowth, whereas deficiency of endogenous Lmnb1

184 in cortical neurons substantially increased axonal outgrowth, whereas distal axonal attenuation of e

185 n of the exon 41 ortholog caused deficits in axonal outgrowth, whereas suppression of other exons phe

186 urin-NFAT signaling have dramatic defects in axonal outgrowth, yet have little or no defect in neuron