ライフサイエンスコーパス: backbone

1 ydrase (CA) inhibitors with an acetazolamide backbone.

2 acids along dynein's one-dimensional peptide backbone.

3 itioning of sugar groups on the core steviol backbone.

4 mplexes, the two duplexes share a common PNA backbone.

5 static interactions of peptoids with the DNA backbone.

6 the 2' and 3' positions of the diglucosamine backbone.

7 ng mode leads to the cleavage of the peptide backbone.

8 t interactions by chemical tuning of the MOF backbone.

9 nsaturated carbonyl moiety along the polymer backbone.

10 d by the presence of a long-chain base (LCB) backbone.

11 nto the characteristic serrulatane diterpene backbone.

12 modified augmented Berlin-Frankfurt-Munster backbone.

13 the sn-1 and sn-2 positions of the glycerol backbone.

14 ers with a heterometallic metal-metal bonded backbone.

15 cosylases, cleaving within the peptidoglycan backbone.

16 polymers feature a truly conjugated polymer backbone.

17 compared to those with the more polar ether backbone.

18 bial properties and share a common diterpene backbone.

19 at every possible position along the protein backbone.

20 t incorporates a benzophenone methacrylamide backbone.

21 mplex with phenyl substituents on the borate backbone.

22 tal is further incorporated into the polymer backbone.

23 (2-methylene-4-methyl-1,3-dioxolane) (PFMMD) backbone.

24 on of poorly specific factors within the TAD backbone.

25 ibonuclease (Nb-DNase II) to degrade the DNA backbone.

26 notubes based on a hydrogen-bonded hydrazide backbone.

27 d mus-ms time-scale dynamics in the beta(2)m backbone.

28 and Q41 interacting exclusively with the DNA backbone.

29 l chains that are tethered to the conjugated backbone.

30 tically tuning the charge density of protein backbones.

31 odic decoration of isopropyl groups on their backbones.

32 ew Ti(salen) catalysts with modified diamine backbones.

33 NtBu)(2) ]Si: (R=H or methyl) with saturated backbones.

34 ious conditions and within different polymer backbones.

35 CWRL4) on both native and non-native protein backbones.

36 s and a database search strategy for peptide backbones.

37 set of (13)Calpha, (13)Cbeta, (1)Halpha, and backbone (13)CO and (15)N assignments.

38 al fragmentation of cross-links over peptide backbones, a desired feature for MS(n) analysis.

39 rin macrocycle) and position of the xanthene backbone about the chlorin periphery.

40 does a cohesin molecule diffusing on the DNA backbone achieve speeds necessary to form the large loop

41 in label as close as possible to the protein backbone, achieving high resolution in double electron-e

42 dataset involves rotation of the inner-gate backbone along residues S168-G169-I170.

43 The method is applicable for backbone amide and side chain methyl groups and represen

44 acids preferentially interact with both the backbone amide and the side-chain hydroxyl (bidentate in

45 ing only unsigned chemical shift changes for backbone amides and carbonyls ((1)H, (15)N, and (13)C').

46 These values were obtained at 33 backbone amides from hydrogen/deuterium fractionation fa

47 nt groups in proteins, including the peptide backbone, amino acid side chains, internal water molecul

48 aracterized by an ~30-amino acid-long cyclic backbone and a cystine knot motif.

49 root and possesses a triterpenic hydrophobic backbone and a hydrophilic headgroup built from two suga

50 ten new hangman chlorins bearing a xanthene backbone and a pendant carboxylic acid.

51 n, which is largely influenced by the chiral backbone and adamantyl groups on the salicylaldehyde moi

52 polymers that differ drastically in aromatic backbone and alkyl side chain chemistry.

53 We observe changes in the protein backbone and aromatic residues as well as disulfide brid

54 Viruses with the wild bird virus backbone and either PB1, NP, or the entire polymerase co

55 contacts were determined between the protein backbone and glycosite glycan based on available three-d

56 ", that codifies arginine readout of cognate backbone and guanine nucleobase interactions in a variet

57 The combination of extended pai-conjugated backbone and interlayer noncovalent pai-pai interactions

58 does not perturb the overall conformation of backbone and key side-chain residues.

59 c binding kinetics of nucleosomes on the DNA backbone and leads to predictions of lower loop formatio

60 imetic with three triazole insertions in its backbone and maintained biological activity.

61 O-methoxyethyl (MOE) with a phosphorothioate backbone and morpholino with a phosphorodiamidate backbo

62 that can predict the complete spectra (both backbone and nonbackbone ions) directly from peptide seq

63 cleobases at Calpha or Cgamma on the aeg-PNA backbone and open up ways to design programmed supramole

64 mation and enhances contacts between the DNA backbone and RNA polymerase.

65 O, N, and C unified atoms of the polypeptide backbone and side chains.

66 dies previously implied extraordinary carbon backbone and side-chain rearrangements.

67 Expression of genes in the terpenoid backbone and sterol biosynthesis pathways upstream of pr

68 d that a genuine interaction between the COF backbone and the cobaloxime facilitates recoordination o

69 (i) arginine interactions with the phosphate backbone and the major-groove edge of guanine and (ii) s

70 or better performance on I-TASSER predicted backbones and the backbones perturbed from experimental

71 e inherent stability provided by the polymer backbones and their ability to capture micropollutant gu

72 -1) , full conjugation throughout the carbon backbone, and an electrical conductivity of 6(2)x10(-4)

73 copolymer mechanically remodels the polymer backbone, and subsequent lactonization slowly (~days) de

74 rain simpler DNN models that enhance protein backbone angle prediction.

75 extensively studied in cyclic peptides whose backbones are cyclized from head to tail, like the membr

76 uses DndABCDE to insert sulfur into the DNA backbone as a double-stranded phosphorothioate (PT) modi

77 ows: How does the knot, which constricts the backbone as well as forms the SAM-binding pocket with it

78 d inside a MOF matrix as part of a framework backbone, as a ligand side group, or as a guest.

79 e recently discovered, the logic for peptide backbone assembly has remained a mystery.

80 phosphate moiety does not interact with the backbone at all, emerged most frequently.

81 f storing the trapped hydrogen in the ligand backbone, avoiding metal-hydride formation.

82 Our results reveal generic backbone-backbone hydrogen bonding constraints as a dete

83 e surface of which runs the TSC1 coiled-coil backbone, breaking the symmetry of the dimer.

84 Two conjugated polymers with rigid planar backbones, but with disordered crystalline structures, e

85 Polymers with less polar backbones (butadiene and siloxane) show stronger ion agg

86 Partial amorphization of the ZIF-backbone by ball-milling results in significant enhancem

87 sured the spin dynamics of nuclei in the CTT backbone by NMR spectroscopy to explore the mechanism of

88 We furthermore show that the LUXendin backbone can be optimized for intravital two-photon imag

89 is373 in the C-terminal alpha5-helix and the backbone carbonyl of Arg38 in the N-terminal alphaN-heli

90 bonding was observed between avanafil and a backbone carbonyl oxygen of an adjacent alpha-helix, who

91 monomer is stabilized at low pH and that its backbone chemical shifts, (15)N relaxation rates, and (1

92 Here we examine in detail the impact of ASO backbone chemistry, 2'-modifications, and buffer environ

93 that processes DNA intermediates through its backbone cleavage activity.

94 on of some sequence ions that originate from backbone cleavages exclusively along the putative epitop

95 that the correlation length scales with the backbone concentration, [Formula: see text], in striking

96 efficacy of the Cu2+-DPA in reporting on DNA backbone conformations for sufficiently long base pair s

97 The presence of two different backbone conformations within the same fibril may explai

98 tributions of that side chain in each of the backbone conformations.

99 eaction, providing conjugated oligomers with backbones consisting of para-linked phenylenes connected

100 -miR-193a-3p) as the subject, a compound DNA-backboned construct was synthesized, fusing all building

101 he synthesis of fused bioactive heterocyclic backbones containing quinoline, pyrrolidone, and beta-la

102 f post-translationally modified proteins and backbone cyclized proteins.

103 The isomerizable azobenzene-peptide backbone defines the size and shape of the catalytic poc

104 When backbone degradation is needed, the degradability can be

105 mation of chitin unaccompanied by noticeable backbone degradation or deacetylation.

106 ying the cross-linker loading or bottlebrush backbone degree of polymerization yields predictable low

107 es were attributable to 11 different peptide backbones, derived from IgG1, IgG2/3, IgG4, IgA1, IgA2,

108 We describe a protein backbone design method for generating a wide range of ri

109 interface using a two-stage flexible protein backbone design process that improved affinity for the R

110 nstead, a multidimensional picture involving backbone dihedral angles and distance between hydrogen b

111 ein structures via the representations using backbone dihedral angles has recently achieved significa

112 In natural photosynthesis, the protein backbone directs and positions primary and secondary ele

113 The resulting backbone diversity represents a major challenge for an u

114 combination pattern changed from an L8 to L1 backbone during 2014-2018 for Chinese PRRSVs, whereas L1

115 and also the picosecond-nanosecond timescale backbone dynamics of this domain.

116 The backbone dynamics profiles are reproducible and striking

117 ile Gly to Pro substitution, we have altered backbone dynamics, completely severing the allosteric si

118 h as GB1, offers little information on local backbone dynamics.

119 istidine side chains and those of remote key backbone elements of the protein.

120 ous amino acids Lys, Arg, or His adjacent to backbone ester bonds generally promote RNA duplex therma

121 ecific incorporation of these non-canonical, backbone-extended monomers at the N- and C- terminus of

122 Ribosome-mediated polymerization of backbone-extended monomers into polypeptides is challeng

123 For the assessment on native backbones, FASPR achieved a good performance by correctl

124 For the assessment on non-native backbones, FASPR showed an equivalent or better performa

125 ide chain fast time-scale dynamics and (15)N backbone fast time-scale dynamics are fully consistent,

126 ance, strongly depend on the polyelectrolyte backbone flexibility and the solvent quality.

127 The inherent glycan complexity and backbone flexibility require single-molecule approaches

128 U-TrmD family contain trefoil knots in their backbone fold.

129 Innate immunity to nucleic acids forms the backbone for anti-viral immunity and several inflammator

130 ability to efficiently sequence the peptide backbone for de novo identification, delineating multipl

131 f fluorophore moieties appended to a polymer backbone for sensing applications is far from mature.

132 roteins, provide an intrinsic macromolecular backbone for the construction of anisotropic brush polym

133 ultiple myeloma, and is a suitable treatment backbone for the development of combinations of four dru

134 dramatically accelerated and will serve as a backbone for the future of clinical research.

135 nese PRRSVs, whereas L1 was always the major backbone for US PRRSVs.

136 the synthetic modification of the conjugated backbone, for example, by altering aromatic cores or by

137 rich product ion spectra where all possible backbone fragment ion types (a/x, b/y, and c/z) are typi

138 Additionally, we demonstrate native top-down backbone fragmentation of noncovalent protein complexes,

139 Changes in covalent backbone fragments produced by electron capture dissocia

140 formation of urea and squaramide artificial backbones from minimally modified 3'- and 5'-amino oligo

141 nt relies on the excellent resolution of the backbone H,N correlation spectra even in these low compl

142 Backbone HDX is mediated by opening/closing (unfolding/r

143 ) that contain site-specifically substituted backbone heteroatoms is one of the essential goals that

144 that asymmetric proton conduction requires a backbone hinge motion, whereas bidirectional conduction

145 ine (aeg) repeating unit in the standard PNA backbone hosts a second nucleobase at Calpha through a s

146 We surprisingly found that OmpW backbone hydrogen bond energies do not vary over a wide

147 The magnitudes of the backbone hydrogen bond free energy changes in our study

148 of the water-induced polarity gradient upon backbone hydrogen bond strength has not been systematica

149 uring the free energy change for a number of backbone hydrogen bonds in the transmembrane protein Omp

150 Overall, our work suggests that backbone hydrogen bonds provide modest thermodynamic sta

151 m protein chains stacked into beta-sheets by backbone hydrogen bonds, they display distinct structura

152 es the feasibility of exploiting alpha-helix backbone in structure-based drug design.

153 tcome depends on relative orientation of the backbone in the "hotspot" region.

154 of spectroscopic measurements that the TAML backbone in the anionic complex [Co(III)(TAML(red))](-)

155 far greater contributions from the inhibitor backbone in the cathepsin-G-bound form.

156 hemical calculations reveal that the helical backbone in these molecules offers not only through-bond

157 in the biosynthesis of other known diterpene backbones in Eremophila.

158 The cyclobutane keeps polymer backbone intact under conditions that hydrolyze the lact

159 gger alone, the pristine polymer retains its backbone integrity, and delivering high mechanical force

160 t, suggests a decreased nanoparticle-peptide backbone interaction and an increased contribution of de

161 scription assay, we have now discovered that backbone interactions between the amino terminus of ExsD

162 pocket for sulfotyrosine and makes extended backbone interactions with CIF2.

163 Amino acids that promote backbone interactions within the beta2-beta3 loop were a

164 In practice, backbone ions only account for <70% of total ion intensi

165 eir neutral loss derivatives (referred to as backbone ions).

166 binant AP endonuclease 1 (APE1) when the DNA backbone is facing the histone core (THF-in) compared to

167 n various contexts, the associated chromatin backbone is modified by specific enhancer-enhancer and e

168 A hydrolytically active polycarbonate backbone is used to construct the polymer with pH-depend

169 tion of lipid isomer standards, including sn backbone isomers, acyl chain isomers, and double-bond po

170 electrics generally have conjugated aromatic backbones, leading to limited bandgaps and hence high co

171 tic copolymers with 1,1-disubstituted alkene backbone linkages.

172 the phosphodiester bond of the nucleic acid backbone, linking 5' phosphate of the nucleic acid with

173 In addition, NMR-detected backbone mobility is significantly higher in the polyIRM

174 cability of this approach beyond a removable backbone modification to a cleavable linker.

175 ten modified using the phosphorothioate (PS) backbone modification which enhances stability from nucl

176 y modified and include phosphorothioate (PS) backbone modifications and different ribose and base mod

177 ility to design for low polymer T(g) through backbone modulation, separately from controlling ion-pol

178 gyl group provides access to the benefits of backbone N-alkylation, while preserving the ability for

179 Peptides featuring backbone N-amino substituents exhibit unique conformatio

180 ction in the amplitudes and/or timescales of backbone N-H bond motions, corresponding to a rigidifica

181 Here, we describe the use of peptide backbone N-methylation as a new strategy to transform me

182 About half of the backbone NH sites exhibited a canonical scenario, where

183 etween compound sulfone oxygen atoms and Ral backbone nitrogen atoms.

184 1a,b are promising precursors for the novel backbone nitrogen-substituted N(2)[8](A)GNRs 2a,b.

185 rt the effect of force applied to the biaryl backbone of a bisphosphine ligand on the rate of oxidati

186 chains and hydrophilic interactions with the backbone of Abeta, as confirmed by extended (1-mus-long)

187 he poly(organophosphazenes): polymers with a backbone of alternating phosphorus and nitrogen atoms an

188 oday, monoclonal antibodies comprise the new backbone of anti-MM therapy, and T-cell therapies target

189 Protected areas form the backbone of biodiversity conservation, yet their effecti

190 ause of strong hydrogen bonding with the RNA backbone of C2469, as suggested by a molecular model bas

191 Inputs to molecular pathways that are the backbone of cellular activity drive the cell to certain

192 emical assays, we demonstrate that the amide backbone of CTA is assembled in an unusual thiotemplated

193 structure-a van der Mer (vdM)-that maps the backbone of each amino acid to statistically preferred p

194 Systemic chemotherapy remains the backbone of many cancer treatments.

195 death (BD) model constitutes the theoretical backbone of most phylogenetic tools for reconstructing s

196 terically demanding spiro junctions into the backbone of nanohoops, enables the manipulation of solid

197 m of nicks at predetermined positions on the backbone of native double-stranded DNA.

198 via spatial juxtaposition with the phosphate backbone of neighboring helices, resulting in an azimuth

199 The DNA backbone of NETs not only presents intrinsic neutrophil

200 eractions between TPYs and Zn(II) folded the backbone of P into a right- or left-handed metallo-helic

201 ince chemotherapy represents the established backbone of PDAC treatment we evaluated the interaction

202 g N-(hydroxy)glycine (Hyg) residues into the backbone of peptides.

203 sembly transcript 1 (NEAT1), which forms the backbone of subnuclear "paraspeckle" bodies, has been id

204 The mechanism involves syndecan-1, the backbone of the endothelial glycocalyx.

205 tionality is asymmetrically placed along the backbone of the eventual brush polymer.

206 ver 80% of the world trade volume and is the backbone of the global economy.

207 that ET is mediated solely by the conjugated backbone of the molecule.

208 - moiety replaces a -CHMe-CH(2)- unit in the backbone of the natural product.

209 inal segment interact with the phospho-sugar backbone of the non-target strand.

210 crosslinked peptide stem from the saccharide backbone of the peptidoglycan on one side is a pre-requi

211 stant domains of the Fabs are located in the backbone of the phagemid vector and the library insert c

212 of response after transplantation and is the backbone of treatment of patients who are not eligible f

213 hen VTE is diagnosed, anticoagulation is the backbone of treatment, with more advanced therapies bein

214 her to a bidentate ketal at the carbohydrate backbone of uridine, facilitates a switchable diastereos

215 s that synthesize the beta-1,4-linked glycan backbones of cellulose and most hemicellulosic polysacch

216 In addition, the backbones of phylogenetic trees exhibit bursts of divers

217 Moreover, despite the less ordered backbones of the extended fused-ring cores that have rec

218 articular functional architecture: a stable 'backbone' of stimulus representation formed by neurons w

219 teric demand of the substituent in the ylide-backbone on the catalytic activity.

220 trast, eIF2alpha-R53 interacts with the rRNA backbone only in the open complex, and the R53E substitu

221 In contrast, the best-performed backbone only models can only achieve an average similar

222 fatty acyl regiochemistry along the glycerol backbone or carbon-carbon double bond position(s) in uns

223 rands by either nuclease incision of the DNA backbone or glycosylase cleavage of the crosslinked nucl

224 We have previously discovered that backbone or side chain methylation of NRP residues is ca

225 cal force on chemical bonds within a polymer backbone or to generate force-responsive materials.

226 nstructions carried in their oligosaccharide backbones or by a Ca2+-mediated process that involves th

227 usually strong chain extension and excellent backbone ordering in all films, which likely contributes

228 -specific while fragment ions of the peptide backbone originating from different labeling channels ar

229 ance on I-TASSER predicted backbones and the backbones perturbed from experimental structures.

230 lly hydrogen bond energy or length/angle and backbone phi/psi angles.

231 ngle-strand versus double-strand crossovers, backbone phosphate positions, and single-strand breaks.

232 ggested the location of the ribonucleic acid backbone phosphates in the ribonucleotide-binding groove

233 conjugation length (and therefore conjugated backbone planar to non-planar conformational transition)

234 s of simulations which indicate that polymer backbone polarity does impact the microstructure and the

235 , several BINOL-based chiral phosphoric acid backbones presenting one or two visible-light-sensitive

236 RslO9 then oxidatively rearranges the carbon backbone, presumably via lactone-forming Baeyer-Villiger

237 used to study the impact of glycosylation on backbone proton exchange.

238 th nearby phosphates, yielding a two-pronged backbone readout.

239 onformational changes, including high-energy backbone rearrangements, that cooperatively organized th

240 t, and last, successful modification of this backbone regimen, which has endured now for almost 20 ye

241 -thick membranes was tested using different "backbone" reinforcement structures.

242 resistance mutations into a recombinant VSV backbone resulted in the recovery of replication-compete

243 L including the sugar residues and sphingoid backbone (SB) was inferred by collision-induced dissocia

244 ered electron-rich conjugated thiophene ring backbones separated by insulating alkyl side chains.

245 hotodissociation (UVPD) to yield informative backbone sequence ions are compared to those of higher-e

246 th direction, including diverse sidechain-to-backbone, sidechain-to-sidechain, and sidechain-to-water

247 s or phenolics released from the melanoidins backbone (specially pyrogallol, 2-(3,4-dihydroxyphenyl)a

248 Other models (SSD with a ResNet50 backbone, SSD with focal loss, and RetinaNet) yielded lo

249 intrinsically conflicting properties, i.e., backbone stability and accessible degradability, can mak

250 nd ordered HBC arrays with the poly(ene-yne) backbones stretching along the column direction, based o

251 The conjugation of azido moiety to chitin backbone strongly diminishes the toxicity of the azido p

252 5-HT(3) receptor (5HT3R) which restrains the backbone structure to that of the parent channel protein

253 redicts secondary structure elements (SSEs), backbone structure, and Calpha atoms, combining the resu

254 lass of materials featuring an unprecedented backbone structure, the polyallophanates (PAs).

255 natural endogenous Egr1 transcription factor backbone structure.

256 rs in the data, both with respect to polymer backbone structures and their individual side groups.

257 These activities together account for the backbone structures of the major cork triterpenoids.

258 O-Acetyl moieties are the dominant backbone substituents of glucuronoxylan in dicots and pl

259 oic acids (LTAs) with poly-(beta1->4)-ManNAc backbones substituted with phosphoethanolamine.

260 e first examples of isopeptide and thioamide backbone substitutions in ribosomal proteins, the former

261 one with sulfur introduce chirality into the backbone such that a full PS 16-mer oligonucleotide is c

262 nd DPPB, along with others with more complex backbones, such as DPPF and Xantphos.

263 icate unnatural base pairs (UBPs), unnatural backbones, tags, or other evolutionarily novel features

264 s from acoustic data and offers promise as a backbone technology for global collaborative autonomous

265 However, cis-trans isomerization of the backbone tertiary amides may impair the peptoid's adopti

266 pounds mediate interactions with the protein backbone that are critical for antagonizing viruses cont

267 nternal GalNAc unit of a Gb5 pentasaccharide backbone that furnishes a Neu5Acalpha(2,6)GalNAc-linked

268 nd subsequent repair of the nicked phosphate backbone that remains following the procedure.

269 ysts immobilized on a hydrazone-based COF-42 backbone that show improved and prolonged photocatalytic

270 e than 1.5 million markers and an imputation backbone that successfully tags over 94% of common genet

271 s of interest, and pessimism constitute the "backbone" that sustains depressive symptoms in late-life

272 n-hydrogen bonds in biomolecules and polymer backbones, the development of a photocontrolled polymeri

273 Furthermore, as CoA contains an ADP backbone this may extend beyond CoA-binding sites and in

274 by exploiting (i) "flexible" linear polymer backbone to facilitate interactions with biomembrane sys

275 s provide molecular attachment points on the backbone to the gold electrodes, thereby giving rise to

276 Protein secondary structure and backbone torsion angle prediction can provide important

277 Predictions of protein backbone torsion angles ( and psi) and secondary structu

278 ormance for predicting secondary structures, backbone torsion angles, beta-turns and gamma-turns, res

279 However, predicting the backbone trace of a protein has remained a challenge on

280 ing algorithm was used to produce an initial backbone trace with Calpha placements.

281 improvements to the alpha-helix SSEs of the backbone trace.

282 hat a serine/threonine-rich stretch causes a backbone twist in the N-terminal beta strand, stabilizin

283 olecular graft is positioned at each monomer backbone unit.

284 ly incorporated into a poly(anhydride-ester) backbone via melt-polymerization, with the active antime

285 hoxy groups on a benzene or benzene-methanol backbone were clustered into one group with similar rete

286 ted, and aglycones with differing polyphenol backbones were studied, in addition to bulk food ingredi

287 A common approach is to design molecular backbones where destructive quantum interference (QI) be

288 n, affording the shortest linkage to protein backbone which is essential for advanced studies involvi

289 in the Indian study cohort consensus p24 Gag backbone), which was also associated with significantly

290 typically enabled by cleavable groups on the backbone, which can be attacked by stimuli in ambient co

291 he degradable functionalities on the polymer backbone, which diminishes polymer properties during sto

292 three-dimensional packing of the conjugated backbone, which is likely responsible for the remarkable

293 reduction due to the closo-C(2)B(10) cluster backbone, which is prone to accept up to two electrons t

294 ers are synthesized with rigid and contorted backbones, which incorporate hydrophobic fluorinated and

295 d scaffold is characterized by an amino acid backbone with a free carboxylate, an N-linked aromatic o

296 Modification of their backbone with N-methyl amides inhibits folding, which di

297 r, substituting oxygen in the phosphodiester backbone with sulfur introduce chirality into the backbo

298 here comprise ether, butadiene, and siloxane backbones with grafted imidazole side-chains, with disso

299 one and morpholino with a phosphorodiamidate backbone-with the same or extended target sequence as nu

300 crease in the local bending of DNA's helical backbone without evidence of DNA wrapping around the pro