ライフサイエンスコーパス: backup

1 se and interventional radiology and surgical backup.

2 d that the SMUG1 glycosylase might provide a backup.

3 ersons cannot be recommended without culture backup.

4 U:dG lesion with uracil excision providing a backup.

5 ase WSS1A, and the phosphodiesterase TDP1 as backup.

6 at centers without on-site cardiac surgical backup.

7 linical events compared with PTCA with stent backup.

8 rolysis using dedicated renewables with grid backup.

9 07088 for advancement as a clinical lead and backup.

10 ays, allowing alt-EJ to function as rescuing-backup.

11 , and outputs can be archived for sharing or backup.

12 gesting combinatorial control or a molecular backup.

13 t H-NS is the progenitor of varied molecular backups.

14 odify signaling; and can allow for signaling backups.

15 oly(ADP)ribose polymerase 1 (PARP1) serve as backups.

16 cantly different between the DDD arm and the backup AAI arm.

17 o either DDD pacing for 3 months followed by backup AAI pacing for 3 months, or the same study arms i

18 ed to 3 months each of DDD pacing and pacing backup (AAI-30) in a double-blind, crossover study desig

19 sence of Fpg and MutY, endo VIII serves as a backup activity to remove 8-oxoG.

20 posed that transcriptional reprogramming and backup among duplicates is a genomewide phenomenon in th

21 Surgical backup and acute management skills for treating tamponad

22 Decisions about energy backup and cooling options for parabolic trough (PT) con

23 aluation: syncope facilities with specialist backup and interactive decision-making software.

24 ndrial thioredoxin system provide functional backup and maintain plant viability.

25 y emerge from the need for extensive modular backup and the requirement to integrate transcriptional

26 y Service tool for automated instrument file backup and the ScanSifter tool for data conversion.

27 Communication, backup, and emergency systems must be integrated, often

28 Delayed (or "backup") antibiotic prescription, where the patient is g

29 o had symptomatic improvement during the AAI backup arm.

30 cally arranged in hierarchies, with magnetic backup as a last resort when celestial information is un

31 oom, where the radiologist was available for backup as needed.

32 e oxidative species due to upstream electron backup at the FMN site of complex I, thus resulting in a

33 ng partner XRCC1, this interaction acts as a backup attempt to intercept the more error-prone alterna

34 ope localization, enhanced histopathology, a backup axillary dissection, and judicious case selection

35 lternative form of end joining, operating as backup (B-NHEJ) functions robustly throughout the cell c

36 alternative form of NHEJ that operates as a backup (B-NHEJ) to the DNA-PK-dependent (D-NHEJ) pathway

37 (HON1), XRCC1, and PARP1, participate in a 'backup' (b)NHEJ process.

38 vive selection they cannot simply serve as a backup but rather must acquire distinct functions requir

39 ification of HCV NS3 inhibitors as potential backup candidates to our first generation drug candidate

40 Thus escl appears to function in a backup capacity during development that becomes importan

41 s clinical candidate, BMS-986120 (43), and a backup clinical candidate, BMS-986141 (49).

42 selected for further evaluation as potential backup compounds to 1.

43 ss was further explored, seeking efficacious backup compounds with improved solubility and safety.

44 (SC-77774), respectively, were identified as backup compounds.

45 Genomically encoded backup control circuitry thus provides the mechanism und

46 arios to identify the highest-scoring energy backup-cooling combination for each preference scenario.

47 as well as those devices with defibrillator backup (CRT-D).

48 true disease status and obviate the need for backup cultures if specificity can be improved.

49 sis regulatory pathway and reiterated that a backup cytokinesis pathway is activated by inhibiting th

50 One enhancer acts as an inducible backup ('dark' shadow enhancer) that is normally repress

51 leaving messenger RNA, which could provide a backup defense.

52 cal toxicology studies and was selected as a backup development candidate for the program.

53 J) and single-strand annealing (SSA) provide backup DSBs repair pathways.

54 ty for monoubiquitinated APE1 and because of backup E3 ligases in the cells.

55 adult dogs in complete heart block and with backup electronic pacemakers.

56 upport the role of V nitrogenase as a viable backup enzymatic system for BNF in natural ecosystems.

57 brinolytic system, serves as a physiological backup enzyme for ADAMTS13 in the degradation of patholo

58 raise the possibility that NEIL1 serves as a backup enzyme to APE1 in stimulating 8-oxoG repair in vi

59 f copper amine oxidase by a flavin-dependent backup enzyme.

60 microhomology, a signature associated with a backup, error-prone double-strand break repair pathway k

61 committee, site examining neurologists, site backup examining neurologists, and site examining techni

62 hermal energy storage (TES), and fossil fuel backup (FF)) and different cooling options (wet (WC) and

63 sent and requires alphavbeta3/5 integrins as backup fibronectin receptors.

64 ular, we present compound 40 (ARN24092) as a backup/follow-up lead with in vivo efficacy in a mouse m

65 6 (10a) was selected as a potential clinical backup for 1.

66 ation on endothelial cells acts as a natural backup for ADAMTS13 to degrade obstructive platelet-VWF

67 so suggested that BiP/GRP78 could serve as a backup for calnexin and calreticulin in retaining the fr

68 In the search of a potential backup for clopidogrel, we have initiated a HTS campaign

69 texposure treatment should be used only as a backup for failure of primary prevention methods, such a

70 erent Lon substrates and appears to act as a backup for Lon under certain conditions.

71 question the idea that p18(INK4c) acts as a backup for loss of p16(INK4a) and suggest that the appar

72 s conditions, providing both specificity and backup for protection from oxidative damage.

73 its helicase activity, and Pif1 serves as a backup for Rrm3 in suppressing mutagenesis.

74 enge superoxide anion radicals and provide a backup for superoxide dismutase enzymes.

75 ytes, demonstrating that Synpo-T serves as a backup for Synpo-long in synpo(-/-) podocytes.

76 3'-->5' Exo of Pol delta as a supplement or backup for the Rad27/Fen1 5' flap endonuclease.

77 mU-excision in mice as well as the major UNG-backup for U-excision.

78 ) picking of surrogate tagSNPs that serve as backups for tagSNPs whose failure would result in a sign

79 ort and device programming who had immediate backup from an electrophysiologist.

80 placed by a bedside nursing-based team with backup from the Interventional Radiology department.

81 ts DSB repair to mutagenic NHEJ, revealing a backup function of 53BP1 when cNHEJ fails.

82 Yen1 serves a backup function responsible for resolving intermediates

83 e replicating strand, with NEIL2 providing a backup function.

84 cells with nuclear storage and developmental backup functions are reminiscent of multipotent stem cel

85 54, and thus, H189 may be able to serve as a backup general base at a lower efficiency compared to H1

86 endant customer responses (e.g., relocation, backup generation).

87 these variables, or waterproof protection of backup generators, could have mitigated or prevented the

88 a wall elevation, and location and status of backup generators.

89 We did not detect a backup glycosylase or glycosylase/AP lyase activity for

90 ow we plan for unit shipment and the role of backup grafts.

91 may benefit from a higher, more physiologic backup heart rate than the nominal 60 beats per minute (

92 o be present downstream of genes to act as a backup in case of read-through of the real stop codon.

93 plicates are unlikely to provide substantial backup in the context of large natural populations.

94 Data suggest that a backup in the magma plumbing system at the long-lived Pu

95 These 'dormant' origins provide a backup in the presence of stalled forks and may confer f

96 mologous recombination provides an essential backup in vertebrate rad18 mutants, we show that in chic

97 on with PCT rather than switching to another backup IOL demanding wound enlargement.

98 eekend hours and how cardiovascular surgical backup is arranged.

99 performed at centers without onsite surgical backup is not associated with any mortality hazard.

100 or direct backup, the prevalence of indirect backup is poorly understood.

101 and land use suggest a preference for TES if backup is require for PT plants to compete with baseload

102 cision was made to implant the kidney into a backup kidney recipient.

103 tion capabilities that can be recruited as a backup kinase for both gatekeeper tumor suppression and

104 Reliance on the backup ligase is accompanied by a drastic loss of fideli

105 However, preparation of backup liver transplantation should be considered in sel

106 In search of a backup M(2) muscarinic receptor antagonist to the previo

107 engrafted without infusion of unmanipulated "backup" marrow (n = 14).

108 of PT with different backup options (minimal backup (MB), thermal energy storage (TES), and fossil fu

109 roliferating cell nuclear antigen provides a backup mechanism for accurate bypass of these sequences

110 d1 provides the intestinal epithelium with a backup mechanism for rapidly activating innate immunity

111 and stochastically, revealing a first-order backup mechanism for rhodopsin deactivation.

112 We propose that this backup mechanism may be a general feature of endocrine r

113 equate rate of cycling and likely provides a backup mechanism to enable polymerase release when the o

114 s may employ stress-related suppression as a backup mechanism to guard against lapses in reproductive

115 ar movement into the neck and can serve as a backup mechanism to move the nucleus into the neck when

116 e presence of RAP1 at telomeres appears as a backup mechanism to prevent NHEJ when topology-mediated

117 within the IRF8 PTC were found to provide a backup mechanism when combined, safeguarding IRF8 expres

118 In this backup mechanism, strong ligand-receptor binding between

119 ed end-joining (MMEJ) has been regarded as a backup mechanism.

120 t role in cell division, although cells have backup mechanisms for dividing if centrioles are missing

121 rnative cell death mechanisms as primary and backup mechanisms is discussed.

122 sts (RADTs) do not require confirmation by a backup method in adults, whereas laboratory-based guidel

123 replicative polymerases, and the presence of backup Mg(2+)-dependent endonuclease activity in early s

124 0.2 to 0.7), the patient's device reset to a backup mode.

125 rium tuberculosis LigC can also support this backup NHEJ pathway.

126 sion repair, single strand break repair, and backup nonhomologous end-joining pathway.

127 Albeit not excluding the agency of a backup nuclease, our findings suggest that mycobacterial

128 cumulation of clathrin-coated vesicles and a backup of newly reformed vesicles in the cytomatrix-rich

129 rrantly low XRCC1 consistent with defects in backup Okazaki fragment processing (OFP).

130 sponsive pacing as compared with ventricular backup-only pacing worsens the combined end point of mor

131 0.98-1.68; Pr(benefit): 0.969) compared with backup-only pacing.

132 d RVP (intervention) followed by 3 months of backup-only RVP (control), or vice versa.

133 ly worse than, and was likely equivalent to, backup-only ventricular pacing.

134 ial pacing is a safe alternative to minimal (backup-only) ventricular pacing in defibrillator recipie

135 ed independently and can be used either for "backup" operation or for parallel operation with other m

136 use gas (GHG) emissions of PT with different backup options (minimal backup (MB), thermal energy stor

137 recent years, energy policies do not address backup or cooling option requirements, and very few stud

138 ks to this, AGC could be useful not only for backup or transfer purposes but also for routine analysi

139 arise either due to redundancy, i.e. direct backup, or due to distributed architecture, i.e. indirec

140 nce of DNA lesions, leading to the firing of backup origins that help maintain robustness in S-phase

141 ted that the activation of non-constitutive (backup) origins are indispensable for replication to be

142 The AVJ is a primary backup pacemaker to the sinoatrial node.

143 vs. 50.4 +/- 0.4 beats/min; p = 0.01), lower backup pacemaker utilization (45 +/- 2.6% vs. 94.6 +/- 1

144 vs. 50.1 +/- 0.4 beats/min; p = 0.05), less backup pacemaker utilization (53 +/- 8.2% vs. 95 +/- 1.6

145 ve pacing (dual-chamber pacing at 70 bpm) or backup pacing (atrial pacing at 30 bpm).

146 e pacing and in 27 of 41 (66%) randomized to backup pacing (control), yielding a hazard ratio of 0.25

147 ffers no clinical advantage over ventricular backup pacing and may be detrimental by increasing the c

148 d to have the ICDs programmed to ventricular backup pacing at 40/min (VVI-40; n = 256) or dual-chambe

149 with a lower rate of 60 ppm is compared with backup pacing at DDI with a lower rate of 30 ppm.

150 ere randomized to 6 months of active PPoP or backup pacing in a crossover design.

151 00 microg/900 microg) and was supported with backup pacing when needed.

152 130 beats/min), no dependence on electronic backup pacing, and enhanced modulation of pacemaker func

153 associated with similar outcomes as with VVI backup pacing.

154 160 beats/min, and low to absent electronic backup pacing.

155 e, escape time, and dependence on electronic backup pacing.

156 NHEJ-deficient cells via a poorly understand backup pathway (or pathways) often termed alternative en

157 The backup pathway creates a threshold such that ATRi select

158 use of nucleotide excision repair (NER) as a backup pathway for RER in RNase HII-deficient cells and

159 This indicates that TDP1 defines a minor backup pathway in the repair of DPCs.

160 ase I (LigI) joins most Okazaki fragments, a backup pathway involving poly(ADP-ribose) synthesis, XRC

161 Suspecting existence of a backup pathway protecting from toxic sequelae of replica

162 Our data indicate that the backup pathway that normally ensures proper segregation

163 that nucleotide incision repair may act as a backup pathway to base excision repair to remove uracils

164 cell types that are more dependent upon the backup pathway to complete DNA replication and that PARP

165 sDNA and triggers a DNA-PK and Chk1-mediated backup pathway to suppress origin firing.

166 vage, and is stimulated by components of the backup pathway.

167 epair process that typically functions as a "backup" pathway if double-strand break repair by homolog

168 When a cell fails to complete pyroptosis, backup pathways will initiate apoptosis.

169 r; P=0.01), a caregiver who has identified a backup plan (P=0.02), and a caregiver who is able to pro

170 -line stabilization, cricoid pressure, and a backup plan for a surgical airway is still the most effi

171 e results suggest that Rev1 could serve as a backup polymerase in BER and could potentially contribut

172 its absence, cells do not have an efficient backup polymerase or a repair/tolerance mechanism facili

173 drogen fuel cell electric vehicles (HFCEVs), backup power generation, and its use in transportation,

174 Adaptations, including the use of backup power generators, on-site troubleshooting, and pr

175 Doubling backup power penetration moderates GDP losses by 11%-14%

176 ld be greatly enhanced if fully operational, backup power systems were mandated, not only for acute c

177 rticularly in the G2-phase and is thought to backup predominantly D-NHEJ.

178 e may reflect motivations to use condoms for backup pregnancy prevention.

179 As part of a backup program around this scaffold, we explored heteroa

180 Within a backup program for the clinical investigational agent pr

181 initially studied for tuberculosis within a backup program for the clinical trial agent pretomanid (

182 a half-life (5 h) in human volunteers, and a backup program was initiated to remove metabolic liabili

183 ntigenic stimulation, providing nonredundant backup protection for the host when granzyme B fails.

184 Ou/var/www/html/elife/12-05-2020/backup/r analyses reveal: genetic heterogeneity of non-t

185 ypocapnia, which combined with the lack of a backup rate and wakefulness drive can lead to central ap

186 irway pressure of 4 (IQR, 4-5) cm H2O, and a backup rate of 14 (IQR, 14-16) breaths/minute.

187 jects, we examined whether the presence of a backup rate on assist-control ventilation would decrease

188 model is consistent with PPAT serving as a "backup" regulator of pathway flux relative to pantothena

189 ng (alt-NHEJ) was originally identified as a backup repair mechanism in the absence of classical NHEJ

190 We describe a novel backup repair mechanism that occurs when the homologous

191 hese studies suggest that MMEJ not only is a backup repair pathway in mammalian cells, but also has i

192 Backup repair processes can compensate when the normal m

193 s such as hybrid electric vehicles and power backup require rechargeable batteries that combine high

194 RIF1, such that 53BP1-RIF1 appear to play a backup role for DNA-PKcs during blunt DSB NHEJ, but func

195 e glutaredoxin system and glutathione have a backup role to keep Trx1 reduced in cells with loss of T

196 Thus, thymine DNA glycosylase may play a backup role to the more efficient general uracil DNA gly

197 xidative stress genes whereas SpxA2 served a backup role.

198 a substrate of CK1 but that D1 plays only a 'backup' role in PER2 degradation.

199 forces vulval development through an unknown backup signal for vulval induction.

200 ing a behavioral function of neurons induces backup signal production from muscle.

201 This rule lacks experimental backup, since, to the best of our knowledge, no rational

202 resistance generally develops, necessitating backup strategies for therapy.

203 e plus treatment also serves as an important backup strategy if treatment systems are partially effec

204 e plus treatment also serves as an important backup strategy if treatment systems are partially effec

205 LE also uses mimicry of ICP1's pac site as a backup strategy to ensure genome packaging.

206 such as redundancy, node recovery time, and backup supply available.

207 e to pathogen perturbations, plants mobilize backup surveillance mechanisms involving RKs and RLCKs t

208 The two proteins also form a backup system for engulfment.

209 s mediation of Okazaki fragment joining as a backup system for LIG1 perturbation.

210 act and thus has been proposed as a possible backup system for post-stroke rehabilitation even for th

211 ion-mediated transcriptional repression as a backup system for post-translational protein degradation

212 progenitor cells do not function solely as a backup system in chronic liver injury; rather, they also

213 Thus, an "over-engineered" backup system in the form of distributed architecture is

214 We hypothesized that there should exist a backup system to reduce Trx1 when only TrxR1 activity wa

215 hereas the error-free pathway functions as a backup system.

216 these heterologous elements may represent a "backup" system capable of catalyzing P-choline incorpora

217 oxins and glutathione peroxidases with their backup systems as well as by catalase.

218 ssion activities do not function as cryptic 'backup' systems, but that each contributes quantitativel

219 both the SRP and GET pathways, and act as a backup targeting system.

220 for GAS have relatively low sensitivity, and backup testing is recommended in children.

221 sting method for GAS pharyngitis and obviate backup testing on negative results.

222 Despite clear evidence for direct backup, the prevalence of indirect backup is poorly unde

223 th mismatch recognition of dU:dG providing a backup; the second phase of hypermutation (essentially i

224 ipt cleavage accompanied significant RNAP II backup, thereby providing access of the repair enzyme to

225 de that combines patient flow-triggering and backup time-triggering.

226 Seventh, surveillance requires laboratory backup to confirm a diagnosis.

227 more, CXCR4-Lo may also provide a functional backup to CXCR4 during embryogenesis.

228 cloud-scale computing resources, from robust backup to high-speed data transfer to scalable compute a

229 ressed copy and the plasmid operon acts as a backup to maintain appropriate gene dosages.

230 e Holliday junction but acts as an essential backup to MUS81 for resolution of toxic replication stru

231 test can be used as the primary test or as a backup to negative antigen tests.

232 egulation of E2F1 and may serve as a partial backup to prevent E2F1-mediated apoptosis in the absence

233 this signaling can indeed act as a redundant backup to the exogenous gradient, it introduces a positi

234 etic toxicity issues and was considered as a backup to vilanterol.

235 with therapeutic tactics serving strictly as backups to these natural regulators.

236 heir therapeutic or recreational use because backup transporters and alterations in receptor gene exp

237 Laser therapy may still be required as a backup treatment for patients who do not respond to an I

238 There is an urgent need for backup treatment options for patients with cephalosporin

239 We present the Backup Utility Service tool for automated instrument fil

240 ardioverter defibrillator (ICD) therapy with backup ventricular pacing increases survival in patients

241 re, depending on how cardiovascular surgical backup was provided.

242 hnical personnel and cardiovascular surgical backup were already covered.

243 Dormant origins are activated as backups when DNA synthesis stalls, allowing for complete

244 e to distributed architecture, i.e. indirect backup where multiple genes contribute to the functionin