ライフサイエンスコーパス: bacteriophage T4

1 f the symmetry-mismatched portal vertex from bacteriophage T4.

2 the B Family replicative DNA polymerase from bacteriophage T4.

3 colleagues test portal rotation models using bacteriophage T4.

4 is critical for homologous recombination in bacteriophage T4.

5 east eight proteins to form the replisome in bacteriophage T4.

6 -damaging agents was described previously in bacteriophage T4.

7 ng candidate for the translocating ATPase in bacteriophage T4.

8 ordination of the broken ends during DSBR in bacteriophage T4.

9 tion are tightly linked in the life cycle of bacteriophage T4.

10 d in vitro using purified factors encoded by bacteriophage T4.

11 esembles that proposed for the tail fibre of bacteriophage T4.

12 nt endonuclease from the double-stranded DNA bacteriophage T4.

13 characterization of the rapid-lysis genes of bacteriophage T4.

14 characterization of a headful nuclease from bacteriophage T4.

15 member of this family is the AsiA protein of bacteriophage T4.

16 ng motor protein, gene product 17 (gp17), in bacteriophage T4.

17 ulting in different triangulation numbers in bacteriophage T4.

18 orm (15)N- and [epsilon-(15)N]lysine-labeled bacteriophage T4.

19 gle-stranded (ss) DNA binding protein of the bacteriophage T4.

20 e baseplate "tail spike" of Escherichia coli bacteriophage T4.

21 macromolecular complex display system using bacteriophage T4.

22 The bacteriophage T4 59 protein (gp59) plays a vital role in

23 The bacteriophage T4 59 protein (gp59) plays an essential ro

24 In bacteriophage T4, a clamp loading pathway that utilizes

25 In bacteriophage T4, a major portion of DNA replication is

26 te the functional role of the D-loop using a bacteriophage T4 ABC protein, Rad50 (gp46).

27 In a process called sigma appropriation, bacteriophage T4 activates a class of phage promoters us

28 The heptameric Gp31 co-chaperonin from bacteriophage T4, an analogue of GroES, was used as a sc

29 ed in this study, gp41 and Dda, are from the bacteriophage T4, an excellent system for studying enzym

30 fically with enzymes encoded by the virulent bacteriophage T4 and 2) its roles in regulating metaboli

31 ingle-stranded DNA-binding protein gp32 from bacteriophage T4 and a strand-displacing DNA polymerase.

32 machines in the double-stranded DNA (dsDNA) bacteriophage T4 and dsRNA bacteriophage varphi12 is con

33 M2, which is similar to the DNA resolvase of bacteriophage T4 and is encoded adjacent to an intron-co

34 al for efficient homologous recombination in bacteriophage T4 and is the functional analog of the euk

35 Double-stranded DNA packaging in bacteriophage T4 and other viruses occurs by translocati

36 The RegA proteins from the bacteriophage T4 and RB69 are translational repressors t

37 is a member of a group of nucleases found in bacteriophage T4 and T5, eubacteria, archaebacteria, yea

38 review, antimutator mutants are discussed in bacteriophage T4 and the bacterium Escherichia coli, wit

39 This research quantifies the uptake of the bacteriophage T4 and the enteric virus echovirus 11 when

40 cation of the spike with similar features in bacteriophages T4 and P22 suggests that the spike might

41 The DNA polymerases (gp43s) of the related bacteriophages T4 and RB69 are B family (polymerase alph

42 exemplified by the B family polymerases from bacteriophages T4 and RB69, not only replicate DNA but a

43 ch on the bacterium Escherichia coli and its bacteriophages T4 and T7 have defined the roles of many

44 The bacteriophage T4 anti-sigma factor AsiA is a molecular s

45 The bacteriophage T4 anti-sigma70 protein, AsiA, binds tight

46 Bacteriophage T4 antisigma protein AsiA (10 kDa) orchest

47 For activation of its middle genes, bacteriophage T4 appropriates Escherichia coli RNA polym

48 a possible dispersal mechanism, we show that bacteriophage T4, archaeal virus Sulfolobus spindle-shap

49 Eight proteins encoded by bacteriophage T4 are required for the replicative synthe

50 ther support the role of the clamp-loader in bacteriophage T4 as a catalyst which loads the clamp ont

51 quantification of Escherichia coli based on bacteriophage T4 as a natural bioreceptor for living bac

52 Bacteriophage T4 AsiA is a homodimeric protein that orch

53 Bacteriophage T4 AsiA is a versatile transcription facto

54 The bacteriophage T4 AsiA protein inhibits transcription fro

55 The bacteriophage T4 AsiA protein is a bifunctional regulato

56 The bacteriophage T4 AsiA protein is a multifunctional prote

57 The bacteriophage T4 AsiA protein is an inhibitor of sigma70

58 Bacteriophage T4 AsiA, a protein of 90 amino acid residu

59 In bacteriophage T4, at least three proteins are required f

60 The bacteriophage T4 ATPase has the greatest similarity to m

61 bound state of the clamp loader complex from bacteriophage T4, bound to an open clamp and primer-temp

62 hotspots have previously been discovered in bacteriophage T4 by two different approaches, marker res

63 Bacteriophage T4 can reproduce in an Escherichia coli nd

64 The bacteriophage T4 capsid (100 x 70 nm) is well suited for

65 cture of the 860-A-diameter isometric mutant bacteriophage T4 capsid has been determined.

66 Bacteriophage T4 capsid heads were found to be statistic

67 Bacteriophage T4 capsid is a prolate icosahedron compose

68 Bacteriophage T4 capsid is an elongated icosahedron deco

69 By both genetic and biochemical criteria, bacteriophage T4 catalyzes replication repair with two a

70 on are revealed by new crystal structures of bacteriophage T4 clamp loader-clamp-DNA complexes that c

71 The mechanism by which the trimeric bacteriophage T4 clamp protein (the 45 protein) loads an

72 ed fluorescence spectroscopy of the trimeric bacteriophage T4 clamp protein labeled across its three

73 elicase-primase (primosome) component of the bacteriophage T4-coded DNA replication complex.

74 nstruct with a nonprocessive, weakly binding bacteriophage T4-coded helicase hexamer initiation compl

75 elicase (gp41) subunits interact to form the bacteriophage T4-coded primosome at the DNA replication

76 Bacteriophage T4 controls its development in this way us

77 UvsW protein from bacteriophage T4 controls the transition from origin-dep

78 Compared to previous published structures of bacteriophage T4 Dam, three major new observations are m

79 Bacteriophage T4 Dda helicase has recently been shown to

80 In order to understand the mechanism of the bacteriophage T4 Dda helicase, the potential requirement

81 s approach to address this question with the bacteriophage T4 Dda helicase.

82 that a 15mer PNA strand does not bind to the bacteriophage T4 Dda helicase.

83 of nick sealing by both ASFV DNA ligase and bacteriophage T4 DNA ligase was determined in the steady

84 Ligation experiments using bacteriophage T4 DNA ligase were carried out with purine

85 A commonly used enzyme for this reaction is bacteriophage T4 DNA ligase, which requires ATP as the e

86 Bacteriophage T4 DNA metabolism is largely insulated fro

87 The bacteriophage T4 DNA packaging machine consists of a mol

88 to measure the binding interactions between bacteriophage T4 DNA polymerase (gp43) and various model

89 nt are compared to that of the high-fidelity bacteriophage T4 DNA polymerase and reveal distinct diff

90 site an abasic site are measured between the bacteriophage T4 DNA polymerase and the Klenow fragment.

91 This report uses the bacteriophage T4 DNA polymerase as a model to probe the

92 ive DNA synthesis reactions catalyzed by the bacteriophage T4 DNA polymerase holoenzyme are initiated

93 , and the clamp loader (gp44/62) to form the bacteriophage T4 DNA polymerase holoenzyme is a multiste

94 The bacteriophage T4 DNA polymerase holoenzyme is composed o

95 The bacteriophage T4 DNA polymerase holoenzyme, consisting o

96 ty DNA polymerases such as pol delta and the bacteriophage T4 DNA polymerase replicating 8-oxo-G in a

97 mechanism for the observed autoregulation of bacteriophage T4 DNA polymerase synthesis by binding to

98 we quantify the ability of the high-fidelity bacteriophage T4 DNA polymerase to incorporate various p

99 in probing the ability of the high-fidelity bacteriophage T4 DNA polymerase to replicate this class

100 Previous kinetic studies of the bacteriophage T4 DNA polymerase using a series of non-na

101 f translesion DNA synthesis catalyzed by the bacteriophage T4 DNA polymerase was quantitatively evalu

102 the interaction of the COOH terminus of the bacteriophage T4 DNA polymerase with its trimeric, circu

103 enzymes possessing 3'-exonuclease activity: bacteriophage T4 DNA polymerase, Escherichia coli DNA po

104 Using the bacteriophage T4 DNA polymerase, we have measured the in

105 ating and nontemplating DNA catalyzed by the bacteriophage T4 DNA polymerase.

106 rporation into normal and damaged DNA by the bacteriophage T4 DNA polymerase.

107 Bacteriophage T4 DNA replication proteins catalyze compl

108 A reconstituted in vitro bacteriophage T4 DNA replication system was studied on a

109 In the bacteriophage T4 DNA replication system, T4 gene 59 prot

110 In the bacteriophage T4 DNA replication system, T4 RNase H remo

111 o study the initiation and regulation of the bacteriophage T4 DNA replication system.

112 mbly pathway of the primosome complex of the bacteriophage T4 DNA replication system.

113 Three structures are described for bacteriophage T4 DNA-adenine methyltransferase (T4Dam) i

114 Bacteriophage T4 effects host lysis with a holin, T, and

115 Tailed bacteriophage T4 employs one of the fastest and most pow

116 The bacteriophage T4-encoded activator, MotA, is one such fa

117 vivo assay for the inhibitory effect of the bacteriophage T4-encoded anti-sigma factor AsiA on sigma

118 The association of the bacteriophage T4-encoded AsiA protein with the final sig

119 The PDG enzyme is a homologue of the bacteriophage T4-encoded endonuclease V.

120 The bacteriophage T4-encoded RegB endoribonuclease is produc

121 nsists of a DNA-binding protein fused to the bacteriophage T4-encoded transcription regulator AsiA.

122 be required for the 3'-maturation of certain bacteriophage T4-encoded tRNAs, was overexpressed and pu

123 The td intron of bacteriophage T4 encodes a DNA endonuclease that initiat

124 Bacteriophage T4 encodes a transcription factor, MotA, t

125 Bacteriophage T4 encodes almost all of the proteins requ

126 inct properties have been characterized from bacteriophages (T4 endo VII, T7 endo I, RusA and Rap), B

127 erial and eukaryotic lysyl-tRNA synthetases, bacteriophage T4 endonuclease VII, and several uncharact

128 Here, we show that the bacteriophage T4 enzymes RNA ligase 1 and polynucleotide

129 The mechanisms of recombinational repair in bacteriophage T4, Escherichia coli, and Saccharomyces ce

130 bers of the RecA family of recombinases from bacteriophage T4, Escherichia coli, yeast, and higher eu

131 between the human Ad type 5 (Ad5) fiber and bacteriophage T4 fibritin proteins, has resulted in the

132 Gene product (gp) 24 of bacteriophage T4 forms the pentameric vertices of the ca

133 The virus bacteriophage T4, from the family Myoviridae, employs an

134 Translational initiation region of bacteriophage T4 gene 25 contains three potential Shine

135 Escherichia coli SSB and bacteriophage T4 gene 32 protein (gp32) completely faile

136 Bacteriophage T4 gene 32 protein (gp32) is a single-stra

137 Bacteriophage T4 gene 32 protein (gp32) is a single-stra

138 Bacteriophage T4 gene 32 protein (gp32) is a well-studie

139 Bacteriophage T4 gene 32 protein (gp32) specifically bin

140 igonucleotides bound to intact and truncated bacteriophage T4 gene 32 protein have been elucidated by

141 Bacteriophage T4 gene 32 protein, a model for single-str

142 The bacteriophage T4 gene 59 helicase assembly protein is re

143 Bacteriophage T4 gene 59 helicase loading protein accele

144 Bacteriophage T4 gene 59 protein greatly stimulates the

145 mRNA between the two open reading frames of bacteriophage T4 gene 60 in order to synthesize a topois

146 A 50-nucleotide coding gap divides bacteriophage T4 gene 60 into two open reading frames.

147 bosomes bypass a 50 nucleotide coding gap in bacteriophage T4 gene 60 mRNA between codons 46 and 47 i

148 Ribosomes translating bacteriophage T4 gene 60 mRNA bypass 50 noncoding nucleo

149 his puzzling phenomenon is expression of the bacteriophage T4 gene 60.

150 und in the two open reading frames (ORFs) of bacteriophage T4 gene 60.

151 Two new, small, early bacteriophage T4 genes, repEA and repEB, located within

152 nd DNA recombination proteins encoded by the bacteriophage T4 genome, plus two homologous DNA molecul

153 licated in the replication and repair of the bacteriophage T4 genome.

154 Production of wild-type bacteriophage T4 Gp39.2, a 58-amino-acid protein, (a) en

155 investigations of the solution structure of bacteriophage T4 gp45 by analytical ultracentrifugation,

156 yme contact polymerase by DNA looping, while bacteriophage T4 gp45 functions as a sliding clamp that

157 The sliding clamps of bacteriophage T4 (gp45), Escherichia coli (beta clamp),

158 The Mre11-Rad50 complex (MR) from bacteriophage T4 (gp46/47) is involved in the processing

159 Bacteriophage T4 gp59 helicase assembly protein (gp59) i

160 Bacteriophage T4 has a very efficient mechanism for infe

161 Bacteriophage T4 has an efficient mechanism for injectin

162 The DNA replication complex of bacteriophage T4 has been assembled as a single unit on

163 The structure and assembly of bacteriophage T4 has been extensively studied.

164 The bacteriophage T4 has long served as a model for the stud

165 n and recombination in the DNA metabolism of bacteriophage T4 has moved into the spotlight with its c

166 Dda helicase from bacteriophage T4 has served as an excellent model for un

167 The bacteriophage T4 has served as an in vitro model for the

168 The three-dimensional structure of mature bacteriophage T4 head has been determined to 22-A resolu

169 aI can function as a monomer, similar to the bacteriophage T4 helicase, Dda.

170 were designed to serve as substrates for the bacteriophage T4 helicase, Dda.

171 ed the ssDNA-stimulated ATPase activity of a bacteriophage T4 helicase, Dda.

172 ly pathway and DNA unwinding activity of the bacteriophage T4 helicase-primase (primosome) complex.

173 In bacteriophage T4, helicase and primase are separate poly

174 ormation about the solution structure of the bacteriophage T4 holoenzyme.

175 Bacteriophage T4 homologous recombination events are pro

176 In the bacteriophage T4 homologous recombination system, presyn

177 In bacteriophage T4, homologous genetic recombination event

178 Helper T-cell epitopes in bacteriophage T4 Hsp10 have been mapped by restimulation

179 Three variants of the bacteriophage T4 Hsp10 were constructed with deletions i

180 We show that replication of bacteriophage T4 in cells expressing the mutA allele of

181 ated the genomes of several relatives of the bacteriophage T4, including three coliphages (RB43, RB49

182 ased physical assay that measures SSA during bacteriophage T4 infection and apply this assay to the g

183 Bacteriophage T4 infection ultimately reduces this compe

184 Bacteriophage T4 infects the bacterial host (Escherichia

185 Bacteriophage T4 initiates origin-dependent replication

186 Bacteriophage T4 is a large-tailed Escherichia coli viru

187 The UvsX protein from bacteriophage T4 is a member of the RecA/Rad51/RadA fami

188 The contractile tail of bacteriophage T4 is a molecular machine that facilitates

189 The head of bacteriophage T4 is a prolate icosahedron with one uniqu

190 The head of bacteriophage T4 is decorated with 155 copies of the hig

191 Bacteriophage T4 is decorated with 155 copies of the hig

192 The clamp loader complex (CLC) of bacteriophage T4 is essential for viability and has anal

193 The UvsW protein of bacteriophage T4 is involved in many aspects of phage DN

194 Mutation of the zinc-hook in bacteriophage T4 is lethal, indicating the ability to bi

195 The distal-half tail fiber of bacteriophage T4 is made of three gene products: trimeri

196 The gene product 60 (gp60) of bacteriophage T4 is synthesized as a single polypeptide

197 The gene 32 protein (gp32) of bacteriophage T4 is the essential single-stranded DNA (s

198 dies show that the N-terminal ATPase site of bacteriophage T4 large terminase protein gp17 is critica

199 Activated transcription of the bacteriophage T4 late genes is generated by a mechanism

200 Transcription of bacteriophage T4 late genes requires concomitant DNA rep

201 55 protein (gp55), the sigma protein of the bacteriophage T4 late genes, is one of the smallest and

202 Activated transcription of the bacteriophage T4 late genes, which is coupled to concurr

203 ins participate directly in transcription of bacteriophage T4 late genes: the sigma-family protein gp

204 Bacteriophage T4 late promoters consist solely of an ext

205 Bacteriophage T4 late promoters, which consist of a simp

206 Bacteriophage T4, like all other viruses, is required to

207 Bacteriophage T4-like networks of highly branched mp1 co

208 Bacteriophage T4 Lysozyme (T4L) catalyzes the hydrolysis

209 ier that the mutation of Leu99 to alanine in bacteriophage T4 lysozyme creates an internal cavity of

210 By introducing cysteines at locations where bacteriophage T4 lysozyme molecules contact each other i

211 Transcriptional activation of bacteriophage T4 middle promoters requires sigma70-conta

212 Transcription from bacteriophage T4 middle promoters uses Escherichia coli

213 Bacteriophage T4 middle-mode transcription requires two

214 Using a bacteriophage T4 model system, we have developed a novel

215 Using a bacteriophage T4 model system, we have previously shown

216 based on recently resolved structures of the bacteriophage T4 motor protein gp17 suggests that this m

217 The bacteriophage T4 motor, a pentamer of the large terminas

218 ies of C-terminal deletions and mutations in bacteriophage T4 Mre11.

219 lf of the ribosomes translating a particular bacteriophage T4 mRNA bypass a region of 50 nt, resuming

220 which is formed during replication from the bacteriophage T4 origin, ori(34).

221 tant-frequency phenotype) were discovered in bacteriophage T4 over three decades ago, but there is on

222 We observed that a single bacteriophage T4 packaging machine can package multiple

223 Recent structural studies of the bacteriophage T4 packaging motor have led to a proposed

224 Gene 3 of bacteriophage T4 participates at a late stage in the T4

225 The gene 59 protein (gp59) of bacteriophage T4 performs a vital function in phage DNA

226 ilar to the hexameric building blocks of the bacteriophages T4, phi29, P22, and HK97.

227 The bacteriophage T4 PinA protein inhibited degradation of [

228 The bacteriophage T4 PinA protein, expression of which leads

229 The Gp59 protein of bacteriophage T4 plays critical roles in recombination-d

230 d extracts by addition of human PNK, but not bacteriophage T4 PNK.

231 ding mode of CthPnk is distinct from that of bacteriophage T4 Pnk.

232 study further defines the dynamic process of bacteriophage T4 polymerase holoenzyme assembly.

233 idle turnover measurements confirm that the bacteriophage T4 polymerase more stably incorporates 5-N

234 Here we report the structure of the bacteriophage T4 portal assembly, gene product 20 (gp20)

235 To examine bacteriophage T4 portal functions, we constructed, expre

236 Assembly of the bacteriophage T4 primosome on individual molecules of ss

237 Bacteriophage T4 produces a GroES analogue, gp31, which

238 The Gp59 protein of bacteriophage T4 promotes DNA replication by loading the

239 electron microscopy of DNA replicated by the bacteriophage T4 proteins showed a single complex at the

240 Bacteriophage T4 provides a useful model system for diss

241 Bacteriophage T4 provides an important model system for

242 Bacteriophage T4 pyrimidine dimer glycosylase (T4-Pdg) i

243 lyases and the structural information on the bacteriophage T4 pyrimidine dimer glycosylase (T4-pdg),

244 cted mutations to perturb this domain in the bacteriophage T4 Rad50 homolog.

245 f, four of its five residues were mutated in bacteriophage T4 Rad50, and their respective ATPase and

246 In the bacteriophage T4, Rad50 (gene product 46) enhances the n

247 function and showed that homologs of 39.2 in bacteriophages T4, RB43, and RB49 similarly modulate Gro

248 Recent single-molecule studies of bacteriophage T4 recombination proteins revealed that, s

249 During infection, bacteriophage T4 regulates three sets of genes: early, m

250 ics of translesion DNA replication using the bacteriophage T4 replication apparatus as a model system

251 The bacteriophage T4 replication complex is composed of eigh

252 1WT) and mutant (gp41delta C20) forms of the bacteriophage T4 replication helicase.

253 In vitro reconstitution of the bacteriophage T4 replication machinery provides a novel

254 were reconstituted using the eight purified bacteriophage T4 replication proteins and synthetic circ

255 d template or lagging strand template on the bacteriophage T4 replisome.

256 The bacteriophage T4 requires its own version of GroES, gp31

257 Bacteriophage T4 RNA ligase (gp63) is the best-studied m

258 Bacteriophage T4 RNA ligase 2 (Rnl2) exemplifies a polyn

259 Here we report that bacteriophage T4 RNA ligase 2 (Rnl2) is an efficient cat

260 g compounds against the most closely related bacteriophage T4 RNA ligase 2, as well as against human

261 Bacteriophage T4 RNase H belongs to a family of prokaryo

262 Bacteriophage T4 RNase H, a flap endonuclease-1 family n

263 The bacteriophage T4 rnh gene encodes T4 RNase H, a relative

264 RNA ligase type 1 from bacteriophage T4 (Rnl1) is involved in countering a host

265 The t protein of bacteriophage T4 shares with other holins the ability to

266 mobile loop in Hsp10s from mycobacteria and bacteriophage T4 suggests that the mobile loop facilitat

267 for this pathway is endonuclease V from the bacteriophage T4 (T4 bacteriophage pyrimidine dimer glyc

268 ase excision by the 3' --> 5' exonuclease of bacteriophage T4 (T4 pol) was examined.

269 Bacteriophage T4 tail fibers have a quaternary structure

270 Contraction of the bacteriophage T4 tail in the act of host cell penetratio

271 A hexamer of the bacteriophage T4 tail terminator protein, gp15, attaches

272 Functional domains of the bacteriophage T4 terminase and portal gene 20 product (g

273 ith gp17, the large catalytic subunit of the bacteriophage T4 terminase.

274 MotA is a transcription factor from bacteriophage T4 that helps adapt the host Escherichia c

275 In bacteriophage T4, the motor consists of the portal prote

276 In bacteriophage T4, the primase (gp61) interacts with the

277 In bacteriophage T4, the terminase complex constituted by t

278 In bacteriophage T4, there is a baseplate, which is a multi

279 ich confers resistance to a dmd(-) mutant of bacteriophage T4 through the activity of the LsoA toxin.

280 From bacteriophage T4 to eukaryotes, these factors include a

281 During infection, the bacteriophage T4 transcriptional activator MotA, the co-

282 Finally, the peptides inhibit the bacteriophage T4 type II topoisomerase and several restr

283 The contractile tail of bacteriophage T4 undergoes major structural transitions

284 The replication system of bacteriophage T4 uses a trimeric ring-shaped processivit

285 Bacteriophage T4 uses two modes of replication initiatio

286 During infection of Escherichia coli, bacteriophage T4 usurps the host transcriptional machine

287 Bacteriophage T4 UvsW helicase contains both unwinding a

288 Bacteriophage T4 UvsY is a recombination mediator protei

289 ilarity of Escherichia coli RecO protein and bacteriophage T4 UvsY protein to eukaryotic Rad52 protei

290 rs insights into the architectural design of bacteriophage T4 virion, one of the most stable viruses

291 The primosome helicase of bacteriophage T4 was assembled from six (gp41) helicase

292 Bacteriophage T4 was covalently immobilized on optical f

293 The gene product 61 primase protein from bacteriophage T4 was expressed as an intein fusion and p

294 Dda helicase, from bacteriophage T4, was able to unwind the DNA-PNA substra

295 amp-loading in the DNA replication system of bacteriophage T4, we report the results of a series of p

296 e (BGT) is a DNA-modifying enzyme encoded by bacteriophage T4 which catalyses the transfer of glucose

297 The class includes AsiA form bacteriophage T4, which inhibits Escherichia coli sigma

298 the recombination mediator protein (RMP) of bacteriophage T4, which promotes homologous recombinatio

299 The 9-kDa outer capsid protein (Soc) of bacteriophage T4, which stabilizes the virus, attaches t

300 he baseplate protein gene product (gp) 10 of bacteriophage T4, whose structure was determined to 1.2