ライフサイエンスコーパス: bacteriophage

1 nt viruses being those that infect bacteria (bacteriophages).

2 their environment, including their viruses (bacteriophages).

3 opportunistic co-evolution of inhibitors by bacteriophage.

4 ions of at least one ancestral plasmid and a bacteriophage.

5 diverse mechanisms to fend off predation by bacteriophages.

6 higa toxins that are encoded within lambdoid bacteriophages.

7 STING pathway in prokaryotic defence against bacteriophages.

8 lipoproteins promotes resistance to multiple bacteriophages.

9 inal structure of the encapsidated genome in bacteriophages.

10 phage systems and highlight their evasion by bacteriophages.

11 lutionary pressure from their viral invaders-bacteriophages.

12 es, that mediate protection against specific bacteriophages.

13 iability deriving from Bacteroides-targeting bacteriophages.

14 ckish water where it interacts with virulent bacteriophages.

15 is hampered by their apparent similarity to bacteriophages.

16 NA-binding domain related to excisionases of bacteriophages.

17 ding the components of the immune system and bacteriophages.

18 host LPS alterations caused by selection by bacteriophages.

19 tudies, for the detection of diverse unknown bacteriophages.

20 al arrangements influences the adsorption of bacteriophages.

21 creases in viral diversity and proportion of bacteriophages.

22 lations through transmission by transposable bacteriophages.

23 haeal defence systems active against diverse bacteriophages.

24 nter selection by both antibiotics and lytic bacteriophages.

25 , encoded exclusively in the genomes of huge bacteriophages.

26 detect Salmonella using luciferase reporter bacteriophages.

27 on the pathway of antitermination by Q from bacteriophage 21 (Q21): Q21, the Q21-QBE complex, the Q2

28 The mature virion of the tailed bacteriophage 29 is an ~33 MDa complex that contains mor

29 eplate structures of the (DNA-containing) T4 bacteriophage(5).

30 dsRNA genome structure of the tri-segmented bacteriophage 6 of the Cystoviridae family, we show that

31 During morphogenesis of double-stranded DNA bacteriophages, a molecular motor drives the viral genom

32 TF2 and TF6 derived from the tail fibers of bacteriophages AB2 and AB6, can recognize A. baumannii c

33 ood matrix studies, a cocktail of engineered bacteriophages accurately detected 1 CFU in either 25 g

34 For this study, bacteriophages against Clavibacter michiganensis subsp.

35 cter michiganensis subsp. nebraskensis (CN8) bacteriophages against dehydration during storage.

36 Five tailed bacteriophages against K pneumoniae ST258 clade 1 were s

37 obiome in situ through the use of engineered bacteriophages-akin to human gene therapies delivered by

38 ecture very similar to those of other tailed bacteriophages, allowing us to directly compare structur

39 Furthermore, applying this chemistry to bacteriophage allows facile chemical modification of pha

40 (2020) identify harbored bacteriophages among a Proteobacteria-dominant community

41 and assembly of a structural complex from a bacteriophage and a bacterial RNA-synthesizing machine.

42 ommodating for the negative effects of lytic bacteriophage and antibiotic exposure on diagnostic posi

43 lex is an essential player in all aspects of bacteriophage and herpesvirus assembly.

44 The portal proteins of tailed bacteriophage and Herpesvirus capsids form dodecameric r

45 Encoded by bacteriophage and phage-derived bacterial genes, Acrs pr

46 ature spanning January 2007 to March 2019 on bacteriophage and phage-encoded protein therapies of rel

47 ically as V. cholerae O139, lacks the CTXphi bacteriophage and the ability to produce cholera toxin.

48 and the predatory relationship between lytic bacteriophage and the etiologic agent Vibrio cholerae sh

49 stant Klebsiella pneumoniae was treated with bacteriophages and antibiotics.

50 Whilst the use of bacteriophages and antibodies has been partly implemente

51 The genome packaging motor of tailed bacteriophages and herpesviruses is a powerful nanomachi

52 assembly by enabling invasion of biofilms by bacteriophages and intruder cells of different species.

53 Differences between these bacteriophages and other well-described model systems ma

54 uclease, provides bacterial immunity against bacteriophages and plasmids but also serves as a tool fo

55 tems employ the Cas10-Csm complex to destroy bacteriophages and plasmids, using a guide RNA to locate

56 rammed pathways for detecting and destroying bacteriophages and plasmids.

57 ed immunity against genetic invaders such as bacteriophages and plasmids.

58 logists may wish to acquaint themselves with bacteriophages and their antibacterial components and, s

59 ntimicrobial peptides, bacterial antibodies, bacteriophages, and bacterial DNA/RNA hybrid nucleotide

60 ly challenged by foreign invaders, including bacteriophages, and have evolved a variety of defenses a

61 have suggested that DNA is in the B-form in bacteriophages, and our study is a direct visualization

62 l functions; they can serve as receptors for bacteriophages, and provide a substrate for binding of s

63 accharides (CWPSs) act as receptors for many bacteriophages, and their structural diversity among str

64 Bacteriophage are abundant at sites of bacterial infecti

65 Bacteriophages are abundant within the human gastrointes

66 Bacteriophages are being actively explored as therapeuti

67 mechanisms to express dG-free DNA.IMPORTANCE Bacteriophages are in a constant evolutionary struggle t

68 Bacteriophages are the most abundant members of the micr

69 Temperate bacteriophages are viruses that can incorporate their ge

70 cation by the transcription polymerase of T7 bacteriophage as an experimental model, we identify hund

71 linical, and scientific concern is how lytic bacteriophage, as well as antibiotics, impact diagnostic

72 lly in the genomes of organisms ranging from bacteriophages, bacteria, and yeasts to plants and anima

73 ce, using nanoparticle-loaded stem cells and bacteriophage bio-nanowires as a photosensitizer carrier

74 Collectively, these results indicate that bacteriophages can alter mucosal immunity to impact mamm

75 Temperate bacteriophages can enter one of two life cycles followin

76 ber proteins derived from the tail fibers of bacteriophages can recognize specific bacterial surface

77 We show that bacteriophages can specifically target cytolytic E. faec

78 identification and selection of therapeutic bacteriophage candidates against this serious pathogen.

79 a virus-like particle composed of the Qbeta bacteriophage capsid protein encapsulating an immunostim

80 by packaging programmed CRISPR-Cas13a into a bacteriophage capsid to target antimicrobial resistance

81 sure the assembly kinetics of individual MS2 bacteriophage capsids around MS2 RNA.

82 HGT is driven by 2 bacteriophages carried by the resident strain, which cau

83 The Escherichia coli O157:H7 bacteriophage CBA120 genome encodes four distinct tailsp

84 e specificity of three tailspike proteins of bacteriophage CBA120-TSP2, TSP3 and TSP4 (orf211 through

85 method for the rapid enhancement of desired bacteriophage characteristics.

86 tapped enzymatic resources hidden in the bee bacteriophage community.

87 a significant reduction in the proportion of bacteriophages compared with other intestinal viruses.

88 Changes to bacteriophage composition are associated with disease, b

89 ive phases in virus removal and 99.9% of MS2 bacteriophages could be removed.

90 CRISPR-targeted plasmids outnumbered their bacteriophage counterparts by at least fivefold, highlig

91 by lysogenic infection with the filamentous bacteriophage CTXphi.

92 We found that these bacteriophages decrease cytolysin in the liver and aboli

93 gn invaders, including a broadly distributed bacteriophage defense system termed CBASS (cyclic oligon

94 Exploiting bacteriophage-derived homologous recombination processes

95 bacteria, Cas12a enzymes can be inhibited by bacteriophage-derived proteins, anti-CRISPRs (Acrs), to

96 ponse to Chi binding that switch RecBCD from bacteriophage destruction and CRISPR spacer acquisition

97 formance was assessed as a function of lytic bacteriophage detection and exposure to the first-line a

98 One accommodation is using bacteriophage detection as a proxy for pathogen detectio

99 eer a miniature AAV encoding a 465 bp lambda bacteriophage DNA (AAV-lambda465), enabling sequencing o

100 nment of intact 70S ribosomes in filamentous bacteriophage enabled measurement of RDCs in the mobile

101 Some archaeal viruses and bacteriophage encode a potent ring nuclease anti-CRISPR,

102 Bacteriophages encoding anti-CRISPR proteins (Acrs) must

103 Flagellotropic bacteriophages engage flagella to reach the bacterial su

104 nctionality, thereby providing a roadmap for bacteriophage engineering.

105 MP) of a prophage found in the genome of the bacteriophage Enterococcus hirae Mice bearing E. hirae h

106 BREX (for BacteRiophage EXclusion) is a superfamily of common bact

107 ne-bound, cytoplasmic complexes, whereas the bacteriophages exploit sequence-specific "packaging sign

108 aracterization of distinct, highly divergent bacteriophage families.

109 shoviruses are single-stranded, circular DNA bacteriophages found in metagenomic datasets from divers

110 Bacteriophages from active UC patients induced more IFN-

111 re likely conserved among a larger family of bacteriophages from human pathogens implicated in transf

112 ed 71 Bacteroides thetaiotaomicron-infecting bacteriophages from two locations in the United States.

113 b mosquito-borne diseases, (ii) causation by bacteriophage genes, cifA and cifB, that modify sexual r

114 For any given bacteriophage genome or phage-derived sequences in metag

115 rforming long-read assembly of bacterial and bacteriophage genomes and a standalone virtual machine c

116 Bacteriophage genomes rapidly evolve via mutation and ho

117 NanoLuc-expressing bacteriophages had a limit of detection of 10-100 CFU pe

118 e and counterdefense systems of bacteria and bacteriophages has been driving the evolution of both or

119 nt bacteria at an alarmingly increased rate, bacteriophages have been developed as a controlling bioa

120 More recently, plant viruses and bacteriophages have been developed as nanocarriers for d

121 terized, despite the fact that diverse ssDNA bacteriophages have been discovered via metagenomic stud

122 Bacteriophages have been proposed as an alternative to p

123 t's cellular pathways for their replication, bacteriophages have evolved strategies to alter the meta

124 Bacteriophages have in turn evolved inhibitory "anti-CRI

125 Some of these MGEs, including bacteriophages, have in turn evolved different strategie

126 chainmails that ensure the integrity of the bacteriophage head.

127 ost, temperate viruses that infect bacteria (bacteriophages; hereafter referred to as phages) enter e

128 Tailed double-stranded DNA (dsDNA) bacteriophages, herpesviruses, and adenoviruses package

129 merous icosahedral viruses, including tailed bacteriophages, herpesviruses, and archaeal viruses.

130 it and the site of tail attachment; however, bacteriophage HK97 capsid proteins assemble efficiently

131 Although bacteriophages hold great promise as medical tools, clin

132 e structural and biochemical mechanisms of a bacteriophage immunity pathway found in a broad array of

133 ecules activate diverse effectors to mediate bacteriophage immunity via abortive infection.

134 To address how bacteriophages impact bacterial communities in the gut,

135 should translate well to a broad variety of bacteriophage in vitro transcription systems and provide

136 rapidly, and therefore, detection of unknown bacteriophages in sequence datasets is a challenge.

137 t gut is stepwise, first mainly by temperate bacteriophages induced from pioneer bacteria, and later

138 SPO1 bacteriophage infection of Bacillus subtilis results in

139 I CRISPR-Cas systems defend prokaryotes from bacteriophage infection through the acquisition of short

140 es DNA replication forks at late times of T4 bacteriophage infection.

141 NA-guided nucleases to protect bacteria from bacteriophage infection.

142 ptive immune system in prokaryotes to combat bacteriophage infection.

143 ccharides (CPSs), but their contributions to bacteriophage interactions are unknown.

144 romotes CRISPR-Cas adaptive immunity against bacteriophage invasion.

145 M13 bacteriophage is a well-established versatile nano-build

146 Biological control of bacteria with bacteriophages is a viable alternative to antibiotics.

147 rstanding of Wolbachia's mobilome beyond its bacteriophages is incomplete.

148 ic exchange mediated by viruses of bacteria (bacteriophages) is the primary driver of rapid bacterial

149 he vegetative cycle of bacterial viruses, or bacteriophages, is lysis of the host.

150 The long flexible tail tube of bacteriophage lambda connects its capsid to the tail tip

151 Bacteriophage lambda encodes a DNA recombination system

152 Genetic elements in the bacteriophage lambda immunity region contribute to stabl

153 aking is derived from simple models, such as bacteriophage lambda infection, in which lambda chooses

154 ion of natural biological machinery, such as bacteriophage lambda proteins for recombineering and CRI

155 coli, this pathway confers immunity against bacteriophage lambda through an abortive infection mecha

156 ool in 1964, and to study gene regulation in bacteriophage lambda when I was there.

157 Additionally, increasing bacteriophage levels exacerbated colitis via TLR9 and IF

158 ng the steps of Darwinian evolution onto the bacteriophage life cycle and allows directed evolution t

159 ma-associated herpesvirus (KSHV) begins at a bacteriophage-like portal complex that nucleates formati

160 phene oxide, integrated with the filamentous bacteriophage M13, forms a 3D large-scale multifunctiona

161 Whilst attempting to link bacteriophage-mediated transduction to observed gene tra

162 Genome-wide analysis reveals that bacteriophage Mini is distantly related to the known ssD

163 Bacteriophage Mini seems to have lost the spike protein

164 rve any environmental contamination with the bacteriophage MS-2 when bleach solution spray or wipes w

165 Bacteriophage MS2 is a positive-sense, single-stranded R

166 es covalently conjugated to the surface of a bacteriophage MS2 VLP.

167 The target of the fourth Sgl, L from bacteriophage MS2, is still unknown, but we review evide

168 virions of Herpes Simplex Type 1 viruses and bacteriophage MS2.

169 partite BMV viral capsid and the monopartite bacteriophages MS2 and Qbeta for which a dominant RNA co

170 activation of three-human adenovirus and two bacteriophages-MS2 and phiX174-in surface waters and was

171 To be successful, biological control bacteriophages must be stable when exposed to the enviro

172 For successful infection, bacteriophages must overcome multiple barriers to transp

173 Bacteriophages must rapidly deploy anti-CRISPR proteins

174 strains and tested them against novel lytic bacteriophages (n = 65).

175 We report the cocrystal structure of bacteriophage N15 Cro with a symmetric consensus site.

176 Bacteriophages, naturally occurring bacterial viruses, h

177 These patterns are driven by bacteriophages, not eukaryotic viruses.

178 Here, we report that T7 bacteriophage Ocr, a DNA mimic protein that protects the

179 nvestigated the genetic switch of TP901-1, a bacteriophage of Lactococcus lactis, controlled by the C

180 VOH) provided the greatest stability for CN8 bacteriophages on seed when coatings did not contain a s

181 Bacteriophages, or "phages" for short, are viruses that

182 Coexistence of bacteriophages, or phages, and their host bacteria plays

183 Bacteriophage- or prophage-region-encoded anti-CRISPR (a

184 Bacteriophages-or phages-are viruses that infect bacteri

185 ed by equally short sequences of plasmid and bacteriophage origin known as spacers(1-3).

186 We demonstrate the method using bacteriophage oX174, the first DNA genome to be sequence

187 Bacteriophage P22, a paradigm for this class of viruses,

188 Here, we show that in bacteriophage P22, residue W61 at the tip of the E-loop

189 However, for bacteriophage P22, the role of its portal protein in ini

190 Here we identified gp83 of the thermophilic bacteriophage P74-26 as the TerS protein.

191 posed that DNA is not a passive substrate of bacteriophage packaging motors but is instead an active

192 Working with purified PP7 bacteriophage particles small enough to be classifiable

193 We describe for the first time the use of a bacteriophage-peptide display library to identify heptap

194 Bacteriophage (phage) have attractive advantages as deli

195 ve immune systems that protect bacteria from bacteriophage (phage) infection(1).

196 is based on Escherichia coli (E. coli) EV36, bacteriophage (phage) K1F and human cerebral microvascul

197 indicate a rich diversity of uncharacterized bacteriophage (phage) species.

198 evaluated the concept of the application of bacteriophage (phages) to eliminate targeted intestinal

199 Bacteriophages (phages) are critical players in the dyna

200 Bacteriophages (phages) are incredibly abundant and gene

201 Bacteriophages (phages) are the most abundant biological

202 st in utilizing viruses of bacteria known as bacteriophages (phages) as potential antibacterial thera

203 Although bacteriophages (phages) continue to lack drug approval i

204 Bacteriophages (phages) dramatically shape microbial com

205 The use of bacteriophages (phages) for antibacterial therapy is und

206 Use of lytic bacteriophages (phages) for the treatment of drug-resist

207 The application of bacteriophages (phages) is proposed as a highly specific

208 Bacteriophages (phages) may constitute a natural, safe,

209 ine a strategy that harnesses the ability of bacteriophages (phages) to impose strong selection on th

210 re-independent methods capable of connecting bacteriophages (phages) to their target host bacteria wi

211 Viruses that infect bacteria, bacteriophages (phages), are no exception and have evolv

212 Bacteria are under constant attack from bacteriophages (phages), bacterial parasites that are th

213 The viruses that infect bacteria, bacteriophages (phages), must avoid immune pathways that

214 untapped repertoire of bacterial viruses, or bacteriophages (phages), that could be harnessed to comb

215 wn about other microbial components, such as bacteriophages (phages).

216 s the most abundant microbes on Earth, novel bacteriophages (phages; bacteria-specific viruses) are r

217 h on viruses that infect bacteria, known as 'bacteriophages' (phages), has gained importance due to t

218 Pinholin S(21)68 triggers the lytic cycle of bacteriophage phi21 in infected Escherichia coli Activat

219 cal analyses of the C-terminal domain of the bacteriophage phi29 ATPase (CTD) that suggest a structur

220 genotypes of the double-stranded RNA (dsRNA) bacteriophage phi6 (wild type and two isogenic host rang

221 ee RNA viruses, i.e. the double-stranded RNA bacteriophage Phi6, and the positive-sense single-strand

222 r study, we used a tail spike protein from a bacteriophage (PhiAB6TSP) that digests Pse-containing ex

223 Bacteriophages play critical roles in the biosphere, but

224 gained importance due to the potential role bacteriophages play in the resilience and functionality

225 Bacteriophage-polymer coatings which are stable during d

226 Bacteriophage populations also differed depending on whe

227 Bacteriophage PR772, a member of the Tectiviridae family

228 h rhamnan and PSP can increase resistance to bacteriophage predation and that LTA galactosylation alt

229 absence of CPSs, B. thetaiotaomicron escapes bacteriophage predation by altering expression of eight

230 s that allow these bacteria to persist under bacteriophage predation, and hold important implications

231 bacterial pathogens are vulnerable to lytic bacteriophage predation.

232 A custom-made, lytic bacteriophage preparation was administered to the patien

233 CG258-specific bacteriophages primarily targeted the capsule, but succe

234 entified pathogenic roles for filamentous Pf bacteriophage produced by Pseudomonas aeruginosa (Pa) in

235 Here, we assessed the potential for bacteriophage prophylaxis in the context of experimental

236 Tailed, double-stranded DNA bacteriophages provide a well-characterized model system

237 200-fold upon replacement of liposomes with bacteriophage Qbeta virus-like particles that displayed

238 ride was conjugated with a powerful carrier, bacteriophage Qbeta, as a vaccine candidate.

239 Bacteriophages recognize their host cells with the help

240 Prophylactically administered nebulized bacteriophages reduced lung bacterial burdens and improv

241 chromosomal island-like elements (PLEs) are bacteriophage satellites found in Vibrio cholerae.

242 In contrast to previously characterized bacteriophage satellites, expression of the PLE initiati

243 methods rely on sequence similarity to known bacteriophage sequences, impeding the identification and

244 Bacteriophages shape bacterial ecosystems, including com

245 equence similarity, portal structures across bacteriophages share the portal fold and maintain a cons

246 psid proteins of double-stranded DNA (dsDNA) bacteriophages, some archaeal viruses, and the herpesvir

247 assembly of many tailed double-stranded DNA bacteriophages, some archaeal viruses, herpesviruses, an

248 d its interaction with the RNA polymerase of bacteriophage SP6.

249 -atomic resolution cryo-EM structures of the bacteriophage SPP1 procapsid, the intermediate expanded

250 Single-stranded RNA bacteriophages (ssRNA phages) infect Gram-negative bacte

251 Bacteriophages stability when coated on seed depended on

252 re sequenced and CG258 isolates selected for bacteriophage susceptibility testing.

253 ogen-defining serovar antigen, that mediates bacteriophage susceptibility, is necessary and sufficien

254 n in vitro, and when introduced in vivo, the bacteriophage switch is unable to choose the lytic life

255 This research quantifies the uptake of the bacteriophage T4 and the enteric virus echovirus 11 when

256 nd DNA recombination proteins encoded by the bacteriophage T4 genome, plus two homologous DNA molecul

257 The virus bacteriophage T4, from the family Myoviridae, employs an

258 f the symmetry-mismatched portal vertex from bacteriophage T4.

259 The large (90-nm) icosahedral capsid of bacteriophage T5 is composed of 775 copies of the major

260 Using bacteriophage T7 as a model system, we determined cryo-e

261 tion kinetics of the human mitochondrial and bacteriophage T7 DNA polymerases on free-ssDNA, in compa

262 Bacteriophage T7 encodes its own DNA polymerase, the pro

263 In contrast, bacteriophage T7 Pol generates NTS mutations predominant

264 common reaction conditions and components on bacteriophage T7 RNA polymerase (RNAP) activity using a

265 DNA polymerase from bacteriophage T7 undergoes large, substrate-induced conf

266 atomic-resolution insights into contractile bacteriophage tails, bacterial type six secretion system

267 sfer agents (GTAs) are thought to be ancient bacteriophages that have been co-opted into serving thei

268 en studied in-depth, especially in classical bacteriophages that infect Escherichia coli or Salmonell

269 Currently, 32 bacteriophages that infect multiple lineages of roseobac

270 Bacteria, bacteriophages that prey upon them, and mobile genetic e

271 , we investigated the therapeutic effects of bacteriophages that target cytolytic E. faecalis.

272 Here, we report the isolation of several bacteriophages that target E. faecalis strains isolated

273 oxide vapor (HPV) to inactivate MS2 and Phi6 bacteriophages, the latter a recommended surrogate for E

274 Bacteriophages, the most abundant biological entity on E

275 However, the bacteriophages themselves directly stimulated an immune

276 n, and hold important implications for using bacteriophages therapeutically to target gut symbionts.

277 tudies have uncovered a novel means by which bacteriophages thwart host immunity.

278 My life and research has taken me from bacteriophage to Agrobacterium tumefaciens-mediated DNA

279 olutionary pressure by CRISPR-Cas has driven bacteriophage to evolve small protein inhibitors, anti-C

280 nd opportunities associated with engineering bacteriophages to control and manipulate the gut microbi

281 Double-stranded DNA tailed bacteriophages typically code for 50-200 genes, of which

282 Bacteriophages typically have small genomes(1) and depen

283 Tailed bacteriophages use a DNA-packaging motor to encapsulate

284 Bacteriophages use an extensive battery of counter-defen

285 The genome of Escherichia coli O157:H7 bacteriophage vB_EcoM_CBA120 encodes four distinct tails

286 Bacteriophages, viruses that infect bacteria, are the mo

287 Numerous bacteriophages-viruses of bacteria, also known as phages

288 ude several human pathogens as well as dsDNA bacteriophages-viruses that infect bacteria.

289 their invading genetic parasites, including bacteriophages/viruses and plasmids.

290 I, 0.022 to 0.649), respectively, when lytic bacteriophage were detected.

291 Bacteriophages were engineered to express NanoLuc, a nov

292 Nevertheless, genomes of bacteriophages were predicted to infect nearly every maj

293 densely colonizing microorganisms including bacteriophages, which are in dynamic interaction with ea

294 effective control of K pneumoniae CG258 with bacteriophage will require mixes of diverse lytic viruse

295 e, we show time-resolved DNA ejection from a bacteriophage with a contractile tail, the multi-O-antig

296 ssDNA phage isolates and represents the DNA bacteriophage with the least number of ORFs.

297 Leviviruses are bacteriophages with small single-stranded RNA genomes co

298 Myoviruses, bacteriophages with T4-like architecture, must contract

299 These distinct mechanisms equip bacteriophages with tools to evade CRISPR-Cas12a and sup

300 in some capsid-associated proteins in tailed bacteriophages, with which herpesviruses are believed to