ライフサイエンスコーパス: barrier

1 taneous release without affecting the fusion barrier.

2 her products through this highly impermeable barrier.

3 ty and function of the glomerular filtration barrier.

4 in determining the electron transport tunnel barrier.

5 hydrophobicity (Syt1(4W)), lowers the energy barrier.

6 to its ability to penetrate the blood-brain barrier.

7 dispensable for maintaining the blood-brain barrier.

8 -path transients that precede the nucleation barrier.

9 uctive cues and providing a protective brain barrier.

10 and a higher permeability of the blood-brain barrier.

11 rmined, with Pt leading to the lowest energy barrier.

12 factor that helps Pol II across a nucleosome barrier.

13 1-CoV, which has not yet crossed the species barrier.

14 complexes to efficiently work as topological barriers.

15 tic cycle is devoid of high transition-state barriers.

16 LC2 responses and type 2 immunity at mucosal barriers.

17 flow, perivascular transport, drainage, and barriers.

18 operative origin firing and replication fork barriers.

19 ts show that membrane necks become diffusion barriers.

20 ation, social determinates, and facilitators/barriers.

21 ates with increased leakiness of endothelial barriers.

22 s C, 10 bar), and with a low reaction-energy barrier (47.3 kJ mol(-1) ).

23 n only be attributed to the strong transport barriers across internal interfaces, as supported by dir

24 o inhibit I(SOC) and protect the endothelial barrier against calcium entry-induced disruption.

25 microbes are known to provide a competitive barrier against invading bacterial pathogens in the inte

26 the outer membrane serves as a permeability barrier against noxious compounds in the external enviro

27 chitinous structure that forms a protective barrier against oral pathogens and abrasive particles(1)

28 host and pathogen and provides a protective barrier against the immune response and antibiotics.

29 ves are not or inadequately informed or that barriers against genetic counseling are present.

30 These barriers also confer stability of the OLED to repeated b

31 rent GPCRs, is able to cross the blood-brain barrier and acts as slowly diffusing and insurmountable

32 sulting in compromised intestinal epithelial barrier and chronic mucosal inflammation.

33 r GLUT1 targeting, capable of traversing the barrier and delivering active antibody to cells within t

34 osomal spherical nucleic acids overcome this barrier and enable topical delivery of antisense oligonu

35 actors and viruses may cross the blood-brain barrier and enter the central nervous system, activating

36 rrier maintenance versus a newly established barrier and functionally identify differential ceramide

37 epair is critical to reestablish the mucosal barrier and homeostasis.

38 amaging the pulmonary epithelial-endothelial barrier and increasing pulmonary oedema.

39 The capacity of S epidermidis to degrade the barrier and induce inflammation was examined by using hu

40 easure ABCC1 activity at the lung epithelial barrier and may be applicable in humans to assess the ef

41 s at each end of the substrate overcome this barrier and promote release by stepwise exchange of hydr

42 umin-1 can efficiently cross the blood-brain barrier and provides excellent contrast for Abeta plaque

43 orced displacement; the health systems-level barriers and facilitators in addressing these needs; and

44 tools to accelerate our ability to identify barriers and facilitators to success in environmental he

45 entation based on the consideration of known barriers and facilitators.

46 We then consider economic and non-cost barriers and incentives for land managers implementing t

47 very system capable of overcoming biological barriers and leveraging on several synergistic cancer ce

48 s with respect to their mechanical, thermal, barrier, and processability properties.

49 ualitative data to understand the processes, barriers, and facilitators to implement family-centered

50 transformation because they have few kinetic barriers apart from ionic diffusion.

51 related species; however, these reproductive barriers are challenging to measure within natural popul

52 icial during break-induced replication where barriers are expected to pose a problem to efficient DNA

53 The reaction free energies and free energy barriers are found to be significantly influenced by the

54 ds comprising goblet cells and a thick mucin barrier as an intestinal model to investigate Pic's role

55 s the compromised blood-brain and intestinal barriers as important sources of microbial DNA in the CN

56 Notwithstanding the barriers associated with this reaction, significant prog

57 ith (n = 92) or without (n = 90) blood-brain barrier (BBB) disruption and a diseased control group wi

58 We investigated controlled blood-brain barrier (BBB) disruption using a low-frequency clinical

59 angiopathy (CAA), which impairs blood-brain barrier (BBB) function and accelerates cognitive degener

60 Chronic social stress alters blood-brain barrier (BBB) integrity through loss of tight junction p

61 F biomarkers of inflammation and blood-brain barrier (BBB) integrity were measured preoperatively and

62 es remain limited by ineffective blood-brain barrier (BBB) penetrance.

63 nervous system (CNS) through the blood-brain barrier (BBB) remains poorly understood.

64 l these biological barriers, the blood-brain barrier (BBB) strongly impede hurdle for drug transport

65 pharmacologic restoration of the blood-brain barrier (BBB), 12 mo after murine TBI, is associated wit

66 ist behind a functionally intact blood-brain barrier (BBB), and so are shielded from exposure to ther

67 as P-glycoprotein (P-gp) at the blood-brain barrier (BBB).

68 us precursors and the existence of an energy barrier before nuclei formation.

69 ctors in cerebrospinal fluid (CSF) and a key barrier between blood and brain.

70 investigate the mechanisms of blood-retinal barrier (BRB) breakdown at a global level, we studied th

71 nhance the transport across the blood-testis barrier (BTB) of contraceptive drugs or to treat male in

72 idney transplantation (ILDKT) across HLA/ABO barriers, but added immunomodulation might put patients

73 peptides (AMPs), can disrupt this protective barrier by formation of leaky pores.

74 is, the efficient disruption of a nucleosome barrier by Pif1 could lead to the futile re-replication

75 VEGF quickly relaxes the endothelial cell barrier by triggering signaling events that post-transla

76 However, we also found that kinetic barriers can be encountered in these systems and limit f

77 Therefore, social barriers can contribute to the difference between the ph

78 Barriers can include transcription complexes and R-loops

79 r fragmentation by dams, presenting physical barriers, can limit the climatically induced spatial red

80 diet (WD)-induced loss of colonic epithelial barrier (CEB) function in mice with a genetic impairment

81 Among barrier cells, intestinal epithelial cells (IECs) are pa

82 dicted (16)O/(18)O isotope effect and energy barrier close to observed values.

83 The second barrier comes from the intensive computing time for epis

84 e is an essential physical and immunological barrier comprised of a monolayer of diverse and speciali

85 regulation is correlated with disrupted cell barrier, compromised angiogenesis and enhanced monocyte

86 This study demonstrates how the costs of barrier crossings in prevailing winds can disrupt migrat

87 c dermatitis (AD) is characterized by a skin barrier defect aggravated by mechanical injury inflicted

88 approaches to diagnose and target epithelial barrier defects are currently being developed.

89 different axial ligands and that rotational barriers depend on their steric size.

90 The nuclear permeability barrier depends on closure of nuclear envelope (NE) hole

91 uggest that chronic exposure to IFNs induces barrier disruption that allows for higher S. aureus colo

92 es gamma-irradiation-induced colonic mucosal barrier dysfunction and endotoxemia.

93 60 and ameliorates the Lm-induced intestinal barrier dysfunction by blocking the nuclear factor-kappa

94 cially in HIV infection where gut-intestinal barrier dysfunction could facilitate T cell exposure to

95 Epithelial barrier dysfunction facilitates transepithelial allergen

96 Barrier dysfunction was also observed in mice that lacke

97 rate Plasmodium parasite growth, blood-brain barrier dysfunction, and mortality in a mouse model of m

98 ets for diseases associated with endothelial barrier dysfunction.

99 can be toxic to epithelial cells and lead to barrier dysfunction.

100 criptional mechanisms play a key role in gut barrier dysfunction.

101 Importantly, our barriers end on the same energy on which they start.

102 ectivity is achieved by exploiting the lower barrier for C-CN oxidative addition and reductive elimin

103 thesis that cardiomyocyte polyploidy poses a barrier for cardiomyocyte proliferation and subsequent h

104 We found that the energy barrier for diffusion is larger when diffusion on MTs is

105 he successive bending of the linkers and the barrier for isopropyl-substituted derivative 10 was expe

106 ctate through astrocyte networks, creating a barrier for neuronal access to an astrocytic energy rese

107 ficient (k(p)), reveals the transition state barrier for polycarbonate formation: DeltaG(*) = +92.6 +

108 The human skin is a significant barrier for protection against pathogen transmission.

109 d in detail, revealing that the lower energy barrier for the formation of alpha-lapachone is a result

110 osurface and consequently reduces the energy barrier for the HER.

111 een humans and animals suggest a low species barrier for transmission of the virus to farm animals.

112 rface leads to a lowering of the free-energy barrier for unfolding, resulting in rapid unfolding of t

113 The data reveal small intrinsic barriers for electron transfer proximate to conductive i

114 due to an abrupt decrease in the free-energy barriers for lateral mobility of outer-spherically adsor

115 n potential energy surface, increasing local barriers for Li(+) ion diffusion.

116 mechanistic avenues, which can open when the barriers for reactions that for other metals would be re

117 issue regeneration (GTR) using bioabsorbable barriers for root coverage therapy.

118 were found to be responsible for high energy barriers for the anions to enter EcYfdC.

119 to be higher than 50 kcal mol(-1), while the barriers for the formation of alkoxyl radicals are as lo

120 The barriers for the formation of dioxetane derivatives are

121 tal Fc receptor (FcRn) transports IgG across barriers, for example, the placenta, enhancing fetal hum

122 CRT-knockout organoids also had diminished barrier formation.

123 ling of vessel morphogenesis and blood-brain barrier formation.

124 iate, separated by a significant free energy barrier from the dimer with a native binding interface.

125 overgrowth/dysbiosis and altered intestinal barrier function (gut-liver axis) and by episodes of sep

126 ication, impaired S1pr2(-/-) mouse epidermal barrier function allowed deeper bacterial penetration an

127 Intact mucociliary barrier function and early airway neutrophil responses a

128 s that modulate SI microbiome, immunity, and barrier function and identify dietary, epithelial, and i

129 characterized pathological tissue integrity, barrier function and metabolic stability over time.

130 SCFAs maintained intestinal barrier function and reduced lipopolysaccharides content

131 The physical barrier function of the airway epithelium is tightly int

132 tem cells regenerated both the structure and barrier function of the JE.

133 This barrier function typically requires a contiguous cell la

134 Intestinal barrier function was assessed by analyzing immunofluores

135 genetic impairment in intestinal epithelial barrier function, junctional adhesion molecule A knockou

136 onged approach, not only restoring cutaneous barrier function, microbial flora, and immune homeostasi

137 ch IDL improves skin hydration and epidermal barrier function, supporting IDL as an effective interve

138 In addition to its barrier function, the NE acts as a critical signaling no

139 IECs and macrophages to maintain intestinal barrier function.

140 pression of genes that are known to regulate barrier function.

141 in IECs and thereby epithelial integrity and barrier function.

142 sence is linked to an impairment in the skin barrier function.

143 no acid tryptophan, in regulating intestinal barrier function.

144 tural integrity of the cuticle, and impaired barrier function.

145 of oxidative stress, and altered intestinal barrier function.

146 e a glucosamine-coated NISV, for blood-brain barrier GLUT1 targeting, capable of traversing the barri

147 th penetrate the oral epithelium, a modified barrier has evolved, called the junctional epithelium (J

148 ky contact to p-type one with reduced energy barrier height.

149 ines will gradually allow us to overcome the barriers identified on the demanding path toward manufac

150 to the contribution of gammadelta T cells to barrier immunity.

151 lial regeneration, which prolongs epithelial barrier impairment and creates an environment in which d

152 chain of MJ0366 increase the folding energy barrier in a magnitude close to the energy cost of formi

153 ions, indicating the presence of diffusional barriers in intact cells.

154 on of charge give rise to additional kinetic barriers in NCA and nonmetallic LTMOs in general.

155 Cited barriers include lack of knowledge about the potential d

156 Mixed-methods identified treatment barriers including, alcohol abuse, family conflicts, and

157 major cellular components of the blood-brain barrier, including endothelial cells and astrocytes.

158 incubation of opioid craving after electric barrier-induced voluntary abstinence and determined whet

159 opment of better BRB/BBB models and novel EC barrier-inducing therapeutics.

160 t infection while leaving the maternal-fetal barrier intact.

161 ain fatty acids and bile acids, improved gut barrier integrity and increased intestinal T regulatory

162 ner, induced a rapid drop in the endothelial barrier integrity of HLMVECs.

163 is method generated monolayers with enhanced barrier integrity, so that directional (basal or apical)

164 RS and characterized by impaired blood-brain barrier integrity.

165 in processing, a function vital to epidermal barrier integrity.

166 locking agents, appears to protect epidermal barrier integrity.

167 The blood-brain barrier is a major impediment for targeted central nervo

168 Barrier islands are ubiquitous coastal features that cre

169 es, such as breaches in immune tolerance and barriers, leading to the promotion of immune-mediated di

170 bility up to 5 V and a low activation energy barrier (<0.2 eV) for microscopic lithium-ion diffusion.

171 nd mouse genetics, we characterize epidermal barrier maintenance versus a newly established barrier a

172 s play in CNS angiogenesis and neurovascular barrier maturation have been elucidated in recent years.

173 ation of DNA synthesis across strong protein barriers may be beneficial during break-induced replicat

174 ng AF detection and screening, several major barriers may impede their effectiveness.

175 sts due to the complex structure and various barrier mechanisms surrounding the brain.

176 indicate that existing records underestimate barrier numbers by about 61 per cent.

177 en evolution reaction (HER) and the reaction barrier of ambient electrochemical NRR are significant c

178 lene)pyridine and elimination of N(2) with a barrier of ca. 26 kcal/mol.

179 supplant depth of sequencing to overcome the barrier of cfDNA abundance.

180 voluntary abstinence induced by an electric barrier of increasing intensity near the drug-paired lev

181 The energy barrier of P-isomerization is lower than that of olefina

182 protomers in a dimer that reduces the energy barrier of rate-limiting steps of the catalytic cycle of

183 The skin barrier of subjects with PA without AD (AD(-)PA(+)) has

184 s that are consistent with activation energy barriers of ~10 +/- 3 kcal/mol.

185 Treated barriers on untreated bednets were equally effective, wi

186 sion of mannitol induces osmotic blood-brain barrier opening (OBBBO) and that method has been used fo

187 Skin is the largest barrier organ and an important interface between the bod

188 Ron (APN receptor agonist) was a blood-brain barrier penetrant.

189 good plasma exposure and partial blood-brain barrier penetration.

190 ation and normalized compromised blood-brain barrier permeability and tight junction protein expressi

191 ejunal inoculation that bypasses the gastric barrier, plasmid-deficient Chlamydia produced infectious

192 These considerations include overcoming the barriers presented by opportunity costs, spending on hea

193 Geographic and financial barriers prevent access to specialty care.

194 Future research should explore the key barriers preventing the adoption of national screening p

195 n occur (either through a classical over-the-barrier process or through quantum-mechanical tunnelling

196 disease activity have functions in epidermal barrier properties and immune modulation.

197 An investigation into barrier proteins revealed that heme primarily affected t

198 eper water when temperatures rise because of barriers, reduced light availability, altered water chem

199 the mechanisms and relative contributions of barrier regulation, transendothelial sieving, and transp

200 he duration of VEGF exposure influenced both barrier relaxation and anti-VEGF-mediated closure.

201 ol parameters, suggesting a tipping point in barrier response to external drivers.

202 covery time-a relaxation time characterizing barrier's resiliency to storm impacts-changes rapidly wi

203 efined crystalline symmetry and large energy barriers separating different states in crystals.

204 layer of epithelial cells that forms a tight barrier, separating luminal antigens and microbes from u

205 strip profiling detected distinct immune and barrier signatures in lesional and nonlesional AD and ps

206 a solution by addressing transplant-specific barriers: specifically, providing accurate information a

207 tory responses, prosurvival, and endothelial barrier stabilization.

208 ndant T-lymphocyte subset in some epithelial barriers such as mouse skin.

209 on how gammadelta T cells traffic to various barrier surfaces and how recent investigation into their

210 We confirmed the relevance of this glial barrier system in human multiple sclerosis active lesion

211 Barrier systems also protect interior coastal communitie

212 the approach necessarily breaks a protective barrier, temporarily, which plays a fundamental role in

213 kite and graphene interface presents a lower barrier than gold for charge injection.

214 tached to the objective lens arm were better barriers than those of comparable size hung by the ocula

215 egative bacteria is a selective permeability barrier that allows uptake of nutrients while simultaneo

216 Secondary cell walls provide a physical barrier that protects plants from pathogens, promotes to

217 e diversity and assess efforts to reduce the barriers that exist for potential non-White populations

218 has focused on understanding the biological barriers that hinder tissue-specific drug delivery and s

219 This review focuses on the barriers that impact pulmonary siRNA delivery and succes

220 mbient temperatures help overcome activation barriers that impede diffusion and reactions.

221 safe housing conditions, confront structural barriers that limit access to affordable housing, and ar

222 s as quickly as possible removes competitive barriers that may slow the growth of resistant cells.

223 on of the chromatin landscape and epigenetic barriers that must be overcome for cardiac regeneration

224 chia coli and 12 rhizobia) help identify the barriers that must be overcome to engineer a bacterium t

225 Among all these biological barriers, the blood-brain barrier (BBB) strongly impede

226 Barrier tissues are heavily innervated by nociceptors, t

227 D8(+) T cells mediate protective immunity in barrier tissues, but the cues promoting Trm cell generat

228 IL-23/IL-17 axis can lead to inflammation of barrier tissues, whereas its role in internal organ infl

229 recent or prior injection drug use remains a barrier to accessing direct-acting antiviral treatment (

230 osed technique that bypasses the blood-brain barrier to achieve noninvasive and localized brain drug

231 d after postnatal day-6 (P6), representing a barrier to building new cardiac muscle in adults.

232 -derived cardiomyocytes may be a significant barrier to clinical translation of cardiomyocyte cell th

233 human clinical use - representing a further barrier to clinical translation.

234 all infected individuals and that is a major barrier to curing HIV infection, the in vivo proliferati

235 77), identifying the Indian Ocean basin as a barrier to dispersal.

236 is occurs in the testes, behind a protective barrier to ensure safeguarding of germline DNA from envi

237 arge NCs infiltrate this vital intracellular barrier to enter the nuclear interior.

238 accumulating with divergence generate a weak barrier to gene flow for long periods of time, until the

239 scaling potential water, where scaling is a barrier to high water recovery.

240 emory CD4+ T cells, which represent the main barrier to HIV eradication.

241 t, is key to creating an almost impenetrable barrier to hydrophobic molecules that can otherwise pass

242 The thick mucus layer of the gut provides a barrier to infiltration of the underlying epithelia by b

243 The upper airways present a barrier to inhaled allergens and microbes, which alter i

244 teroperable data across hospitals is a major barrier to model transportability.

245 e from clinical trials remains a significant barrier to optimizing real-world outcomes for patients w

246 in physiology of CD8(+) T cells, acting as a barrier to prevent premature differentiation and control

247 reduce this threat due to DTG's high genetic barrier to resistance.

248 6-1.14, p = 0.214) but reduced the financial barrier to seeking healthcare for sick children (DD = -2

249 immune suppression and as an underestimated barrier to successful melanoma immunotherapy.

250 aPR, 0.51 [95% CI, .31-.82]) was the primary barrier to suppression.

251 tro measurements suggest that the nucleosome barrier to TF binding is modulated by dynamic nucleosome

252 cteria functions as a selective permeability barrier to the environment.

253 By putting the epithelial barrier to the forefront of the pathophysiology of airwa

254 required for these techniques remain a major barrier to translatability.

255 HLA antibodies pose a significant barrier to transplantation and current strategies to red

256 d biogeography, which presents a substantial barrier to understanding community dynamics and ecosyste

257 serving either to facilitate or to impose a barrier to V(D)J recombination.

258 or simplifying delivery and reducing current barriers to access and persistence.

259 sation between coach and patient to identify barriers to adherence and possible solutions.

260 dominantly unintentional and originates from barriers to adherence that are often multifactorial and

261 Barriers to authorship and representation of women in HF

262 Barriers to care must be decreased at the societal, heal

263 tein apheresis for severe FH; and addressing barriers to care.

264 rch members-could reduce financial and other barriers to conference attendance for all members and im

265 objective was to determine patient-reported barriers to diagnostic colonoscopy following abnormal FI

266 g prolonged intravenous antibiotics may face barriers to discharge, which could prolong hospital leng

267 ecificity of microbial characterization) are barriers to drawing robust conclusions.

268 on the gearing mechanism, and the activation barriers to gearing were calculated using density functi

269 In this Personal View, we describe barriers to high-quality care that have constrained the

270 strategies to overcome social and structural barriers to HIV care will be required to reach national

271 ough uncoordinated management and artificial barriers to human movement, such as border fences.

272 ess and implementation of the Guidelines and barriers to implementation.

273 timing, and we need to understand more about barriers to implementation.

274 cal experimental platform to address current barriers to improved prevention, diagnosis, and treatmen

275 We discuss barriers to integration of phenotypic data and make reco

276 uld increase the use of MOUD and to identify barriers to MOUD during admission and at the time of dis

277 We explored barriers to MOUD uptake using chart review.

278 little coding required, thus lowering entry barriers to new users.

279 illness-specific, cultural, and system-based barriers to palliative care integration and optimal end-

280 pesticides) to target larval sea lamprey and barriers to prevent adult lamprey from reaching spawning

281 ver, being a cancer survivor, predicted more barriers to receiving health care, especially in the fir

282 o understand prescribing practices, identify barriers to reducing prescribing, and tailor interventio

283 Here we propose the use of soluble wax barriers to selectively and temporarily accumulate the t

284 led us to question the permeability of these barriers to species dispersal.

285 of all partners, identifying and addressing barriers to success, and earning and maintaining trust a

286 Community-based testing might address barriers to testing access.

287 SecA generates mechanical force to overcome barriers to translocation posed by structured substrate

288 whether physical distancing, masks and other barriers to transmission, or social bubbles will be most

289 ustria) in an effort to lower implementation barriers to ultimately improving power assessment in med

290 Overcoming barriers to universal sanitation coverage and sustainabl

291 Barriers to uptake and compliance involved information t

292 ogistical reasons and lack of motivation are barriers to uptake and compliance.

293 neous coronary intervention may overcome the barriers to utilization.

294 ve bacteria, disrupts the alveolar-capillary barrier, triggering pulmonary vascular leak thus inducin

295 Diet modulates the mucous barrier via alterations in gut microbiota, resulting in

296 To ease this computational barrier, we have created a dynamic web-based platform, N

297 abundantly expressed at the lung epithelial barrier, where it may influence the pulmonary dispositio

298 electrophoresis implemented with a diffusion barrier, which isolates the dispersed phase from the ele

299 n and dace were significantly constrained by barriers, which included anthropogenic water diversions,

300 esults in high positive electrostatic energy barriers within the interlayer, creating a penalty for c