ライフサイエンスコーパス: axonal transport

1 t, inter-tubular spacing, and, by extension, axonal transport.

2 sphatase PTP1B is required to prime TrkA for axonal transport.

3 that perturbations in tau metabolism impair axonal transport.

4 d in the neuronal soma and conveyed via slow axonal transport.

5 sting that other factors must regulate their axonal transport.

6 s for how gE/gI and US9 initiate anterograde axonal transport.

7 icantly less effect on all microtubule-based axonal transport.

8 ive of a putative dysfunction of anterograde axonal transport.

9 he restrictive temperature of mammalian fast axonal transport.

10 g load, which is vital for robust retrograde axonal transport.

11 y, but also reaches the CNS after retrograde axonal transport.

12 his denervation results from disturbances of axonal transport.

13 filament networks associated with defects in axonal transport.

14 t HTT and Rab2, 7 or 19 move together during axonal transport.

15 nd shape of the axon as well as facilitating axonal transport.

16 as a role in MHV pathogenesis and retrograde axonal transport.

17 ly due to differential effects on retrograde axonal transport.

18 called neurofilaments, which are cargoes of axonal transport.

19 esulted from local protein synthesis and not axonal transport.

20 ctural proteins into proximal axons to begin axonal transport.

21 smic proteins reaching the axon tip via slow axonal transport.

22 lase inhibitor trichostatin A (TSA) restores axonal transport.

23 etase processing of APP is impairment of APP axonal transport.

24 ing to microtubules, does not interfere with axonal transport.

25 s of non-functional GSK-3beta did not affect axonal transport.

26 ic associations with vesicles moving in fast axonal transport.

27 ubule depolymerization are known to decrease axonal transport.

28 pha-Syn aggregates with proteins involved in axonal transport.

29 accumulation, an indicator of disrupted fast axonal transport.

30 ins, but only if the mRNAs were targeted for axonal transport.

31 US9(-) mutants are not absolutely blocked in axonal transport.

32 oviding further insight into KIF1A's role in axonal transport.

33 site-specific neuronal cargo delivery during axonal transport.

34 eurons and noted markedly reduced retrograde axonal transport.

35 lay an adaptive role to stresses that impair axonal transport.

36 lying cause of the deficits in mitochondrial axonal transport.

37 ident protein tyrosine phosphatase, prior to axonal transport.

38 ignaling cascade that leads to disruption of axonal transport, a critical function for neuronal survi

39 not released from the axons via anterograde axonal transport after infection of the cell bodies.

40 Retrograde axonal transport also plays a major role in neurotrophic

41 to promote dynamic microtubules required for axonal transport and activity-dependent remodeling of pr

42 UL37, is an essential effector of retrograde axonal transport and also houses a deamidase activity th

43 involved in the loss of synapses, defective axonal transport and cognitive decline, in patients with

44 se terminals occurs with similar anterograde axonal transport and DCV half-lives.

45 we show that these Rab7 mutants dysregulated axonal transport and diminished the retrograde signaling

46 , both activating dynein-mediated retrograde axonal transport and enhancing microtubule stability thr

47 of let-7 overcomes this barrier by promoting axonal transport and enrichment of the EFF-1 fusogen at

48 exerts a neuroprotective role in APP-induced axonal transport and functional locomotion defects.

49 a pathogenic sphingolipid able to block fast axonal transport and is the first to provide a molecular

50 Furthermore, unambiguous evidence of mRNA axonal transport and local translation in vivo, in the c

51 uncovered new mechanisms for regulating the axonal transport and localized translation of mRNAs, wit

52 Sirt2, or administration of TSA rescues both axonal transport and locomotor behavior.

53 ncluding SNAP-25, Rab3A and PSD-95, and with axonal transport and microtubules, including KIF3A, dyne

54 ue) gE/gI extracellular (ET) domains in both axonal transport and neuron-to-epithelial cell spread ha

55 s of the neuronal cytoskeleton that regulate axonal transport and neuronal function.

56 ing to further deficits in the mitochondrial axonal transport and onset of disease.

57 e role between Tip60 HAT activity and APP in axonal transport and provide insight into the importance

58 ed phosphoinositide lipid binding to promote axonal transport and restore axon growth.

59 sic cytosolic/soluble protein moving in slow axonal transport and reveal previously unknown links bet

60 ement of dynamic MTs for kinesin-1-dependent axonal transport and shed light on the role of the MT cy

61 tau ratio has an impact on the regulation of axonal transport and specifically in APP dynamics, which

62 ystem showed both a reduction in anterograde axonal transport and spread from axons to nonneuronal ce

63 ic domain of pUS9 contributes to anterograde axonal transport and spread of HSV-1 from neurons to the

64 how a key viral protein plays a role in both axonal transport and spread of the virus from nerve cell

65 an essential role in the inhibition of fast axonal transport and tau polymerization.

66 to constricted axons with signs of impaired axonal transport and to paranodal defects and abnormal o

67 al nerves into skeletal muscle as a model of axonal transport and transynaptic spread.

68 ), and subsequently reversible disruption of axonal transport, and are regulated by stable tubulin-on

69 coprotein gE/gI is important for anterograde axonal transport, and gE/gI cytoplasmic domains play imp

70 rotein expression and microtubule stability, axonal transport, and mitochondrial dysfunction were add

71 tions such as the regulation of MT dynamics, axonal transport, and neurite outgrowth.

72 ex that determines axonal diameter, supports axonal transport, and provides independent control of sy

73 regulated Ca(2+) dynamics for mitochondrial axonal transport, and the therapeutic promise of TRPV4 a

74 f impaired mitochondrial function, disrupted axonal transport, and/or dysfunctional intracellular Ca(

75 ted in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and

76 Of interest, anterograde and retrograde axonal transport appear to be interdependent, as perturb

77 in vivo studies on whether perturbations in axonal transport are indeed integral to the pathogenesis

78 onsible for the spatiotemporal regulation of axonal transport are not completely understood.

79 e conclusion that anterograde and retrograde axonal transport are not necessarily interdependent.

80 spacing, is regulated and how it impinges on axonal transport are unclear.

81 These results further support defects in axonal transport as a common factor in models of ALS tha

82 the central mediator, and kinesin-3 mediated axonal transport as the key effector.

83 d in synaptic function, the cytoskeleton and axonal transport, at 1-16 months of age.

84 adaptor to link Nav channels to KIF5 during axonal transport before anchoring them to the AIS and no

85 the impact of a few pathogenic mutations on axonal transport but a broad survey across a range of mo

86 tabilize microtubules, inhibit kinesin-based axonal transport, but not dynein-based transport, wherea

87 es have shown that actin is conveyed in slow axonal transport, but the mechanistic basis for this mov

88 Excess of active GSK-3beta perturbed axonal transport by causing axonal blockages, which were

89 Impaired axonal transport can contribute to axon degeneration and

90 The amyloid precursor protein (APP) is a key axonal transport cargo in Alzheimer's disease since pert

91 le high-molecular-weight tau, the failure of axonal transport, clumping of mitochondria, disruption o

92 st a mechanism involving impaired retrograde axonal transport contributing to human neurodegenerative

93 Axonal transport defects and axonopathy are prominent in

94 a clear correlation between the severity of axonal transport defects and motor ability.

95 Axonal transport defects are an early pathology occurrin

96 We found that axonal transport defects are common across all models te

97 Axonal transport defects are rescued by CRISPR/Cas9-medi

98 (ER)-mitochondrial overlay, and restore the axonal transport defects in patient-derived MNs.Amyotrop

99 Strikingly, GSK-3beta-activity-dependent axonal transport defects were enhanced by reduction of P

100 ormalities have been linked to mitochondrial axonal transport defects, but the temporal and spatial r

101 isruption of APP function is associated with axonal transport defects, raising the possibility that a

102 (HD) protein, was previously shown to cause axonal transport defects.

103 gy, hypoexcitability, as well as progressive axonal transport defects.

104 ablation of PINK1 rescued the mitochondrial axonal transport deficit in ALS mutant SOD1-expressing c

105 propagating tau pathology display selective axonal transport deficits but remain viable and electric

106 of tau prevents neuronal overexcitation and axonal transport deficits caused by recombinant Abeta ol

107 Protein aggregation and axonal transport deficits have been implicated in the di

108 dings suggest that Abeta trimers might cause axonal transport deficits in AD.

109 Axonal transport deficits in Alzheimer's disease (AD) ar

110 results from transcriptional inhibition and axonal transport deficits mediated by mutant huntingtin,

111 ed in mutant Hsp27 neurons, implicating that axonal transport deficits primarily affect mitochondria

112 FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cel

113 y characterised by microtubule breakdown and axonal transport deficits.

114 We also determined that fast axonal transport delivers Nrxns to the neuronal surface

115 eurons to measure anterograde and retrograde axonal transport, demonstrating the usefulness of this n

116 dies suggested that Smcr8 deficiency impairs axonal transport dependent autophagy-lysosomal function

117 cked NAP's protective effects, by preventing axonal transport disruption and improving behavioural de

118 haracterised by microtubule destabilisation, axonal transport disruption, synaptic defects and behavi

119 sm, impaired cytoskeletal integrity, altered axonal transport dynamics, and DNA damage accumulation d

120 rved only in the myogenic model, even though axonal transport dysfunction is characteristic of both m

121 ved adverse effects on microtubule dynamics, axonal transport, endoplasmic reticulum, and endosomal t

122 and US9 initiate the process of anterograde axonal transport, ensuring that virus particles are tran

123 After initial axonal transport failure, retinal terminal densities did

124 Disruption of fast axonal transport (FAT) and intracellular Ca(2+) dysregul

125 Disruption of fast axonal transport (FAT) is an early pathological event in

126 ed variants (G230C, R521G and R495X) on fast axonal transport (FAT), a cellular process critical for

127 acellular trafficking events, including fast axonal transport (FAT), may contribute to HSP pathogenes

128 , Trpv1(-/-) accelerated both degradation of axonal transport from retinal ganglion cells to the supe

129 rain can induce optic neuritis by retrograde axonal transport from the brain to the retina through th

130 o reveal dynamic neuronal activity and intra-axonal transport function as well as any associated neur

131 critical contribution of pUL37 to retrograde axonal transport functions independently of this activit

132 The underlying mechanism of slow axonal transport has been under debate during the past t

133 Defects in axonal transport have been linked to Alzheimer's and oth

134 ssue, Sorbara et al. (2014) demonstrate that axonal transport impairment is an early feature of neuro

135 hes the zebrafish as a model system to study axonal transport in a whole developing vertebrate organi

136 of the microtubule cytoskeleton and loss of axonal transport in branches that will subsequently dism

137 cultured human neuronal SK-N-SH cells and on axonal transport in mouse sciatic nerves.

138 tophagy-lysosomal functions due to disrupted axonal transport in mutant motor neurons.

139 Long-range retrograde axonal transport in neurons is driven exclusively by the

140 The study of axonal transport in neurons of adult animals requires in

141 The small GTPase Ran coordinates retrograde axonal transport in neurons, spindle assembly during mit

142 sin-3 motor KIF1A is involved in long-ranged axonal transport in neurons.

143 with deacetylated microtubules, and inhibits axonal transport in primary neurons and in Drosophila, c

144 iro1) is a master regulator of mitochondrial axonal transport in response to cytosolic calcium (Ca2+)

145 Using dual-colour live-cell imaging of axonal transport in SCG primary culture neurons, we find

146 with refined properties, such as retrograde axonal transport in specific subtypes of neurons, as sho

147 highlight the importance of kinesin-3 based axonal transport in synaptic transmission and provide no

148 8 phosphorylated Tau regulates inhibition of axonal transport in the disease state.

149 avioral analyses highlight the importance of axonal transport in the maintenance of synaptic structur

150 rmers of Abeta and tau cooperatively disrupt axonal transport independently from plaques and tangles.

151 corrects the synaptotoxicity and deficits of axonal transport induced by Abeta.

152 heral lesion and can explain the increase in axonal transport induced by conditioning.

153 ls in aged mice exhibiting varying levels of axonal transport integrity.

154 ive axon degeneration-whether, when, and how axonal transport is affected in this condition is unknow

155 Defective axonal transport is an early neuropathological feature o

156 Disruption to axonal transport is an early pathological feature in Alz

157 Abnormal axonal transport is associated with neuronal disease.

158 Axonal transport is critical for maintaining synaptic tr

159 Axonal transport is critical for neuronal homeostasis an

160 Axonal transport is essential for neuronal function, and

161 pposing kinesin and dynein motors that drive axonal transport is essential to maintain neuronal homeo

162 Defective axonal transport is hypothesized to be a key factor in t

163 Defective microtubule-based axonal transport is hypothesized to contribute to Parkin

164 Axonal transport is indispensable for the distribution o

165 nally, we demonstrate that Tip60 function in axonal transport is mediated by APP and that, remarkably

166 Long-distance intracellular axonal transport is predominantly microtubule-based, and

167 Axonal transport is required for neuronal development an

168 Axonal transport is seen as an early pathogenic event th

169 A current limitation in the study of axonal transport is the lack of a robust imaging techniq

170 Axonal transport is the process whereby motor proteins a

171 Microtubule-based axonal transport is tightly regulated by numerous pathwa

172 Axonal transport is typically divided into two component

173 sicle-motor complex that contains HTT during axonal transport is unknown.

174 been shown to be required for kinesin-driven axonal transport, is also critically required for the dy

175 Ps and directly activates UNC-104/KIF1A, the axonal-transport kinesin for SVPs in C. elegans.

176 ted with epigenetic misregulation of certain axonal transport-linked Tip60 target genes.

177 ficits primarily affect mitochondria and the axonal transport machinery itself is less affected.

178 rative diseases result from mutations in the axonal transport machinery.

179 ent alpha-Syn species act divergently on the axonal transport machinery.

180 resulting from mutation or impairment in the axonal transport machinery.

181 been shown to be involved in the retrograde axonal-transport machinery, but many of its specific fun

182 ation was inhibited, suggesting a retrograde axonal transport mechanism for delivery into the CNS.

183 contributes to the neuroinvasive retrograde axonal transport mechanism.

184 ndria without producing any defects in their axonal transport, morphology, or metabolic state.

185 sive (piggybacking upon MTs at rates of slow axonal transport) motion of bound tau.

186 Although we have a basic understanding of axonal transport, much less is known about transport in

187 c dynein, the major motor driving retrograde axonal transport, must be actively localized to axon ter

188 ty in motor neurons involves diminished fast axonal transport, observed both in transgenic mice and,

189 and biased polymerization generate the slow axonal transport of actin without involvement of microtu

190 veal that PI3Kdelta inhibition decreases the axonal transport of APP by eliciting the formation of hi

191 The Akt-HTT pathway and axonal transport of APP thus regulate APP presynaptic le

192 Axonal transport of ATP-producing mitochondria along neu

193 D knock-in mice is sufficient to disrupt the axonal transport of autophagosomes.

194 ules, huntingtin dephosphorylation increases axonal transport of BDNF, a crucial factor for hippocamp

195 followed by a delayed increase in retrograde axonal transport of BoNT/A-Hc carriers.

196 We also provided evidence that axonal transport of capsids requires the kinesin-1 molec

197 These results suggest that axonal transport of certain proteins is required for the

198 Time-lapse imaging of the axonal transport of chimeric filaments demonstrated that

199 lead us to propose a new model for the slow axonal transport of cytosolic cargos, based on short-liv

200 is, we provide evidence that CKA facilitates axonal transport of dense core vesicles and autophagosom

201 Here, we assessed the axonal transport of different cargos in multiple Drosoph

202 connectivity relies on molecular motor-based axonal transport of diverse cargoes.

203 n virus HSV assembly, a process required for axonal transport of enveloped particles.IMPORTANCE Herpe

204 ts in envelopment can explain the defects in axonal transport of enveloped virions.

205 s and infected the cortical neurons to study axonal transport of H129 viral particles.

206 been shown to play a role in the anterograde axonal transport of herpes simplex virus 1 (HSV-1), yet

207 s cause a local impairment in the retrograde axonal transport of lysosome precursors, leading to thei

208 family member Unc-104/KIF1A is required for axonal transport of many presynaptic components to synap

209 Kinesin-1 drives axonal transport of membrane cargoes to fulfill the meta

210 Axonal transport of mitochondria and mitochondrial fissi

211 ovide evidence that ALS mutant SOD1 inhibits axonal transport of mitochondria by inducing PINK1/Parki

212 n Cu/Zn superoxide dismutase 1 (SOD1) impair axonal transport of mitochondria in motor neurons isolat

213 o identify the mechanism underlying impaired axonal transport of mitochondria in mutant SOD1-related

214 Further, RanBP9 retards the anterograde axonal transport of mitochondria in primary neurons and

215 Here we demonstrate deficits in anterograde axonal transport of mitochondria in primary neurons from

216 Axonal transport of mitochondria was also increased in t

217 functional electrophysiological profiles and axonal transport of mitochondria, suggestive of maturity

218 to the mitochondria, and via Parkin arrested axonal transport of mitochondria.

219 ing defects, and changes in the geometry and axonal transport of mitochondria.

220 also represent potential bottlenecks for the axonal transport of neurofilaments, which move along axo

221 ysis of postmortem tissue suggested impaired axonal transport of neurturin from putamen to substantia

222 Here we investigate the mechanism of fast axonal transport of Nmnat2 and its site of action for ax

223 or stable membrane association and vesicular axonal transport of Nmnat2.

224 C3, dynactin, and AnkB that together promote axonal transport of organelles and are required for norm

225 JNK was also required for the proper axonal transport of p75-positive endosomes.

226 sion) at axo-dendritic contact sites promote axonal transport of presynaptic components for synapse f

227 ion at axo-dendritic contact sites regulates axonal transport of presynaptic components remain unknow

228 rative diseases, impairment of PI31-mediated axonal transport of proteasomes may contribute to these

229 els a new molecular system for vesicle-based axonal transport of proteins in male and female flies (D

230 in anterograde trafficking, we analyzed the axonal transport of pseudorabies virus in the presence a

231 , endosome swelling and selectively impaired axonal transport of rab5 endosomes.

232 l protein expression but is not required for axonal transport of ribosomes or its target mRNAs.

233 We simulate the motor-based axonal transport of short MTs to test the hypothesis tha

234 Thus alpha-syn pathology impairs axonal transport of signaling and degradative organelles

235 hich upregulates the Imac motor in promoting axonal transport of SV components for R8 presynaptic ass

236 Loss of bdl disrupts axonal transport of SV components in photoreceptor R8 ax

237 lays a novel and specific role in regulating axonal transport of SV components.

238 spersin, and blos-9/MEF2BNB-cause defects in axonal transport of SVPs, leading to ectopic accumulatio

239 Here we show that slow axonal transport of synapsin, a prototypical member of t

240 Axonal transport of synaptic cargo via the lysosomal kin

241 embrane skeleton, and impaired bidirectional axonal transport of synaptic cargo.

242 ciated periodic skeleton as well as enabling axonal transport of synaptic cargo.

243 Thus, BORC regulates the axonal transport of synaptic materials and synapse forma

244 Axonal transport of synaptic vesicle precursors (SVPs) i

245 -B (AnkB), and dynactin, which promotes fast axonal transport of synaptic vesicles, mitochondria, end

246 ng the UNC-104/Imac/KIF1A motor in promoting axonal transport of synaptic-vesicle components for pres

247 trophin receptor TrkB and mediate retrograde axonal transport of the kinase Akt1.

248 tures of the auditory system by means of the axonal transport of two bidirectional tracers, which wer

249 neurons to epithelial cells: (i) anterograde axonal transport of virus particles from neuron bodies t

250 pathway during synapse growth but not during axonal transport or synapse stabilization.

251 t to the widely accepted model of long-range axonal transport, our studies suggest that DAT traffics

252 ila, this is a tractable system for studying axonal transport over the life span of an animal and thu

253 This review provides an overview of axonal transport pathways and discusses their role in ne

254 cerebrospinal fluid (CSF) flux and hijacking axonal transport pathways.

255 In turn, MT organization determines axonal transport progression: cargoes pause at polymer t

256 differs from other viral proteins regarding axonal transport properties.

257 c and progressive synaptic, cytoskeletal and axonal transport protein abnormalities that may accompan

258 lso observed, along with accumulation of the axonal transport proteins JNK-interacting protein 1 and

259 with exocytic vesicles and motion at a fast axonal transport rate.

260 However, it remains largely unknown whether axonal transport regulates synaptic APP processing.

261 genous relative content of tau isoforms over axonal transport regulation.

262 erstanding how HSV gE/gI and US9 function in axonal transport relates to observations that gE(-), gI(

263 the nonspecific agents, tracers that rely on axonal transport showed the greatest tissue specificity;

264 ation of microtubules in neurons and affects axonal transport, shows remarkable heterogeneity, with m

265 constantly transported down the axon at slow axonal transport speeds; inhibition of the kinesin-1-dyn

266 The pathological traits include reduced axonal transport, synapse loss, defective climbing abili

267 Downregulating either Sac1 or DVAP disrupts axonal transport, synaptic growth, synaptic microtubule

268 is positioned downstream of CCB within this axonal transport system.

269 ripheral injury induces a global increase in axonal transport that is not restricted to the periphera

270 wer overall velocities than vesicles in fast axonal transport, the fundamental basis for this slow mo

271 lations do not cause a generalized defect in axonal transport; the inclusions do not fill the axonal

272 7 and gE-348 did not function in anterograde axonal transport; there were markedly reduced numbers of

273 ugh Snapin-mediated dynein-driven retrograde axonal transport, thereby suggesting a potential approac

274 Thus, tau allows Abeta oligomers to inhibit axonal transport through activation of GSK3beta, possibl

275 alyses showed that psychosine inhibited fast axonal transport through the activation of axonal PP1 an

276 n of retromer trafficking through retrograde axonal transport to fulfil its function in promoting lys

277 forming functions that range from retrograde axonal transport to mitotic spindle assembly(1,2).

278 ings and sustaining long-distance retrograde axonal transport to reach neuronal nuclei in ganglia of

279 s simplex virus 1 (HSV-1) virions travel via axonal transport to sensory ganglia and establish a life

280 in regions, indicating the virus can move by axonal transport to synaptically coupled brain loci.

281 from axonal guidance, synapse formation, or axonal transport to the development of 3D models of the

282 their distal axons and spread by retrograde axonal transport to the neuronal cell bodies.

283 in rats prevented degradation of anterograde axonal transport to the superior colliculus and degenera

284 This is consistent with APP axonal transport to the synapse, where APP is involved i

285 t the axon tip and undergo robust retrograde axonal transport toward the cell body, but the factors r

286 mine whether Tip60 HAT activity functions in axonal transport using Drosophila CNS motor neurons as a

287 the initiation of dynein-mediated retrograde axonal transport using live-cell imaging of cargo motili

288 We recently reported that loss of axonal transport vesicle association through mutations i

289 ated and analyzed presumptive APP-containing axonal transport vesicles from mouse cortical synaptosom

290 t palmitoylation and stable association with axonal transport vesicles.

291 although it increased the overall numbers of axonal transport vesicles.

292 the functional consequences of impaired APP axonal transport, we isolated and analyzed presumptive A

293 The defects in axonal transport were manifest in neuronal cell bodies,

294 Changes in axonal transport were only elicited by a peripheral lesi

295 h motility and processivity of mitochondrial axonal transport were reduced by expression of either Wt

296 cating that paclitaxel inhibited anterograde axonal transport, whereas eribulin did not.

297 mage-induced APP processing might impair APP axonal transport, which could result in failure of synap

298 between tau isoform imbalance and defects in axonal transport, which induce an abnormal APP metabolis

299 We review recent advances in the field of axonal transport, with a focus on conceptual development

300 , but whether it is also an effector of fast axonal transport within axons is unknown.