ライフサイエンスコーパス: bacterial load

1 further phagocytosis, resulting in elevated bacterial load.

2 Cytobrushes collected a higher total bacterial load.

3 in male mice and was associated with greater bacterial load.

4 ects of antimicrobial on milk microbiome and bacterial load.

5 recruitment in granulomas, and decreased the bacterial load.

6 MAIT cells did not restrict M. tuberculosis bacterial load.

7 -/- mice showed a dramatic increase in renal bacterial load.

8 decreased production of IL-10 and a reduced bacterial load.

9 nergizes with noncognate T cells to restrict bacterial load.

10 amma production by T cells, and an increased bacterial load.

11 eriological cure, pathogen clearance rate or bacterial load.

12 yo excision to determine the location of the bacterial load.

13 rier rather than a response to the increased bacterial load.

14 emic animals reduced both airway glucose and bacterial load.

15 h defective microbial clearance and elevated bacterial load.

16 of neutrophils induced an increased mammary bacterial load.

17 on, organ damage, immune cell apoptosis, and bacterial load.

18 MAITs migrated to the bladder and decreased bacterial load.

19 orly in specimens having a low volume or low bacterial load.

20 +) T cell trafficking to the uterus and high bacterial load.

21 al wound infection significantly reduced the bacterial load.

22 R (RT-qPCR) showed minimal loss in estimated bacterial load.

23 ction of time after infection, and the total bacterial load.

24 animals also exhibited marked reductions in bacterial load.

25 eonam was only evident in patients with high bacterial load.

26 PZP in sputum was directly related to airway bacterial load.

27 mpared with placebo but did not change total bacterial load.

28 d antibiotics would be predicted by baseline bacterial load.

29 suggesting that tumor sizes affected optimal bacterial loads.

30 uthanasia and vitreous harvest to quantitate bacterial loads.

31 nd found a 5- to 10-fold decrease in gastric bacterial loads.

32 caused by hyperglycaemia leads to increased bacterial loads.

33 in neutropenic patients transfused with high bacterial loads.

34 infections as well as the characteristics of bacterial loads.

35 ology without affecting pendrin synthesis or bacterial loads.

36 yte recruitment and a subsequent decrease in bacterial loads.

37 gitidis DNA from clinical specimens with low bacterial loads.

38 f target cells by the TCR was independent of bacterial loading.

39 Efficacy was determined by a reduction in bacterial load 4 weeks after challenge.

40 RA patients had a higher bacterial load, a more diverse microbiota, an increase i

41 ly dependent on parameter values and initial bacterial load, a significant common trend is identified

42 ESBL gene family) and 16S rRNA (a proxy for bacterial load) abundance data from 833 rectal swabs fro

43 dietary fat composition affect survival and bacterial load after experimental septic infection and n

44 st cells growth and were capable of reducing bacterial load and accelerating wound healing in an exci

45 tives: To determine the relationship between bacterial load and clinical outcomes, assess the stabili

46 strate sensitive and rapid quantification of bacterial load and cytokines from human biological sampl

47 c mice showed increased skin lesion size and bacterial load and decreased PGE2 secretion and Th17 cel

48 a decrease in its activity results in higher bacterial load and exacerbated organ damage, ultimately

49 Furthermore, miR-263a mutants have increased bacterial load and expression of antimicrobial peptides.

50 ated in immune-compromised flies with higher bacterial load and gut cell death.

51 early information on the rate of decline in bacterial load and has technical advantages over culture

52 ne was amplified, allowing quantification of bacterial load and identification of communities by 16S

53 Quantitative PCR was used to compare bacterial load and Illumina MiSeq sequencing of the V1-V

54 rivatives increases the survival and reduces bacterial load and inflammation in mice with polymicrobi

55 Hc-cath treatment significantly reduced the bacterial load and inflammation in mouse models of P. ae

56 t to understand the relationship between CSF bacterial load and inflammation, and their respective im

57 This is correlated with a reduced bacterial load and inflammatory response in these mice.

58 Despite a 10,000-fold reduction in gut bacterial load and long-lasting diminution in bacterial

59 34.78%), lower bacterial load and milder histological severity than the

60 hich are indistinguishable by measurement of bacterial load and not consistently differentiated by th

61 ish extends the conventional measurements of bacterial load and number of bacterial foci to include m

62 during murine enteric infection by reducing bacterial load and preventing systemic dissemination of

63 Milk from the mastitic quarter had a higher bacterial load and reduced microbial diversity compared

64 l and fluoride therapy significantly reduced bacterial load and suggested reduced caries increment in

65 R12 and D-IK8 significantly reduced both the bacterial load and the levels of the pro-inflammatory cy

66 Ebselen 1% and 2% significantly reduced the bacterial load and the levels of the pro-inflammatory cy

67 could act not only as a guide to assess the bacterial load and use of antibiotics but also as a pred

68 effect was independent of richness and total bacterial load and was associated with reduced proinflam

69 iptional signatures correlate with increased bacterial loads and exacerbate pathology during Mycobact

70 t mice exhibited significantly lower bladder bacterial loads and fewer intracellular bacterial commun

71 IF immunoglogulin G (IgG) antibodies reduced bacterial loads and improved survival in a mouse model o

72 of IgA resulted in a significant increase in bacterial loads and reduced survival.

73 ent mice induces hypoferremia that decreases bacterial loads and rescues these mice from death, regar

74 haled antibiotics are well tolerated, reduce bacterial load, and achieve a small but statistically si

75 showed increased weight and survival, lower bacterial load, and attenuated intestinal pathology comp

76 ed the virulence in terms of mice mortality, bacterial load, and inflammation.

77 eutrophils in the peritoneal cavity, reduced bacterial load, and multiorgan dysfunction.

78 ng after the ulcerative phase despite stable bacterial load, and mycolactone toxin was not detected i

79 ce had significantly increased mortality and bacterial load, and reduced tissue-specific cytokine res

80 ciated with invasive pneumococcal pneumonia, bacterial loads, and death.

81 Differences in mortality and bacterial load are due to injury of the thorax and can b

82 ction is significantly increased and minimal bacterial loads are sufficient to invade enterocytes fro

83 tended phenotypes as the conjunction between bacterial load as the mode of action, timing of multipli

84 e for S. aureus-positive blood cultures with bacterial loads as low as ~ 7,000 colony-forming units/m

85 ens produced a more rapid initial decline in bacterial load, as compared with the control group.

86 es do not "preserve" the carcass by reducing bacterial load, as is commonly supposed.

87 We applied culture and the novel molecular bacterial load assay (MBLA) to measure the loss of M. tu

88 are expected to limit the notably increased bacterial load associated with hRV coinfection and there

89 ored and the phenoloxidase (PO) response and bacterial load at 24-hr postinfection were ascertained.

90 gative correlation between nitrite and total bacterial load at 6 months (FMS + CHX) and one positive

91 at 24 hours after tick attachment, with peak bacterial load at day 6 after tick attachment.

92 effector responses are associated with lower bacterial loads at the expense of gastric pathology.

93 peri-implant sulcus but significantly lower bacterial loads at the inner portion of the implant conn

94 hase of sepsis, decreased local and systemic bacterial load, attenuated cytokine production, and redu

95 Efficacy endpoints assessed were bacterial load, bacterial eradication from sputum, frequ

96 While baseline levels of total bacterial load, Bacteroidetes, Firmicutes, and Enterobac

97 e attributed to differences in IgA levels or bacterial load between the 2 groups.

98 NLRP3 inhibitor-treated mice displayed lower bacterial load but no impairment in neutrophil recruitme

99 Depletion of NK cells led to higher bacterial loads but less severe colonic inflammation, as

100 n (determined by myeloperoxidase assay), and bacterial load, but it diminished PMN bactericidal activ

101 lls postinjection, such as induced by higher bacterial loads, but in the longer term did not correlat

102 mg/kg (15.6 mumol/kg) conjugate reduced the bacterial load by 99% and demonstrated nearly an order o

103 Treatment with doxycycline decreased bacterial load by a mean 2.60 log10 (n = 56; P < .0001).

104 However, reducing the bacterial load by antibiotic treatment or breeding mice

105 However, reducing the bacterial load by antibiotic treatment or breeding mice

106 Finally, bacterial loads (colony-forming units per milliliter) in

107 s additive effects and significantly reduces bacterial loads compared with isoniazid treatment alone.

108 H. pylori bacterial load correlated positively with intensity of O

109 The Chlamydia trachomatis (CT) bacterial load could have impact on transmission and seq

110 ontrast, patients with high pretreatment CSF bacterial loads, cytokine concentrations, and neutrophil

111 CD-TREAT and EEN produced similar changes in bacterial load (decrease 0.3 +/- 0.3 log(10) 16S rRNA ge

112 red and infected mice was increased and lung bacterial load decreased by airway leptin administration

113 ally led to enhanced protection with reduced bacterial load, decreased chemokine expression, and redu

114 RNA sequencing, immunohistochemistry, and bacterial load determination were performed at each cavi

115 Notably, increasing bacterial loads did not necessarily produce better long-

116 c treatment in bronchiectasis is that airway bacterial load drives inflammation, and therefore antibi

117 licated in clinical sputum samples, with the bacterial load dropping by 0.65 +/- 0.17 log(10) from 5.

118 ucose as a critical determinant of increased bacterial load during diabetes.

119 8 weeks had increased survival and decreased bacterial load during sepsis compared with mice fed a sa

120 L-10, showed a significant reduction in lung bacterial loads during chronic M. tuberculosis infection

121 mation, decreases tissue injury, and reduces bacterial loads during concurrent pneumococcal infection

122 ajor importance for the accumulation of high bacterial loads during infection of the urinary tract.

123 nged the bleeding time, it did not impact on bacterial loads during pneumococcal pneumonia.

124 ithelial cells had significantly higher lung bacterial loads, enhanced mortality, decreased caspase a

125 bacterial qPCR of total 16S rDNA revealed a bacterial load exceeding that of background DNA controls

126 ough its action on potential mediators (oral bacterial load, fluoride levels, and overall caries risk

127 ted with anti-CD71 Ab showed reduced splenic bacterial load following bacterial challenge compared wi

128 Prevalence of positive sites and bacterial loads for 10 microorganisms were obtained with

129 The ability to clear the bacterial load from the lung remained preserved in sham

130 Despite higher bacterial loads, GPVI-depleted mice showed reduced plate

131 u/g), moderate (10(5)-10(6) cfu/g), and high bacterial load (>=10(7) cfu/g) using quantitative sputum

132 Bacterial load, histology, cellular distribution, cytoki

133 We found no difference in bacterial load, histopathology, or host mortality betwee

134 ation in vitro, and is effective at lowering bacterial load in a mouse model of infection.

135 We measure bacterial load in a non-invasive manner using a lucifera

136 dendritic cell (DC) functions and increased bacterial load in alveolar bone in vivo and whether DC i

137 per L) concentrations reduced the pathogenic bacterial load in broth culture by 2 to over 6 logs depe

138 o detrimental impacts on milk microbiome and bacterial load in cows with a healthy mammary gland.

139 h and significantly decreased the cumulative bacterial load in developing and established biofilms.

140 ases decreased significantly with increasing bacterial load in drinking water in the first year of li

141 Cumulative bacterial load in drinking water was higher (median [IQR

142 contaminated health care workers (HCWs), and bacterial load in environment.

143 Antibiotics reduced bacterial load in feces and could promote the formation

144 irulent ST2 strain NCTC 7466 by reducing the bacterial load in lung tissue and blood.

145 6), more neutrophil recruitment, and a lower bacterial load in lung tissue than mice infected with wi

146 an acute pneumonia with a rapid decrease of bacterial load in lungs and with an increase of endothel

147 ow thoracic lesions, significantly increased bacterial load in lungs.

148 either novel heteroglycan or the LTA reduced bacterial load in mouse liver or kidney tissue.

149 emic infection and significantly reduces the bacterial load in murine organs including the spleen and

150 significantly enhanced survival and reduced bacterial load in several organs.

151 GC-C-/- mice had an increase in C. rodentium bacterial load in stool relative to GC-C+/+.

152 These effects may be achieved by reducing bacterial load in the airways in stable state and/or bro

153 tive in a mouse model of UTI by reducing the bacterial load in the bladder by about 1000-fold.

154 n vivo functional activity by decreasing the bacterial load in the blood and tissues, with IgG2a and

155 ed quantitative index of microbial exposure (bacterial load in the drinking water measured during the

156 iling effect and a greater estimated fall in bacterial load in the higher dosing groups.

157 ry tract infections and did not increase the bacterial load in the livers of mice infected with the i

158 A-targeted carriers significantly diminished bacterial load in the lungs and caused recruitment of T

159 During the first 2 weeks after birth, the bacterial load in the lungs increased, and representatio

160 ucing B cells positively correlated with the bacterial load in the lungs.

161 ipoLLA was able to kill H. pylori and reduce bacterial load in the mouse stomach.

162 impairment in DC functions and an increased bacterial load in the oral cavity.

163 increased inflammatory cell recruitment and bacterial load in the pleural cavity, and heightened lev

164 This effect was associated with increased bacterial load in the spleen, liver, and blood.

165 porphyrin IX to mice resulted in an enhanced bacterial load in various organs and was associated with

166 ppress inflammation and significantly reduce bacterial loads in a high-density Staphylococcus aureus

167 oducing persistent infection with high titer bacterial loads in both the host (up to 10(5) colony-for

168 Hi phagocytosis and increased nasopharyngeal bacterial loads in ccl3(-/-) mice.

169 PCIH restricted mycobacterial growth at high bacterial loads in culture, a property not observed with

170 In contrast to the reduced bacterial loads in GRK5 KO mice following a sublethal do

171 combined treatment led to a decrease in the bacterial loads in infected organs.

172 remia model, as assessed on the basis of the bacterial loads in internal organs and overall lethality

173 l, DeltasapA yielded significantly decreased bacterial loads in liver, spleen and intestine, reduced

174 neutrophil LKB1 deficient mice had increased bacterial loads in lungs from 6 to 40 hours after infect

175 eminated to all tissues tested with greatest bacterial loads in lungs, but also spleen, lymph nodes,

176 p = 0.003), which was associated with higher bacterial loads in lungs, spleen, and blood.

177 Joint bacterial loads in MyD88(-/-) mice were significantly gr

178 on in NKT cells is inversely correlated with bacterial loads in response to bacterial infection, furt

179 This coating also significantly reduced bacterial loads in seedlings grown from contaminated see

180 survival advantage, accompanied by decreased bacterial loads in the blood, lungs, liver, and spleen.

181 ions, with the L154A variant showing reduced bacterial loads in the chronic pneumonia model, while in

182 evere ataxia, which was associated with high bacterial loads in the CNS as well as clear histopatholo

183 Bacterial loads in the gastric tissues were also much hi

184 s of FyuA-specific serum IgG correlated with bacterial loads in the kidneys [Spearman's rank correlat

185 Interestingly, bacterial loads in the lungs are similar early after ino

186 ation of CG combined with NE does not reduce bacterial loads in the lungs of M. tuberculosis-infected

187 increased mortality accompanied by enhanced bacterial loads in the lungs, blood, and distant organs

188 . typhi and develop comparable pathology and bacterial loads in the organs, demonstrating that the pl

189 emented group presented significantly higher bacterial loads in the peri-implant sulcus but significa

190 on, as P2X5-deficient mice exhibit increased bacterial loads in the spleen and liver, increased tissu

191 eudomonas aeruginosa substantially decreased bacterial loads in the wound and prevented the spread of

192 cular fluid do not dramatically reduce total bacterial loads in this in vitro biofilm model, but caus

193 culture and in macrophages, and also reduced bacterial loads in vivo.

194 with a mastitis-causing E. coli strain, the bacterial load increased rapidly, triggering an intense

195 lly infected Smurf1(-/-) mice have increased bacterial load, increased lung inflammation, and acceler

196 WT) mice, as demonstrated by higher systemic bacterial loads, increased organ injury, and impaired su

197 riforme manifesting as a relapsing-remitting bacterial load, interspersed by periods when the organis

198 and soil, 16S rRNA as an indicator of total bacterial load, intI1 as a gene commonly associated with

199 neumonia and otitis), and that high neonatal bacterial load is a key contributor to the development o

200 o associated vertical transmission, and that bacterial load is carried in the seed coat, crease tissu

201 loma function based on three metrics - total bacterial load, macrophage activation levels, and apopto

202 Bacterial load may be a useful biomarker of severity of

203 We evaluated the use of the molecular bacterial load (MBL) assay, for measuring viable Mycobac

204 ation, AT-RvD1-treated mice had reduced NTHi bacterial load, mediated by enhanced clearance by macrop

205 fection treatment with RvD1 and RvD5 reduced bacterial loads, mitigated inflammation, and rescued the

206 ungs and an increased mortality rate without bacterial load modifications in the lungs, indicating th

207 Bacterial loads, MODS, leukopenia, neutrophil infiltrati

208 ture time-to-positivity (TTP; a surrogate of bacterial load), MTB/RIF TB-specific and internal positi

209 Lung injuries were assessed by bacterial load, myeloperoxidase activity, endothelial pe

210 sed enterocyte death resulted in the highest bacterial load observed starting from early adulthood.

211 In vivo, reduced bacterial loads occur in the airways of MRC-1-deficient

212 udy to date providing a comparison of the CT bacterial load of all three anatomic sites estimated by

213 h the MC001 candidate was able to reduce the bacterial load of EHEC O157:H7 strain in feces, colon an

214 Bacterial load of leaves increased significantly over ti

215 seased versus healthy animals, and the total bacterial load of newborn calves at day 3 was higher for

216 reduction of two orders of magnitude in the bacterial load of the rats was observed within a few hou

217 Bacterial loads of Porphyromonas gingivalis, T. forsythi

218 riants on the course of infection and on the bacterial loads of the two variants in the genital tract

219 Compared to the bacterial loads of untreated controls, NALC-NaOH treatme

220 ocesses may lead to the observed increase in bacterial load on the carcass surface in the presence of

221 No such difference in bacterial load or lesion size was detected in galectin-3

222 However, this was independent of bacterial load or variation in PO, providing evidence fo

223 The daily fall in bacterial load over 14 days was 0.176, 0.168, 0.167, 0.2

224 d clinical outcomes, assess the stability of bacterial load over time, and test the hypothesis that r

225 (>/= 12 wk) hyperglycemia features increased bacterial load, overproduction of several cytokines, and

226 Azithromycin did not affect bacterial load (P = 0.37) but did significantly decrease

227 ferences in clinical scores (P >/= 0.440) or bacterial loads (P = 0.736), however, 4/12 (33%) of the

228 Week 12 (62% vs. 38%; P = 0.01) only in high bacterial load patients.

229 d by the assay may be used as a biomarker of bacterial load prior to and during TB treatment.

230 ntrations of LAM in sputum as a biomarker of bacterial load prior to and during treatment in pulmonar

231 cing gut barrier integrity, increasing tumor bacterial load, promoting exhaustion of CD8(+) T cells,

232 hyperalgesia in mice is correlated with live bacterial load rather than tissue swelling or immune act

233 ans, either opsonized or not, with different bacterial load ratios.

234 t SAM has a bacterial origin, with increased bacterial loads, reduced diversity and altered compositi

235 sence of gingival SCCs (gSCCs) increases the bacterial load, reduces bacterial diversity, and renders

236 der more aggressive antimicrobials for rapid bacterial load reduction in high-risk SaB patients.

237 tuberculosis infection in mice (with ~8-fold bacterial load reduction in mouse lungs).

238 y without antibiotics on milk microbiome and bacterial load, respectively.

239 ty14 mice, the increased splenic and hepatic bacterial load resulted from an intrinsic defect in inna

240 In study 3, patients with high bacterial load showed an improvement in the primary endp

241 Coinfection resulted in a bacterial load similar to monospecies infection but with

242 ion on nonerythroid cells (EPOR rescued) had bacterial loads similar to those of wild-type mice follo

243 FQ and compare efficacy by multiple metrics: bacterial load, sterilization rates, early bactericidal

244 ed a relatively high proportion of the total bacterial load, suggesting that routine CF culture may u

245 provided greater reductions of PI, GI, total bacterial load, T. forsythia, A. actinomycetemcomitans,

246 d pendrin knockout (KO) mice had higher lung bacterial loads than infected pendrin-expressing mice bu

247 caused larger lesions and resulted in higher bacterial loads than protease-lacking bacteria.

248 ation results in minimal mortality and lower bacterial loads than thorax inoculation.

249 recruitment early after infection, and lower bacterial loads, than wild-type (WT) mice.

250 The bacterial load that potentially occurs in a sample is th

251 , variation with depth and time of the total bacterial load, the abundance of faecal indicator bacter

252 As a test of bacterial load, the assay produced similar results when

253 nes in serum correlate with increased tissue bacterial loads throughout 4 weeks of infection.

254 cellular cAMP) reduced kidney infection (ie, bacterial load, tissue destruction); this was associated

255 Median bacterial load (TTP in days) was the strongest associate

256 We investigated the absolute bacterial load using qPCR: hemolymph samples contained 2

257 S. epidermidis infections, determination of bacterial load using the qPCR test targeting the tuf gen

258 llenge in Cmah(-/-) mice leads to heightened bacterial loads, virulence, and NanA expression.

259 Measurements and Main Results: Bacterial load was a stable trait associated with worse

260 The nasopharyngeal bacterial load was assessed in naive animals of both str

261 The decline in lung bacterial load was assessed monthly using charcoal-conta

262 Increasing bacterial load was associated with increasing disease se

263 This increase in bacterial load was directly correlated with the density

264 The bacterial load was estimated in sequential sputum sample

265 Bacterial load was greater at seven days postpartum than

266 The bacterial load was higher inside IH implants (P = 0.000)

267 lture was better at capturing organisms when bacterial load was low, and allowed incidental recovery

268 The enhancement of bacterial load was mediated by human CD4(+) cells and as

269 vaccinated mice, a significant reduction in bacterial load was observed in intestinal tissues and th

270 Lastly, total bacterial load was quantitated using quantitative real-t

271 A significantly higher bacterial load was recovered from the vitreous of PLY pa

272 Unexpectedly, bacterial load was reduced.

273 Bacterial load was significantly higher in the mastitis

274 encing-based bacterial detection to absolute bacterial load, we find that the within-host abundance o

275 y, pharmacokinetics of rifampin, and fall in bacterial load were assessed.

276 egatibacter actinomycetemcomitans, and total bacterial load were determined by a real-time polymerase

277 mice were bacteremic, but no differences in bacterial load were identified between wild-type and Vil

278 Clinical disease activity and bacterial load were monitored.

279 The increases in mortality and bacterial load were reversed by a GABAA antagonist, bicu

280 s, T. forsythia, Parvimonas micra, and total bacterial load were significantly higher at peri-implant

281 Bacterial loads were also calculated for 8 bacterial pat

282 es (ITC), amino acids (AA), free sugars, and bacterial loads were analysed throughout the supply chai

283 Bacterial loads were assessed in the lungs and spleen.

284 The bacterial loads were detected in murine blood, spleen, a

285 Lung bacterial loads were not different between the two group

286 , a critical caveat to those results is that bacterial loads were not quantified.

287 Twenty-seven specimens with low bacterial loads were processed by SWGA before sequencing

288 oth WT and Gal3-deficient mice, although the bacterial loads were still higher in the latter.

289 okines and RANKL, as well as the periodontal bacterial load, were quantified by quantitative polymera

290 c lung injury, it resulted in increased lung bacterial load when Akt2(-/-) mice were infected with Ps

291 host and for attaining a threshold level of bacterial load, which is a prerequisite for the onset of

292 in a significant reduction of intracellular bacterial load while host cell viability was restored, s

293 Infection also increased the bacterial load while reducing the abundance of the Archa

294 suggested that a combination of intermediate bacterial loads with low levels TNFalpha administration

295 associated with an increased nasopharyngeal bacterial load, with subsequent development of secondary

296 population and quantify the heterogeneity in bacterial load; with infected badgers shedding between 1

297 acids, which strongly suggests an increased bacterial load within the host tissue, as well as hexosy

298 oplanin in improving survival and decreasing bacterial load within the lungs of rats infected with me

299 isplayed significantly reduced intracellular bacterial loads within human macrophages.

300 the hypothesis that disease severity and/or bacterial loads would be significantly higher in a Type