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1 ctivate (i.e., induce Fos expression in) the basal forebrain.
2 nstem pedunculopontine tegmental nucleus and basal forebrain.
3 ssessment, and volumetric measurement of the basal forebrain.
4 receive extensive cholinergic input from the basal forebrain.
5 ceive dense cholinergic projections from the basal forebrain.
6 se routes depending on their location in the basal forebrain.
7 he location of the cholinergic neuron in the basal forebrain.
8 on and largely through nicotinic inputs from basal forebrain.
9 stsynaptic currents and elevated dopamine in basal forebrain.
10 e hippocampus, cerebral cortex, amygdala and basal forebrain.
11 rior neural plate that will give rise to the basal forebrain.
12 mainly produce noncholinergic neurons in the basal forebrain.
13 n the striatum and projection neurons in the basal forebrain.
14 onnectivity within the nucleus accumbens and basal forebrain.
15 ave widespread projections, including to the basal forebrain.
16 ferences in key brain regions, including the basal forebrain.
17 ith US-evoked acetylcholine release from the basal forebrain.
18 o evidence of direct synaptic input from the basal forebrain.
19 ease (PD) is degeneration of the cholinergic basal forebrain.
20 cuits, as well as on their modulation by the basal forebrain.
21 NR3C1 in the cerebral cortex and SRF in the basal forebrain.
22 t), tuberomammillary nuclei (histamine; HA), basal forebrain (acetylcholine; ACh), dorsal raphe (sero
25 This facilitation was reduced by half during basal forebrain activation due to differential response
27 Using optogenetics, it was confirmed that basal forebrain afferents mediate IPSCs on granule and d
29 ewise, stimulation of MLR projections to the basal forebrain also enhanced cortical responses, sugges
30 quires local release of acetylcholine in the basal forebrain and activation of cortically projecting,
32 e predominant VGLUT isoform expressed in the basal forebrain and brainstem, including PVH-projecting
33 ns in the brain norepinephrine system in the basal forebrain and cingulate cortex may mediate allosta
34 and rdAcbSh would be but one of many in the basal forebrain and conclude by reiterating the longstan
35 uced depletion of cholinergic neurons in the basal forebrain and decreased innervation of the hippoca
36 e examined whether longitudinal decreases in basal forebrain and entorhinal cortex grey matter volume
38 neuronal loss in the cortex, hippocampus and basal forebrain and gliosis and microgliosis in the hipp
39 between both discrete anatomic regions (e.g. basal forebrain and hippocampus) and cell types (neurona
42 ivation, that PB projections to the preoptic-basal forebrain and lateral hypothalamus, but not to the
43 stant symptoms are associated with losses of basal forebrain and striatal cholinergic neurons, sugges
47 infusions of 192 IgG-saporin (SAP) into the basal forebrain and/or 6-hydroxydopamine (6-OHDA) into t
48 vast majority of cholinergic neurons in the basal forebrain, and appears to be an important regulato
49 n to receive numerous afferents from cortex, basal forebrain, and brainstem and the SNc is widely per
50 ateral thalamus, basal ganglia, hippocampus, basal forebrain, and brainstem) was assessed across (1)
51 ulate deep in the brain, even as deep as the basal forebrain, and demonstrate that alteration of acti
52 ity locally within the nucleus accumbens and basal forebrain, and reversed the gamma and high-frequen
53 eased size in FXS, such as the orbital gyri, basal forebrain, and thalamus, suggests delayed or other
55 number of structures within the rostromedial basal forebrain are critical for affiliative behaviors a
57 ls of the alpha1- adrenergic receptor in the basal forebrain as well as alpha2- and beta1-adrenergic
58 ally connected with the olfactory system and basal forebrain, as well as with the chemosensory and ba
59 ide variety of sites in the cerebral cortex, basal forebrain, bed nucleus of the stria terminalis, am
60 ergic inputs to the auditory cortex from the basal forebrain (BF) are important to auditory processin
62 lysis, we report that optical stimulation of basal forebrain (BF) cholinergic neurons in mice increas
67 aneously with electrical stimulations of the basal forebrain (BF) in urethane-anesthetized rats, we i
68 optogenetic activation of PV+ neurons in the basal forebrain (BF) increases amyloid burden, rather th
69 Pharmacological studies had implicated the basal forebrain (BF) inducible nitric oxide (NO) synthas
74 tant, low wattage optogenetic stimulation of basal forebrain (BF) neurons containing the calcium-bind
76 vivo whether selective activation of either basal forebrain (BF) or cholinergic innervation is suffi
80 ding the control of sleep-wake states by the basal forebrain (BF) poses a challenge due to the interm
82 inic receptors by cholinergic axons from the basal forebrain (BF) significantly impacts cortical func
84 y a functional GABAergic projection from the basal forebrain (BF) to the lateral habenula (lHb) that
85 ctional connections between the amygdala and basal forebrain (BF), a brain area long implicated in at
86 neurons excite wake-promoting neurons in the basal forebrain (BF), and a reciprocal projection from t
87 al correlate of motivational salience in the basal forebrain (BF), defined independently of RT, is co
88 ctures including striatum, substantia nigra, basal forebrain (BF), pedunculopontine nucleus (PPN), an
93 nosine-sensitive biosensors in slices of the basal forebrain (BFB) to study both depolarization-evoke
94 in contrast, do not receive inputs from the basal forebrain but do receive inhibition from other PG
97 vivo inhibition of GABAergic neurons in the basal forebrain by targeted expression of designer recep
99 nimal models, development of the cholinergic basal forebrain (cBF) is selectively vulnerable to adver
100 including early degeneration of cholinergic basal forebrain (CBF) neurons and impairments in functio
101 hin receptor (p75(NTR)) in adult cholinergic basal forebrain (cBF) neurons is unclear due to conflict
104 eoptic area, and diagonal band nuclei of the basal forebrain; central, medial, cortical, and basal nu
107 addition to innervating the cerebral cortex, basal forebrain cholinergic (BFc) neurons send a dense p
108 ew discusses recent advances in the roles of basal forebrain cholinergic and noncholinergic neurons i
110 gic medications and prior dementia, in which basal forebrain cholinergic degeneration is a prominent
111 effects of a GPR30 agonist and antagonist on basal forebrain cholinergic function and cognitive perfo
114 neuritic dystrophy and complete reversal of basal forebrain cholinergic neurite degeneration relativ
116 propose that differential recruitment of two basal forebrain cholinergic neuron types generates behav
117 acquisition of the cholinergic phenotype in basal forebrain cholinergic neurons (BFCN) during develo
118 etylcholine (ACh) synthesis and release from basal forebrain cholinergic neurons (BFCN) innervating t
123 complexity underlying the selective loss of basal forebrain cholinergic neurons (BFCNs), a well-reco
124 ere investigated in PC12 cells, cultured rat basal forebrain cholinergic neurons (BFCNs), and BFCNs f
126 immunotoxic lesion that destroyed 40-50% of basal forebrain cholinergic neurons and later, after ext
127 t there is a topographic mapping between the basal forebrain cholinergic neurons and their axonal pro
128 unctional, heteromeric alpha7beta2-nAChRs on basal forebrain cholinergic neurons and their high sensi
129 issue of Neuron, Guo et al. (2019) implicate basal forebrain cholinergic neurons as providing a link
131 he cortex through optogenetic stimulation of basal forebrain cholinergic neurons decreases the depend
132 umulation is a relatively selective trait of basal forebrain cholinergic neurons early in adult life,
133 Defining the full morphologies of individual basal forebrain cholinergic neurons has, until now, been
134 ular mechanisms are not well understood, the basal forebrain cholinergic neurons have been implicated
135 hin receptor expressed almost exclusively in basal forebrain cholinergic neurons in adult brain.
136 otential contributors to the degeneration of basal forebrain cholinergic neurons in Alzheimer's disea
137 These results underscore the causal role of basal forebrain cholinergic neurons in fast, bidirection
138 selective vulnerability of the magnocellular basal forebrain cholinergic neurons in neurodegenerative
139 fibrillogenic 42-amino acid isoform, within basal forebrain cholinergic neurons in normal young, nor
140 esponsible for the phenotypic maintenance of basal forebrain cholinergic neurons in the mature and fu
142 ation sounds likely results in activation of basal forebrain cholinergic neurons increasing release o
144 pressed channelrhodopsin or halorhodopsin in basal forebrain cholinergic neurons of mice with optic f
148 we found that dynorphin-A directly inhibits basal forebrain cholinergic neurons via kappa-opioid rec
149 long been known that orexin-A and -B excite basal forebrain cholinergic neurons, but orexin-producin
151 in mediating direct effects of estradiol on basal forebrain cholinergic neurons, with corresponding
155 image warping and a cytoarchitectonic map of basal forebrain cholinergic nuclei to a large cross-sect
156 ur findings suggest that degeneration of the basal forebrain cholinergic projection system is a robus
160 e results are consistent with a role for the basal forebrain cholinergic system in dynamically regula
161 -p75-sap) to induce selective lesions of the basal forebrain cholinergic system in mice, mimicking ea
164 b of the diagonal band of Broca (HDB) of the basal forebrain complex, which are areas highly implicat
166 al fibrillary amyloid-beta pathology and the basal forebrain connectivity at rest in cognitively inta
167 egion connecting the olfactory bulb with the basal forebrain, contains several neural areas that have
168 ured along a rostral to caudal extent in the basal forebrain correlated with a ventral to dorsal and
169 ral systems related to sleep and wake in the basal forebrain, diencephalon, midbrain, and pons of the
170 trol and regulation of sleep and wake in the basal forebrain, diencephalon, midbrain, and pons of the
171 urons in the rostral and caudal parts of the basal forebrain differentially innervate the superficial
173 s) were found predominantly in the posterior basal forebrain, displayed strong theta rhythmicity and
175 plasticity, acetylcholine released from the basal forebrain during periods of heightened arousal dir
176 nd delta activity by adenosine infusion into basal forebrain during the normally active dark period a
177 stinct in vivo association between posterior basal forebrain dynamics and global fibrillary amyloid-b
180 trast, type 1 PG cells are not innervated by basal forebrain fibres but do interact with other PG cel
181 We then retrogradely labeled inputs to the basal forebrain from the upper brainstem, and found a su
182 at axonal projections emanating from diverse basal forebrain GABAergic neurons densely project in all
184 e developed cholinergic neuronal loss in the basal forebrain, GABAergic neuronal loss in the cortex,
185 relationship between realignment to PHC and basal forebrain gray matter volume despite this region d
187 e lines to target specific cell types in the basal forebrain have led to a renaissance in this field
188 basalis of Meynert (NbM), a subregion of the basal forebrain heavily populated by cortically projecti
189 rmore, disruption of orexin signaling in the basal forebrain impairs the cholinergic response to an a
191 dings reveal a novel role for the excitatory basal forebrain in regulating appetite suppression throu
192 nit of the AChR (Chrna2) is expressed in the basal forebrain, in the septum, and in some amygdalar nu
194 we found that electrical stimulation of the basal forebrain increased cortical choline transporter (
195 inergic [acetylcholine (ACh)] axons from the basal forebrain innervate olfactory bulb glomeruli, the
196 demonstrates that optogenetic activation of basal forebrain input is sufficient to train reward timi
197 PG cells receive robust and target-specific basal forebrain inputs but have little local interaction
203 ocrine cells in the rostral hypothalamus and basal forebrain is the key regulator of vertebrate repro
204 tructures critical to arousal, including the basal forebrain, lateral hypothalamus, midline thalamus,
206 rtebrate basal ganglia derive from embryonic basal forebrain lineages that are specified by an evolut
209 ific atrophy in the midbrain, basal ganglia, basal forebrain, medial temporal lobe, and discrete cort
211 ntral cholinergic input originating from the basal forebrain might remove a key check on microglial i
212 that cholinergic input originating from the basal forebrain might similarly regulate inflammatory im
213 mework for integration of information within basal forebrain networks and for the modulation of corti
214 arising from cortical, extended amygdala and basal forebrain networks to ultimately generate a highly
217 work demonstrates assembly formation in rat basal forebrain neuronal populations during a selective
218 pyramidal neurons, interneurons, cholinergic basal forebrain neurons and striatal neurons, correspond
220 MENT When attention is required, cholinergic basal forebrain neurons may trigger increased release of
221 of conditioning, bulk imaging of cholinergic basal forebrain neurons revealed sustained sound-evoked
222 of conditioning, optogenetically identified basal forebrain neurons that encode the aversive US scal
223 ence demonstrated that virtually all ChAT-ir basal forebrain neurons were also p75(NTR) -positive.
224 nced by temporal coordination among coactive basal forebrain neurons, or the emergence of "cell assem
225 nt modulation of excitability in cholinergic basal forebrain neurons, our findings implicate PrP(C) r
226 pocampal granule cells (GCs) and cholinergic basal forebrain neurons, that the correlation of ionic c
228 e nucleus basalis magnocellularis (NBM), the basal forebrain nuclei that provide the majority of neoc
229 corpus callosum, internal capsule, thalamus, basal forebrain, occipital, parietal and temporal lobes,
230 r of endo-lysosomal membrane rupture) in the basal forebrain of DLBD, but not in age-matched controls
231 demonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cort
232 tubercle, a trilaminar structure within the basal forebrain, of anesthetized mice revealed that olfa
238 GABA/PV inhibitory input to TRN arising from basal forebrain parvalbumin neurons (BF-PV) and; (ii) lo
240 mulation of the substantia innominata of the basal forebrain phase shifts the circadian clock in a ma
242 report that cholinergic neurons of the mouse basal forebrain potently influence food intake and body
243 l and ventral torus semicircularis); and (4) basal forebrain, preoptic area, and hypothalamic nuclei.
246 y, and freezing behavior, while thalamic and basal forebrain projections generate freezing behavior a
251 ble brain activity patterns in the projected basal forebrain regions upon MgRA-driven optogenetic sti
253 , we found that cholinergic projections from basal forebrain regulate OB output by increasing the spi
254 cate neurotransmitter co-transmission in the basal forebrain regulation of this inhibitory olfactory
255 E genotype impacted the associations between basal forebrain RSFC and the global amyloid deposition (
256 SUVR values correlated with lower posterior basal forebrain RSFC in the hippocampus and the thalamus
259 onnectivity (RSFC) of anterior and posterior basal forebrain seeds was investigated, as well as PET-m
260 in the cerebellum, hippocampus, thalamus and basal forebrain seem to constitute a separate phenomenon
261 dopsin to stimulate GABAergic axons from the basal forebrain selectively and show that this stimulati
262 he firing rates, but has no effect on either basal forebrain serotonin levels or conflict-anxiety mea
263 n of the subgenual anterior cingulate cortex/basal forebrain (sgACC) drives learning only when we are
264 ry cues to govern feeding behavior, and that basal forebrain signaling, mediated through projections
265 uditory cortex effects and regions including basal forebrain sites along acetylcholinergic and dopami
266 of the cerebellum, hippocampus, thalamus and basal forebrain still remained associated with delirium
268 ility to elevate extracellular ACh following basal forebrain stimulation, in parallel with a diminish
269 ites and axons of cholinergic neurons in the basal forebrain, striatum and pedunculopontine nuclei, i
270 ound in discrete neuronal systems, including basal forebrain structures, anterior nuclear group of th
271 hat a phylogenetically conserved ensemble of basal forebrain structures, especially the septohypothal
272 enular neurons primarily received input from basal forebrain structures, the bed nucleus of stria ter
273 a prefrontal cortex, that reach the specific basal forebrain subgroups from which they receive affere
277 red an excitatory neuronal population in the basal forebrain that is activated by food-odor related s
278 emely dense cholinergic innervation from the basal forebrain that is critical for memory consolidatio
279 These findings identify a plasticity in the basal forebrain that supports learned associations betwe
280 s a significant source of projections to the basal forebrain, the phenotype(s) of these inputs and th
281 ally projecting neurons of the magnocellular basal forebrain; thus, there is a circuit substrate thro
283 leus and precoeruleus region, relayed by the basal forebrain to the cerebral cortex, may be critical
284 s served by cholinergic projections from the basal forebrain to the frontal cortex and supported by v
285 we examined how cholinergic projections from basal forebrain to the olfactory bulb (OB) modulate outp
286 inputs, like the cholinergic inputs from the basal forebrain, to determine threshold set points for f
287 rain areas-the anterior cingulate cortex and basal forebrain-tracks these contextual factors and medi
288 to hypothesize that the rdAcbSh represents a basal forebrain transition area, in the sense that it is
289 ity of cortex with both central thalamus and basal forebrain underlies decreasing levels of conscious
291 ognitively normal to AD, we demonstrate that basal forebrain volume predicts longitudinal entorhinal
294 he CNS, indexed by longitudinal decreases of basal forebrain volume, interacts with multiple biomarke
295 and basal ganglia nuclei, respectively; the basal forebrain was atrophied in proportion to patients'
296 umber and size of cholinergic neurons in the basal forebrain was examined in surgically menopausal yo
297 cortical afferents from the thalamus or the basal forebrain were more important in maintaining arous
298 are distributed in cholinergic parts of the basal forebrain, where application of orexin peptides in
299 genetic activation of cholinergic neurons in basal forebrain, which led to a mixture of mitral/tufted
300 tion of the neuroendocrine GnRH cells to the basal forebrain, which results in reduced fertility in a