ライフサイエンスコーパス: basal body

1 referentially near the posterior face of the basal body.

2 otein, which is located around the flagellar basal body.

3 1 is specifically expressed in photoreceptor basal body.

4 around an effective hinge located below the basal body.

5 ed correlated fluctuations of the cilium and basal body.

6 rsion of the mother centriole into the cilia basal body.

7 tes proteasomal activity specifically at the basal body.

8 te protein Cep290 to both satellites and the basal body.

9 s to both actin filaments and the centrosome/basal body.

10 in in the region of the CP that contains the basal body.

11 vated Dishevelled-1 (Dvl-1) localized to the basal body.

12 alizing to a polar structure adjacent to the basal body.

13 d with the loss of Dvl-1 localization to the basal body.

14 d from the cytoplasm by the ciliary neck and basal body.

15 BBP65 for maintaining their stability in the basal body.

16 6 and TbBLD10 for their stabilization in the basal body.

17 th NPHP-RC, localized to the vicinity of the basal body.

18 component macromolecular machine we call the basal body.

19 that Gle1 is enriched at the centrosome and basal body.

20 etric mechanical forces that are resisted by basal bodies.

21 evented the association of Inturned with the basal bodies.

22 ated Ca(2+)-binding proteins associated with basal bodies.

23 nction as microtubule-organizing centers and basal bodies.

24 is in directing the orientation of cilia and basal bodies.

25 n is crucial for the recruitment of TTBK2 to basal bodies.

26 m to be necessary for the patterning of cone basal bodies.

27 and a pattern of growth common to euconodont basal bodies.

28 e flagellar pocket collar and bi-lobe to the basal bodies.

29 TEM and IF demonstrate mislocalized basal bodies.

30 ay components for the production of multiple basal bodies.

31 scale centriole amplification that generates basal bodies.

32 pulation (E2) with only two cilia and unique basal bodies.

33 ojections that assemble on centriole-derived basal bodies.

34 ures demonstrates a marked compaction of the basal body (4 nm) occurs when the needle tip contacts th

35 were localized to the flagellar pocket, the basal bodies, a tripartite attachment complex linking th

36 Each flagellum consists of a basal body, a hook, and a filament.

37 uctural foundation of the injectisome is the basal body, a molecular lock-nut structure composed pred

38 lular mechanism regulated the positioning of basal bodies after the transition to the adult mosaic an

39 bule glutamylation are required to stabilize basal bodies against ciliary beating forces.

40 mylation and Bld10, Poc1, and Fop1 stabilize basal bodies against the forces produced by ciliary beat

41 her motile cilia and functions in regulating basal body alignment.

42 om the basal-foot cap, together with loss of basal-body alignment and cilium orientation, defects in

43 s (ciliary transcription factor genes versus basal body amplification genes).

44 ants display abnormal rotational polarity of basal bodies and a decrease in apical actin and RhoA act

45 ed-coil protein that localizes to centrioles/basal bodies and plays a crucial role in the formation a

46 how TbRP2 is targeted and tethered at mature basal bodies and provide novel insight into TbRP2 functi

47 Cp110 localizes to cilia-forming basal bodies and rootlets, and is required for ciliary a

48 stead that pore proteins localize to ciliary basal bodies and that their perturbation leads to congen

49 esis due to impaired association between the basal bodies and the actin cytoskeleton, suggesting that

50 t that both mutants had wild type numbers of basal bodies and the flagellar motors were functional.

51 al adhesion (FA) proteins associate with the basal bodies and their striated rootlets and form comple

52 elated to the cell cycle and to flagella and basal bodies and to assign isoforms of duplicated enzyme

53 is cell assembles approximately 26 flagellar basal bodies and we show that basal body number is contr

54 bs a variety of signaling pathways along its basal body and axoneme that are critical for embryonic d

55 at the transition zone, located between the basal body and axoneme, to regulate the localization of

56 n is the transition zone, which lies between basal body and axoneme.

57 nexpected findings include the following: 1) basal body and bilobe duplication are concurrent; 2) mat

58 Here we report that Fuzzy localizes to the basal body and ciliary axoneme and is essential for cili

59 MARK4 associated with the basal body and ciliary axoneme in human and murine cell

60 In the mouse retina, ARL2BP localized to the basal body and cilium-associated centriole of photorecep

61 ting it to Rab8-positive vesicles and to the basal body and cilium.

62 oplasmic sorting platform, envelope-spanning basal body and external needle with tip complex.

63 l for ciliogenesis by delivering Rab8 to the basal body and primary cilium.

64 e cells, Inturned and Fuzzy localized to the basal body and proximal region of cilia, and cilium form

65 lla is a structural intermediate between the basal body and the axoneme that regulates ciliary traffi

66 oreover, RNAi of SPBB1 confined TbPLK at the basal body and the bilobe structure, resulting in consti

67 n addition, AEE788 blocks duplication of the basal body and the bilobe without affecting mitosis.

68 SPBB1 localizes to both the mature basal body and the probasal body throughout the cell cyc

69 assembly is triggered by mature centrioles (basal bodies) and requires centrosomal protein 164kDa (C

70 egulated early, when most cells were forming basal bodies, and 73 genes genes upregulated late, when

71 izes to centrioles and to the distal ends of basal bodies, and interacts with septin2, a protein impl

72 d tissues, localizes to ciliary axonemes and basal bodies, and is required for ciliogenesis.

73 er, these precursors cannot produce multiple basal bodies, and mature into single ciliated cells.

74 n of central MT pairs, proper orientation of basal bodies, and synchronized beating of motile cilia.

75 The asymmetric positioning of basal bodies, and therefore cilia, is often critical for

76 asmic sorting platform, an envelope-spanning basal body, and an extracellular needle with tip complex

77 a large cytoplasmic complex, a transmembrane basal body, and an extracellular needle.

78 ing proteins associated with the centrosome, basal body, and transition zone.

79 a long cytoplasmic region extending from the basal body, and transitions to a canonical membrane-boun

80 d by localization of TbSAS6 at newly forming basal bodies; and 3) kinetoplast division is observed in

81 de-gated (CNG) channel, as well as disrupted basal body apical migration in postnatal olfactory senso

82 Basal bodies are assembled rapidly (< 5 min) but the ass

83 on tomography on mouse trachea, we show that basal bodies are collectively hooked at the cortex by a

84 3a function precedes ciliogenesis as ciliary basal bodies are mispositioned in mutant photoreceptors.

85 We conclude that pro-centrioles/pro-basal bodies are multipotent and not committed to form e

86 We find that basal bodies are not positioned randomly on the cell sur

87 Basal bodies are radially symmetric, microtubule-rich st

88 on, specific triplet microtubules within the basal body are more susceptible to loss, probably due to

89 ctural genes required for the flagellar hook-basal body are required for robust activation of sigma(D

90 the cilium and its anchoring structure, the basal body, are the major contributors to both disease c

91 e in the recruitment of Ttbk2 to the ciliary basal body as well as the removal of Cp110 from the cili

92 but how they cooperate in the regulation of basal body assembly remains elusive.

93 ong BBP164 and the other three regulators of basal body assembly revealed that BBP164 and BBP65 are i

94 y TbRP2 recruitment, is coupled with nascent basal body assembly, monitored by localization of TbSAS6

95 Chibby (Cby), a basal-body associated protein, regulates beta-catenin-me

96 d microtubule glutamylation incorporate into basal bodies at distinct stages of assembly, culminating

97 e of ciliated cells, where it localizes with basal bodies, basal feet, rootlets, and actin filaments.

98 ized at a different axial level bridging the basal body (BB) and other TZ proteins.

99 fically leads to defects in ciliogenesis and basal body (BB) biogenesis, as its absence hampers the e

100 Planar cell polarity (PCP) regulates basal body (BB) docking and positioning during cilia for

101 ied into three subdomains: the intracellular basal body (BB) that templates cilium formation, the ext

102 surface is determined by the location of the basal body (BB) that templates the cilium.

103 is nucleated by the mother centriole-derived basal body (BB) via as yet poorly characterized mechanis

104 Basal bodies (BBs) are macromolecular complexes required

105 Cilia-organizing basal bodies (BBs) are microtubule scaffolds that are vi

106 Tetrahymena basal bodies (BBs) nucleate and position cilia, whereby

107 kinetoplast DNA), duplication of organelles (basal body, bilobe, kinetoplast, nucleus), and cytokines

108 4 and found that it has an essential role in basal body biogenesis in T. brucei Further investigation

109 ific protein, BBP65, play essential roles in basal body biogenesis in T. brucei, but how they coopera

110 f a membranous protrusion extending from the basal body but lacking axonemal structure and remains un

111 Root is required for cohesion of basal bodies, but the cilium structure appears normal in

112 d that the protein localized not only to the basal body, but also to the axoneme, proving the functio

113 e five centrins associate with the flagellar basal body, but no centrin has been found to regulate fl

114 These findings demonstrate that basal body cartwheel proteins are required for stabilizi

115 Two evolutionarily conserved centriole/basal body cartwheel proteins, TbSAS-6 and TbBLD10, and

116 actor C domain-containing protein TbRP2 is a basal body (centriolar) protein essential for axoneme fo

117 ein, a truncated paralogue of the ubiquitous basal body/centriole protein SAS6, has been characterise

118 oreceptor markers and exhibited axonemes and basal bodies characteristic of outer segments.

119 tion, we find that Presenilin-2 localizes to basal bodies/cilia through a conserved VxPx motif.

120 om its characterised roles at the centrosome/basal body/cilia network.

121 endent polarized exocytosis acts through the basal body-ciliary complex to spatially regulate Notch s

122 Basal body/ciliary perturbation in murine pancreatic isl

123 nced by, but does not strictly require, hook-basal body completion and instead demands a minimal subs

124 Mice lacking the basal body component Chibby (Cby) exhibit impaired mucoc

125 ether, these results suggest that bbof1 is a basal body component required in MCCs to align and maint

126 proteins are required for stabilizing other basal body components and uncover that regulation of pro

127 ed into several families based on structural basal body components.

128 Removal of galectin-3, one of basal-body components, provokes misrecruitment of gamma-

129 Basal bodies comprise nine symmetric triplet microtubule

130 vel players in actin-dependent centrosome to basal body conversion.

131 ted FlaH binding to FlaI form the archaellar basal body core.

132 retinal proliferation, altered placement of basal bodies crucial for components of the cilium (trans

133 diffusion delays return of kinesin-II to the basal body, depleting kinesin-II available for anterogra

134 These sperm centrioles appear as vestigial basal bodies, destroyed in the mid-to-lower corpus.

135 a serovar Typhimurium pathogenicity island 1 basal body, determined using single-particle cryo-electr

136 Additionally, the majority of photoreceptor basal bodies did not dock properly at the apical edge of

137 deficient in filamentary connections between basal bodies display markedly different synchronization

138 n centrosome polarization at the synapse and basal body docking during ciliogenesis [1, 4-8], suggest

139 y regulator of ciliary vesicle formation and basal body docking during the differentiation of airway

140 kif3a is dispensable for basal body docking in otic vesicle sensory epithelia and

141 ding, but not a global loss of ciliogenesis, basal body docking or PCP signaling leads to dysfunction

142 ithelial cells, we show that Cby facilitates basal body docking to the apical cell membrane through p

143 t the distal end of centrioles to facilitate basal body docking to the plasma membrane.

144 npoint TAp73 as necessary and sufficient for basal body docking, axonemal extension, and motility dur

145 gulates centriole duplication in metazoa and basal body duplication in flagellated and ciliated organ

146 clusive to ciliated AECs and associated with basal bodies during and after motile ciliogenesis.

147 hat actin plays a role in IFT recruitment to basal bodies during flagellar elongation and that when a

148 robably due to force distribution within the basal body during ciliary beating.

149 ll cycle, and co-localizes with TbPLK at the basal body during early cell cycle stages.

150 erentiation, motile cilia are templated from basal bodies, each extending a basal foot-an appendage l

151 (emb)Kif3a(-/-) and in (emb)Ift88(-/-) mice, basal bodies failed to extend transition zones (connecti

152 ion between the cell cycle and its centriole-basal body-flagellar cycle.

153 We also demonstrate that basal body formation in the male testes and the producti

154 entiates ciliogenesis, but the regulation of basal body formation is not fully understood.

155 ating tissue-specific roles in centriole and basal body formation.

156 Furthermore, pro-basal bodies formed under conditions conducive for 9+2 a

157 ctions associated with the centriole-derived basal body, from which axonemal microtubules grow and wh

158 tly, we show that Asl is required for proper basal body function and spermatid axoneme formation.

159 d beta-cells along with misregulated ciliary/basal body gene expression in pancreatic islets in a dia

160 Drosophila ciliated cells, it also regulates basal-body growth and docking to the plasma membrane dur

161 ns of the centriole, the centrosome, and the basal body have an impact upon many aspects of developme

162 lagella by initiating the production of hook basal bodies (HBBs), protein structures that anchor the

163 ubtilis by fluorescently labelling flagellar basal bodies, hooks and filaments.

164 c novel component is linked to the flagellar basal body; however, nothing is known about the proteins

165 air assembly as they are not continuous with basal bodies in contrast to the nine outer MT doublets.

166 erved component of centrioles in animals and basal bodies in flagellated organisms.

167 WDR34 concentrates around the centrioles and basal bodies in mammalian cells, also showing axonemal s

168 localized to the base of axonemes and at the basal bodies in MCCs.

169 osome and transition zone marker, identified basal bodies in Nphp5(-/-) photoreceptors, but without f

170 s establish the asymmetrical localization of basal bodies in red-, green-, and blue-sensitive cones i

171 er centrioles, aberrant mitoses, and reduced basal bodies in sensory organs.

172 d concentrates at the centrosome and ciliary basal body in addition to the nucleus in interphase cell

173 aused the loss of ARL2BP localization at the basal body in ciliated nasal epithelial cells.

174 ns of the centriole, the centrosome, and the basal body in different tissues and cultured cells of Dr

175 nstrate KIAA0586 protein localization at the basal body in human and mouse photoreceptors, as is comm

176 tion of the maturation of a second flagellar basal body in late G1 phase, DNA replication in S phase,

177 ct--PtdIns(4)P--accumulate at the centrosome/basal body in non-ciliated, but not ciliated, cells.

178 nusual control mechanism for assembly of the basal body in T. brucei.

179 racterization of the major components of the basal body in the assembled state, including that of the

180 The basal body in the human parasite Trypanosoma brucei is s

181 cilium of stimulated beta-cells and ciliary/basal body integrity is required for activation of downs

182 to how the ciliopathy protein Poc1 maintains basal body integrity.

183 le for Dzip1 and Fam92 in mediating membrane/basal-body interactions and show that these interactions

184 The recruitment of IFT components to basal bodies is a function of flagellar length, with inc

185 The centriole/basal body is a eukaryotic organelle that plays essentia

186 The centriole, or basal body, is the center of attachment between the sper

187 till localizes to intercellular borders, but basal body localization is lost.

188 We show that basal body localization of TbRP2 is mediated by twinned,

189 WDR62 depletion reduced KIF2A's basal body localization, and enhanced KIF2A expression p

190 small GTPase ARF4 is required for Presenilin basal body localization, Notch signaling, and subsequent

191 in cilia length and number, due to defective basal body maturation and apical docking.

192 cient MCCs restored ciliogenesis by rescuing basal body maturation and docking.

193 ions exhibit cell type specific functions in basal-body maturation and TZ organization.

194 let microtubules, suggesting that the mother basal body microtubule structure does not template the d

195 and number of cilia and displays defects in basal body migration and docking to the apical surface o

196 cilia formation defects due to impairment of basal body migration and docking.

197 se in IFT mutants, which display much weaker basal body mispositioning.

198 h to monitor the movements of the kinocilium basal body (mother centriole) and its daughter centriole

199 aft that couples the torque generated by the basal body motor to the extracellular hook and filament.

200 rotubule network and mitotic spindle and, as basal bodies, nucleate cilia and flagella.

201 y 26 flagellar basal bodies and we show that basal body number is controlled by SwrA.

202 Rather, basal bodies occupy a grid-like pattern organized symmet

203 in axonemes and the unidirectional array of basal bodies of cilia on the MCCs.

204 Unexpectedly, basal bodies of injectisomes inside the bacterial cells

205 L, have aberrant localization of AHI1 at the basal bodies of PC and at cell-cell junctions, likely th

206 We confirmed that KIF11 localized to the basal bodies of primary cilia in multiple cell types, in

207 se, we found that ADAMTS9 localized near the basal bodies of primary cilia in the cytoplasm.

208 M92A colocalizes with Cby1 at the centrioles/basal bodies of primary cilia, while FAM92B is undetecta

209 We report that, in the adult retina, the basal bodies of red-, green-, and blue-sensitive cone ph

210 greater than 100 centrioles, which form the basal bodies of their motile cilia.

211 In contrast, no patterning was seen in the basal bodies of ultraviolet-sensitive cones or in rod ph

212 lls; IFT components are not recruited to the basal body of cilia.

213 We show that Pk3 is enriched at the basal body of GRP cells but is recruited by Vangl2 to an

214 dition, antibodies against TTLL5 stained the basal body of photoreceptor cells in rat and the centros

215 We show that SSX2IP localizes to the basal body of primary cilia in human and murine ciliated

216 e we describe localization of SDCCAG3 to the basal body of primary cilia.

217 tor, Cdc20, is specifically recruited to the basal body of primary cilia.

218 th and promotes CEP170's localization to the basal body of primary cilium, where CEP170 recruits micr

219 nohistology revealed KIZ localization at the basal body of the cilia in human fibroblasts, thus shedd

220 We show that ARMC9 localizes to the basal body of the cilium and is upregulated during cilio

221 the single-unit mitochondrial genome to the basal body of the flagellum and mediates the segregation

222 the linkage of the mitochondrial DNA to the basal body of the flagellum.

223 terface between the sorting platform and the basal body of the injectisome.

224 cular plate (CP), and they also encircle the basal body of the kinocilium.

225 called the BBSome which is localized at the basal body or ciliary axoneme and regulates the ciliary

226 ion to cell polarity, PCP components control basal body organization and function.

227 suggesting that Pk3 has a novel function in basal body organization.

228 hrough which the microtubule doublets of the basal body pass.

229 Basal body patterning was unaffected in the cones of the

230 ensity of multiciliated cells, the number of basal bodies per multiciliated cell, and the numbers of

231 Despite the severity of their basal body phenotype, kif3a mutant photoreceptors surviv

232 dle orientation, kinocilium positioning, and basal body planar polarity, accompanied by defects in th

233 sory microtubule structures that extend from basal bodies, plasma membrane-docked mother centrioles.

234 Basal body position is genetically determined by FlhF an

235 ng the length of the FAZ filament to control basal body positioning and life cycle transitions in T.

236 n 16 flagella, we find diverse symmetries of basal body positioning and of the flagellar apparatus th

237 ci expression that drives the second step of basal body production for multiciliation.

238 Taken together, our data indicate that basal body proteasomal regulation governs paracrine sign

239 Altogether, these results identified a basal body protein as a TbPLK substrate and its essentia

240 quitous but functionally enigmatic flagellar basal body protein FliL is involved in P. mirabilis surf

241 Here we demonstrate that the centriolar and basal body protein HYLS-1, the C. elegans orthologue of

242 Mutations in the basal body protein MKS1 account for 7% of cases of MKS.

243 The evolutionarily conserved centriole/basal body protein SAS-4 regulates centriole duplication

244 omes in neuroblasts, both requiring Bld10, a basal body protein with varied functions.

245 agellar proteins that includes the FliF/FliG basal body proteins, the flagellar type III export appar

246 hat a specialized autophagy pathway near the basal body regulates cilium assembly.

247 ver, the molecular components that stabilize basal bodies remain poorly defined.

248 d flagellum and repositioned kinetoplast and basal body, reminiscent of epimastigote-like morphology.

249 These results indicate that mammalian basal body replication and ciliogenesis occur independen

250 eukaryotes, Centrin2 (CETN2) is required for basal body replication and positioning, although its fun

251 on by the actin cytoskeleton surrounding the basal body results in active ciliary movement.

252 , including cell cycle control, flagella and basal bodies, ribosome biogenesis, and energy metabolism

253 in is secreted in response to flagellar hook-basal body secretion and can be used as a secretion sign

254 ubstrate and its essential role in promoting basal body segregation and flagellum attachment zone fil

255 st SPBB1 in procyclic trypanosomes inhibited basal body segregation, disrupted the new flagellum atta

256 n Trypanosoma brucei plays multiple roles in basal body segregation, flagellum attachment, and cytoki

257 cells display cilia with large, star-shaped basal bodies, similar to the Ecc cells described for the

258 functionally interacts with the established basal body stability components Bld10 and Poc1.

259 ass flagellar gene expression until the hook-basal body structural intermediate is completed and FlgM

260 sis and chloroplast biogenesis, flagella and basal body structure/function, cell growth and division,

261 as significantly reduced at (tam)Arl13b(-/-) basal bodies, suggesting impairment of intraflagellar tr

262 distribution between cytoplasm and flagellar basal bodies, suggesting that FlhG effects flagellar loc

263 ARL3, caused displacement of ARL2BP from the basal body, suggesting that ARL2 is vital for recruiting

264 ulin and Nedd1 no longer associated with the basal body, suggesting that Pk3 has a novel function in

265 iscovered that TRPV1 receptors also regulate basal body temperature in multiple species from mice to

266 rsed these behavioral consequences, although basal body temperature remained elevated, comparable to

267 TRPV1 KO mice have a normal basal body temperature, indicative of developmental comp

268 Basal bodies that are missing triplets likely remain com

269 other cytoskeletal components including the basal bodies that seed the flagellum and the flagellar p

270 These include the basal bodies, the bilobe, and the flagellar attachment z

271 ter FAZ, accompanied by repositioning of the basal body, the kinetoplast, Golgi, and flagellar pocket

272 s the core of the centrosome but also as the basal body, the structure that templates the formation o

273 The ciliopathy protein Poc1 stabilizes basal bodies through an unknown mechanism.

274 ntriolar protein homologs and constructs the basal body through unknown mechanisms.

275 GCP2-GCP4, and is primarily localized in the basal body throughout the cell cycle.

276 l13b(-/-) photoreceptors revealed docking of basal bodies to cell membranes, but mature transition zo

277 ization of microtubules that polymerize from basal bodies to form the axoneme, which consists of hund

278 nt fashion and are responsible for anchoring basal bodies to the actin cytoskeleton during ciliogenes

279 a tripartite attachment complex linking the basal bodies to the kinetoplast, and a segment of microt

280 show that CP110 is required for anchoring of basal bodies to the membrane during cilia formation.

281 er these proteins help connect the flagellar basal body to the peptidoglycan wall, we surveyed a set

282 d transport system that moves cargo from the basal body to the tip of flagella [1].

283 Upon cell cycle exit, centriole-to-basal body transition facilitates cilia formation.

284 le (CV) stage to promote mother centriole to basal body transition.

285 Our data indicate that Poc1 stabilizes basal body triplet microtubules through linkers between

286 ell as the removal of Cp110 from the ciliary basal body, two critical steps in initiating ciliogenesi

287 st these forces, distinct regions within the basal body ultrastructure and the microtubules themselve

288 show that CYLD localizes at centrosomes and basal bodies via interaction with the centrosomal protei

289 The asymmetric localization of basal bodies was consistent in all regions of the adult

290 e majority of cilia, and the polarity of the basal bodies was disorganized.

291 en in 7-days-postfertilization (dpf) larvae; basal bodies were randomly distributed in all the photor

292 tood ciliopathy-associated protein Jbts17 at basal bodies, where they act to recruit a specific subse

293 We also found that Dlg5 is localized at the basal body, where it associates with another pathway com

294 1 localizes to the centrosome and/or ciliary basal body, whereas defective TAPT1 mislocalizes to the

295 arge numbers of centrioles that convert into basal bodies, which are required for producing multiple

296 face, and for the rotation of the duplicated basal bodies, which positions the new flagellum so that

297 Centrioles can also be modified to form basal bodies, which template the formation of cilia and

298 -tubulin kinase-2 (TTBK2) recruitment to the basal body, which promotes the removal of microtubule ca

299 n of the ciliary basal foot, an appendage of basal bodies whose main role is to provide a point of an

300 lets likely remain competent to assemble new basal bodies with nine triplet microtubules, suggesting