ライフサイエンスコーパス: axotomize

1 ory neurons in dissociated cell culture were axotomized.

2 res recorded in rats that had the LG-S nerve axotomized 3 d before data collection.

3 discharge characteristics and synaptology of axotomized abducens internuclear neurons, which mediate

4 tablishment of gap junctional coupling among axotomized adult motor neurons may occur by modulation o

5 ed with axonal regeneration, we have assayed axotomized adult rat DRGs for evidence of jun kinase act

6 levels that benefit the intrinsic ability of axotomized adult rat sensory neurons to undergo axonal r

7 nerve injury at the spinal nerve level, some axotomized afferent neurons develop ongoing discharges (

8 prevented the decline in EPSP amplitude from axotomized afferents (stimulate MG, record LGS) observed

9 itude of LG-S EPSPs evoked by stimulation of axotomized afferents was significantly larger than that

10 ltered probability of transmitter release of axotomized afferents.

11 ce of activated microglia around motoneurons axotomized after nerve injuries has been intensely debat

12 well as in the contralateral intact side of axotomized aged rats.

13 rsal skin of KC-Tie2 animals were surgically axotomized and beginning 1 day after denervation, CD11c(

14 mTBI that allows for identification of both axotomized and intact neurons in the living cortical sli

15 Both axotomized and intact neurons recorded within injured co

16 e photoreceptor histology was similar in the axotomized and nonaxotomized areas.

17 nied by pronounced spontaneous plasticity of axotomized and spared reticulospinal axons.

18 ded the field of labeled cortical cells into axotomized and unaxotomized groups.

19 observed in reticulospinal neurons that when axotomized are known to be "bad regenerators." Results i

20 spinal regeneration of anterogradely labeled axotomized ascending primary sensory fibers in the adult

21 aration, light-evoked IPSCs could only reach axotomized BC terminals via the lateral feedback pathway

22 ght stimulation evoked ON and OFF L-IPSCs in axotomized BCs, which had distinct onset latencies ( app

23 SNB motoneurons were axotomized bilaterally and BDNF or PBS was applied to th

24 ipolar cells with axon terminals, but not in axotomized bipolar cells.

25 In extracts from ischemic or axotomized brain compartments, c-Jun phosphorylation cor

26 ye-coupled motor neurons were observed among axotomized, but not control, lumbar spinal motor neurons

27 LGN neurons were axotomized by a visual cortex lesion in 31 adult rats.

28 s of adult locusts (Locusta migratoria) were axotomized by crushing the base of the antenna.

29 hese ganglia corresponded to that of neurons axotomized by this procedure.

30 tions of L4/5 DRG neurons in adult rats were axotomized by transection of the sciatic nerve and the L

31 ury, following frequencies were increased in axotomized C-type neurons and decreased in axotomized no

32 ings that macrophages also accumulate around axotomized cell bodies.

33 ic tree of the physiologically characterized axotomized cells was significantly reduced compared with

34 In a subpopulation of the axotomized cells, abnormally high motoneurone excitabili

35 (DPDPE), was without effect on control or on axotomized cells.

36 To examine the mechanism by which axotomized cholinergic neurons die in vivo, lentiviral v

37 These results provide evidence that adult axotomized cholinergic neurons die of apoptotic death th

38 fficient to mediate NGF-promoted survival of axotomized cholinergic neurons in vivo.

39 rophin-3 (NT-3) contributes to the rescue of axotomized Clarke's nucleus (CN) neurons in adult rats.

40 Axotomized CN neurons had also atrophied by 14 days, but

41 sults indicate that even limited exposure of axotomized CN neurons to NT-3 produces permanent rescue

42 Death of axotomized CNS neurons in vivo is prevented when the for

43 ansplants in producing long-term survival of axotomized CNS neurons.

44 nerves treated directly with vehicle; other axotomized controls were administered subcutaneous NT-3.

45 eurons and no evidence for TUNEL staining of axotomized cortical motoneurons.

46 s of apoptotic cell death in a proportion of axotomized cortical motor neurons after SCI, suggesting

47 RNA above background levels was detected for axotomized cortical neurons at 1, 3 or 7 days after inju

48 continuity is a sufficient condition for the axotomized corticospinal neurons to regain some of their

49 injury site and exerts protective effects on axotomized corticospinal projection neurons.

50 ls does not enhance the growth of neonatally axotomized DC axons.

51 etected in Schwann cells associated with the axotomized distal stump.

52 ile inflammation within the distal nerve and axotomized dorsal root ganglia (DRGs).

53 )1.3 has been linked to hyperexcitability of axotomized dorsal root ganglion (DRG) neurons, which und

54 ued Kcna2 mRNA and protein expression in the axotomized DRG and attenuated the development of nerve i

55 lar to Na(v)1.3, contactin is upregulated in axotomized DRG neurons and accumulates within the neurom

56 unced suppression of Ca2+ channel current in axotomized DRG neurons by nociceptin led to a reduction

57 howed that 75.6 and 65.1% of the chronically axotomized DRG neurons displaying ectopic discharges enh

58 s in SNS and NaN mRNA and protein levels, in axotomized DRG neurons in vitro.

59 SNS and NaN protein levels, in peripherally axotomized DRG neurons in vivo.

60 ctin and its colocalization with Na(v)1.3 in axotomized DRG neurons may contribute to the hyper-excit

61 rtant in nociception, the effects of GDNF on axotomized DRG neurons may have important implications f

62 st growth factor-inducible-14 (Fn14) mRNA in axotomized DRG neurons was verified by Northern analysis

63 noceptor agonists evoked activity in 7 of 28 axotomized DRG neurons, which did not show ongoing disch

64 through epigenetic silencing of Kcna2 in the axotomized DRG.

65 its post-injury transcriptional activity in axotomized DRGs has been characterized.

66 In axotomized DRGs, few hematogenous leukocytes are detecte

67 Myeloid cells in the injured nerve, but not axotomized DRGs, strongly express receptors for the cyto

68 was used to accurately collect uninjured and axotomized facial motor nuclei of WT and presymptomatic

69 n found to play a crucial role in preventing axotomized fibers from regenerating after adult rat spin

70 Retrograde labeling of axotomized ganglion cells resulted in 5D4+ cells in the

71 Using patch-clamp recordings from axotomized goldfish Mb bipolar cell (BC) terminals with

72 ophin-3 (NT-3) and NT-4/5 on the function of axotomized group Ia afferents and motoneurons comprising

73 limited extent NT-4/5, promotes recovery of axotomized group Ia afferents but not axotomized motoneu

74 smission strength at spinal synapses made by axotomized group IA primary sensory neurons.

75 that the region of cortex within 1 mm of the axotomizing injury had less than 10% of the expected neu

76 the right side of the rostral spinal cord to axotomize ipsilateral reticulospinal (RS) neurons.

77 tors) with SA increased in intact L4 but not axotomized L5 DRGs in SNA and mSNA (to 35%), and in L4/L

78 he mean size of SP-positive neurons from the axotomized L5 ganglia was greater at 2, 4, 7, and 14 dpo

79 ium-sized (30-39 microM) neurons, as well as axotomized L5 or adjacent L4 DRG neurons from hyperalges

80 n of low-threshold afferents proximal to the axotomized L5 spinal nerve attenuated the spontaneous ac

81 Among large neurons (>800 microm2) from the axotomized L5, the percentage of SP-positive neurons inc

82 Among small neurons from the axotomized L5, the percentage of SP-positive neurons was

83 ensitive currents, which are reduced in both axotomized (L5) and adjacent (L4) neurons.

84 SNL decreases total I(K(Ca)) in axotomized (L5) neurons, but increases total I(K(Ca)) in

85 y 1 month after injury, the vast majority of axotomized labeled cells appeared to have died.

86 We wished to determine the effect of axotomizing lesions on survival of transcallosally proje

87 The results suggest that axotomized LVN neurons express many genes thought to be

88 The axotomized medial gastrocnemius (MG) nerve was provided

89 rated taste buds in Il1r KO compared with WT axotomized mice.

90 ue, we examined the electrical properties of axotomized motoneurons following reinnervation.

91 Microglia behaviors close to axotomized motoneurons greatly differ from those within

92 effect on the morphometric parameters of the axotomized motoneurons in aged rats, but slightly enhanc

93 ery of axotomized group Ia afferents but not axotomized motoneurons or the synapses on them.

94 Microgliosis around axotomized motoneurons starts and peaks within 2 weeks a

95 stripping of synapses from the cell somas of axotomized motoneurons was studied by using synaptophysi

96 Axotomized motoneurons were retrogradely-labeled from mu

97 round 10% reduction at days 3, 7, and 14) in axotomized motoneurons.

98 urrent theories on microglia function around axotomized motoneurons.

99 Androgens can rescue axotomized motor neurons from cell death.

100 ediated recovery of excitatory synapses onto axotomized motor neurons in adult mice.

101 That GDNF:TTC provided neuroprotection of axotomized motor neurons in neonatal rats further reveal

102 Our findings indicate that: (i). axotomized motor neurons increase expression of estrogen

103 te signaling that maintains the viability of axotomized motor neurons until synaptic connections are

104 onadally intact males have more cells in the axotomized N.IX-X than castrated animals, suggesting tha

105 pressing cells are severely decreased in the axotomized N.IX-X.

106 ays was most prominent in the P stump of the axotomized nerve.

107 Controls were preparations with axotomized nerves treated directly with vehicle; other a

108 approach to periodically photo-stimulate the axotomized neuron, we can enhance its regeneration.

109 eleon to track in vivo calcium fluxes in the axotomized neuron.

110 Within these same axotomized neuronal populations, TAI was also found to i

111 Axotomized neurons (HX) upregulated genes commonly assoc

112 This DRG synchrony is initiated by axotomized neurons and mediated by local purinergic sign

113 r, these results demonstrate that intact and axotomized neurons are both affected by mTBI, resulting

114 afterhyperpolarization duration decreased in axotomized neurons at 1 and 2 d postinjury.

115 The rheobase is significantly increased in axotomized neurons at 1 d postinjury.

116 In contrast, in the adult all axotomized neurons begin to express HSP27.

117 abeling in the SCG and MICG is restricted to axotomized neurons but that in addition there is extensi

118 A plasmid encoding this gene to determine if axotomized neurons destined to undergo retrograde death

119 esponse to sustained depolarization, whereas axotomized neurons fired a single short burst or short r

120 ggest an initial decrease in excitability in axotomized neurons followed by an increase in excitabili

121 Axotomized neurons from rats made hyperalgesic by SNL lo

122 In axotomized neurons from rats made hyperalgesic by spinal

123 a pseudosubstrate blocker of CaMKII, whereas axotomized neurons from SNL animals that failed to devel

124 After spinal nerve ligation, axotomized neurons had less I(h) compared to control neu

125 Thus, the peptide phenotype of these axotomized neurons is regulated both by the induction of

126 This increase in p55-ir in axotomized neurons may play a pivotal role in the connec

127 r, lasting c-Jun phosphorylation occurred in axotomized neurons negative for Fas-ligand or TUNEL and

128 o induction and phosphorylation in all adult axotomized neurons of the small heat shock protein Hsp27

129 whether apoptotic cell death occurs in these axotomized neurons remains unanswered.

130 However, TTX-S currents in axotomized neurons reprimed four times faster than contr

131 al root ganglion (DRG) neurons as a model of axotomized neurons to investigate early changes in prote

132 There is controversy about whether axotomized neurons undergo death or only severe atrophy

133 monly associated with axonal growth, whereas axotomized neurons whose axons were apposed to the PNG s

134 Axotomized neurons within the damaged CNS are thought to

135 ing axons, a lack of trophic support for the axotomized neurons, and intrinsic neuronal changes that

136 G is dramatically reduced, but all surviving axotomized neurons, as identified by c-jun immunoreactiv

137 ift in gene expression pattern must occur in axotomized neurons.

138 to promote the survival and regeneration of axotomized neurons.

139 dult mammals causes atrophy or death of some axotomized neurons.

140 least 2 weeks after injury had clear loss of axotomized neurons.

141 DI was unaffected, but CDF was eliminated in axotomized neurons.

142 Spinal cord injury axotomizes neurons and induces many of them to die, wher

143 at the tracer predominated in injured (i.e., axotomized) neurons.

144 n axotomized C-type neurons and decreased in axotomized non-inflected A-type neurons.

145 es ectopic expression of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1, a hypoxia

146 In the axotomized, non-EAU eyes, 4Di-10ASP-labeled ganglion cel

147 Axotomized optic axons of Xenopus laevis, in contrast to

148 trocytes, and was present in both normal and axotomized optic nerve but not in peripheral nerves.

149 ncreases in galanin expression that occur in axotomized peripheral neurons have functional consequenc

150 ins at the T-junction of C-type neurons with axotomized peripheral processes could enhance the transm

151 ation and cleaved caspase-3 were detected in axotomized PPNs and motoneurons, suggesting apoptosis as

152 In contrast to sham-operated animals, axotomized preparations did not sensitize, reflecting th

153 Axotomized presymptomatic SOD1 FMNs displayed a dynamic

154 of abnormal pain (e.g., ectopic discharge in axotomized primary afferent neurons) that underlie the c

155 fter cervical hemisection, local rewiring of axotomized projections at the lesion site versus compens

156 Axotomized pyramidal cells, identified by retrograde tra

157 Axotomized rats had near-total loss of PGP9.5(+) innerva

158 e following injury above that present in non-axotomized rats of the same age.

159 Finally, a group of axotomized rats was injected with the S-antigen peptide

160 Another group of such axotomized rats were immunized with S-antigen peptide an

161 The ChAT staining intensity of the axotomized RDLN declined in both age groups after 7 days

162 With regard to axotomized RDLN neurons, 7 days of GM1 restored the cell

163 gnificantly more retrogradely labeled right (axotomized) red nucleus (RN) neurons were seen in Ch'ase

164 sage levels were reduced dramatically in all axotomized reticulospinal neurons, on the basis of semiq

165 h factor (bFGF) on the long-term survival of axotomized retinal ganglion cells (RGCs) were studied in

166 -triggered response from purified intact and axotomized retinal ganglion cells (RGCs).

167 Axotomized retinal ganglion cells were retrograde labele

168 The death of axotomized RGCs can be prevented if they are simultaneou

169 Axotomized RGCs were significantly enlarged and elongate

170 ed and new protein synthesis was impaired in axotomized RGCs, which may contribute to the regeneratio

171 pathways of the unfolded protein response in axotomized RGCs.

172 owth factor-deprived sympathetic neurons and axotomized RGCs.

173 elatively long recovery times (12-16 weeks), axotomized RS neurons displayed firing patterns and afte

174 of lamprey HVA calcium and SKKCa channels in axotomized RS neurons were significantly reduced at shor

175 that the downregulation of Ca2+ channels in axotomized RS neurons, and the associated reduction in c

176 For axotomized RS neurons, the fAHP was significantly larger

177 heral nerves triggers a cascade of events in axotomized sensory neurones that are generally believed

178 at excessive BH4 is produced in mice by both axotomized sensory neurons and macrophages infiltrating

179 we demonstrate molecular cross-talk between axotomized sensory neurons and macrophages, revealing po

180 results in the death of the majority of the axotomized sensory neurons by 7 d after injury.

181 hibitors were administrated to embryonic and axotomized sensory neurons in vitro to block the activat

182 In axotomized sensory neurons, reduction of SPRR1A function

183 growth factor (NGF) gene transfer protected axotomized septal cholinergic neurons, we injected linea

184 s was increased in both the intact (14%) and axotomized sides (75%).

185 ositive cells was compared in the intact and axotomized sides of N.IX-X of gonadectomized males that

186 AR mRNA in N.IX-X on both the intact and the axotomized sides, suggesting that the increase is indepe

187 Delayed application of BDNF to the axotomized SNB motoneurons restored the AR-LI to the int

188 t of BDNF on androgen receptor expression in axotomized SNB motoneurons, and examined whether delayed

189 diminished mitochondrial Ca(2+) buffering in axotomized SNL L5 neurons but enhanced Ca(2+) buffering

190 ain density of up to 8-fold were measured in axotomized spinal cord motor neurons used as positive co

191 d in reactive CXCR4-positive astrocytes near axotomized spinal cord motor neurons, consistent with au

192 urons remain unknown, and until now death of axotomized spinal-projecting neurons has not been descri

193 For example, axotomized sympathetic, sensory, and motor neurons begin

194 on to study light-evoked IPSCs recorded from axotomized terminals of ON-type mixed rod/cone BCs (Mb)

195 9 transection of the dorsal funiculus, which axotomizes the dorsal CST, and introduction of the retro

196 Axotomized transcallosal neurons were compared with near

197 eneration in Drosophila larval MNs, and when axotomized WD proceeded stereotypically in milton distal

198 dorsal lateral geniculate nucleus (LGN) are axotomized, which leads to their atrophy and death.

199 cantly delayed and propagated more slowly in axotomized Wld(S) RGCs compared with wild-type axons.