ライフサイエンスコーパス: azoospermia

1 putative RNA-binding protein DAZ (Deleted in Azoospermia).

2 s and lack of spermatozoa in the epididymis (azoospermia).

3 elated with male infertility associated with azoospermia.

4 successful sperm retrieval in patients with azoospermia.

5 o had received a diagnosis of nonobstructive azoospermia.

6 with the occurrence and development of human azoospermia.

7 dditional subjects with cryptozoospermia and azoospermia.

8 ociated with normospermia, oligospermia, and azoospermia.

9 and FSH values for identifying patients with azoospermia.

10 urvivors of childhood cancer are at risk for azoospermia.

11 ermatids leading to oligoteratozoospermia or azoospermia.

12 e and men at risk for temporary or permanent azoospermia.

13 f DNA repair defects in human nonobstructive azoospermia.

14 icular sperm retrieval in different types of azoospermia.

15 e more beneficial in cases of nonobstructive azoospermia.

16 CP3 is associated with human non-obstructive azoospermia.

17 in 5.8% of Japanese patient population with azoospermia.

18 small subgroup of males with nonobstructive azoospermia.

19 f1 exhibit male infertility characterized by azoospermia.

20 who had documented low ejaculate volumes and azoospermia.

21 tations, which occurred in 7 of 289 men with azoospermia (2.4%), were absent in 384 controls with nor

22 fer significantly between the subgroups with azoospermia (20/185, 11%), oligozoospermia (18/181, 10%)

23 After treatment, 34 (89%) patients had azoospermia, 4 (11%) had other dysspermia, and no patien

24 as 10 830 mg/m(2) (SD 7274) in patients with azoospermia, 8480 mg/m(2) (4264) in patients with oligos

25 e of the deletion males lack DAZ (Deleted in AZoospermia), a candidate gene for the azoospermia facto

26 homozygous male mutants are infertile due to azoospermia, a condition that was not appreciated in the

27 emen samples obtained from 289 patients with azoospermia and 384 controls.

28 risk for clinically defined oligospermia and azoospermia and improved prediction of normospermic, oli

29 serum testosterone levels, which resulted in azoospermia and infertility.

30 3' ends and, when disrupted in mice, causes azoospermia and male infertility.

31 perm and boule mutant flies exhibit complete azoospermia and male sterility.

32 skeletal myopathy, hypocellular bone marrow, azoospermia and mitochondrial abnormalities in these mic

33 Disruption of spermatogenesis found in azoospermia and oligozoospermia is thought to be of prim

34 patients with varicoceles and nonobstructive azoospermia and to review predictors of successful outco

35 ility factors encoded by the DAZ (Deleted in Azoospermia) and DAZL (DAZ-like) genes.

36 The DAZ (Deleted in AZoospermia) and DAZLA (DAZ-like autosomal) genes may be

37 inding motif, Y chromosome), DAZ (deleted in azoospermia), and four recently isolated genes, have bee

38 ion into the testis, accompanied by atrophy, azoospermia, and reduced numbers of mitotically active g

39 fertility, atrophic testes with vacuolation, azoospermia, and spermatogenesis arrest.

40 The impact of this agent on spermatogenesis, azoospermia, and the developing fetus is discussed.

41 blood samples obtained from 15 patients with azoospermia, and we performed mutation screening by mean

42 About 13% of cases of non-obstructive azoospermia are caused by deletion of the azoospermia fa

43 Oligo- and azoospermia are severe forms of male infertility.

44 ome core composition and recruits deleted in azoospermia-associated protein 1 to polysomes to prime t

45 Here, we identify Deleted in Azoospermia-associated protein 2 (DAZAP2), a small adapt

46 Oligozoospermia is far more common than azoospermia, but little is known about genetic causes.

47 epididymides and usually led to obstructive azoospermia by spermatoceles.

48 However, they were sterile, with azoospermia caused by a complete arrest of spermiogenesi

49 knowledge gap of X-linked genetic causes of azoospermia/cryptozoospermia contributing to the develop

50 iated with and 34 moderately associated with azoospermia/cryptozoospermia not previously linked to ma

51 e other is BOULE, a member of the Deleted in Azoospermia (DAZ) gene family].

52 The Deleted in AZoospermia (DAZ) genes encode potential RNA-binding pro

53 Mutations in Deleted in Azoospermia (DAZ), a Y chromosome gene, are an important

54 ngation factor 1 alpha 1 (EF1A1), deleted in azoospermia (DAZ)-associated protein 2 (DAZAP2), ferriti

55 ZF) has been identified and named Deleted in Azoospermia (DAZ).

56 ain of Boule and a conserved DAZ (deleted in azoospermia) domain implicated in interactions with othe

57 ment, we found that Tra2b PE deletion causes azoospermia due to catastrophic cell death during meioti

58 ot considered possible just two decades ago, azoospermia due to testicular failure, including 47,XXY

59 A candidate gene for the Y-chromosome azoospermia factor (AZF) has been identified and named D

60 Deletion of the Azoospermia Factor (AZF) region of the human Y chromosom

61 ve azoospermia are caused by deletion of the azoospermia factor (AZF), a gene or gene complex normall

62 e is a candidate for the human Y-chromosomal Azoospermia Factor (AZF).

63 e previously sequenced one of these regions, azoospermia factor a (AZFa) and found that it spanned ap

64 Y, in both humans and mice and in humans the azoospermia factor AZF has been separated from HYA.

65 rst re-sequencing study of the Y-chromosomal Azoospermia Factor c (AZFc) region, combined with gene d

66 Deletions of the AZFc (azoospermia factor c) region of the Y chromosome are the

67 in male fertility and is a candidate for the azoospermia factor gene.

68 Y chromosome is a strong candidate for the 'azoospermia factor' (AZF).

69 t maps to the same deletion interval as the 'azoospermia factor' (AZF).

70 Deletions of the AZFa region (AZoospermia Factor-a) region of the human Y chromosome c

71 ed in AZoospermia), a candidate gene for the azoospermia factor.

72 he human Y chromosome-AZFa, AZFb, and AZFc ("azoospermia factors" a, b, and c)-are essential for norm

73 LE, the oldest member of the DAZ (Deleted in AZoospermia) family of genes, appears to have maintained

74 reby mimicking the etiologies of obstructive azoospermia found in human male infertility.

75 ng humans, suggests that the DAZ (Deleted in Azoospermia) gene and a closely related homolog, DAZL (D

76 The human DAZ (deleted in azoospermia) gene family on the Y chromosome and an auto

77 gene, a member of the human DAZ (deleted in azoospermia) gene family, within primates, within mammal

78 ologue of the human Y linked DAZ (deleted in azoospermia) gene from mouse.

79 h single-cell RNA sequencing data shows that azoospermia genes can be grouped into molecular subforms

80 for couples with reconstructible obstructive azoospermia have improved tremendously.

81 Regular menses in the patient and azoospermia in her husband delayed the diagnosis.

82 Targeted disruption of Dnmt3L caused azoospermia in homozygous males, and heterozygous progen

83 enetic variants in NKAPL are associated with azoospermia in humans, while mice carrying an NKAPL fram

84 ns were a common cause of meiotic arrest and azoospermia in infertile men.

85 perm concentration, their ability to predict azoospermia in survivors of childhood cancer remains unc

86 The genetic basis of nonobstructive azoospermia is unknown in the majority of infertile men.

87 ith the Xenopus homolog of human Deleted for Azoospermia-like (DAZL) and the embryonic poly(A)-bindin

88 expression of the testis antigen deleted in azoospermia-like (DAZL) in CAFs.

89 Deleted in azoospermia-like (DAZL) is a germ cell RNA-binding prote

90 Deleted in azoospermia-like (DAZL) is an RNA-binding protein critic

91 cell-specific RNA-binding protein deleted in azoospermia-like (Dazl) is phosphorylated by MAPKAP kina

92 ted by ring canals, and show that Deleted in azoospermia-like (Dazl), a conserved vertebrate RNA-bind

93 cellular mRNA-specific regulator, Deleted in Azoospermia-like (Dazl), also employs the PABP-eIF4G int

94 le splice isoforms 2 (Rbpms2) and Deleted in azoospermia-like (Dazl).

95 or the RNA-binding proteins DAZL (deleted in azoospermia-like) and CPEB (cytoplasmic polyadenylation

96 We observed that human DAZL (deleted in azoospermia-like) functions in primordial germ-cell form

97 Loss of boule function results in azoospermia; meiotic divisions are blocked, although lim

98 nic failure in patients with non-obstructive azoospermia (NOA) and severe oligospermia (SO).

99 late in up to 56% of men with nonobstructive azoospermia (NOA) following varicocele repair.

100 Non-obstructive azoospermia (NOA) is the most severe form of male infert

101 cessfully derived from eight non-obstructive azoospermia (NOA) participant-derived hPSC lines using t

102 Nonobstructive azoospermia (NOA) remains a challenging condition in rep

103 n the testes of patients with nonobstructive azoospermia (NOA) revealed enhanced expression of CYP19,

104 le infertility is idiopathic non-obstructive azoospermia (NOA), a complete sperm absence in the ejacu

105 The most severe form is non-obstructive azoospermia (NOA), which is, in part, caused by an arres

106 common loci contributing to non-obstructive azoospermia (NOA).

107 About 10% of males with idiopathic azoospermia or oligospermia have microdeletions in this

108 Azoospermia or oligozoospermia due to disruption of sper

109 Nine of the infertile men had azoospermia or severe oligospermia (sperm concentration,

110 Some infertile men with azoospermia or severe oligospermia have small deletions

111 deletion in a high percentage of males with azoospermia or severe oligospermia, and its homology wit

112 a significant proportion of men do not reach azoospermia or severe oligozoospermia, commensurate with

113 h an increased risk per 1000 mg/m(2) CED for azoospermia (OR 1.22, 95% CI 1.11-1.34), and for oligosp

114 ession of BRD7 was detected in the testes of azoospermia patients exhibiting spermatogenesis arrest t

115 ocalization accounts for the infertility and azoospermia phenotype in patients.

116 loss, which was identical in 2 patients with azoospermia, predicts a deletion of 79 amino acids withi

117 There was no difference in azoospermia rate between patients treated with BEACOPP b

118 nited States reported a total of 14 cases of azoospermia secondary to inguinal vasal obstruction rela

119 of procedure should be based on the type of azoospermia, specific clinical circumstances, as well as

120 ve similar retrieval outcomes in obstructive azoospermia, testicular sperm extraction procedures appe

121 ations in human Piwi (Hiwi) in patients with azoospermia that prevent its ubiquitination and degradat

122 ion was present in a man with nonobstructive azoospermia (that is, no sperm was detected in semen), b

123 Of these men with azoospermia, the absence of sperm in semen, one in eight

124 protein homologous to human DAZ (Deleted in Azoospermia), vertebrate DAZL and Drosophila Boule prote

125 Azoospermia was noted in 53 (25%) of 214 participants, o

126 concentration >0 and <15 million per mL) and azoospermia were calculated with logistic regression mod

127 iddle Eastern descent who had nonobstructive azoospermia were found to carry mutations in PNLDC1: the

128 s will lead to a lack of mature sperm cells (azoospermia), which is a major cause of male infertility

129 ions were detected in 33 patients (15%) with azoospermia who received a diagnosis of azoospermia with

130 ed in an infertile male with oligospermia or azoospermia with low ejaculate volume, normal secondary

131 with azoospermia who received a diagnosis of azoospermia with meiotic arrest.

132 A null mutation of Sycp3 in mice causes azoospermia with meiotic arrest.

133 In contrast, testes of patients who had azoospermia with TEX11 mutations had meiotic arrest and

134 Azoospermia, with failure of the latter stages of sperma