ライフサイエンスコーパス: barbiturate

1 to physiological dependence on alcohol and a barbiturate.

2 AA Rs) by photolabelling with an anaesthetic barbiturate.

3 of inhibition, may be important targets for barbiturates.

4 f compounds, including the neurosteroids and barbiturates.

5 blocking GABA(A) receptors and was slowed by barbiturates.

6 functional features previously observed for barbiturates.

7 se particular residues, as already shown for barbiturates.

8 l and medicinally relevant bi- and tricyclic barbiturates.

9 latile anesthetics, etomidate, propofol, and barbiturates.

10 out the structural rearrangements induced by barbiturates.

11 arious barbiturate anions such as the parent barbiturate, 1,3-dimethylbarbiturate, 2-thiobarbiturate,

12 sized enantiomers of a novel, photoactivable barbiturate, 1-methyl-5-propyly-5-(m-trifluoromethyldiaz

13 d in detergent with [(3)H]azietomidate and a barbiturate, [(3)H]R-mTFD-MPAB, photoreactive anesthetic

14 ms involving therapeutic use were lowest for barbiturates (6.3%), benzodiazepines (11.1%), nonopioid

15 The guanidine barbiturate 7e (3,5-di-Br) demonstrated promising in viv

16 nic acetylcholine receptor (nAChR), in which barbiturates act as noncompetitive antagonists.

17 nthase inhibitor oligomycin, indicating that barbiturates act by inhibiting electron transport suffic

18 e agonists, an inverse agonist, as well as a barbiturate agonist.

19 d a rapid block of currents activated by the barbiturate alone or by the barbiturate in the presence

20 Decerebrate unanaesthetized or barbiturate-anaesthetized preparations were used.

21 )) and saline-treated control hemispheres of barbiturate-anaesthetized, critical-period kittens (n =

22 Each of the barbiturate analogs inhibited the binding of [(3)H]tetra

23 he Torpedo californica nAChR and a series of barbiturate analogs to characterize the barbiturate bind

24 Likewise, 17PA did not affect barbiturate and benzodiazepine potentiation.

25 Barbiturates and benzodiazepine receptor agonists, for e

26 atments, including sedative anticonvulsants (barbiturates and benzodiazepines) and ECT.

27 ess central nervous system function, such as barbiturates and benzodiazepines, results in the product

28 many known modulators of GABA(A)Rs, such as barbiturates and benzodiazepines.

29 In both groups, stage 3 treatments (barbiturates and decompressive craniectomy) were used if

30 y drugs, such as the benzodiazepines (BDZs), barbiturates and ethanol.

31 iety of compounds including benzodiazepines, barbiturates and neuroactive steroids.

32 Barbiturates and neurosteroids augment GABA-currents and

33 nd yielded strong maximum effects similar to barbiturates and neurosteroids.

34 ventional bonded phase for the separation of barbiturates and phenylthiohydantoin amino acids (PTH-am

35 g by allosteric GABAergic modulators such as barbiturates and steroid anesthetics have provided insig

36 tentiating effects (like benzodiazepines and barbiturates), and interactions with dopamine transporte

37 he positive genetic correlations among EtOH, barbiturate, and benzodiazepine withdrawal.

38 Agents such as chloral hydrate, barbiturates, and benzodiazepines that have been used fo

39 ry drugs such as the benzodiazepines (BDZs), barbiturates, and ethanol.

40 We show here that general anesthetics, barbiturates, and local anesthetics all display the same

41 anesthetics, including etomidate, propofol, barbiturates, and neuroactive steroids, as well as volat

42 ic modulation by agents such as anesthetics, barbiturates, and neurosteroids, the cellular mechanisms

43 resence of antidepressants, benzodiazepines, barbiturates, and opiates was more common among clinicia

44 ng high individual doses of benzodiazepines, barbiturates, and propofol.

45 diazepines, antidepressants, antipsychotics, barbiturates, and sleep medications).

46 The results indicate that BZDs, barbiturates, and steroids, as well as GABA itself, are

47 drug proguanil, certain antidepressants and barbiturates, and the prototype substrate S-mephenytoin.

48 ed by anesthetic concentrations of propofol, barbiturates, and the volatile agent isoflurane, at low

49 of GABARs to regulation by benzodiazepines, barbiturates, and Zn2+.

50 ent depending on the ligand, indicating that barbiturate- and GABA-induced channel gating, antagonist

51 ailed to control RSE, the evidence points to barbiturate anesthesia as the next frequently used optio

52 Male rats under barbiturate anesthesia were used to determine whether ne

53 Under barbiturate anesthesia, pigs underwent placement of a) a

54 tensity, could not be obtained in rats under barbiturate anesthesia.

55 acid (R-mTFD-MPAB), a potent stereospecific barbiturate anesthetic, to photolabel expressed human al

56 Propofol, etomidate, and barbiturate anesthetics are allosteric coagonists at pen

57 ty, we recorded intracellularly in vivo from barbiturate anesthetized rats while increasing the veloc

58 In barbiturate anesthetized rats, microinjection of agonist

59 rized superficial dorsal horn neurons in the barbiturate-anesthetized cat spinal cord, and to determi

60 ts in response to 300 ms tones in the LSO of barbiturate-anesthetized cats using detection theory.

61 cordings in vivo in the barrel cortex of the barbiturate-anesthetized rat.

62 dynamic range and nociceptive specific) from barbiturate-anesthetized rats that were non-inflamed or

63 In seven barbiturate-anesthetized rats, 16 vasomotor presympathet

64 e constants (k2) of the reactions of various barbiturate anions such as the parent barbiturate, 1,3-d

65 The nucleophilic reactivities of barbiturate anions were compared with those of structura

66 The reactivity parameters N and sN of the barbiturate anions were derived from the linear plots of

67 We report that a barbiturate anticonvulsant, phenobarbital, alleviates th

68 Most barbiturates are anaesthetics but a few unexpectedly are

69 Most barbiturates are anaesthetics but unexpectedly a few are

70 Barbiturates are common targets for molecular recognitio

71 The work shows that MMP-inhibitory barbiturates are suitable scaffolds for hybrid design, t

72 Barbiturates are widely used as anesthetics, anticonvuls

73 also be extended to prepare thiazole-linked barbiturates as well as imidazole-linked pyrazoles.

74 o general anesthetics and, as shown here, to barbiturates, at clinically relevant concentrations.

75 However, all of the barbiturates attenuated NMDA-induced calcium elevations

76 We describe a new type of barbiturate-based matrix metalloproteinase (MMP) inhibit

77 UT-1 mediated transport, are consistent with barbiturates being noncompetitive inhibitors of Glc tran

78 GABARs are regulated by numerous positive (barbiturates, benzodiazepines, and neurosteroids) and ne

79 receptor distinct from that interacting with barbiturates, benzodiazepines, and steroids.

80 Drug type, including amphetamines, barbiturates, benzodiazepines, cannabis, cocaine, fentan

81 To investigate how electronic effects impact barbiturate binding in bifurcated Hamilton receptors, a

82 Characteristics of the barbiturate binding site on the resting nAChR include: (

83 es helped us unambiguously identify a unique barbiturate binding site within the central ion channel

84 s of barbiturate analogs to characterize the barbiturate binding site(s) on this superfamily member.

85 esthetic that is well-suited for identifying barbiturate binding sites on Cys-loop receptors.

86 Interactions with these two classes of barbiturate binding sites on GABAA Rs underlie the enant

87 Benzodiazepines (BZ) and barbiturates both potentiate chloride currents through G

88 dy, we present the first X-ray structures of barbiturates bound to GLIC, a cationic prokaryotic pLGIC

89 steroid anesthetic, reduced sensitivity to a barbiturate, but not propofol.

90 ite of GABA(A) receptors are much safer than barbiturates, but are still liable to abuse.

91 However, unlike barbiturates BZ do not impair autonomic control of heart

92 pentobarbital induces complete uncoupling of barbiturate-BZD site interactions, partial uncoupling of

93 prepared and studied an analogous series of barbiturate C5-alkyl alcohols that were unable to releas

94 ve use of medications containing opioids and barbiturates, caffeine overuse, stressful life events, d

95 Decompressive craniectomy and barbiturate coma are often used as second-tier strategie

96 <20 mm Hg once the conventional therapy and barbiturate coma as outlined above failed to control int

97 of the time and was more cost-effective than barbiturate coma in 78% of cases if our willingness-to-p

98 consultations, mannitol use, treatment with barbiturate coma, decompressive craniectomy, number of n

99 1.5 quality-adjusted life years relative to barbiturate coma, with an incremental cost-effectiveness

100 res decreased in those patients treated with barbiturate coma.

101 alue in terms of costs and health gains than barbiturate coma.

102 nt strategies: decompressive craniectomy and barbiturate coma.

103 ntre trial is currently comparing it against barbiturate coma.

104 Barbiturates completly blocked alpha1G currents with pot

105 ach potentiated NMDA-induced neuron death at barbiturate concentrations relevant to clinical and expe

106 k of NMDA-induced current flux at millimolar barbiturate concentrations.

107 These N,N'-dialkylated-5,5-disubstituted barbiturates consist of an achiral barbiturate scaffold

108 Several derivatives of barbiturates containing anomalous scatterers were synthe

109 AR-null cells indicating that FMR-Red-Dye, a barbiturate derivative, activates GABAAR-mediated outwar

110 phore to nitroalkenes, delivering the chiral barbiturate derivatives in high yields and high enantios

111 ahydrofurans and spirocyclic tetrahydrofuran-barbiturate derivatives.

112 lude that the sites for binding steroids and barbiturates do not overlap with the GABA-binding site.

113 d the interactions of gender, adult age, and barbiturate dose on the course of phenobarbital inductio

114 ts into the regulation of gene expression by barbiturate drugs.

115 ptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure rec

116 iturates on NMDA neurotoxicity and show that barbiturate effects on neuronal mitochondria can be func

117 On the basis of the barbiturate effects we propose a model for the action of

118 It is notably unknown whether the barbiturate electron acceptor group retains the pharmaco

119 de benzodiazepine sedatives and anxiolytics, barbiturates, endogenous and synthetic neurosteroids, an

120 ls, chromanes, cyclopentanoids, amino acids, barbiturates, etc., novel synthetic strategies emerge th

121 The structural heterogeneity of barbiturate, etomidate, and propofol derivatives is acco

122 Benzodiazepines (BZDs), anesthetics, and barbiturates exert their CNS actions by binding to GABA(

123 efold increase in the incidence of tumors in barbiturate-exposed rats of both sexes and a three- to f

124 mer concentration increases, selectivity for barbiturate extraction over other cyclic imides becomes

125 rs exhibit high selectivity and affinity for barbiturate guests, relatively few of these systems have

126 nesthetics, isomers of anesthetic ethers and barbiturates have been discovered that act as convulsant

127 When both midazolam and barbiturates have failed, use of isoflurane or ketamine

128 lton's bis(acetamidopyridinyl)isophthalamide-barbiturate hydrogen-bonding host-guest complexes are se

129 zing escalating bolus doses of diazepam, and barbiturates if necessary, significantly reduced the nee

130 activated by the barbiturate alone or by the barbiturate in the presence of 1 microM GABA.

131 arbonyls by SmI2-H2O, convert simple achiral barbiturates in one step to hemiaminal- or enamine-conta

132 ng rhodamine-123 under quenching conditions, barbiturates in this concentration range were shown to d

133 nity complexes of phenobarbital antibody and barbiturates, including the sequential loading, washing,

134 Barbiturates induce anesthesia by modulating the activit

135 he antagonistic effect of the peptide on the barbiturate-induced anesthesia (measure of the activatio

136 Barbiturate-induced anesthesia is a complex mechanism th

137 l voltage imaging of mice transitioning from barbiturate-induced anesthesia to wakefulness (N = 5) an

138 Barbiturate-induced mitochondrial depolarization was inc

139 In contrast, the same low dose of barbiturate inducing an equal percent increase in CYP2B2

140 ing medical treatment with the option to add barbiturate infusion (medical group).

141 th millimolar affinity, whereas propofol and barbiturates inhibit binding but do not bind in a mutual

142 Barbiturates inhibit GLUT-1 mediated hexose transport bo

143 In the present study, the mechanism by which barbiturates inhibit GLUT-1 mediated hexose transport wa

144 omidate in the alpha4 and beta3 subunits and barbiturate-inhibitable labeling by [(3)H]R-mTFD-MPAB in

145 binding site sheds light on the mechanism of barbiturate inhibition of cationic pLGICs and allows the

146 CF(3) and Et (BITE) in a series of modified barbiturate inhibitors.

147 t a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of smal

148 thin the channel, the pyrimidine ring of the barbiturate is located just above the highly conserved l

149 outine use of hyperventilation and high-dose barbiturates is no longer recommended.

150 For example, the barbiturate isobarbital [5-ethyl-5'-(2-methylbutyl) barb

151 ABAA receptor complex to control levels in a barbiturate-like fashion.

152 lecule adamantane, which prefers the TID (or barbiturate) locus instead of the TCP site.

153 were rechallenged with a nominal dose of the barbiturate, males and females neonatally exposed to phe

154 However, barbiturates may also inhibit mitochondrial respiration,

155 Overall, these results imply that barbiturates may more strongly inhibit GLUT-1 mediated G

156 We propose, therefore, that barbiturates may prevent or alter the conformational cha

157 -elements that are thought to be involved in barbiturate-mediated induction of CYP genes.

158 In multivariate models, use of barbiturates, meprobamates, phenothiazines, and lithium

159 ined the effects of propofol, etomidate, the barbiturate methohexital, and the steroid alphaxalone on

160 g AChR, probably by a steric mechanism; (iv) barbiturates modulate CrV binding to the resting AChR by

161 alone, but distinct from that obtained when barbiturates modulate the response to GABA.

162 ically folded supramolecular polymers from a barbiturate monomer containing an azobenzene-embedded ri

163 amely, a stoppered thread (1) with a central barbiturate motif and an optimized doubly anthracene-ter

164 The cell-impermeant barbiturate N-glucoside amobarbital did not influence mi

165 Barbiturates offer an alternative antihypertensive thera

166 Although the effects of barbiturates on alphabetagamma isoforms, thought to domi

167 t cortical cultures to examine the effect of barbiturates on neuronal mitochondria and responses to N

168 Effects of barbiturates on neuronal mitochondria should be consider

169 cile previous reports of opposing effects on barbiturates on NMDA neurotoxicity and show that barbitu

170 We further compared the separation of barbiturates optimized by the T3C approach with that opt

171 ne did not interact with the benzodiazepine, barbiturate, or neurosteroid binding sites in the GABAAR

172 iabetes and subjects taking anticonvulsants, barbiturates, or steroids.

173 3 wt %, the selectivity of the extraction of barbiturates over similar molecules could be improved.

174 The barbiturate pentobarbital binds to gamma-aminobutyric ac

175 At high concentrations, the barbiturate pentobarbital opens GABA(A)R channels with s

176 At saturating GABA concentrations, the barbiturate pentobarbital substantially increased the am

177 TL) with a large effect on predisposition to barbiturate (pentobarbital) withdrawal to a 0.44 Mb inte

178 Interestingly, a low concentration of the barbiturate phenobarbital had a similar exacerbating eff

179 structural features similar to those of the barbiturate phenobarbital were synthesized; one DHPM use

180 as continued therapy, which was the case for barbiturates, phenytoin and valproate.

181 pies the two beta (+)/alpha (-) pockets, the barbiturate photolabel R-5-allyl-1-methyl-5-(m-trifluoro

182 model of the desensitized state, showed that barbiturates preferentially stabilize the closed state.

183 The barbiturate prevented the increase of intrinsic tryptoph

184 At high concentrations, the barbiturates produce a channel blocking action that limi

185 Propofol, etomidate, and barbiturates produce profound amnesia and hypnosis, but

186 nes, ethanol, clomethiazole, antipsychotics, barbiturates, propofol, and dexmedetomidine) is detailed

187 anesthetic agents, nitrous oxide, ketamine, barbiturates, propofol, pentobarbital, phenobarbital.

188 g of beta3Met-227 in betaM1 by an anesthetic barbiturate, R-[(3)H]methyl-5-allyl-5-(m-trifluoromethyl

189 of a plasticized PVC membrane containing the barbiturate receptor (or host) creates a spatial concent

190 lic imides becomes better in the presence of barbiturate receptor and worse without receptor.

191 A barbiturate receptor has proven effective in improving s

192 r clips, molecular tweezers, and a synthetic barbiturate receptor.

193 Synthetic barbiturate receptors have been utilized for many applic

194 B), a photoreactive analog of the convulsant barbiturate S-MPPB, inhibits alpha1beta3gamma2 but poten

195 bstituted barbiturates consist of an achiral barbiturate scaffold with two cationic groups and two li

196 ulose use, rifaximin use, and benzodiazepine/barbiturate sedation.

197 of these systems to function as fluorescent barbiturate sensors.

198 Medications containing opioids and barbiturates should be reserved for a few selected cases

199 Barbiturates similarly amplified the effects of NMDA on

200 lline competes for binding at the steroid or barbiturate sites.

201 A difference in the barbiturate solute (substrate or guest) concentration in

202 ic and heteroaromatic systems present in the barbiturate substrates.

203 ison of the SAR of inhibitory and excitatory barbiturates suggested that conformationally constrained

204 The barbiturates tested, secobarbital, amobarbital, and thia

205 inylphenyl)barbituric acid), a photoreactive barbiturate that is a potent and stereoselective anesthe

206 zed and characterized a novel pair of chiral barbiturates that are capable of photolabelling their bi

207 assisted suicide by ingestion of prescribed barbiturates, the second involves withdrawal of artifici

208 s of three randomized trials of prophylactic barbiturate therapy for neonatal hypoxic-ischemic enceph

209 potent than the most potent clinically used barbiturate, thiopental, and its general anesthetic EC(5

210 In conjunction with the effect of a barbiturate to decrease the frequency of gamma oscillati

211 uscle length changes passively after using a barbiturate to suppress gamma-motor firing.

212 ult in fewer deaths, just as the change from barbiturates to benzodiazepines has reduced the number o

213 ic steroid) and pentobarbital (an anesthetic barbiturate) to directly activate recombinant GABAA rece

214 Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be

215 tive of an oxidative damage response only to barbiturate-type induction and probably related to 2B su

216 es to obtain spirocyclopropylpyrazolones and barbiturates, using iodosylbenzene (PhIO) or the combina

217 reatment with ketamine, phenobarbital, other barbiturates, vagus nerve stimulator, and ketogenic diet

218 Potentiation by high concentrations of barbiturates was also reduced by 3beta-hydroxysteroids.

219 The response to the barbiturates was similar to that produced by GABA, altho

220 iatric illness, including benzodiazepines or barbiturates, was associated with chronic prescription o

221 The effects of the barbiturate were dose-dependent.

222 Other barbiturates were found to inhibit sugar flux in human e

223 electivity in solid-phase microextraction of barbiturates when doped into plasticized poly(vinyl chlo

224 Inhibition by barbiturates, which was pharmacologically specific and s

225 bility states in mice, including alcohol and barbiturate withdrawal and convulsions elicited by chemi

226 region as a gene that influences alcohol and barbiturate withdrawal convulsions.

227 CNS hyperexcitability, including alcohol and barbiturate withdrawal, involve MPDZ interaction with 5-

228 n of the unusual charge-separated pyridinium barbiturate zwitterion 2 from 1,3-dimethylbarbituric aci